9 The AMP-activated protein kinase: more than an energy sensor
... inhibition of mitochondrial respiration [22]. In relation to the effect of these anti-diabetic drugs, AMPK deficiency has been proposed to underlie the progression of the metabolic syndrome, which is characterized by insulin resistance [24]. This syndrome corresponds to a combination of various meta ...
... inhibition of mitochondrial respiration [22]. In relation to the effect of these anti-diabetic drugs, AMPK deficiency has been proposed to underlie the progression of the metabolic syndrome, which is characterized by insulin resistance [24]. This syndrome corresponds to a combination of various meta ...
Metabolic Engineering for Production of Complex Lipids in Tobacco
... addition to these examples of oils with broad usage, castor oil, tung oil and high-erucic rapeseed oil are specially produced for some specific non-food applications (Vanhercke et al., 2013b). Plant oils are composed almost entirely of TAGs containing three of the major five fatty acids listed abov ...
... addition to these examples of oils with broad usage, castor oil, tung oil and high-erucic rapeseed oil are specially produced for some specific non-food applications (Vanhercke et al., 2013b). Plant oils are composed almost entirely of TAGs containing three of the major five fatty acids listed abov ...
The PRT protein family Sangita C Sinha* and Janet L Smith
... on states of PRTases relevant to catalysis, effectively providing snapshots along the reaction pathway [31,40]. The closed-loop structures, in particular, provide a remarkably consistent picture of Mg•PRPP binding. Mg•PRPP binds in a virtually identical manner in these structures, despite the absenc ...
... on states of PRTases relevant to catalysis, effectively providing snapshots along the reaction pathway [31,40]. The closed-loop structures, in particular, provide a remarkably consistent picture of Mg•PRPP binding. Mg•PRPP binds in a virtually identical manner in these structures, despite the absenc ...
αII-Spectrin interacts with Tes and EVL, two actin
... studies showed that the interaction between Tes and spectrin is mediated by a LIM (Lin-11, Isl-1 and Mec3) domain of Tes and by the α10 repeat of αII-spectrin whereas EVL interacts with the Src homology 3 domain located within the α9 repeat. Moreover, we describe an in vitro interaction between Tes ...
... studies showed that the interaction between Tes and spectrin is mediated by a LIM (Lin-11, Isl-1 and Mec3) domain of Tes and by the α10 repeat of αII-spectrin whereas EVL interacts with the Src homology 3 domain located within the α9 repeat. Moreover, we describe an in vitro interaction between Tes ...
Stress Induction of Mitochondrial Formate Dehydrogenase in Potato
... from spinach (and, to a lesser extent, that from beet and tobacco) can oxidize formate with a tight coupling to oxidative phosphorylation. The first plant FDH cDNA to be published encodes a potato (Solanum tuberosum L.) enzyme (Colas des Francs-Small et al., 1993) that is 8 to 10 times more abundant ...
... from spinach (and, to a lesser extent, that from beet and tobacco) can oxidize formate with a tight coupling to oxidative phosphorylation. The first plant FDH cDNA to be published encodes a potato (Solanum tuberosum L.) enzyme (Colas des Francs-Small et al., 1993) that is 8 to 10 times more abundant ...
Oral free and dipeptide forms of glutamine supplementation
... Due to increased requirements triggered by catabolic processes, high inflammatory and oxidative stress profiles in humans and animal models of sepsis (e.g., endotoxemia) lead to an imbalance of the body’s most abundant amino acid, glutamine. Under stressful situations, such as sepsis, glutamine is ter ...
... Due to increased requirements triggered by catabolic processes, high inflammatory and oxidative stress profiles in humans and animal models of sepsis (e.g., endotoxemia) lead to an imbalance of the body’s most abundant amino acid, glutamine. Under stressful situations, such as sepsis, glutamine is ter ...
Get PDF - Wiley Online Library
... As expected, FLAG-PABP was co-precipitated with GST– eIF4GI(45–160), but not with GST–eIF4GI(45–155) (Figure 3D, compare lanes 1 and 2). While GST alone did not interact with FLAG-PABP (lane 4), the GST– eIF4GI(132–160) amino acid fusion protein bound FLAGPABP (lane 3). To examine whether the 29 ami ...
... As expected, FLAG-PABP was co-precipitated with GST– eIF4GI(45–160), but not with GST–eIF4GI(45–155) (Figure 3D, compare lanes 1 and 2). While GST alone did not interact with FLAG-PABP (lane 4), the GST– eIF4GI(132–160) amino acid fusion protein bound FLAGPABP (lane 3). To examine whether the 29 ami ...
Glucosamine-Induced Insulin Resistance in Primary Rat
... The amount of glucose in the bloodstream is tightly regulated by actions of insulin and glucagon during fed and fasting states (Flakoll PJ 2000). Insulin, a hormone secreted by the P- cells of the islets of Langerhans in the pancreas, plays an important role in maintaining glucose homeostasis and is ...
... The amount of glucose in the bloodstream is tightly regulated by actions of insulin and glucagon during fed and fasting states (Flakoll PJ 2000). Insulin, a hormone secreted by the P- cells of the islets of Langerhans in the pancreas, plays an important role in maintaining glucose homeostasis and is ...
Open the publication - UEF Electronic Publications
... The disruptions of the system have been linked to variety of diseases, including obesity, diabetes, certain cancers and mental problems, such as depression and schizophrenia16,19. Pgc1α, key regulator of cellular metabolism, has been identified as the key link between changes in metabolism and circa ...
... The disruptions of the system have been linked to variety of diseases, including obesity, diabetes, certain cancers and mental problems, such as depression and schizophrenia16,19. Pgc1α, key regulator of cellular metabolism, has been identified as the key link between changes in metabolism and circa ...
A chitin-binding domain in a marine bacterial
... (pChiAl; see below) with a portion of chiA produces a protein which is recognized by antibodies raised against the 85 kDa excreted chitinase (Svitil et al., 1997). These data confirmed that the sequenced ORF does encode the excreted chitinase, ChiA. The sequence contains the elements necessary for t ...
... (pChiAl; see below) with a portion of chiA produces a protein which is recognized by antibodies raised against the 85 kDa excreted chitinase (Svitil et al., 1997). These data confirmed that the sequenced ORF does encode the excreted chitinase, ChiA. The sequence contains the elements necessary for t ...
Intestinal peptidases form functional complexes with the neutral
... Protein complexes containing APN and other brush-border peptide hydrolases have been isolated from intestinal brush-border membranes using Blue native electrophoresis [19], but these did not seem to contain membrane transporters. There is also evidence of a role for intestinal microvillar micro-doma ...
... Protein complexes containing APN and other brush-border peptide hydrolases have been isolated from intestinal brush-border membranes using Blue native electrophoresis [19], but these did not seem to contain membrane transporters. There is also evidence of a role for intestinal microvillar micro-doma ...
Src protein–tyrosine kinase structure and regulation
... surface of the SH2 domain and point toward basic residues on the surface. The Src SH2 domain, however, can bind to a variety of sequences that do not conform to this optimal sequence, and other parts of proteins beyond the vicinity of the phosphotyrosine contribute to binding affinity. The human Src g ...
... surface of the SH2 domain and point toward basic residues on the surface. The Src SH2 domain, however, can bind to a variety of sequences that do not conform to this optimal sequence, and other parts of proteins beyond the vicinity of the phosphotyrosine contribute to binding affinity. The human Src g ...
World Index of BioMolecular Visualization Resources
... Cross-indexing terms: immunoglobulin and Ig domains; IgG; epitope structure, lysozyme bound to antibody; disulfide bonds in immunoglobulin; complementaritydetermining regions in antibody; glycosylation of antibody, N-linked; lesson plan, antibody. At MolviZ.Org: A tutorial on IgG structure in Chime ...
... Cross-indexing terms: immunoglobulin and Ig domains; IgG; epitope structure, lysozyme bound to antibody; disulfide bonds in immunoglobulin; complementaritydetermining regions in antibody; glycosylation of antibody, N-linked; lesson plan, antibody. At MolviZ.Org: A tutorial on IgG structure in Chime ...
The Miraculous Benefits of Non Denatured Whey Protein Powder
... You should also then recognize the colossal importance, over and above anything else you can do for your clients, is helping them get ahead of detoxification. With unheated whey protein powder, you will now do a lot more to help your clients achieve 24 hour a day, optimal cellular detoxification th ...
... You should also then recognize the colossal importance, over and above anything else you can do for your clients, is helping them get ahead of detoxification. With unheated whey protein powder, you will now do a lot more to help your clients achieve 24 hour a day, optimal cellular detoxification th ...
Multiple Lines of Evidence Localize Signaling
... cytosol to enter mitochondria, it also acts as a barrier for molecules to leave mitochondria. Thus, the outer mitochondrial membrane may also contain proteins involved in signal transduction and mediating retrograde signals from the mitochondrion to the nucleus or even from the mitochondrion to the ...
... cytosol to enter mitochondria, it also acts as a barrier for molecules to leave mitochondria. Thus, the outer mitochondrial membrane may also contain proteins involved in signal transduction and mediating retrograde signals from the mitochondrion to the nucleus or even from the mitochondrion to the ...
Protein metabolism in exercising human with special reference to
... If the body is in positive nitrogen balance, then protein is retained as new tissue is being synthesized. This is often observed in children, during pregnancy, in recovery from illness, and during resistance exercise training where protein synthesis occurs in muscle cells. A greater output of nitrog ...
... If the body is in positive nitrogen balance, then protein is retained as new tissue is being synthesized. This is often observed in children, during pregnancy, in recovery from illness, and during resistance exercise training where protein synthesis occurs in muscle cells. A greater output of nitrog ...
PDF - Geoff McFadden`s Lab
... pathways for fatty acids and isoprenoids (FIG. 4). Dark plastids also require energy and reducing power, which they usually obtain by importing glucose for use in a plastid-localized glycolytic pathway. No evidence has been found to indicate that the apicoplast can import or process hexoses, so its ...
... pathways for fatty acids and isoprenoids (FIG. 4). Dark plastids also require energy and reducing power, which they usually obtain by importing glucose for use in a plastid-localized glycolytic pathway. No evidence has been found to indicate that the apicoplast can import or process hexoses, so its ...
Ana Maria da Silva Esteves Dissertation presented to obtain
... aspartate residues from helices TM2 and TM3. Site-directed mutagenesis of conserved amino acid residues from the family consensus sequence or residues considered relevant for substrate binding validated the results obtained with bound CDP-inositol and allowed us to propose the catalytic mechanism fo ...
... aspartate residues from helices TM2 and TM3. Site-directed mutagenesis of conserved amino acid residues from the family consensus sequence or residues considered relevant for substrate binding validated the results obtained with bound CDP-inositol and allowed us to propose the catalytic mechanism fo ...
CP1 Domain in Escherichia coli Leucyl
... steps; amino acids larger than the cognate substrate are rejected by a “coarse sieve”, while the reaction products of amino acids smaller than the cognate substrate will go through a “fine sieve” and be hydrolyzed. This “double-sieve” mechanism has been proposed for IleRS, a class I aminoacyl-tRNA s ...
... steps; amino acids larger than the cognate substrate are rejected by a “coarse sieve”, while the reaction products of amino acids smaller than the cognate substrate will go through a “fine sieve” and be hydrolyzed. This “double-sieve” mechanism has been proposed for IleRS, a class I aminoacyl-tRNA s ...
STRIVE Report Series No.65
... Although every effort has been made to ensure the accuracy of the material contained in this publication, complete accuracy cannot be guaranteed. Neither the Environmental Protection Agency nor the author(s) accept any responsibility whatsoever for loss or damage occasioned or claimed to have been o ...
... Although every effort has been made to ensure the accuracy of the material contained in this publication, complete accuracy cannot be guaranteed. Neither the Environmental Protection Agency nor the author(s) accept any responsibility whatsoever for loss or damage occasioned or claimed to have been o ...
Chlamydia Exploit the Mammalian Tryptophan-Depletion
... © 2014 Bonner, Byrne and Jensen. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publicat ...
... © 2014 Bonner, Byrne and Jensen. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publicat ...
BIF CH4 5th proofs.qxd
... Because homology implies a common ancestor, it can also imply a common function or structure for two homologous proteins, which can be a useful pointer to function if one of the proteins is known only from its sequence. The operation of natural selection tends to result in the acceptance of mutation ...
... Because homology implies a common ancestor, it can also imply a common function or structure for two homologous proteins, which can be a useful pointer to function if one of the proteins is known only from its sequence. The operation of natural selection tends to result in the acceptance of mutation ...
Wax ester biosynthetic pathway - Iowa State University Digital
... amounts of these chemicals. Sperm whale oil contains up to 95% of wax ester consisting of 34 carbons (Crisp, Eaton et al. 1984). Whales were an excellent source of wax ester, until whale hunting was banned internationally in the 1980s. The best alternative to whale oil is now jojoba oil, which occur ...
... amounts of these chemicals. Sperm whale oil contains up to 95% of wax ester consisting of 34 carbons (Crisp, Eaton et al. 1984). Whales were an excellent source of wax ester, until whale hunting was banned internationally in the 1980s. The best alternative to whale oil is now jojoba oil, which occur ...
Cytochrome P450-enzymes involved in the biosynthesis of mono
... et al. 2011). This finding was not only unexpected because of the low sequence identity with other flavonoid 30 -hydroxylases (35–37 % identity on amino acid level), but also because of the different locations of the biosynthesis of flavonoids and monoterpenoids in planta (Kaltenbach et al. 1999; Ou ...
... et al. 2011). This finding was not only unexpected because of the low sequence identity with other flavonoid 30 -hydroxylases (35–37 % identity on amino acid level), but also because of the different locations of the biosynthesis of flavonoids and monoterpenoids in planta (Kaltenbach et al. 1999; Ou ...
The use of deuteration for the structural study of larger proteins
... • If these external magnetic fields fluctuate randomly over time and the changes occur in the appropriate range of frequencies, (α β transitions) this leads to nuclear relaxation. • The required fluctuations of the local magnetic fields can be caused by e.g. brownian motion (overall rotational tumbl ...
... • If these external magnetic fields fluctuate randomly over time and the changes occur in the appropriate range of frequencies, (α β transitions) this leads to nuclear relaxation. • The required fluctuations of the local magnetic fields can be caused by e.g. brownian motion (overall rotational tumbl ...