Cinteny is a flexible and efficient tool for analysis of synteny and
... for multiple genomes. In addition to annotated genomes, which are available for interactive browsing and assessment of synteny and evolutionary distances in terms of orthologous genes, Cinteny can be used with user provided discrete objects, such as sequence tags or other evolutionarily conserved ma ...
... for multiple genomes. In addition to annotated genomes, which are available for interactive browsing and assessment of synteny and evolutionary distances in terms of orthologous genes, Cinteny can be used with user provided discrete objects, such as sequence tags or other evolutionarily conserved ma ...
ces-1 ces-2 - Development - The Company of Biologists
... that ces(nl952) is not located between lin-10 and unc-29, and survives, whereas the sister of the left-side cell MCL normally dies (Sulston et al. 1983). At 20°C the NSM sisters again all so cannot be an allele of ces-1, and suggest that ces(n!952) died, but in 19/205 animals an extra cell was prese ...
... that ces(nl952) is not located between lin-10 and unc-29, and survives, whereas the sister of the left-side cell MCL normally dies (Sulston et al. 1983). At 20°C the NSM sisters again all so cannot be an allele of ces-1, and suggest that ces(n!952) died, but in 19/205 animals an extra cell was prese ...
Gene Section USP1 (ubiquitin specific peptidase 1) Atlas of Genetics and Cytogenetics
... repress USP1 transcription by a mechanism that involves p21 cyclin dependent kinase inhibitor (Rego et al., 2012). Transcription produces 10 different mRNAs, 6 alternatively spliced variants and 4 unspliced forms. There are 5 probable alternative promotors, 2 non overlapping alternative last exons a ...
... repress USP1 transcription by a mechanism that involves p21 cyclin dependent kinase inhibitor (Rego et al., 2012). Transcription produces 10 different mRNAs, 6 alternatively spliced variants and 4 unspliced forms. There are 5 probable alternative promotors, 2 non overlapping alternative last exons a ...
RET Proto-Oncogene
... MEN 2B patients as young as 3 years (30). Therefore, identification of the specific RET mutation in at-risk patients allows for effective clinical screening and optimal clinical and surgical management (31). RET Proto-Oncogene Biology and physiology The RET gene is located on chromosome 10q11.2 near ...
... MEN 2B patients as young as 3 years (30). Therefore, identification of the specific RET mutation in at-risk patients allows for effective clinical screening and optimal clinical and surgical management (31). RET Proto-Oncogene Biology and physiology The RET gene is located on chromosome 10q11.2 near ...
Sporadic Hypertrophic Cardiomyopathy Due to De Novo Myosin
... rounds of PCR amplification. Amplified sequences were hybridized to RNA probes transcribed from a normal gene and RNase A protection assays performed as described previously (20, 21 ). The entire # cardiac MHC coding sequence was examined in all probands, using both sense and antisense riboprobes. A ...
... rounds of PCR amplification. Amplified sequences were hybridized to RNA probes transcribed from a normal gene and RNase A protection assays performed as described previously (20, 21 ). The entire # cardiac MHC coding sequence was examined in all probands, using both sense and antisense riboprobes. A ...
Analysis of Biological Networks: Genetic Interaction Networks
... Synthetic-interaction: Two genes a,b have a synthetic interaction if mutations in a,b separately do not have an effect on the wild-type phenotype, but the combined mutation has an effect. A synthetic interaction usually describe two genes on parallel pathways that have the same function. When both ...
... Synthetic-interaction: Two genes a,b have a synthetic interaction if mutations in a,b separately do not have an effect on the wild-type phenotype, but the combined mutation has an effect. A synthetic interaction usually describe two genes on parallel pathways that have the same function. When both ...
DNA methylation profiling identifies epigenetic dysregulation in
... in CGI shores (Doi et al, 2009; Irizarry et al, 2009). We used bioinformatic tools to determine the distance of differentially methylated CpGs to the nearest CGI. Utilising CGI prediction (Bock et al, 2007), we found that B50% of the differentially methylated CpG sites are located 42 kb from the nea ...
... in CGI shores (Doi et al, 2009; Irizarry et al, 2009). We used bioinformatic tools to determine the distance of differentially methylated CpGs to the nearest CGI. Utilising CGI prediction (Bock et al, 2007), we found that B50% of the differentially methylated CpG sites are located 42 kb from the nea ...
1 Meiotic sex chromosome inactivation is disrupted in
... a musculusPWK X chromosome are sterile or nearly so whereas males with a domesticusLEWES X are normal (Good et al. 2008a; 2008b). Strikingly, a large number of genes on the musculusPWK X chromosome are over-expressed in the testes of sterile F1 males (Good et al. 2010). However, because whole testes ...
... a musculusPWK X chromosome are sterile or nearly so whereas males with a domesticusLEWES X are normal (Good et al. 2008a; 2008b). Strikingly, a large number of genes on the musculusPWK X chromosome are over-expressed in the testes of sterile F1 males (Good et al. 2010). However, because whole testes ...
599 KB - CSIRO Publishing
... The X chromosome is a relatively normal, middle-sized chromosome with a complex g-banding pattern. Sex-linkage studies showed that many genes were located on the X; these revealed themselves because boys, having only a single copy, expressed mutations such as colour blindness and haemophilia that we ...
... The X chromosome is a relatively normal, middle-sized chromosome with a complex g-banding pattern. Sex-linkage studies showed that many genes were located on the X; these revealed themselves because boys, having only a single copy, expressed mutations such as colour blindness and haemophilia that we ...
Combined expression patterns of QTL
... For instance, catecholamines up (catsup) is associated with naturally occurring variation in multiple traits such as locomotor behavior and longevity (Carbone et al., 2006), Additionally, we also tested two genes that are either up-regulated (CG10383) and down-regulated (cyp6a13) early in the heat-s ...
... For instance, catecholamines up (catsup) is associated with naturally occurring variation in multiple traits such as locomotor behavior and longevity (Carbone et al., 2006), Additionally, we also tested two genes that are either up-regulated (CG10383) and down-regulated (cyp6a13) early in the heat-s ...
Manipulating Yeast Genome Using Plasmid Vectors. In: Gene Expression Technology.
... available, the most common being yeast genes that complement a specific auxotrophy. For example, the LEU2 gene encodes fl-isopropylmalate dehydrogenase7 and complements the leucine auxotrophy of a leu2- mutant. Of equal importance to the selectable marker is the cognate chromosomal mutation that cau ...
... available, the most common being yeast genes that complement a specific auxotrophy. For example, the LEU2 gene encodes fl-isopropylmalate dehydrogenase7 and complements the leucine auxotrophy of a leu2- mutant. Of equal importance to the selectable marker is the cognate chromosomal mutation that cau ...
Inheritance of Red Green - Department Of Biological Sciences
... affect a given cone type. However, a true complementation test (requiring expression of both alleles in the same cell) is not possible because each cell in a female expresses only one of her two X chromosomes (6). The evidence for allelism rests instead on the lack of recombination between two defec ...
... affect a given cone type. However, a true complementation test (requiring expression of both alleles in the same cell) is not possible because each cell in a female expresses only one of her two X chromosomes (6). The evidence for allelism rests instead on the lack of recombination between two defec ...
Eukaryotic Genes and Genomes II
... activating Gal1 transcription. However, it now seems that one extra protein involved in this chain of events. The Gal3 protein turns out to be directly bound by galactose (or a derivative); this allows Gal3 to move from the cytoplasm into the nucleus, the galactose/Gal3 moiety binds to Gal80 to faci ...
... activating Gal1 transcription. However, it now seems that one extra protein involved in this chain of events. The Gal3 protein turns out to be directly bound by galactose (or a derivative); this allows Gal3 to move from the cytoplasm into the nucleus, the galactose/Gal3 moiety binds to Gal80 to faci ...
Screening for Colorectal Cancer - US Preventive Services Task Force
... For the operator-dependent tests—flexible sigmoidoscopy, CT colonography, and colonoscopy— better operator training and more experience have a high likelihood of improving sensitivity. Approaches related to certification, such as quality standards and possibly minimum volume requirements, could be u ...
... For the operator-dependent tests—flexible sigmoidoscopy, CT colonography, and colonoscopy— better operator training and more experience have a high likelihood of improving sensitivity. Approaches related to certification, such as quality standards and possibly minimum volume requirements, could be u ...
Prevention of DNA Rereplication Through a Meiotic Recombination
... In the budding yeast Saccharomyces cerevisiae, unnatural stabilization of the cyclin-dependent kinase inhibitor Sic1 during meiosis can trigger extra rounds of DNA replication. When programmed DNA double-strand breaks are generated but not repaired due to absence of DMC1, a pathway involving the ...
... In the budding yeast Saccharomyces cerevisiae, unnatural stabilization of the cyclin-dependent kinase inhibitor Sic1 during meiosis can trigger extra rounds of DNA replication. When programmed DNA double-strand breaks are generated but not repaired due to absence of DMC1, a pathway involving the ...
Supplementary Information (doc 1628K)
... primeview assay for target synthesis and labeling. Samples were hybridized to the Genechip primeview human gene expression array and those demonstrating a cutoff greater or less than 1.5-fold difference from the parental cell line used for further analysis. The quality of the total RNA was confirmed ...
... primeview assay for target synthesis and labeling. Samples were hybridized to the Genechip primeview human gene expression array and those demonstrating a cutoff greater or less than 1.5-fold difference from the parental cell line used for further analysis. The quality of the total RNA was confirmed ...
Dia 1 - BeSHG
... Geert Mortier, MD, PhD – Center for Medical Genetics – Ghent University Hospital ...
... Geert Mortier, MD, PhD – Center for Medical Genetics – Ghent University Hospital ...
CURRICULUM VITAE Name: Antonella Spinazzola Nationality
... The study showed that MNGIE results from a deficiency of thymidine phosphorylase, an enzyme that catalyzes the reversible breakdown of thymidine to thymine plus deoxyribose-1-phosphate. The report underlies the importance of understanding the nature and sources of mitochondrial DNA precursor pools s ...
... The study showed that MNGIE results from a deficiency of thymidine phosphorylase, an enzyme that catalyzes the reversible breakdown of thymidine to thymine plus deoxyribose-1-phosphate. The report underlies the importance of understanding the nature and sources of mitochondrial DNA precursor pools s ...
Article The Effect of Selection Environment on the
... the level of fitness, lower at the level of phenotypes, lower still at the level of the genes themselves, and lowest at the level of individual mutations or nucleotides. A second step involves making more quantitative predictions about the factors governing the probability of parallel evolution. Gen ...
... the level of fitness, lower at the level of phenotypes, lower still at the level of the genes themselves, and lowest at the level of individual mutations or nucleotides. A second step involves making more quantitative predictions about the factors governing the probability of parallel evolution. Gen ...
Bacterial genospecies that are not ecologically
... [4– 6]. Alternatively, these clusters might reflect the underlying ecological niches provided by the environment, and this idea has been developed into the ecotype model, in which genotypic clusters map onto ecological niches and periodic selective sweeps purge genetic variation within each niche se ...
... [4– 6]. Alternatively, these clusters might reflect the underlying ecological niches provided by the environment, and this idea has been developed into the ecotype model, in which genotypic clusters map onto ecological niches and periodic selective sweeps purge genetic variation within each niche se ...
Ph.D. THESIS Analysis of the chromatin structure of MDR1 gene in
... ADA2B and GCN5 specific siRNA treatment resulted in no change of MDR1 expression in MCF7-KCR cells. However, simultaneous knockdown of PCAF and GCN5 resulted in a reduction of MDR1 mRNA level in the drug resistant cells. This finding suggests that these HATs substitute each other in maintaining the ...
... ADA2B and GCN5 specific siRNA treatment resulted in no change of MDR1 expression in MCF7-KCR cells. However, simultaneous knockdown of PCAF and GCN5 resulted in a reduction of MDR1 mRNA level in the drug resistant cells. This finding suggests that these HATs substitute each other in maintaining the ...
Differential Expression Analysis
... Most Expression Analysis is Comparative Frequently the important investigations with microarrays are to identify the genes whose expression levels change between two sample groups. To understand the effect of a drug we may ask which genes are up-regulated (increased in expression) or down-regulated ...
... Most Expression Analysis is Comparative Frequently the important investigations with microarrays are to identify the genes whose expression levels change between two sample groups. To understand the effect of a drug we may ask which genes are up-regulated (increased in expression) or down-regulated ...
Mouse Genome Informatics (MGI)
... We have seen that MGI makes it easy to find genotypes associated with particular phenotypes but the web forms currently do not allow you to export genotype details in tab-delimited formats. If you used the Mammalian Phenotype (MP) Browser to find genotypes associated with emphysema (MP:0001958) and ...
... We have seen that MGI makes it easy to find genotypes associated with particular phenotypes but the web forms currently do not allow you to export genotype details in tab-delimited formats. If you used the Mammalian Phenotype (MP) Browser to find genotypes associated with emphysema (MP:0001958) and ...
The making of the Fittest: Natural Selection and Adaptation
... armor or none at all. In addition, freshwater stickleback fish have evolved to be slightly smaller and more streamlined than their sea-run ancestors, allowing them to swim faster and dart more easily into the many hiding places present in lakes. They also have modified gill function and an altered e ...
... armor or none at all. In addition, freshwater stickleback fish have evolved to be slightly smaller and more streamlined than their sea-run ancestors, allowing them to swim faster and dart more easily into the many hiding places present in lakes. They also have modified gill function and an altered e ...
Oncogenomics
Oncogenomics is a relatively new sub-field of genomics that applies high throughput technologies to characterize genes associated with cancer. Oncogenomics is synonymous with ""cancer genomics"". Cancer is a genetic disease caused by accumulation of mutations to DNA leading to unrestrained cell proliferation and neoplasm formation. The goal of oncogenomics is to identify new oncogenes or tumor suppressor genes that may provide new insights into cancer diagnosis, predicting clinical outcome of cancers, and new targets for cancer therapies. The success of targeted cancer therapies such as Gleevec, Herceptin, and Avastin raised the hope for oncogenomics to elucidate new targets for cancer treatment.Besides understanding the underlying genetic mechanisms that initiates or drives cancer progression, one of the main goals of oncogenomics is to allow for the development of personalized cancer treatment. Cancer develops due to an accumulation of mutations in DNA. These mutations accumulate randomly, and thus, different DNA mutations and mutation combinations exist between different individuals with the same type of cancer. Thus, identifying and targeting specific mutations which have occurred in an individual patient may lead to increased efficacy of cancer therapy.The completion of the Human Genome Project has greatly facilitated the field of oncogenomics and has increased the abilities of researchers to find cancer causing genes. In addition, the sequencing technologies now available for sequence generation and data analysis have been applied to the study of oncogenomics. With the amount of research conducted on cancer genomes and the accumulation of databases documenting the mutational changes, it has been predicted that the most important cancer-causing mutations, rearrangements, and altered expression levels will be cataloged and well characterized within the next decade.Cancer research may look either on the genomic level at DNA mutations, the epigenetic level at methylation or histone modification changes, the transcription level at altered levels of gene expression, or the protein level at altered levels of protein abundance and function in cancer cells. Oncogenomics focuses on the genomic, epigenomic, and transcript level alterations in cancer.