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Motor learning in man: A review of functional and clinical studies
Motor learning in man: A review of functional and clinical studies

... observed regardless of the hand used during training, indicating a left-hemispheric dominance in the storage of visuomotor skills. Concerning frontal areas, learned actions of sequential character are represented in the caudal part of the supplementary motor area (SMA proper), whereas the lateral pr ...
Impaired odour discrimination on desynchronization of odour
Impaired odour discrimination on desynchronization of odour

... We have previously shown that picrotoxin (PCT) applied to the locust antennal lobe selectively blocks the fast inhibitory synapse between local and projection neurons and abolishes their oscillatory synchronization: this manipulation altered neither the response profiles of projection neurons to odo ...
High-Level Visual Processing: Cognitive Influences
High-Level Visual Processing: Cognitive Influences

... in primates resulted in loss of the ability to recognize objects. This impairment is distinct from the deficits that accompany lesions of occipital cortical areas in that sensitivity to basic visual attributes, such as color, motion, and distance, remains intact. Because of the unusual type of visua ...
Signaling by truncated Dab1 protein - Development
Signaling by truncated Dab1 protein - Development

... phosphorylation (Howell et al., 2000), suggesting that some other change induced by activated VLDLR and apoER2, for example, possible serine phosphorylation or relocalization of Dab1, triggers changes in the rates of Dab1 synthesis or degradation. Decreased Dab1 protein levels may be part of a negat ...
Cyclooxygenase-2 (COX-2) in Inflammatory and Degenerative Brain
Cyclooxygenase-2 (COX-2) in Inflammatory and Degenerative Brain

... COX-2 expression should be more correctly regarded as ‘‘dynamically’’ regulated since it is dependent on normal synaptic activity, is rapidly increased during seizures or ischemia, and is downregulated by glucocorticoids (6). The dependence of COX-2 expression on natural excitatory synaptic activity ...
8129402
8129402

... complexes of various innate potentials that are developed one way or another depending upon the training. ...
18 Coordination in Behavior and Cognition
18 Coordination in Behavior and Cognition

... must order themselves in new or different ways to accommodate current conditions. The patterns that emerge may be dened as attractor states of the collective variable dynamics; that is, the collective variable may converge in time to a certain limit set or attractor solution. Mathematically, system ...
Interplay of environmental signals and progenitor diversity on fate
Interplay of environmental signals and progenitor diversity on fate

... the two most abundant classes of cortical interneurons with non-overlapping molecular identities and relatively large cell bodies (>20µm; DeFelipe, 1993, 1997; Kawaguchi and Kondo, 2002). GABAergic interneurons expressing PV make up ∼40% of all cortical interneurons of which basket and chandelier ce ...
Optimal Sizes of Dendritic and Axonal Arbors
Optimal Sizes of Dendritic and Axonal Arbors

... 3.2 Other factors affecting arbor sizes One may argue that dendrites and axons have functions other than linking cell bodies to synapses and, therefore, the size of the arbors may be dictated by other considerations. Although I can not rule out this possibility, the primary function ofaxons and dend ...
The Neuropsychology of Sigmund Freud
The Neuropsychology of Sigmund Freud

... My curiosity was piqued by a reference to the "Project for a Scientific Psychology" in Jones's biography (1953). I fully expected the Project (13) to be of historical interest-but if this were all, there would be little use in preparing a chapter such as this. I found rather, that the Project contai ...
A Computational Model of the Amygdala Nuclei`s Role in - laral
A Computational Model of the Amygdala Nuclei`s Role in - laral

... feature of the model (Fig. 1) is the explicit representation of the three major anatomical components of the amygdala [13]: the lateral amygdala (LA), the basolateral amygdala (BLA), and the central nucleus of amygdala (CeA). The model assumes that these components form two functional sub-systems: ( ...
The Calcium Rationale in Aging and Alzheimer`s Disease
The Calcium Rationale in Aging and Alzheimer`s Disease

... intimately involved in a variety of “plastic” changes in the brain. For example, during adaptive processes such as learning and development, changes in transmembrane calcium fluxes correlate with changes in neuronal excitability and structural connectivity. Calcium thus is likely to have key roles i ...
http://www.utdallas.edu/~tres/papers/Disterhoftetal1994.pdf
http://www.utdallas.edu/~tres/papers/Disterhoftetal1994.pdf

... intimately involved in a variety of “plastic” changes in the brain. For example, during adaptive processes such as learning and development, changes in transmembrane calcium fluxes correlate with changes in neuronal excitability and structural connectivity. Calcium thus is likely to have key roles i ...
On the Role of the Pontine Brainstem in Vocal Pattern Generation: A
On the Role of the Pontine Brainstem in Vocal Pattern Generation: A

... were tested: activity type, timing of activity, excitation/inhibition, call-pattern correlation, call specificity, and pre-vocal onset time. Statistical analyses were performed for the syllable pre-onset times by a univariate variance analysis (general linear model) comparing general Figure 2. Front ...
Modulation of Neuronal Activity in the Monkey Putamen Associated
Modulation of Neuronal Activity in the Monkey Putamen Associated

... inside the guide and was advanced using a manual hydraulic microdrive (MO95, Narishige, Tokyo, Japan). The signal from neuronal activity was amplified 5,000 times, filtered at 0.3–1.5 kHz, and converted to digital pulses through a window discriminator (NeuroLog, Digitimer, Hertfordshire, UK). Presen ...
Tracking Whole-Brain Connectivity Dynamics in the Resting State
Tracking Whole-Brain Connectivity Dynamics in the Resting State

... terms (Hagmann et al. 2008; Buckner et al. 2009). This dramatically different view on aspects of brain function may in turn help improve diagnostic relevance for neuropsychiatric disorders, in particular where activation differences are subtle (Fornito and Bullmore 2012). Despite such progress, we a ...
Prediction error for free monetary reward in the human prefrontal
Prediction error for free monetary reward in the human prefrontal

... Studies in both humans and nonhuman primates have shown that frontostriatal circuits are important for mediating the influence of reward expectation on the selection and preparation of actions. Specific dopamine-rich regions within the prefrontal cortex (Goldman-Rakic et al., 1992; Lidow et al., 199 ...
Embodied Cognition and Mirror Neurons
Embodied Cognition and Mirror Neurons

... activity during a task discriminating between hues of gray. Then, within these areas, they tested whether the activity during retrieval of color knowledge (e.g., TAXI = yellow) was greater than that during a control task requiring subjects to evaluate whether a particular motor property was associat ...
Self-organization and interareal networks™in™the™primate cortex
Self-organization and interareal networks™in™the™primate cortex

... the developmental process where the gene is expressed, thereby testifying on the one hand to the complexity of the developmental process, and on the other indicating the limitations of the reductionist approach. An alternative but complementary approach is to record events during development in such ...
Synaptic Distinction of Laminar-specific Prefrontal-temporal Pathways in Primates
Synaptic Distinction of Laminar-specific Prefrontal-temporal Pathways in Primates

... Barbas, 1988). On the other hand, lateral prefrontal areas, such as area 10, have a role in cognitive tasks, including extracting relevant auditory signals from noise and in specialized working memory tasks (e.g. Chao and Knight, 1997, 1998; Koechlin et al., 1999). The termination in auditory associ ...
Continuous transformation learning of translation
Continuous transformation learning of translation

... 2003; Serre et al. 2007) include feedforward connectivity, local lateral inhibition within a layer to implement competition, and then some form of associative learning. We show by simulation how CT learning can be used to build translation invariant representations in a hierarchical network model (V ...
The Neuroscientist
The Neuroscientist

... only using univariate methods such as t-tests and correlation analysis (Voyvodic 1999), the general linear model (GLM), and multiple regression (Voyvodic 1999; Smyser and others 2001; Bagarinao and others 2003; Weiskopf and others 2004) but also with more advanced multivariate methods such as indepe ...
PDF
PDF

... columns, with cell dense cores, are typical of the main posteromedial field in rats (Rice, 1995). Variability is not reported for other columnar systems of connections, but this is likely because many of the systems are harder to visualize globally or require specialized tissue processing. In primar ...
Amyloid-Beta Induced Changes in Vesicular Transport of BDNF in
Amyloid-Beta Induced Changes in Vesicular Transport of BDNF in

... provide insights into the cellular mechanism underlying, for example, Alzheimer’s disease (AD). To analyze the role of BDNF transport in AD, live cell imaging of fluorescently labeled BDNF was performed in hippocampal neurons of different AD model systems. BDNF and APP colocalized with low incidence ...
Descending Pathways in Motor Control
Descending Pathways in Motor Control

... a pathway in a selective manner that allows additional insight into function. Unfortunately, a completed checklist of all these features is still not available for any of the major mammalian descending pathways. We now have advanced anatomical details for many of them, but the functional roles of ea ...
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Activity-dependent plasticity

A defining feature of the brain is its capacity to undergo changes based on activity-dependent functions, also called activity-dependent plasticity. Its ability to remodel itself forms the basis of the brain’s capacity to retain memories, improve motor function, and enhance comprehension and speech amongst other things. It is this trait to retain and form memories that is functionally linked to plasticity and therefore many of the functions individuals perform on a daily basis. This plasticity is the result of changed gene expression that occurs because of organized cellular mechanisms.The brain’s ability to adapt toward active functions has allowed humans to specialize in specific processes based on relative use and activity. For example, a right-handed person may perform any movement poorly with his/her left hand but continuous practice with the less dominant hand can make both hands just as able. Another example is if someone was born with a neurological disorder such as autism or had a stroke that resulted in a disorder, then they are capable of retrieving much of their lost function by practicing and “rewiring” the brain in order to incorporate these lost manners. Thanks to the pioneers within this field, many of these advances have become available to most people and many more will continue to arrive as new features of plasticity are discovered.
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