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Altered gene expression of proinflammatory cytokines and their
Altered gene expression of proinflammatory cytokines and their

... Abnormalities of the immune function have been implicated in the pathophysiology of depression. This is primarily based on the observation that treating cancer patients with a cytokine interferon(IFN)-α causes depressionlike symptoms and that protein levels of proinflammatory cytokines and their sol ...
week4am
week4am

... next neuron synapse or synaptic cleft ◦ the space between neurons where communication occurs postsynaptic membrane ◦ the portion of the neuron (usually dendrite) that receives ...
Technical Data Sheet
Technical Data Sheet

... Gamma-aminobutyric acid type B receptor subunit 2, gb2, GABA-BR2, GABA-B-R2, GABA-B receptor 2, GABA -B receptor, R2 subunit, G protein-coupled receptor 51, G -protein coupled receptor 51, gamma-aminobutyric acid B receptor 2 ...
Syllabus
Syllabus

... Introduction.    Gross  anatomy.    Golgi  vs.  Cajal  in  the  neuron  doctrine.       ...
The Special Senses
The Special Senses

... Special Senses • Olfaction, gustation, equilibrium, hearing, & vision • Found within complex sense organs • Pass information along the cranial nerves to specific areas of the cerebral cortex. ...
The Synapse - University of Toronto
The Synapse - University of Toronto

... synaptic cleft, which in turn stimulates NMDA (blue rectangle), AMPA (red, yellow rectangle), and metabotropic (brown membrane protein) glutamate receptors. In the spine, actin cables (vertical pink filaments) are linked to brain spectrin (red, horizontal molecules). Also present in the spine are en ...
here - York University
here - York University

... post-synaptic potential (EPSP)). GABA causes chloride to enter the neuron causing a hyperpolarization and electrical inhibition of the neuron (this is referred to as an inhibitory post-synaptic potential (IPSP)). ...
Neural Control II
Neural Control II

... and reward, sleep, mood, attention and learning ...
action potential
action potential

... – transplants of fetal dopamineproducing substantia nigra cells – adrenal gland transplants – electrical stimulation of the thalamus has been used to stop tremors ...
Exam 3 Review KEY
Exam 3 Review KEY

... 7) Bundles of afferent and efferent neurons outside the CNS but inside the PNS are referred to as nerves. While bundle of afferent and efferent neurons within the CNS are referred to as tracts. 8) In the PNS the Schwann cells wrap around the axon and are referred to as the neurilemma. Between adjace ...
Chapter 6
Chapter 6

... c. This amino acid neurotransmitter acts as excitatory signals, activating NMethyl-d–aspartate (NMDA) receptors which have been implicated in learning and memory. Overstimulation by this neurotransmitter of NMDA receptors, however, can cause nerve cell damage or cell death. d. This catecholamine neu ...
Document
Document

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Nerve Cells
Nerve Cells

... development? How is parkinsonism treated? • How are neurotransmitters released at the synapse? What proteins are involved? Name the calcium ion sensor • Describe the Otto Loewi experiment and explain its significance. • What is myasthenia gravis and what is the mechanism for its development? • Descr ...
The Nervous System
The Nervous System

... • The binding of the acetylcholine receptors on the sarcolemma signals the release of acetylcholinesterase from the sarcolemma. • This enzyme breaks down acetylcholine in the synaptic cleft. One molecule of acetylcholinesterase breaks down 25,000 molecules of acetylcholine each second. This speed ma ...
Lecture 12
Lecture 12

... a. touch, pressure, vibration, proprioception etc. 2. thermoreceptors - changes in temperature 3. nocireceptors - pain; physical or chemical damage 4. photoreceptors - light; rods & cones of the eye 5. chemoreceptors - shapes of different molecules a. taste, smell, chemicals of blood C. Simplicity o ...
Identification of chemical probes for ionotropic glutamate receptors
Identification of chemical probes for ionotropic glutamate receptors

... Identification of chemical probes for ionotropic glutamate receptors We have an exciting opportunity for a talented, highly motivated scientist with a strong background in organic chemistry to join our centre to study for a DPhil. Project outline Ligand-gated ion channels are cell surface proteins t ...
Unit Test Neuro: Core ( Topic 6.5) and Options E ( Topics 1,2,4) HL
Unit Test Neuro: Core ( Topic 6.5) and Options E ( Topics 1,2,4) HL

... Explain how animal experiments, lesions and FMRI (functional magnetic resonance imaging) scanning can be used in the identification of the brain part involved in specific functions. (3) ...
indirect pathway
indirect pathway

... Group I mGluRs activate adenylyl cyclase and phospholipase C(PLC), while group II and group III mGluRs inhibit adenylyl cyclase. The downstream effects of mGluRs on ion channels and complex and varied. Some of the main actions on ion channels are listed. Note that the actions of group I receptors ar ...
Neurotransmitters
Neurotransmitters

... with the vagus nerve which controls heart rate attached, the other heart on its own. Both hearts were bathed in a saline solution (i.e. Ringer's solution). By electrically stimulating the vagus nerve, Loewi made the first heart beat slower. Then, Loewi took some of the liquid bathing the first heart ...
Cranial Nerve I
Cranial Nerve I

... Figure III from Table 13.2 ...
Tyrosine-Derived Neurotransmitters
Tyrosine-Derived Neurotransmitters

... Serotonin containing neurons have their cell bodies in the midline raphe nuclei of the brain stem and project to portions of the hypothalamus, the limbic system, the neocortex and the spinal cord. After release from serotonergic neurons, most of the released serotonin is recaptured by an active reup ...
초록리스트
초록리스트

... The hypothalamic paraventricular nucleus (PVN) is well known integrative center for autonomic responses to stressors. To study whether corticosterone (CORT) can act directly to the pre-sympathetic neurons in the PVN which modulate sympathetic outflow, we aimed to show the effect of CORT on spontaneo ...
List of vocabulary used in understanding the nervous
List of vocabulary used in understanding the nervous

... for touch, taste, and smell and by collecting information about temperature, light, and sound). The body reflexively responds to external stimuli through a reflex arc. A reflex arc is the pathway along the central nervous system where an impulse must travel to bring about a reflex; e.g., sneezing or ...
Brain Awareness Day - Lakehead Science Education (Matt Roy)
Brain Awareness Day - Lakehead Science Education (Matt Roy)

... • All parts of your tongue can taste all tastes but there are places where certain receptors are concentrated! ….. Or are there? • Let’s map your tongue! ...
Nociceptive system
Nociceptive system

... Somatic sensory analyzer ...
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Endocannabinoid system

The endocannabinoid system is a group of neuromodulatory lipids and their receptors in the brain that are involved in a variety of physiological processes including appetite, pain-sensation, mood, and memory; it mediates the psychoactive effects of cannabis and, broadly speaking, includes: The endogenous arachidonate-based lipids, anandamide (N-arachidonoylethanolamide, AEA) and 2-arachidonoylglycerol (2-AG); these are known as ""endocannabinoids"" and are physiological ligands for the cannabinoid receptors. Endocannabinoids are all eicosanoids. The enzymes that synthesize and degrade the endocannabinoids, such as fatty acid amide hydrolase or monoacylglycerol lipase. The cannabinoid receptors CB1 and CB2, two G protein-coupled receptors that are located in the central and peripheral nervous systems.The neurons, neural pathways, and other cells where these molecules, enzymes, and one or both cannabinoid receptor types are all colocalized form the endocannabinoid system.The endocannabinoid system has been studied using genetic and pharmacological methods. These studies have revealed that cannabinoids act as neuromodulators for a variety of processes, including motor learning, appetite, and pain sensation, among other cognitive and physical processes. The localization of the CB1 receptor in the endocannabinoid system has a very large degree of overlap with the orexinergic projection system, which mediates many of the same functions, both physical and cognitive. Moreover, CB1 is colocalized on orexin projection neurons in the lateral hypothalamus and many output structures of the orexin system, where the CB1 and orexin receptor 1 (OX1) receptors physically and functionally join together to form the CB1–OX1 receptor heterodimer.
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