Galanin in Alzheimer s disease: Neuroinhibitory or neuroprotective?
... which display accelerated plaque deposition compared to APP transgenic mice [62]. Co-labeling of cortical and hippocampal amyloid plaques with GAL revealed peptide containing dystrophic neurites as early as 3 months of age (Fig. 2A – C). Since neuron loss was not evident at this age [63, 64], these ...
... which display accelerated plaque deposition compared to APP transgenic mice [62]. Co-labeling of cortical and hippocampal amyloid plaques with GAL revealed peptide containing dystrophic neurites as early as 3 months of age (Fig. 2A – C). Since neuron loss was not evident at this age [63, 64], these ...
Cortical Connectivity Suggests a Role in Limb
... postcentral convexity as well as the medial bank of the intraparietal sulcus. Modern neuroanatomical methods have allowed the identification of various areas within this region. In the present study, we investigated the corticocortical afferent projections of one of these subdivisions, area PE. Our ...
... postcentral convexity as well as the medial bank of the intraparietal sulcus. Modern neuroanatomical methods have allowed the identification of various areas within this region. In the present study, we investigated the corticocortical afferent projections of one of these subdivisions, area PE. Our ...
Ramayya, A. G., Zaghloul, K. A., Weidemann, C. T., Baltuch, G. H.
... activity using the WaveClus software package (Quiroga et al., 2005). We band-pass filtered each voltage recording from 400 to 5000 Hz and manually removed periods of motion artifact. We identified spike events as positive or negative deflections in the voltage trace that crossed a threshold that was ...
... activity using the WaveClus software package (Quiroga et al., 2005). We band-pass filtered each voltage recording from 400 to 5000 Hz and manually removed periods of motion artifact. We identified spike events as positive or negative deflections in the voltage trace that crossed a threshold that was ...
Deep transcranial magnetic stimulation over the prefrontal cortex
... higher stimulation intensities are needed, as the electric field decreases rapidly as a function of tissue depth. However, even if stimulation intensities could be highly increased at the source, the use of standard TMS coils (such as the figure-8 coil) at such high stimulation intensities does not ...
... higher stimulation intensities are needed, as the electric field decreases rapidly as a function of tissue depth. However, even if stimulation intensities could be highly increased at the source, the use of standard TMS coils (such as the figure-8 coil) at such high stimulation intensities does not ...
A Neural Circuit Basis for Spatial Working Memory
... others 1993), a conditional response task involving a movement in a direction other than the stimulus location (Niki and Watanabe 1976; Takeda and Funahashi 2002), or a spatial match to sample task, demanding a lever release when a stimulus appears at a previously cued location (Sawaguchi and Yamane ...
... others 1993), a conditional response task involving a movement in a direction other than the stimulus location (Niki and Watanabe 1976; Takeda and Funahashi 2002), or a spatial match to sample task, demanding a lever release when a stimulus appears at a previously cued location (Sawaguchi and Yamane ...
APPSWE Microinjected Mouse Model
... inflammation and marker of oxidative stress.15 Abnormalities in synaptic properties are evident. For example, long-term potentiation of neurons in the CA1 and dentate gyrus regions of the hippocampus has been reported to be markedly impaired in older transgenic mice (15-17 months) but not young ones ...
... inflammation and marker of oxidative stress.15 Abnormalities in synaptic properties are evident. For example, long-term potentiation of neurons in the CA1 and dentate gyrus regions of the hippocampus has been reported to be markedly impaired in older transgenic mice (15-17 months) but not young ones ...
Neural Correlates of Executive Control in the Avian Brain
... memory that which is relevant, while restricting access to memory or discarding from memory that which is not. Our data are the first example of neural correlates of executive control in a nonmammalian species. We would also argue that they are the most straightforward example of neural correlates of ...
... memory that which is relevant, while restricting access to memory or discarding from memory that which is not. Our data are the first example of neural correlates of executive control in a nonmammalian species. We would also argue that they are the most straightforward example of neural correlates of ...
Sensory Receptors
... By moving the object to your finger tips where Meissner's corpuscles are abundant, you gather information about its shape, texture, and density, information your brain uses to identify the object. ...
... By moving the object to your finger tips where Meissner's corpuscles are abundant, you gather information about its shape, texture, and density, information your brain uses to identify the object. ...
NIH Public Access
... Serotonergic neurons within the raphe, especially the dorsal raphe, project to diverse forebrain regions, including the key corticolimbic structures involved in the regulation of stress, such as the mPFC, septum, extended amygdala, and hippocampus. Within the DRN, further topological organization su ...
... Serotonergic neurons within the raphe, especially the dorsal raphe, project to diverse forebrain regions, including the key corticolimbic structures involved in the regulation of stress, such as the mPFC, septum, extended amygdala, and hippocampus. Within the DRN, further topological organization su ...
10_VBM
... * Correcting for TIV in VBM statistics may give more powerful and/or more interpretable results * See e.g. Barnes et al., (2010), NeuroImage 53(4):1244-55 ...
... * Correcting for TIV in VBM statistics may give more powerful and/or more interpretable results * See e.g. Barnes et al., (2010), NeuroImage 53(4):1244-55 ...
Neural Basis of Brain Dysfunction Produced by Early Sleep Problems
... Abstract: There is a wealth of evidence that disrupted sleep and circadian rhythms, which are common in modern society even during the early stages of life, have unfavorable effects on brain function. Altered brain function can cause problem behaviors later in life, such as truancy from or dropping ...
... Abstract: There is a wealth of evidence that disrupted sleep and circadian rhythms, which are common in modern society even during the early stages of life, have unfavorable effects on brain function. Altered brain function can cause problem behaviors later in life, such as truancy from or dropping ...
Plasticity of Sensory and Motor Maps in Adult Mammals
... mapsat three levels of cortical processing in the somatosensorycortex, and for changes that cannot be easily attributed to the relay of subcortical reorganizations. To date, the bulk of the evidence for plasticity in maps stems from experiments in the somatosensory system. Thus, "Are other sensory a ...
... mapsat three levels of cortical processing in the somatosensorycortex, and for changes that cannot be easily attributed to the relay of subcortical reorganizations. To date, the bulk of the evidence for plasticity in maps stems from experiments in the somatosensory system. Thus, "Are other sensory a ...
NEUROTRANSMITTER SYSTEMS IN THE VISUAL CORTEX OF
... is focused on NMDA receptors channel which is permeable to Ca++ ions only if the postsynaptic membrane is sufficiently depolarized. Thus the NMDA receptor permits current flow only if there is coincident pre- and postsynaptic activation (26). Therefore it is not surprising that the involvement of NM ...
... is focused on NMDA receptors channel which is permeable to Ca++ ions only if the postsynaptic membrane is sufficiently depolarized. Thus the NMDA receptor permits current flow only if there is coincident pre- and postsynaptic activation (26). Therefore it is not surprising that the involvement of NM ...
MINISTRY OF HEALTH OF UKRAINE VINNYTSIA NATIONAL
... causes contralateral hemiparesis mainly affecting the lower limb, sometimes accompanied by contralateral ataxia and, if the lesion is leftsided, by apraxia. Occasionally there may be apathy, abulia (pathological lack of drive and motivation), and urinary incontinence. Posterior cerebral a. Occlusion ...
... causes contralateral hemiparesis mainly affecting the lower limb, sometimes accompanied by contralateral ataxia and, if the lesion is leftsided, by apraxia. Occasionally there may be apathy, abulia (pathological lack of drive and motivation), and urinary incontinence. Posterior cerebral a. Occlusion ...
- Reppert Lab
... and that the central complex, a midline-spanning group of neuropils in the center of the brain, is the most likely candidate region to comprise an internal sun compass (Heinze and Reppert, 2011). As any functional sun compass needs a circadian clock to compensate for changes in solar position over t ...
... and that the central complex, a midline-spanning group of neuropils in the center of the brain, is the most likely candidate region to comprise an internal sun compass (Heinze and Reppert, 2011). As any functional sun compass needs a circadian clock to compensate for changes in solar position over t ...
article in press - Department of Physiology, Development and
... sounds, with the former unambiguously more speech-like. We used the Bradley – Terry – Luce technique (David, 1988) which converts paired-comparison data into a relative perceptual scale—in this case a scale of Fspeechlikeness_. This technique requires that the stimulus set includes a reasonable dive ...
... sounds, with the former unambiguously more speech-like. We used the Bradley – Terry – Luce technique (David, 1988) which converts paired-comparison data into a relative perceptual scale—in this case a scale of Fspeechlikeness_. This technique requires that the stimulus set includes a reasonable dive ...
Horizontal Interactions in Cat Striate Cortex: 1. Anatomical Substrate
... FB was dissolved at a concentration of 5 % in distilled water, DY at a concentration of 2% in distilled water and FG was dissolved at a concentration of 3 % in 0.2 M phosphate buffer (PB) and injected in amounts of 500 nl. RBs were applied via Hamilton syringe in amounts of 100 nl. In most cases the ...
... FB was dissolved at a concentration of 5 % in distilled water, DY at a concentration of 2% in distilled water and FG was dissolved at a concentration of 3 % in 0.2 M phosphate buffer (PB) and injected in amounts of 500 nl. RBs were applied via Hamilton syringe in amounts of 100 nl. In most cases the ...
Arbib, 2008 - Semantic Scholar
... form for an extensive period of human prehistory. EMSH emphasizes the specific roles of protosign and protospeech, rather than language per se. Sternberg and Christiansen (2006) argue, as does Deacon, that languages have evolved to fit preexisting learning mechanisms, noting that sequential learning i ...
... form for an extensive period of human prehistory. EMSH emphasizes the specific roles of protosign and protospeech, rather than language per se. Sternberg and Christiansen (2006) argue, as does Deacon, that languages have evolved to fit preexisting learning mechanisms, noting that sequential learning i ...
Dysregulating Factors
... the ASD phenotype or influence its expression [16754686]. CACNA1H chromosomal location 16p13.3 is shared with with tuberous sclerosis 2 gene (see below). Similarly, a mutation in the gene encoding for Shank3, a scaffolding protein that forms signalling complexes with at least two of the voltage gate ...
... the ASD phenotype or influence its expression [16754686]. CACNA1H chromosomal location 16p13.3 is shared with with tuberous sclerosis 2 gene (see below). Similarly, a mutation in the gene encoding for Shank3, a scaffolding protein that forms signalling complexes with at least two of the voltage gate ...
fMR-adaptation reveals separate processing regions for the
... can conclude that the neurons in this region do not participate in the processing of this stimulus property. If, however, there is recovery from adaptation (as evidenced by a rise in the BOLD signal), then one can conclude that neurons in this region do play a role in the processing of that stimulus ...
... can conclude that the neurons in this region do not participate in the processing of this stimulus property. If, however, there is recovery from adaptation (as evidenced by a rise in the BOLD signal), then one can conclude that neurons in this region do play a role in the processing of that stimulus ...
damage to oligodendrocytes and axons following endothelin 1
... There has been growing awareness among neurobiologists in recent years regarding the importance of understanding the molecular interactions that occur between neurons and glia in the CNS, particularly as it pertains to CNS pathological states with major impacts on society, such as trauma, stroke, an ...
... There has been growing awareness among neurobiologists in recent years regarding the importance of understanding the molecular interactions that occur between neurons and glia in the CNS, particularly as it pertains to CNS pathological states with major impacts on society, such as trauma, stroke, an ...
Finding a face in the crowd: parallel and serial neural mechanisms
... and parallel selections take place in neurons of the ventral ‘‘object-recognition pathway’’ during visual search tasks in which monkeys freely scan complex displays to find a target object. Furthermore, attentional selection appears to be mediated by changes in the synchrony of responses of neuronal ...
... and parallel selections take place in neurons of the ventral ‘‘object-recognition pathway’’ during visual search tasks in which monkeys freely scan complex displays to find a target object. Furthermore, attentional selection appears to be mediated by changes in the synchrony of responses of neuronal ...
Pacifier Use May Decrease the Risk of SIDS Abstract Introduction
... Non-nutritive sucking is a normal fetal and neonate behavior. Pacifiers (also known as dummies) have been used to fulfill this innate desire for over 2000 years [1]. These mock nipples can soothe or calm infants and are also useful during minor medical procedures [2]. For example, pacifier sucking w ...
... Non-nutritive sucking is a normal fetal and neonate behavior. Pacifiers (also known as dummies) have been used to fulfill this innate desire for over 2000 years [1]. These mock nipples can soothe or calm infants and are also useful during minor medical procedures [2]. For example, pacifier sucking w ...