x-linked female-sterile loci in drosophzla melanogaster
... per locus from the two independent screens are similar (Figure 1). Using the data from these mutagenesis screens, the number of loci on the X chromosome has been estimated to be about 100 (KING and MOHLER 1975) (however, see DISCUSSION for a modification of this estimate). If this estimate reflects ...
... per locus from the two independent screens are similar (Figure 1). Using the data from these mutagenesis screens, the number of loci on the X chromosome has been estimated to be about 100 (KING and MOHLER 1975) (however, see DISCUSSION for a modification of this estimate). If this estimate reflects ...
Transcription factories are nuclear subcompartments that remain in
... profile ACH conformation is largely maintained in fetal liver cells, showing significantly higher cross-linking frequency across the locus when compared with the brain (P < 0.001). However, a significant disruption in the interactions of Hbb-b1 with HS2 and HS3 of the LCR was observed in heat-shock ...
... profile ACH conformation is largely maintained in fetal liver cells, showing significantly higher cross-linking frequency across the locus when compared with the brain (P < 0.001). However, a significant disruption in the interactions of Hbb-b1 with HS2 and HS3 of the LCR was observed in heat-shock ...
Bayesian Networks Classifiers for Gene-Expression Data
... Also dealing with the continuous nature of the gene expression data, Cano et al. [25] use a Gaussian NB. They perform a two steps gene selection: first, a filter selection and, second, using a Selective NB. After that, they learn a Bayesian Network using the selected genes. In [26] the same authors ...
... Also dealing with the continuous nature of the gene expression data, Cano et al. [25] use a Gaussian NB. They perform a two steps gene selection: first, a filter selection and, second, using a Selective NB. After that, they learn a Bayesian Network using the selected genes. In [26] the same authors ...
Phenotypic overlap in the contribution of individual genes to CNV
... for a phenogram by performing the entire analysis 5,000 times with the same CNV phenotypes, but using randomized sets of genes. Our results are highly statistically significant; compared to the analysed 27 CNV diseases, a total of ~480 of their respective phenotypic features could be explained, wher ...
... for a phenogram by performing the entire analysis 5,000 times with the same CNV phenotypes, but using randomized sets of genes. Our results are highly statistically significant; compared to the analysed 27 CNV diseases, a total of ~480 of their respective phenotypic features could be explained, wher ...
7.1 Introduction
... the four meiotic spores out of the ascus). He also demonstrated Mendelian segregation in yeast, established that both haploid and diploid states of the organisms exist, and established that there are two stable mating types. Another important figure in early yeast genetics, Carl C. Lindegren, publis ...
... the four meiotic spores out of the ascus). He also demonstrated Mendelian segregation in yeast, established that both haploid and diploid states of the organisms exist, and established that there are two stable mating types. Another important figure in early yeast genetics, Carl C. Lindegren, publis ...
Genomic approaches for the understanding of aging
... The development of DNA microarray introduced the concept of genomics in biology and presented a valuable and robust tool for the global measurement of gene expression. It is especially useful for the study of complex biological pathways such as aging. In addition, genomic sequence analysis of variou ...
... The development of DNA microarray introduced the concept of genomics in biology and presented a valuable and robust tool for the global measurement of gene expression. It is especially useful for the study of complex biological pathways such as aging. In addition, genomic sequence analysis of variou ...
A Dnmt2-like protein mediates DNA methylation in
... were spotted onto a membrane and stained for 5methylcytosine and DNA, respectively. This revealed a clearly differential staining pattern for 5-methylcytosine, while the DNA staining pattern was equal for all samples (Fig. 1E). As an additional control for the specificity of our immunostaining proto ...
... were spotted onto a membrane and stained for 5methylcytosine and DNA, respectively. This revealed a clearly differential staining pattern for 5-methylcytosine, while the DNA staining pattern was equal for all samples (Fig. 1E). As an additional control for the specificity of our immunostaining proto ...
Towards identifying the full set of genes involved in post
... PPD symptoms involve reactive oxygen species (ROS) at certain steps; while these overall pathways are likely to be complex the signalling components identified here, together with those that we have already characterised promise to add to our understanding of this aspect of the response. Two other s ...
... PPD symptoms involve reactive oxygen species (ROS) at certain steps; while these overall pathways are likely to be complex the signalling components identified here, together with those that we have already characterised promise to add to our understanding of this aspect of the response. Two other s ...
"Vectors in Gene Therapy". In: An Introduction to Molecular Medicine
... VIRAL VECTORS USED FOR GENE THERAPY Based on the virus life cycle, infectious virions are very efficient at transferring genetic information. Most gene therapy experiments have used viral vectors comprising elements of a virus that result in a replication-incompetent virus. In initial studies, immed ...
... VIRAL VECTORS USED FOR GENE THERAPY Based on the virus life cycle, infectious virions are very efficient at transferring genetic information. Most gene therapy experiments have used viral vectors comprising elements of a virus that result in a replication-incompetent virus. In initial studies, immed ...
A natural chimeric yeast containing genetic material from three species
... were also found to be 228 bp long (Fig. 2). The amino acid sequences were identical in all cases, but several silent substitutions were observed. The A TP9 gene sequences of Saccharomyces sp. CID 1 and Saccharomyces sp. I F 0 1802 were identical. Also, the ATP9 sequences from S. pastorianus and S. b ...
... were also found to be 228 bp long (Fig. 2). The amino acid sequences were identical in all cases, but several silent substitutions were observed. The A TP9 gene sequences of Saccharomyces sp. CID 1 and Saccharomyces sp. I F 0 1802 were identical. Also, the ATP9 sequences from S. pastorianus and S. b ...
Mapping strategies for sequence reads (with focus on RNA-seq)
... 0 CPU hours, which is ∼180 000 reads per CPU hour. cle, we describe TopHat, a software package that ce sites ab initio by large-scale mapping of RNA-Seq maps reads to splice sites in a mammalian genome at million reads per CPU hour. Rather than filtering out of splice junctions ine sites with 99% a ...
... 0 CPU hours, which is ∼180 000 reads per CPU hour. cle, we describe TopHat, a software package that ce sites ab initio by large-scale mapping of RNA-Seq maps reads to splice sites in a mammalian genome at million reads per CPU hour. Rather than filtering out of splice junctions ine sites with 99% a ...
MayerFrankiPoster
... the photosynthetic process requires phycobilisome (PBS) light-harvesting protein complexes that efficiently capture solar energy (Figure 2). Cell density and bioproduct formation in cyanobacterial cultures is limited by an ‘overshadowing’ effect. Cells growing at the surface of a culture capture mos ...
... the photosynthetic process requires phycobilisome (PBS) light-harvesting protein complexes that efficiently capture solar energy (Figure 2). Cell density and bioproduct formation in cyanobacterial cultures is limited by an ‘overshadowing’ effect. Cells growing at the surface of a culture capture mos ...
Lessons in rheumatology from extreme phenotypes and subtle
... CD247 ZEB1 SH2B3 BATF NFATC2IP IKZF3 UBASH3A UBE2L3 ANKRD55 SPRED2 C5orf30 RBPJ CCR6 IRF5 PXK ...
... CD247 ZEB1 SH2B3 BATF NFATC2IP IKZF3 UBASH3A UBE2L3 ANKRD55 SPRED2 C5orf30 RBPJ CCR6 IRF5 PXK ...
Genetics Part I
... It is important to note that it is not possible to directly observe an individual's genotype. We can only observe the phenotype and infer the genotype. This learning activity is opposite to real life. However, we do it this way to learn how to decode genotypes. If we treat each allele independently, ...
... It is important to note that it is not possible to directly observe an individual's genotype. We can only observe the phenotype and infer the genotype. This learning activity is opposite to real life. However, we do it this way to learn how to decode genotypes. If we treat each allele independently, ...
Preferential X-chromosome inactivation, DNA
... ing. Silva and White (1988) demonstrated that in the human a number of loci, distinguished by differences in size of tandem repeat sequences (VNTR), may be differently methylated. The methylation pattern specific for a particular allele is heritable through several generations. The allele appears to ...
... ing. Silva and White (1988) demonstrated that in the human a number of loci, distinguished by differences in size of tandem repeat sequences (VNTR), may be differently methylated. The methylation pattern specific for a particular allele is heritable through several generations. The allele appears to ...
Coc - ARVO Journals
... development of neural retina, lens and cornea is severely disturbed.28 Because of the more severe phenotype, the Hesl gene does not seem to be a suitable candidate for the Coc mutation. The alkaptonuria (aim) mutation is the mouse genetic model for human alkaptonuria, an autosomal recessive metaboli ...
... development of neural retina, lens and cornea is severely disturbed.28 Because of the more severe phenotype, the Hesl gene does not seem to be a suitable candidate for the Coc mutation. The alkaptonuria (aim) mutation is the mouse genetic model for human alkaptonuria, an autosomal recessive metaboli ...
Leukaemia Section t(1;14)(q21;q32) MUC1/IGH Atlas of Genetics and Cytogenetics in Oncology and Haematology
... Genes involved and proteins ...
... Genes involved and proteins ...
Cell transformation by animal papillomaviruses
... It is clear that, despite their similar genetic plan and overall homology, papillomaviruses use different strategies to achieve their common goals. Continuous viral gene expression appears to be mandatory for the maintenance of the neoplastic state in some cases, but not in others; the same protein ...
... It is clear that, despite their similar genetic plan and overall homology, papillomaviruses use different strategies to achieve their common goals. Continuous viral gene expression appears to be mandatory for the maintenance of the neoplastic state in some cases, but not in others; the same protein ...
Zygotic genes that mediate torso receptor tyrosine kinase
... fates of cells at the anterior and posterior termini of the Drosophila embryo is transmitted by the torso receptor tyrosine kinase. This paper presents the results of a genetic interaction test for zygotic loci that act downstream of torso in the terminal genetic hierarchy. Tests of 26 zygotic mutan ...
... fates of cells at the anterior and posterior termini of the Drosophila embryo is transmitted by the torso receptor tyrosine kinase. This paper presents the results of a genetic interaction test for zygotic loci that act downstream of torso in the terminal genetic hierarchy. Tests of 26 zygotic mutan ...
Review article Cell transformation by animal papillomaviruses
... It is clear that, despite their similar genetic plan and overall homology, papillomaviruses use different strategies to achieve their common goals. Continuous viral gene expression appears to be mandatory for the maintenance of the neoplastic state in some cases, but not in others; the same protein ...
... It is clear that, despite their similar genetic plan and overall homology, papillomaviruses use different strategies to achieve their common goals. Continuous viral gene expression appears to be mandatory for the maintenance of the neoplastic state in some cases, but not in others; the same protein ...
human genome research
... biomedicine, biotechnology and health care. It will increase our knowledge not just of single gene disorders such as cystic fibrosis, but also of how genes interact with environmental factors and contribute to a range of other diseases including cancers, heart disease, and diabetes. Once the role of ...
... biomedicine, biotechnology and health care. It will increase our knowledge not just of single gene disorders such as cystic fibrosis, but also of how genes interact with environmental factors and contribute to a range of other diseases including cancers, heart disease, and diabetes. Once the role of ...
Genetic Diversity in an Andean Population from Peru and Regional
... Our results show that the frequency of the mitochondrial haplogroups A–D in Peruvians is more similar to the Andean Amerindians than to the Amazon Amerindians, and the geographic distribution of A–D haplogroups may be interpreted as the consequence of at least two migratory routes within the contine ...
... Our results show that the frequency of the mitochondrial haplogroups A–D in Peruvians is more similar to the Andean Amerindians than to the Amazon Amerindians, and the geographic distribution of A–D haplogroups may be interpreted as the consequence of at least two migratory routes within the contine ...
Oncogenomics
Oncogenomics is a relatively new sub-field of genomics that applies high throughput technologies to characterize genes associated with cancer. Oncogenomics is synonymous with ""cancer genomics"". Cancer is a genetic disease caused by accumulation of mutations to DNA leading to unrestrained cell proliferation and neoplasm formation. The goal of oncogenomics is to identify new oncogenes or tumor suppressor genes that may provide new insights into cancer diagnosis, predicting clinical outcome of cancers, and new targets for cancer therapies. The success of targeted cancer therapies such as Gleevec, Herceptin, and Avastin raised the hope for oncogenomics to elucidate new targets for cancer treatment.Besides understanding the underlying genetic mechanisms that initiates or drives cancer progression, one of the main goals of oncogenomics is to allow for the development of personalized cancer treatment. Cancer develops due to an accumulation of mutations in DNA. These mutations accumulate randomly, and thus, different DNA mutations and mutation combinations exist between different individuals with the same type of cancer. Thus, identifying and targeting specific mutations which have occurred in an individual patient may lead to increased efficacy of cancer therapy.The completion of the Human Genome Project has greatly facilitated the field of oncogenomics and has increased the abilities of researchers to find cancer causing genes. In addition, the sequencing technologies now available for sequence generation and data analysis have been applied to the study of oncogenomics. With the amount of research conducted on cancer genomes and the accumulation of databases documenting the mutational changes, it has been predicted that the most important cancer-causing mutations, rearrangements, and altered expression levels will be cataloged and well characterized within the next decade.Cancer research may look either on the genomic level at DNA mutations, the epigenetic level at methylation or histone modification changes, the transcription level at altered levels of gene expression, or the protein level at altered levels of protein abundance and function in cancer cells. Oncogenomics focuses on the genomic, epigenomic, and transcript level alterations in cancer.