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Catalytic, Enantioselective Alkylation of r
Catalytic, Enantioselective Alkylation of r

... Over the past several years, highly effective methods for enantioselective aldol additions catalyzed by Lewis acids have been developed.1 Analogous alkylations of imines, however, have not been nearly as well studied nor as successful.2 R-Imino esters are almost unstudied in Lewis acid-catalyzed rea ...
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... rate-equilibriumrelationships from SN2 reactions to the more complex problems of additions to sp and sp2 centres. It is also necessary to extend experimental investigations of the rate-equilibrium behavior of alpha-nucleophilesto a range of dipolar non-hydroxylic solvents. Finally, it appears that t ...
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... without substituted with another atom or group.  The elimination of HX molecule from alkyl derivatives. While X is a halogen or ester… etc. the hydrogen atom on adjacent carbon with X  Elimination reactions and nucleophilic substitution are similar in cases of affecting factors.  Hence it’s a com ...
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Asymmetric induction



Asymmetric induction (also enantioinduction) in stereochemistry describes the preferential formation in a chemical reaction of one enantiomer or diastereoisomer over the other as a result of the influence of a chiral feature present in the substrate, reagent, catalyst or environment. Asymmetric induction is a key element in asymmetric synthesis.Asymmetric induction was introduced by Hermann Emil Fischer based on his work on carbohydrates. Several types of induction exist.Internal asymmetric induction makes use of a chiral center bound to the reactive center through a covalent bond and remains so during the reaction. The starting material is often derived from chiral pool synthesis. In relayed asymmetric induction the chiral information is introduced in a separate step and removed again in a separate chemical reaction. Special synthons are called chiral auxiliaries. In external asymmetric induction chiral information is introduced in the transition state through a catalyst of chiral ligand. This method of asymmetric synthesis is economically most desirable.
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