T-cell Acute Lymphoblastic Leukemia-The
... motif places SCL/tal in a family of proteins, identified in organisms ranging from yeast to humans, which bind specific DNA sequences and regulate the transcriptional activity of target genes.l0 Other bHLH genes involved in leukemic translocations include C-mycl’ and E2A,I2J3contributing to an emerg ...
... motif places SCL/tal in a family of proteins, identified in organisms ranging from yeast to humans, which bind specific DNA sequences and regulate the transcriptional activity of target genes.l0 Other bHLH genes involved in leukemic translocations include C-mycl’ and E2A,I2J3contributing to an emerg ...
Gene Section TYR (tyrosinase (oculocutaneous albinism IA)) Atlas of Genetics and Cytogenetics
... pigmentation. Patients are advised to protect their skin from sun to prevent sunburn (Ray et al., 2007). Oncogenesis Transcription of tyrosinase has been shown to increase with activation of the tumor suppressor p53, linking both to the tanning response following exposure to UV damage (Khlgatian et ...
... pigmentation. Patients are advised to protect their skin from sun to prevent sunburn (Ray et al., 2007). Oncogenesis Transcription of tyrosinase has been shown to increase with activation of the tumor suppressor p53, linking both to the tanning response following exposure to UV damage (Khlgatian et ...
PDF
... bp (FERRO_contig000001). The gaps between these contigs are thought to contain ribosomal RNA gene clusters since both ends of FERRO_contig000001 and one end of each of the other two contigs contain ribosomal RNA genes. The therefore nearly complete genome sequence of “Ferrovum” strain JA12 consists ...
... bp (FERRO_contig000001). The gaps between these contigs are thought to contain ribosomal RNA gene clusters since both ends of FERRO_contig000001 and one end of each of the other two contigs contain ribosomal RNA genes. The therefore nearly complete genome sequence of “Ferrovum” strain JA12 consists ...
Dissertation zur Erlangung des Doktorgrades der Fakultät für Chemie und Pharmazie
... sequence homology, have been identified. Although the other serotypes have attracted increasing attention during recent years, AAV type 2 is the most prominent serotype for gene therapy, being the first isolated, cloned, and best characterized. Since all following descriptions will refer to AAV type ...
... sequence homology, have been identified. Although the other serotypes have attracted increasing attention during recent years, AAV type 2 is the most prominent serotype for gene therapy, being the first isolated, cloned, and best characterized. Since all following descriptions will refer to AAV type ...
Designed sequences improve distant homology detection
... matrix elements) such that at w 0.9 the contributions of pairwise and single-residue potentials are about equal. Designed sequences used in homology detection We automate the sequence design procedure and similarity searches. For each template protein structure (taken from the Protein Data Bank), ...
... matrix elements) such that at w 0.9 the contributions of pairwise and single-residue potentials are about equal. Designed sequences used in homology detection We automate the sequence design procedure and similarity searches. For each template protein structure (taken from the Protein Data Bank), ...
Pluripotent stem cell metabolism and mitochondria: beyond ATP
... biosynthesis, and in anaplerosis (synthesis of TCA cycle intermediates), while glucose derived carbon is used for macromolecule synthesis [92]. Indeed, in mouse ESC cultured in the presence of glucose, virtually all glutamate, αKG and malate in the TCA are derived from glutaminolysis [83]. In contra ...
... biosynthesis, and in anaplerosis (synthesis of TCA cycle intermediates), while glucose derived carbon is used for macromolecule synthesis [92]. Indeed, in mouse ESC cultured in the presence of glucose, virtually all glutamate, αKG and malate in the TCA are derived from glutaminolysis [83]. In contra ...
The Art of Multiple Sequence Alignment in R
... of DNA, RNA, or amino acid (AA) sequences and returns a merged alignment. For more than two sequences, the function AlignSeqs can be used to perform multiple sequence alignment in a progressive/iterative manner on sequences of the same kind. In this case, multiple alignment works by aligning two seq ...
... of DNA, RNA, or amino acid (AA) sequences and returns a merged alignment. For more than two sequences, the function AlignSeqs can be used to perform multiple sequence alignment in a progressive/iterative manner on sequences of the same kind. In this case, multiple alignment works by aligning two seq ...
A Mutation Causing Reduced Biological Activity and Stability of
... Fig. 3. Detection of the TBG-Gary mutation by Sau3A\ digestion of amplified DNA sequences The strategy of analysis is shown diagrammatically on the upper portion of the figure. The coding sequences of the first exon (stippled area) is contained in the amplified 903 bp fragment having at each end seq ...
... Fig. 3. Detection of the TBG-Gary mutation by Sau3A\ digestion of amplified DNA sequences The strategy of analysis is shown diagrammatically on the upper portion of the figure. The coding sequences of the first exon (stippled area) is contained in the amplified 903 bp fragment having at each end seq ...
mthfr - SpectraCell Laboratories
... and morbidity inthat cancer. One of the steps in metastasis process is the conclusion, Methionine formation of new blood vessels. Aberrant DNA methylation patterns are common in cancer cells. In recent studies, Supplementation useful against angiogenesis as effects a on some S-adenosylmethionine (SA ...
... and morbidity inthat cancer. One of the steps in metastasis process is the conclusion, Methionine formation of new blood vessels. Aberrant DNA methylation patterns are common in cancer cells. In recent studies, Supplementation useful against angiogenesis as effects a on some S-adenosylmethionine (SA ...
(9E10): sc-40 - Santa Cruz Biotechnology
... c-Myc-, N-Myc- and L-Myc-encoded proteins function in cell proliferation, differentiation and neoplastic disease. Amplification of the c-Myc gene has been found in several types of human tumors including lung, breast and colon carcinomas. The presence of three sequence motifs in the c-Myc COOH termi ...
... c-Myc-, N-Myc- and L-Myc-encoded proteins function in cell proliferation, differentiation and neoplastic disease. Amplification of the c-Myc gene has been found in several types of human tumors including lung, breast and colon carcinomas. The presence of three sequence motifs in the c-Myc COOH termi ...
characterisation of novel proteins
... characterisation of the transferred genes, their origin, function and stability; changes at the DNA, protein and whole food levels; compositional analyses; evaluation of intended and unintended changes; and the potential for the newly expressed proteins to be either allergenic or toxic to humans. Hi ...
... characterisation of the transferred genes, their origin, function and stability; changes at the DNA, protein and whole food levels; compositional analyses; evaluation of intended and unintended changes; and the potential for the newly expressed proteins to be either allergenic or toxic to humans. Hi ...
Carcinoembryonic Antigens - The Journal of Cell Biology
... set of four alternatively spliced mRNAs which are expressed in several tumor cell lines, in human fetal liver, and in L-cell transfectants. Deduced amino acid sequences of the encoded isoantigens show extensive similarity to CEA and nonspecific cross-reacting antigens, but in addition demonstrate tr ...
... set of four alternatively spliced mRNAs which are expressed in several tumor cell lines, in human fetal liver, and in L-cell transfectants. Deduced amino acid sequences of the encoded isoantigens show extensive similarity to CEA and nonspecific cross-reacting antigens, but in addition demonstrate tr ...
msb145697-sup-0001-Supp_Info
... and , responding to only Climitation and only A-limitation, respectively. While the C- and A- sector proteins belong only to the and respectively, the “multi-purpose” S-sector proteins belong to both lists. B An illustrative mechanism generating the expression pattern of an S-sector protein: the cor ...
... and , responding to only Climitation and only A-limitation, respectively. While the C- and A- sector proteins belong only to the and respectively, the “multi-purpose” S-sector proteins belong to both lists. B An illustrative mechanism generating the expression pattern of an S-sector protein: the cor ...
Topic guide 12.4: Analysis methods
... an initial set of amino acid sequences, which are believed to represent a given protein family (for example, the prion proteins: http://www.bioinf.manchester.ac.uk/cgi-bin/dbbrowser/ALIGN/ PRINTShtmlalign.cgi?align=PRION); she examines the alignment to discover the most conserved regions or motifs. ...
... an initial set of amino acid sequences, which are believed to represent a given protein family (for example, the prion proteins: http://www.bioinf.manchester.ac.uk/cgi-bin/dbbrowser/ALIGN/ PRINTShtmlalign.cgi?align=PRION); she examines the alignment to discover the most conserved regions or motifs. ...
Lecture 2 Sequence Alignment
... • homologous sequences can be divided into two groups – orthologous sequences: sequences that differ because they are found in different species (e.g. human α -globin and mouse α-globin) – paralogous sequences: sequences that differ because of a gene duplication event (e.g. human α-globin and hum ...
... • homologous sequences can be divided into two groups – orthologous sequences: sequences that differ because they are found in different species (e.g. human α -globin and mouse α-globin) – paralogous sequences: sequences that differ because of a gene duplication event (e.g. human α-globin and hum ...
The Complement of Protein Phosphatase
... 1–12) containing animal EF hand-containing protein phosphatases (PPEFs) sequences and the Drosophila melanogaster protein RdgC. A PP5 cluster (sequences 13–25) contains one Arabidopsis sequence. Sequences 26 through 29 form a cluster consisting of three bacterial sequences plus an Arabidopsis sequen ...
... 1–12) containing animal EF hand-containing protein phosphatases (PPEFs) sequences and the Drosophila melanogaster protein RdgC. A PP5 cluster (sequences 13–25) contains one Arabidopsis sequence. Sequences 26 through 29 form a cluster consisting of three bacterial sequences plus an Arabidopsis sequen ...
ppt - University of Connecticut
... Fig. 9(a) shows that in genes with more transcripts is more difficult to correctly reconstruct all transcripts. As a result Cufflinks performs better on genes with few transcripts since annotations are not used in it standard settings. DRUT has higher sensitivity on genes with 2 and 3 transcripts, b ...
... Fig. 9(a) shows that in genes with more transcripts is more difficult to correctly reconstruct all transcripts. As a result Cufflinks performs better on genes with few transcripts since annotations are not used in it standard settings. DRUT has higher sensitivity on genes with 2 and 3 transcripts, b ...
Constitutive expression of RyhB regulates the heme biosynthesis
... can accumulate ALA using glucose as sole carbon source through the C5 pathway (Kang et al., 2011). However, further regulation of this pathway for high ALA production met with many problems because C5 pathway is already highly regulated. For example, HemA and HemL work synergistically, whereas HemA ...
... can accumulate ALA using glucose as sole carbon source through the C5 pathway (Kang et al., 2011). However, further regulation of this pathway for high ALA production met with many problems because C5 pathway is already highly regulated. For example, HemA and HemL work synergistically, whereas HemA ...
Identification of Novel Non-Metal Haloperoxidases from the Marine
... Cassette PCR primers used in this study consisted of three parts of DNA primers. We first selected the well-conserved domains of the HPO enzyme family genes in the N-terminal region (FHHGWP) and C-terminal region (DDQIVP) for designing degenerate central oligonucleotide primers for the forward direc ...
... Cassette PCR primers used in this study consisted of three parts of DNA primers. We first selected the well-conserved domains of the HPO enzyme family genes in the N-terminal region (FHHGWP) and C-terminal region (DDQIVP) for designing degenerate central oligonucleotide primers for the forward direc ...
Genetic defects causing mitochondrial respiratory
... 1993). Thus, with advancing age in postmitotic (differentiated) tissues, there is thought to be a potentially important level of accumulation of mitochondrial mutations that can exceed the threshold for clinical consequence. In summary, where the metabolic disorder is due to a defect of a mitochondr ...
... 1993). Thus, with advancing age in postmitotic (differentiated) tissues, there is thought to be a potentially important level of accumulation of mitochondrial mutations that can exceed the threshold for clinical consequence. In summary, where the metabolic disorder is due to a defect of a mitochondr ...
Isolation and characterization of (S)
... obtained (Kutchan, 1995). Alkaloids are a group of naturally occurring low-molecular weight nitrogenous compounds found in about 20% of plant species. The majority of alkaloids in plants are derived from the amino acids tyrosine, tryptophan and phenylalanine. They are often basic and contain nitroge ...
... obtained (Kutchan, 1995). Alkaloids are a group of naturally occurring low-molecular weight nitrogenous compounds found in about 20% of plant species. The majority of alkaloids in plants are derived from the amino acids tyrosine, tryptophan and phenylalanine. They are often basic and contain nitroge ...
Cellular DNA Polymerases - DNA Replication and Human Disease
... of proteins that include 85-kD, 70-kD, and 49-kD proteins (S. Linn, pers. comm.). In budding yeast, pol-& was reported to contain a 256-kD catalytic subunit encoded by the POL2 gene and four subunits of 80 kD, 34 kD, 31 kD, and 29 kD encoded by genes DPB2, DPB3, DPB3, and DPBI, respectively. Althoug ...
... of proteins that include 85-kD, 70-kD, and 49-kD proteins (S. Linn, pers. comm.). In budding yeast, pol-& was reported to contain a 256-kD catalytic subunit encoded by the POL2 gene and four subunits of 80 kD, 34 kD, 31 kD, and 29 kD encoded by genes DPB2, DPB3, DPB3, and DPBI, respectively. Althoug ...
Inositol 1,3,4,5,6-Pentakisphosphate 2-Kinase
... have been proposed for higher plants (Brearley and Hanke, 2000; Stevenson-Paulik et al., 2002; Raboy, 2003). Radioisotope labeling experiments with duckweed (Spirodela polyrhiza), an aquatic plant, suggest that a lipid-independent pathway may be operational in plants. The intermediates of this phyti ...
... have been proposed for higher plants (Brearley and Hanke, 2000; Stevenson-Paulik et al., 2002; Raboy, 2003). Radioisotope labeling experiments with duckweed (Spirodela polyrhiza), an aquatic plant, suggest that a lipid-independent pathway may be operational in plants. The intermediates of this phyti ...
Endogenous retrovirus
Endogenous retroviruses (ERVs) are endogenous viral elements in the genome that closely resemble and can be derived from retroviruses. They are abundant in the genomes of jawed vertebrates, and they comprise up to 5–8% of the human genome (lower estimates of ~1%). ERVs are a subclass of a type of gene called a transposon, which can be packaged and moved within the genome to serve a vital role in gene expression and in regulation. Researchers have suggested that retroviruses evolved from a type of transposable gene called a retrotransposon, which includes ERVs; these genes can mutate and instead of moving to another location in the genome they can become exogenous or pathogenic. This means that all ERVs may not have originated as an insertion by a retrovirus but that some may have been the source for the genetic information in the retroviruses they resemble.