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A Stereoscopic Look at Visual Cortex
A Stereoscopic Look at Visual Cortex

... The second difference has to do with correlated versus anticorrelated random-dot stereograms [random arrays of dots that look unstructured when viewed monocularly, but yield disparity-defined structure under binocular inspection (Julesz 1971)]. With random-dot stereograms (RDSs), the task of correct ...
The Biological Bases of Time-to
The Biological Bases of Time-to

... suggested that the LGMD post-synaptically multiplies an excitatory and inhibitory input via two different parts of LGMD neuron’s dendritic tree. In order to provide evidence in support of this model these authors (Gabbiani et al., 2002) have selectively activated and deactivated pre-and post synapti ...
1 Spiking Neurons
1 Spiking Neurons

... This definition of rate has been successfully used in many preparations, particularly in experiments on sensory or motor systems. A classical example is the stretch receptor in a muscle spindle [Adrian, 1926]. The number of spikes emitted by the receptor neuron increases with the force applied to th ...
ppt - UCSD Cognitive Science
ppt - UCSD Cognitive Science

... are nee ded to s ee this picture. ...
Do cortical areas emerge from a protocottex?
Do cortical areas emerge from a protocottex?

... Early events in cortical development A discussion of differentiation of the areas of the neocortex should include the early stages of cortical development. Cortical neurons are generated in the neuroepithelium of the lateral ventricle. They migrate away from this site along the processes of radial g ...
Asynchronous state
Asynchronous state

... large fluctuations in the excitatory and inhibitory currents occur simultaneously and cancel, leading to a significant reduction in the correlation of the total synaptic currents c and output spikes. ...
A dendritic disinhibitory circuit mechanism for pathway
A dendritic disinhibitory circuit mechanism for pathway

... Disinhibiting the branches targeted by one pathway can selectively open the gate for this pathway while keeping the gates closed for other pathways (Fig. 2d). When a gate is open, the neuron’s output firing rate transmits the stimulus selectivity of the corresponding input pathway most effectively (F ...
Vesicular glutamate transporters (VGLUTs): The three musketeers of
Vesicular glutamate transporters (VGLUTs): The three musketeers of

... 212 M. Liguz-Lecznar and J. Skangiel-Kramska 2003) and each isoform is associated with distinct endophilins, the proteins regulating synaptic vesicle formation and trafficking (De Gois et al. 2006). Unexpectedly, VGLUT1 and VGLUT2 mRNA and protein were found in some isolated dopaminergic neurons (D ...
Glial heterogeneity: the increasing complexity of the brain
Glial heterogeneity: the increasing complexity of the brain

... Indeed, numerous examples of glial heterogeneity exist. This is especially conspicuous in the morphological specialization of astrocytes (.  Fig. 2). In some regions such as the cerebellar cortex and the retina, they exhibit a radial orientation. In contrast, astrocytes in the cortex or hippocampus ...
Chapter 7 The Nervous System
Chapter 7 The Nervous System

... Integration of things observed ...
BRAIN DYNAMICS AT MULTIPLE SCALES: CAN ONE RECONCILE
BRAIN DYNAMICS AT MULTIPLE SCALES: CAN ONE RECONCILE

... Dynamics in Brain Activity The above results are consistent with the idea that awake brain activity may be associated with high-dimensional dynamics, perhaps analogous to a stochastic system. To further investigate this aspect, we have examined data from animal experiments in which both microscopic ...
Neuronal networks for induced `40 Hz` rhythms
Neuronal networks for induced `40 Hz` rhythms

A simulation of parahippocampal and hippocampal structures guiding spatial navigation of
A simulation of parahippocampal and hippocampal structures guiding spatial navigation of

... 1992; Quirk et al., 1992; Frank et al., 2002) and in anesthetized animals (Alonso and GarciaAustt, 1987). They could also be due to changes in the magnitude of synaptic transmission due to modulation of synaptic transmission. For example, activation of presynaptic metabotropic glutamate receptors ha ...
Visual Motion Perception using Critical Branching Neural Computation
Visual Motion Perception using Critical Branching Neural Computation

... and the assignment of f(si) is switched for excitatory versus inhibitory neurons. In essence, the critical branching algorithm potentiates synapses when too few descendant spikes occur, and depotentiates when too many occur. Spikes are time-weighted because effects of ancestor spikes on descendant n ...
PDF-document - homepage.ruhr-uni
PDF-document - homepage.ruhr-uni

... attenuated and reappeared with the second push phase at the peripheral target. The activity was attenuated again in the third arm movement phase back to the start position, and low spontaneous or no activity prevailed until the first push phase of the next trial. The time course of somatosensory-mot ...
Got diversity? Wiring the fly brain with Dscam
Got diversity? Wiring the fly brain with Dscam

... These isoforms include 19 008 different ectodomains joined to one of two alternative transmembrane segments. Each ectodomain comprises a unique combination of three variable immunoglobulin domains. Biochemical studies support a model in which each isoform preferentially binds to the same isoform on ...
EXERCISE TRAINING AND SYMPATHETIC NERVOUS SYSTEM
EXERCISE TRAINING AND SYMPATHETIC NERVOUS SYSTEM

... of physical activity dependent plasticity in the central nervous system (CNS). Of particular interest are functional improvements, such as those reported for memory and cognition,35–39 that are associated with changes in the number, structure and function of neurons.35,40 Recent studies indicate tha ...
Avian brains and a new understanding of
Avian brains and a new understanding of

... With these challenges to the classical view of the subpallial relationships among birds, reptiles and mammals came challenges to the classical view of the relationships among their pallia. The mammalian pallium includes the areas known as palaeocortex, archicortex and neocortex; and has been said, m ...
Lack of response suppression follows repeated ventral tegmental
Lack of response suppression follows repeated ventral tegmental

... firing rate. The increases in firing rate and the time to return to basal firing were not significantly different between exposures. Furthermore, the cannabinoid antagonist SR141716A completely prevented the HU210-induced excitation whilst having no effect on its own, thus indicating a CB1-receptor ...
A logical calculus of the ideas immanent in
A logical calculus of the ideas immanent in

... part of the net. The second concerns learning, in which activities concurrent at some previous time have altered the net permanently, so that a stimulus which would previously have been inadequate is now adequate. But for nets undergoing both alterations, we can substitute equivalent fictitious nets ...
A Brief Overview of Molecular Mechanisms of Depression and its
A Brief Overview of Molecular Mechanisms of Depression and its

... metabolic pathways, revealing that depression may be a much more fundamental disturbance in physical function than previously assumed. This paper focuses on some of the current research on the molecular and cellular mechanisms underlying depression and the action of its treatments. ETIOLOGY ...
Neuroscience Newsletter, May 2015 - MSc/PhD/MD
Neuroscience Newsletter, May 2015 - MSc/PhD/MD

... of cytoplasmic channels within the growing myelin sheath enables membrane trafficking to the leading edge. Most of these channels close during development but can be reopened in adults by experimentally raising phosphatidylinositol-(3,4,5)-triphosphate levels, which reinitiates myelin growth. In add ...
Brain-implantable biomimetic electronics as the next era in neural
Brain-implantable biomimetic electronics as the next era in neural

... The computational properties of the prosthetic being developed are based on the hippocampus, a cortical region of the brain involved in the formation of new long-term memories. The hippocampus lies beneath the phylogenetically more recent neocortex, and is composed of several different subsystems th ...
Further Cognitive Science
Further Cognitive Science

... But a correlation is a relationship between two different things and hence is inconsistent with Crick’s eliminativism; ...
Cover page
Cover page

... Our laboratory seeks to understand how the needs of the body determine which sensory cues are attended to, learned, and remembered. In particular, we are investigating how natural and experimentally induced states of hunger modulate neural representations of food cues, and the consequences for obesi ...
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Activity-dependent plasticity

A defining feature of the brain is its capacity to undergo changes based on activity-dependent functions, also called activity-dependent plasticity. Its ability to remodel itself forms the basis of the brain’s capacity to retain memories, improve motor function, and enhance comprehension and speech amongst other things. It is this trait to retain and form memories that is functionally linked to plasticity and therefore many of the functions individuals perform on a daily basis. This plasticity is the result of changed gene expression that occurs because of organized cellular mechanisms.The brain’s ability to adapt toward active functions has allowed humans to specialize in specific processes based on relative use and activity. For example, a right-handed person may perform any movement poorly with his/her left hand but continuous practice with the less dominant hand can make both hands just as able. Another example is if someone was born with a neurological disorder such as autism or had a stroke that resulted in a disorder, then they are capable of retrieving much of their lost function by practicing and “rewiring” the brain in order to incorporate these lost manners. Thanks to the pioneers within this field, many of these advances have become available to most people and many more will continue to arrive as new features of plasticity are discovered.
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