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181lec5
181lec5

... First messengers Neurotransmitters Receptors ...
Is Carbohydrate Addiction Real? - Low
Is Carbohydrate Addiction Real? - Low

... Nora Volkow, director of the National Institute on Drug Abuse commenting on the recent research and the controversy about food addiction states: “The data is so overwhelming the field has to accept it. We find tremendous overlap between drugs in the brain and food in the brain.” ...
Anti-seizure_and_Anti
Anti-seizure_and_Anti

... posture, muscle tone and voluntary movement In Parkinson’s, lack inhibitory dopamine and thus an increase in excitatory acetylcholine ...
Anti-seizure and Anti
Anti-seizure and Anti

... posture, muscle tone and voluntary movement In Parkinson’s, lack inhibitory dopamine and thus an increase in excitatory acetylcholine ...
Introduction to Pharmacology
Introduction to Pharmacology

... alters the structure or function of biological systems (pharmacologist’s view). – Any agent approved by the Food and Drug Administration for the treatment or prevention of disease (legal view). – Any agent taken by some, but disapproved by others (societal view). ...
Advanced Medicinal Chemistry
Advanced Medicinal Chemistry

... Channels are ion selective and comprise groups of glycoprotein subunits in homo- or heteropolymer arrays. Almost no channels have an open rest state Channels are involved in cardiac, neuronal, psychiatric and (?) R&I disorders ...
Advanced Medicinal Chemistry
Advanced Medicinal Chemistry

... Channels are ion selective and comprise groups of glycoprotein subunits in homo- or heteropolymer arrays. Almost no channels have an open rest state Channels are involved in cardiac, neuronal, psychiatric and (?) R&I disorders ...
Activity #4
Activity #4

... Key Words • Informed Consent – a form volunteers sign that states that they have been told about the risks and that they agree to participate in the trial. ...
Effects of Drugs on the Nervous System
Effects of Drugs on the Nervous System

... Cannabis sativa contains >400 compounds in addition to the psychoactive substance, delta-9tetrahydrocannabinol (THC). Marijuana cigarettes are prepared from the leaves and flowering tops of the plant, and a typical marijuana cigarette contains 0.5 to 1 g of plant material. Although the usual THC con ...
Medicinal Chemistry (MDCH) 5220
Medicinal Chemistry (MDCH) 5220

... What groups are normally charged or ionizable? What are groups are lipophilic? What groups are polar? What groups are electron donating or electron withdrawing? (10) What is the relative acidity of benzoic acid compared para-methyl and para-chloro substituted benzoic acid. Ortho-nitro substituted be ...
consisting of diuretics to remove excess water, beta blockers and
consisting of diuretics to remove excess water, beta blockers and

... norepinephrine, serotonin, and histamine) among nerve cells. Specifically, dopamine enables neurotransmission among nerve cells that are involved in voluntary and involuntary motor control. We have identified one highly selective VMAT2 inhibitor that is effective in regulating the levels of dopamine ...
SNARE molecules at the trans-Golgi network and endosome and their roles in neuronal growth and axonal transport.
SNARE molecules at the trans-Golgi network and endosome and their roles in neuronal growth and axonal transport.

... E-mail : [email protected] ...
Neurodegenerative Disorders - London Metropolitan University
Neurodegenerative Disorders - London Metropolitan University

... How does a loss of striatal DA produce profound behavioural disturbances? • Basal ganglia – subcortical system forms a “loop” with the cerebral cortex • Basal ganglia “gate” movement commands originating in motor cortex • DA projections to striatum helps keep gate open • Loss of DA activity impairs ...
Medicinal chemistry
Medicinal chemistry

... systematic study of the structure-activity relationships of the active compounds. Such studies provide the basis for development of better medicinal agents from lead compounds found via random screening, systematic screening and rational design. ...
module 10 Drugs and Consciousness Module Preview Psychoactive
module 10 Drugs and Consciousness Module Preview Psychoactive

... 10-3. Identify the major stimulants, and explain how they affect neural activity and behavior. Stimulants, such as caffeine, nicotine, and the amphetamines and the even more powerful cocaine, Ecstasy, and methamphetamines, excite neural activity and arouse body functions. As with nearly all psychoac ...
Chapter 4
Chapter 4

...  some presynaptic membranes have autoreceptors that regulate amount of NT released; stimulation of autoreceptors causes less NT to be released  drugs that activate autoreceptors act as antagonists  less NT released (Step 8)  drugs that block autoreceptors act as agonists  more NT released (Step ...
Drugs and the Brain teaser (PPT)
Drugs and the Brain teaser (PPT)

... crosses the synapse Hormone: Another type of signaling molecule. The border between neurotransmitter and hormone is blurry, many chemicals are both. Receptor: A protein that detects a specific chemical, by binding to it Ligand: A molecule that binds to a receptor ...
The Brain Injury Definition of Addiction
The Brain Injury Definition of Addiction

... Only the chemical can generate happiness Therefore: family, children, music, chocolate, sex, and work have little ...
Pharmacokinetiks and Pharmacodynamics
Pharmacokinetiks and Pharmacodynamics

... Drugs are metabolised in the liver, lungs, kidneys, blood and intestines.  In order for drugs to pass across the lipid cell membrane they must be lipophilic  The higher the solubility in lipids compared to water, the more rapid the tissue entry  Metabolic rate determines the duration of the actio ...
Psychoactive Drugs
Psychoactive Drugs

... are   also   used   as   medicinal   drugs   and   in   low   doses   they   act   as  tranquilizers   and   analgesics.   Most   people   overlook   the   fact   that  alcohol or ethyl alcohol is ultimately a drug. Its major behavioral  effects are derived from its depressant action on the central  ...
Rash
Rash

... • Plavix® and PPIs (Prilosec®) – PPI inhibits the action of Plavix® a Prodrug that does not work until it Is metabolized ...
Introduction to Central Nervous System Pharmacology
Introduction to Central Nervous System Pharmacology

... Static and Facts • Progression highly variable. Within 10 – 20 years. • Patient age at onset affect progression . ( high rate in older ) • Mortality not caused by disease itself , but, due to complications related to immobility . Complication such as ( Aspiration Pneumonia , cardiovascular and cere ...
Neurotransmitter vs. Neuromodulator??
Neurotransmitter vs. Neuromodulator??

... (ionotropic R) e.g. GABA Glycine (spinal cord) ...
Chapter 2
Chapter 2

... Genes influence our psychological characteristics as well as our physical traits ...
item[`#file`]
item[`#file`]

...  Cannabis – binds to cannabinoid receptors  has a specific receptor!  Hallucinogens – 5-HT (serontonin) receptor agonist  PCP – blocks NMDA (glutamate receptor)  Anabolic Steroids – bind to intracellular androgen receptors Amphetamines  Amphetamine – increases dopamine  by increasing release ...
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Neuropharmacology

Neuropharmacology is the study of how drugs affect cellular function in the nervous system, and the neural mechanisms through which they influence behavior. There are two main branches of neuropharmacology: behavioral and molecular. Behavioral neuropharmacology focuses on the study of how drugs affect human behavior (neuropsychopharmacology), including the study of how drug dependence and addiction affect the human brain. Molecular neuropharmacology involves the study of neurons and their neurochemical interactions, with the overall goal of developing drugs that have beneficial effects on neurological function. Both of these fields are closely connected, since both are concerned with the interactions of neurotransmitters, neuropeptides, neurohormones, neuromodulators, enzymes, second messengers, co-transporters, ion channels, and receptor proteins in the central and peripheral nervous systems. Studying these interactions, researchers are developing drugs to treat many different neurological disorders, including pain, neurodegenerative diseases such as Parkinson's disease and Alzheimer's disease, psychological disorders, addiction, and many others.
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