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CNS Drugs - Centegra Health System
CNS Drugs - Centegra Health System

... GABA+Bz GABA+Bz Complex ...
What Robotics may yet Learn from the Brain
What Robotics may yet Learn from the Brain

... Although neurons as computational elements are 7 orders of magnitude slower than their artificial counterparts, the primate brain grossly outperforms robotic algorithms in all but the most structured tasks. Parallelism alone is a poor explanation, and much recent functional modelling of the central ...
Age Changes Presentation (ppt.28KB)
Age Changes Presentation (ppt.28KB)

... How body acts on drug: • Reduced renal function, resulting in reduced elimination of renally excreted drugs - toxicity • Dosages should be reduced in the elderly (start low go slow) • Acute illness can lead to rapid decrease in renal function ...
Model organisms with simple nervous systems: lamprey, crabs
Model organisms with simple nervous systems: lamprey, crabs

... us with a lifetime of decisions and memories, but also that it allows us to contemplate how the brain itself works. One concludes, however, pretty quickly that the human brain is quite complicated. The brain has an estimated 1011 neurons, and more than a thousand times more connections. How these ne ...
Slide 1
Slide 1

... • Mice without dopamine can still learn a conditioned place preference for morphine or cocaine • Other neurotransmitters are involved ...
Partial Seizures - My Illinois State
Partial Seizures - My Illinois State

... function of the few neurons that are left to produce their own.  Levodopa and carbidopa o Directly replace dopamine o Levodopa can pass through blood-brain barrier to get to site of action in the brain; dopamine cannot o Carbidopa does not cross blood-brain barrier; prevents levodopa breakdown in p ...
AZ compound details for MRC Asset Sharing Sept 2016
AZ compound details for MRC Asset Sharing Sept 2016

... expression of a GABA A subunit in Xenopus oocytes, AZD7325 did not display intrinsic agonist activity at any subtype, but potentiated the response of diazepam at Aα2 and Aα3 (43 and 45%, respectively at 100 nM), but not Aα1 or Aα5. In contrast, AZD7325 acted as a full antagonist of zolpidem at Aα1 c ...
B.P.T. [2 Prof.] Pharmacology
B.P.T. [2 Prof.] Pharmacology

... Antiretro virus drugs should be given in combination. Anticholinergic drug's main side effects is dryness of mouth. Diabetic patients who are taking Insulin should avoid Alcohol drink. In variant Angina beta - blockers are avoided. On and off phenomenon occurs after chronic use of Levodopa in Parkin ...
Addiction as a Disease PowerPoint Slides
Addiction as a Disease PowerPoint Slides

... desire to use drug, preoccupation with using drug, and sometimes withdrawal symptoms. • Features of dependence: • impaired control over use • a strong desire to use drug • preoccupation with using (given greater priority than other activities) • increased tolerance to use • withdrawal symptoms on no ...
Methamphetamine
Methamphetamine

... • Results in the loss of dopamine – This can lead to many mood disorders • Depression, schizophrenia, and an inability to enjoy anything in life • Results are similar to Parkinson’s disease • Can cause damage similar to Alzheimer’s disease or a suffer of a stroke ...
Psychoactive Drugs & The Brain - NSCC NetID: Personal Web Space
Psychoactive Drugs & The Brain - NSCC NetID: Personal Web Space

... Blood-Brain Barrier • Barrier structure protects brain and blood from allowing foreign particles to cross – Very small molecules can get between cells – Fat-soluble substances are more likely to get through cell membranes – Chemical substances can also move across barrier if they have carriers – So ...
4._Bipolar_disorder_def
4._Bipolar_disorder_def

... MAO is responsible for degradation of the biogenic amine neurotransmitters (norepinephrine, serotonin, dopamine) tranylcypromine – nonspecific irreversible inhibitor of MAO; ...
4._Bipolar_disorder_def
4._Bipolar_disorder_def

... MAO is responsible for degradation of the biogenic amine neurotransmitters (norepinephrine, serotonin, dopamine) tranylcypromine – nonspecific irreversible inhibitor of MAO; ...
Basic Biopharmaceutics
Basic Biopharmaceutics

... How Drugs Work • When a drug produces an effect, it is interacting at a molecular level with cellular material or structure. • Cellular material directly involved in the action of the drug is called a receptor. • The receptor is described as a lock into which the drug molecule fits as a key. • Drug ...
1301 Pharmacology Drug List
1301 Pharmacology Drug List

... ataxia, headache, insomnia, paradoxical anxiety, hallucinations, minor changes in EEG patters, pain 2. CV: CV collapse, bradycardia, hypotension 3. Respiratory: respiratory depression, apnea Nursing Implications 1. Monitor periodic hepatic, renal, and hematopoietic function studies in patients recei ...
FOUR MAJOR TARGETS FOR DRUGS
FOUR MAJOR TARGETS FOR DRUGS

... members of the cytochrome P450 (CYP) system that are responsible for many of the phase 1 biotransformations of drugs. These metabolic transformations, such as oxidation, reduction and hydrolysis, produce a molecule that is suitable for conjugation. Those of importance in the metabolism of psychotrop ...
08-neuro3-cns-misc
08-neuro3-cns-misc

... CNS Pharmacology • Peripheral neurotransmitters = 3 • CNS neurotransmitters = at least 12 – Exact actions may be unknown – Areas of brain with no known transmitter ...
Psychopharmacology - the Peninsula MRCPsych Course
Psychopharmacology - the Peninsula MRCPsych Course

... effect of antipsychotic treatment on her fertility. What points would you need to discuss to help her make an informed choice on treatment? 2. A 45 year old man with schizophrenia has recently changed to clozapine treatment. He has a past history of childhood epilepsy and there is a family history o ...
2.exilam details
2.exilam details

... 7. It is without doubt that Etizolam is currently one of the most popular research chemicals available on the market. It easily ranks in popularity with compounds like Methoxetamine (MXE) and many bath salt compounds. 8. Etizolam is a sedative, and should never be mixed with other Sedatives or Depre ...
Drugs of Abuse: Psychedelic Agents
Drugs of Abuse: Psychedelic Agents

... may also have an inhibitory effect on certain areas such as the visual cortex.  Necessary for mechanism of the action of hallucinogens  Inhibition of the firing of neurons in the visual cortex, which are normally involved in the perception of the objects, is thought to be the cause of the visual h ...
Myers Module Fifty Four
Myers Module Fifty Four

... ‘treatment resistant’ patients who have not responded to drug therapy. (Bailine et al., 2010). Perhaps shock-induced seizures calm neural centers where overactivity produces depression. (Bolwig & Madsen, 2007). Placebo effect instead? Most ECT studies fail to contain a control condition in patients ...
Serotonin (5-HT) - Addiction Science Network
Serotonin (5-HT) - Addiction Science Network

... 5HT4 Cisapride treat GI disorders (agonist) 5HT transporter SSRIs (Fluoxetine, sertraline) treat depression, OCD, panic disorder, social phobia, post traumatic stress disorder (inhibitor) ...
Pharmacology introduction Lecture three Dr. nahlah 21-10
Pharmacology introduction Lecture three Dr. nahlah 21-10

... 2. Irreversible which is usually long-lasting for new enzyme synthesis, e.g., irreversible anticholinesterases. Action on specific receptors (Drug Receptor Interactions): receptors are macromolecular protein structures present on cell membrane or within the cell (cytoplasmic or nuclear) that react s ...
Lect8
Lect8

... bidirectional 2. Are very fast 3. Uses A. Electrical synapses first discovered in crayfish neurons involved in escape response B. Synchronizing neural activity, e.g. hormone secreting neurons in the mammalian hypothalamus ...
No Slide Title
No Slide Title

... Some sensory organs have separate receptor cells and synaptic junctions between receptors and afferent nerves (e.g. Vision, hearing, equilibrium, taste). In others, the receptors are specialized ends of nerve fibers (e.g. most cutaneous sense organs). A nice example: Pacinian corpuscle Mostly studie ...
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Neuropharmacology

Neuropharmacology is the study of how drugs affect cellular function in the nervous system, and the neural mechanisms through which they influence behavior. There are two main branches of neuropharmacology: behavioral and molecular. Behavioral neuropharmacology focuses on the study of how drugs affect human behavior (neuropsychopharmacology), including the study of how drug dependence and addiction affect the human brain. Molecular neuropharmacology involves the study of neurons and their neurochemical interactions, with the overall goal of developing drugs that have beneficial effects on neurological function. Both of these fields are closely connected, since both are concerned with the interactions of neurotransmitters, neuropeptides, neurohormones, neuromodulators, enzymes, second messengers, co-transporters, ion channels, and receptor proteins in the central and peripheral nervous systems. Studying these interactions, researchers are developing drugs to treat many different neurological disorders, including pain, neurodegenerative diseases such as Parkinson's disease and Alzheimer's disease, psychological disorders, addiction, and many others.
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