Dynamics of Protein Metabolism in the Ruminant
... glycoproteins of mucus). Energy substrates come from the residual fermentable fibre, the glycocalyx of rumen microorganisms, starch and other polysaccharides that have resisted rumen and enteric digestion. As the amount of fermentable energy from the diet reaching the lower tract increases, microbia ...
... glycoproteins of mucus). Energy substrates come from the residual fermentable fibre, the glycocalyx of rumen microorganisms, starch and other polysaccharides that have resisted rumen and enteric digestion. As the amount of fermentable energy from the diet reaching the lower tract increases, microbia ...
University of Birmingham Armadillo repeat proteins: beyond the
... intracellular tail of cadherin through its Arm repeats [39]; the N-terminus of b-catenin in turn interacts with a-catenin [40], which interacts with actin [41]. Desmosomes – specialized adhesive structures that are prevalent in tissue types such as epithelia and link keratin intermediate filaments t ...
... intracellular tail of cadherin through its Arm repeats [39]; the N-terminus of b-catenin in turn interacts with a-catenin [40], which interacts with actin [41]. Desmosomes – specialized adhesive structures that are prevalent in tissue types such as epithelia and link keratin intermediate filaments t ...
Citrate transporters of Bacillus subtilis Krom, Bastiaan Philip
... inactive mutants showed that pmf-dependent symport is catalyzed by the dimer, while exchange is catalyzed by the monomer as functional unit (41). The oligomeric state of some secondary transporters has been determined. Some were found to be monomers, while others are present in the membrane as highe ...
... inactive mutants showed that pmf-dependent symport is catalyzed by the dimer, while exchange is catalyzed by the monomer as functional unit (41). The oligomeric state of some secondary transporters has been determined. Some were found to be monomers, while others are present in the membrane as highe ...
Identification of a family of BspA like surface proteins of Entamoeba
... with the concept that these genes could have come to E. histolytica via lateral gene transfer from prokaryotes [8]. With the completion of the E. histolytica genome project, we used the InterProScan software (http://www.ebi.ac.uk/ InterProScan) to screen for additional E. histolytica sequences that ...
... with the concept that these genes could have come to E. histolytica via lateral gene transfer from prokaryotes [8]. With the completion of the E. histolytica genome project, we used the InterProScan software (http://www.ebi.ac.uk/ InterProScan) to screen for additional E. histolytica sequences that ...
Macromolecules
... strikingly and obviously different in appearance. You could see the difference if it were out of focus, and you could feel the differences in the dark. This is critically important, because SO CAN AN ENZYME! Such as the enzymes that control the expression of genetic information. DNA usually exists i ...
... strikingly and obviously different in appearance. You could see the difference if it were out of focus, and you could feel the differences in the dark. This is critically important, because SO CAN AN ENZYME! Such as the enzymes that control the expression of genetic information. DNA usually exists i ...
of membrane lipids
... • Always attached to a C-terminal residue • Ethanolamine link to an oligosaccharide linked in turn to inositol of PI • See Figure 9.20 • Examples: surface antigens, adhesion molecules, cell surface hydrolases ...
... • Always attached to a C-terminal residue • Ethanolamine link to an oligosaccharide linked in turn to inositol of PI • See Figure 9.20 • Examples: surface antigens, adhesion molecules, cell surface hydrolases ...
Isoforms of acetyl-CoA carboxylase
... important inhibitory phosphorylation site at Ser79 in rat ACC-1 is phosphorylated by AMP-activated protein kinase (AMP-PK). Additional sites at Ser-1200 and Ser-1215 may be phosphorylated by either AMP-PK or CAMP-dependent protein kinase (PKA), and although these latter two sites are phosphorylated ...
... important inhibitory phosphorylation site at Ser79 in rat ACC-1 is phosphorylated by AMP-activated protein kinase (AMP-PK). Additional sites at Ser-1200 and Ser-1215 may be phosphorylated by either AMP-PK or CAMP-dependent protein kinase (PKA), and although these latter two sites are phosphorylated ...
IOSR Journal of Applied Chemistry (IOSR-JAC) e-ISSN: 2278-5736.
... simulate the possible reaction (and interactions) between two molecules based on their three dimensional structures. The need for a rapid search for small molecules that may bind to targets of biological interest is of crucial importance in the drug discovery process. One way of achieving this is th ...
... simulate the possible reaction (and interactions) between two molecules based on their three dimensional structures. The need for a rapid search for small molecules that may bind to targets of biological interest is of crucial importance in the drug discovery process. One way of achieving this is th ...
Mycobacterial Heat Shock Proteins as Vaccines - A Model
... amino acid sequence homology of 61% to hsp60 (Cpn60-1) and 53% to the GroEL of E. coil [71]. Hsp60 functions as a complex with hsp10 in the classical GroES-GroEL protein folding system. This complex has been extensively reviewed [8-12], thus only a brief overview will be given as shown in Fig. (1). ...
... amino acid sequence homology of 61% to hsp60 (Cpn60-1) and 53% to the GroEL of E. coil [71]. Hsp60 functions as a complex with hsp10 in the classical GroES-GroEL protein folding system. This complex has been extensively reviewed [8-12], thus only a brief overview will be given as shown in Fig. (1). ...
Four-body Statistical Potentials
... Four-Body Potentials Scoring Livebench 6 and CASP5 predictions Livebench Automated evaluation of structure prediction servers Set 6 had 32 “easy” and 66 “hard” targets CASP 5 3D coordinate models submitted for 56 targets Native structure of 33 targets has been released - rank 3D predictions using f ...
... Four-Body Potentials Scoring Livebench 6 and CASP5 predictions Livebench Automated evaluation of structure prediction servers Set 6 had 32 “easy” and 66 “hard” targets CASP 5 3D coordinate models submitted for 56 targets Native structure of 33 targets has been released - rank 3D predictions using f ...
What are the intermolecular forces that lead to this compact folding
... a repeated unit of length 7 amino acids, which is called a heptad repeat. Denote those 7 positions by a through g, then position a and d are hydrophobic and define an apolar stripe, while there exist electrostatic interactions between residues at positions e and g. Prediction methods for coiled-coil ...
... a repeated unit of length 7 amino acids, which is called a heptad repeat. Denote those 7 positions by a through g, then position a and d are hydrophobic and define an apolar stripe, while there exist electrostatic interactions between residues at positions e and g. Prediction methods for coiled-coil ...
Subtype-Specific Sorting of the ETA Endothelin Receptor by a Novel
... membrane pathways. The prevailing model proposes that internalized receptors are prevented from recycling by becoming sequestered and retained in multivesicular bodies (Sorkin and von Zastrow, 2002). According to this model, recycling is considered the default destiny of membrane receptors not being ...
... membrane pathways. The prevailing model proposes that internalized receptors are prevented from recycling by becoming sequestered and retained in multivesicular bodies (Sorkin and von Zastrow, 2002). According to this model, recycling is considered the default destiny of membrane receptors not being ...
In vivo interactions of higher plant Golgi matrix proteins by
... the endoplasmic reticulum (ER). It has long been known that the structure of the plant Golgi apparatus in higher plants is generally different to that in mammalian and fungal systems, comprising many discrete stacks of cisternae (or Golgi bodies) that appear more or less randomly distributed through ...
... the endoplasmic reticulum (ER). It has long been known that the structure of the plant Golgi apparatus in higher plants is generally different to that in mammalian and fungal systems, comprising many discrete stacks of cisternae (or Golgi bodies) that appear more or less randomly distributed through ...
University of Groningen Sugar transport in
... or carbohydrate uptake transporter (CUT)-family, and the di/oligopeptide transport-, or Opp-family [22]. These two families differ not only in substrate specificity but also in the architecture of the transport complex. Members of the bacterial CUT-family are involved in the uptake of glycerol-phosp ...
... or carbohydrate uptake transporter (CUT)-family, and the di/oligopeptide transport-, or Opp-family [22]. These two families differ not only in substrate specificity but also in the architecture of the transport complex. Members of the bacterial CUT-family are involved in the uptake of glycerol-phosp ...
The trans-Golgi network GRIP-domain proteins form α
... golgins specifically associated with the TGN (trans-Golgi network) have recently been identified [6,7] based on the presence of a modestly conserved, 45-residue Golgi targeting sequence located at the C-terminus, called the GRIP domain [8–10]. The importance of the TGN golgins is highlighted by the ...
... golgins specifically associated with the TGN (trans-Golgi network) have recently been identified [6,7] based on the presence of a modestly conserved, 45-residue Golgi targeting sequence located at the C-terminus, called the GRIP domain [8–10]. The importance of the TGN golgins is highlighted by the ...
Protein 4.1, a component of the erythrocyte membrane skeleton and
... with both proteins can be modulated by various factors, such as the binding of calmodulin-Ca2+ to protein 4.1R [92, 129] or the phosphorylation of protein 4.1R [59, 103]. In the presence of Ca2+, calmodulin reduces the affinity of protein 4.1R for the spectrin-actin complex and decreases the membran ...
... with both proteins can be modulated by various factors, such as the binding of calmodulin-Ca2+ to protein 4.1R [92, 129] or the phosphorylation of protein 4.1R [59, 103]. In the presence of Ca2+, calmodulin reduces the affinity of protein 4.1R for the spectrin-actin complex and decreases the membran ...
Section 5.3: Proteins
... Less structurally complex than larger proteins, peptides still have biologically important functions Glutathione is a tripeptide found in most all organisms and is involved in protein and DNA synthesis, toxic substance metabolism, and amino acid transport Vasopressin is an antidiuretic hormone th ...
... Less structurally complex than larger proteins, peptides still have biologically important functions Glutathione is a tripeptide found in most all organisms and is involved in protein and DNA synthesis, toxic substance metabolism, and amino acid transport Vasopressin is an antidiuretic hormone th ...
Serine phosphorylation of the cotton cytosolic pyruvate kinase
... Cotton is one of the most important economical crops cultivated globally. After undergoing a period of fast elongation (~ 20 days) and a secondary wall deposition (~ 30 days), trichomes initiated from cotton ovule epidermal cells develop into spinnable fibers, which is a great textile material with ...
... Cotton is one of the most important economical crops cultivated globally. After undergoing a period of fast elongation (~ 20 days) and a secondary wall deposition (~ 30 days), trichomes initiated from cotton ovule epidermal cells develop into spinnable fibers, which is a great textile material with ...
GENE NOMENCLATURE OF DIFFERENT TYPES OF SPINOCEREBELLAR ATAXIA (SCA) AND
... by either a recessive or dominant gene. Many times people are not aware that they carry the ataxia gene until they have children who begin to show signs of having the disorder [1]. Symptoms manifest between third and fourth decade with death resulting from bulbar dysfunction after 10-20 years. Juven ...
... by either a recessive or dominant gene. Many times people are not aware that they carry the ataxia gene until they have children who begin to show signs of having the disorder [1]. Symptoms manifest between third and fourth decade with death resulting from bulbar dysfunction after 10-20 years. Juven ...
Protein thermal stability: insights from atomic displacement
... determined by high-resolution X-ray crystallographic studies might contain information regarding protein stability. The correlation between experimentally observed B values and stability, unlike the contributions of various other interactions, has not been examined in any great detail. The distribut ...
... determined by high-resolution X-ray crystallographic studies might contain information regarding protein stability. The correlation between experimentally observed B values and stability, unlike the contributions of various other interactions, has not been examined in any great detail. The distribut ...
Pathology - specific Gene Discovery Program
... Example: Proteins A, B, and C Proteins A and B interact Protein A phosphorylates a residue on B ...
... Example: Proteins A, B, and C Proteins A and B interact Protein A phosphorylates a residue on B ...
Enzyme changes in malnutrition - Journal of Clinical Pathology
... The first enzyme to be studied from a nutritional standpoint was also a protein derived from the liver, namely, cholinesterase (EC 3.1.1.8). At about the same time McCance and his colleagues working on adults in Germany (Hutchinson, McCance, and Widdowson, 1951) and I working on infants in West Afri ...
... The first enzyme to be studied from a nutritional standpoint was also a protein derived from the liver, namely, cholinesterase (EC 3.1.1.8). At about the same time McCance and his colleagues working on adults in Germany (Hutchinson, McCance, and Widdowson, 1951) and I working on infants in West Afri ...
Deletion mutant of FGFR4 induces onion
... Fibroblast growth factor receptors 1-4 (FGFR1-4) are high affinity receptors for the large family of fibroblast growth factors, which mediate a range of biological responses such as cell proliferation, differentiation and migration (Burgess and Maciag, 1989; Hughes, 1997; Ornitz and Itoh, 2001). The ...
... Fibroblast growth factor receptors 1-4 (FGFR1-4) are high affinity receptors for the large family of fibroblast growth factors, which mediate a range of biological responses such as cell proliferation, differentiation and migration (Burgess and Maciag, 1989; Hughes, 1997; Ornitz and Itoh, 2001). The ...
Deletion mutant of FGFR4 induces onion
... Fibroblast growth factor receptors 1-4 (FGFR1-4) are high affinity receptors for the large family of fibroblast growth factors, which mediate a range of biological responses such as cell proliferation, differentiation and migration (Burgess and Maciag, 1989; Hughes, 1997; Ornitz and Itoh, 2001). The ...
... Fibroblast growth factor receptors 1-4 (FGFR1-4) are high affinity receptors for the large family of fibroblast growth factors, which mediate a range of biological responses such as cell proliferation, differentiation and migration (Burgess and Maciag, 1989; Hughes, 1997; Ornitz and Itoh, 2001). The ...
G protein–coupled receptor
G protein–coupled receptors (GPCRs), also known as seven-transmembrane domain receptors, 7TM receptors, heptahelical receptors, serpentine receptor, and G protein–linked receptors (GPLR), constitute a large protein family of receptors that sense molecules outside the cell and activate inside signal transduction pathways and, ultimately, cellular responses. Coupling with G proteins, they are called seven-transmembrane receptors because they pass through the cell membrane seven times.G protein–coupled receptors are found only in eukaryotes, including yeast, choanoflagellates, and animals. The ligands that bind and activate these receptors include light-sensitive compounds, odors, pheromones, hormones, and neurotransmitters, and vary in size from small molecules to peptides to large proteins. G protein–coupled receptors are involved in many diseases, and are also the target of approximately 40% of all modern medicinal drugs. Two of the United States's top five selling drugs (Hydrocodone and Lisinopril) act by targeting a G protein–coupled receptor. The 2012 Nobel Prize in Chemistry was awarded to Brian Kobilka and Robert Lefkowitz for their work that was ""crucial for understanding how G protein–coupled receptors function."". There have been at least seven other Nobel Prizes awarded for some aspect of G protein–mediated signaling.There are two principal signal transduction pathways involving the G protein–coupled receptors: the cAMP signal pathway and the phosphatidylinositol signal pathway. When a ligand binds to the GPCR it causes a conformational change in the GPCR, which allows it to act as a guanine nucleotide exchange factor (GEF). The GPCR can then activate an associated G protein by exchanging its bound GDP for a GTP. The G protein's α subunit, together with the bound GTP, can then dissociate from the β and γ subunits to further affect intracellular signaling proteins or target functional proteins directly depending on the α subunit type (Gαs, Gαi/o, Gαq/11, Gα12/13).