Pharmacokinetics-Pharmacodynamics
... – Benzodiazepines are GABA receptor allosteric agonists. • Bind to nearby sites and facilitate GABA, flooding neurons with Cl-, inhibiting neural actions. • Used as sedative, antianxiety, amnestic, antiepileptic. ...
... – Benzodiazepines are GABA receptor allosteric agonists. • Bind to nearby sites and facilitate GABA, flooding neurons with Cl-, inhibiting neural actions. • Used as sedative, antianxiety, amnestic, antiepileptic. ...
Nicotinic Acetylcholine Receptor
... known as deadly nightshade, which has excitatory and hallucinogenic effects. Story time: Belladonna was used by the ancient Hindu's, Roman Empire and the Middle Ages to induce prolonged poisoning. Much of the poison uses were quite fun to the poisoner, watching the victim fall to memory loss, disori ...
... known as deadly nightshade, which has excitatory and hallucinogenic effects. Story time: Belladonna was used by the ancient Hindu's, Roman Empire and the Middle Ages to induce prolonged poisoning. Much of the poison uses were quite fun to the poisoner, watching the victim fall to memory loss, disori ...
SEDATIVES / HYPNOTICS Barbiturates • Second choice as sedative
... Mechanism of Action 1. Facilitation of GABA action on the brain. increase the duration of the GABA gated channel opening but in large dose, they can directly activating chloride channels. (not through BZD receptors). 2. depress excitatory neurotransmitter actions 3. Interfere with Na & K transport a ...
... Mechanism of Action 1. Facilitation of GABA action on the brain. increase the duration of the GABA gated channel opening but in large dose, they can directly activating chloride channels. (not through BZD receptors). 2. depress excitatory neurotransmitter actions 3. Interfere with Na & K transport a ...
(5-Hydroxytryptamine 3).
... In cancer chemotherapy, emetogenic drugs are thought to stimulate the release of serotonin from the enterochromaffin cells of the small intestine; this released serotonin then activates 5-HT3 receptors located on vagal afferent nerves in the CTZ to initiate the vomiting reflex. o Emetogenic drugs- d ...
... In cancer chemotherapy, emetogenic drugs are thought to stimulate the release of serotonin from the enterochromaffin cells of the small intestine; this released serotonin then activates 5-HT3 receptors located on vagal afferent nerves in the CTZ to initiate the vomiting reflex. o Emetogenic drugs- d ...
Pharmaco lecture 2 - pharmacology1lecnotes
... drugs combine in solution, as a result the effect of the active is lost. Examples include the use of chelating agents (e.g. dimercaprol) that bind to heavy metals and thus reduce their ...
... drugs combine in solution, as a result the effect of the active is lost. Examples include the use of chelating agents (e.g. dimercaprol) that bind to heavy metals and thus reduce their ...
Anti-psychotic drugs 2006
... • The main side-effects are on the extrapyramidal motor system - leading to rigidity, tremor, and loss of mobility and dyskinesia • Tardive dyskinesia is a late onset disorder characterised by repetitive abnormal movements of face and upper limbs. This may be due to proliferation of D2 receptors in ...
... • The main side-effects are on the extrapyramidal motor system - leading to rigidity, tremor, and loss of mobility and dyskinesia • Tardive dyskinesia is a late onset disorder characterised by repetitive abnormal movements of face and upper limbs. This may be due to proliferation of D2 receptors in ...
Lacosamide (Vimpat) Drug Monitoring
... • Predose (trough) concentration at steady state should be assessed ...
... • Predose (trough) concentration at steady state should be assessed ...
ِِAntipsychotic Drugs
... • The first effective drug to be used for the treatment of schizophrenia was chlorpromazine then a wide range of drug with differing potency and side effect profile has been introduced it is better to become familiar with small range of these drugs that will cover differing situations. ...
... • The first effective drug to be used for the treatment of schizophrenia was chlorpromazine then a wide range of drug with differing potency and side effect profile has been introduced it is better to become familiar with small range of these drugs that will cover differing situations. ...
Study guide unit 2
... diseases that can occur due to alcohol abuse? 52. Alcohol is excreted in breath. How does breath alcohol relate to blood alcohol levels? 53. What is the affect of alcohol on the developing fetus? 54. What is a breathalyzer test? What is the legal limit in New Jersey for driving under the influence? ...
... diseases that can occur due to alcohol abuse? 52. Alcohol is excreted in breath. How does breath alcohol relate to blood alcohol levels? 53. What is the affect of alcohol on the developing fetus? 54. What is a breathalyzer test? What is the legal limit in New Jersey for driving under the influence? ...
“Drugs of Abuse” Chart, Neil 9e KEY
... THC is an agonist of naturally occurring endocannabinoids that bind to "CB1 receptors" involved in appetite, pain sensation, mood, and memory. THC increases extracellular dopamine concentrations in the NA. How this occurs is unclear. It might be that THC binds to CB1 receptors on neurons that were i ...
... THC is an agonist of naturally occurring endocannabinoids that bind to "CB1 receptors" involved in appetite, pain sensation, mood, and memory. THC increases extracellular dopamine concentrations in the NA. How this occurs is unclear. It might be that THC binds to CB1 receptors on neurons that were i ...
d) Bronchodilator Response
... Affinity. The tendency of a drug to combine with a particular receptor. Agonists. A drug that has both affinity for a receptor and elicits a response is called an agonist. A drug that produces a less than maximal effect is termed a partial agonist. Antagonists. A drug that has affinity for a recepto ...
... Affinity. The tendency of a drug to combine with a particular receptor. Agonists. A drug that has both affinity for a receptor and elicits a response is called an agonist. A drug that produces a less than maximal effect is termed a partial agonist. Antagonists. A drug that has affinity for a recepto ...
22Jan2002 PAGE 1
... 8. Which of the following does not contribute to alcohol and drug abuse costs as measured in cost of illness studies? a. motor vehicle crashes b. value of lost productivity c. direct treatment costs d. crime-related costs e. All of the above contribute to these figures. 9. Which of the following is ...
... 8. Which of the following does not contribute to alcohol and drug abuse costs as measured in cost of illness studies? a. motor vehicle crashes b. value of lost productivity c. direct treatment costs d. crime-related costs e. All of the above contribute to these figures. 9. Which of the following is ...
Overview - science of addiction
... strategies that may result in progress when dealing with the drug abuse problem. There have been remarkable advances in our understanding of addiction in the last two decades. Researchers have worked out the mechanism of action of nearly all drugs of abuse. Neuroscientists have identified a co ...
... strategies that may result in progress when dealing with the drug abuse problem. There have been remarkable advances in our understanding of addiction in the last two decades. Researchers have worked out the mechanism of action of nearly all drugs of abuse. Neuroscientists have identified a co ...
Making Sense of Addiction Behaviors Larry Tyler, M.Ed., LADC, CCS
... The Challenges of Recovery • Everything you know and do has to change • The speed of positive results is going to slow way down • The road back to everything that is “familiar and comfortable” (i.e., relapse) is quick and easy. ...
... The Challenges of Recovery • Everything you know and do has to change • The speed of positive results is going to slow way down • The road back to everything that is “familiar and comfortable” (i.e., relapse) is quick and easy. ...
document
... is insufficient to trigger an action potential. Either one presynaptic neuron must repeatedly release neurotransmitter, or several different pre-synaptic neurons must release neurotransmitter together. The additive effect from multiple releases of neurotransmitter is called summation. A single pos ...
... is insufficient to trigger an action potential. Either one presynaptic neuron must repeatedly release neurotransmitter, or several different pre-synaptic neurons must release neurotransmitter together. The additive effect from multiple releases of neurotransmitter is called summation. A single pos ...
CHAPTER 16 Drug Abuse and Autism Basic Lecture Outline with
... cocaine, 17 percent for pot and 3 percent for heroin.” binds with and deactivates the dopamine reuptake transporter proteins – thus blocking the reuptake of dopamine after it is released by terminal buttons. Amphetamine not only inhibit reuptake of Dopamine, but also stimulates the release of Dopami ...
... cocaine, 17 percent for pot and 3 percent for heroin.” binds with and deactivates the dopamine reuptake transporter proteins – thus blocking the reuptake of dopamine after it is released by terminal buttons. Amphetamine not only inhibit reuptake of Dopamine, but also stimulates the release of Dopami ...
Drugs and the Synapse
... • A drug has an affinity for a particular type of receptor if it binds to that receptor. – Can vary from strong to weak. • The efficacy of the drug is its tendency to activate the receptor. • Drugs can have a high affinity but low efficacy. ...
... • A drug has an affinity for a particular type of receptor if it binds to that receptor. – Can vary from strong to weak. • The efficacy of the drug is its tendency to activate the receptor. • Drugs can have a high affinity but low efficacy. ...
Treatments for Alzheimer`s Disease
... Three drugs in this class have been approved by the Food and Drug Administration (FDA) for treating dementia. They are donepezil (Aricept), galantamine (Razadyne) and rivastigmine (Exelon). These drugs work by slowing the breakdown of a brain chemical that is active in memory and thinking. They have ...
... Three drugs in this class have been approved by the Food and Drug Administration (FDA) for treating dementia. They are donepezil (Aricept), galantamine (Razadyne) and rivastigmine (Exelon). These drugs work by slowing the breakdown of a brain chemical that is active in memory and thinking. They have ...
Topic 7
... neurodegenerative diseases. It is believed their relationship to these disesases is due to their role in excitotoxicity. Overstimulation of glutamate receptors causes neurodegeneration and neuronal damage through the process of excitotoxicity. Excessive glutamate, or exogenous excitotoxins acting on ...
... neurodegenerative diseases. It is believed their relationship to these disesases is due to their role in excitotoxicity. Overstimulation of glutamate receptors causes neurodegeneration and neuronal damage through the process of excitotoxicity. Excessive glutamate, or exogenous excitotoxins acting on ...
