Plastid-Targeting Peptides from the
... LASTIDS, the light-harvesting organelles of plants and algae, are the product of an ancient symbiosis between a cyanobacterium and a non-photosynthetic eukaryote. This process is referred to as primary endosymbiosis, and has given rise to the plastids of green algae and land plants, red algae and gl ...
... LASTIDS, the light-harvesting organelles of plants and algae, are the product of an ancient symbiosis between a cyanobacterium and a non-photosynthetic eukaryote. This process is referred to as primary endosymbiosis, and has given rise to the plastids of green algae and land plants, red algae and gl ...
Protein Structure Analysis and Prediction
... asset. It would help in understanding the structures and functions of the thousands of sequences that are being discovered every day in biotechnology labs [Chan and Dill 1993]. However, predicting tertiary structure from primary structure has proved to be a very difficult problem. This paper describ ...
... asset. It would help in understanding the structures and functions of the thousands of sequences that are being discovered every day in biotechnology labs [Chan and Dill 1993]. However, predicting tertiary structure from primary structure has proved to be a very difficult problem. This paper describ ...
Dr. John Perozich's Full CV
... Lakes Bioinformatics (GLBIO) Conference, May 2012, Ann Arbor, MI. Undergraduate research project by Alyssa Morey in which 60 protein sequences of pyruvate kinases from various species were aligned to elucidate structural, functional and phylogenetic relationships in the enzyme. Comparative Analysis ...
... Lakes Bioinformatics (GLBIO) Conference, May 2012, Ann Arbor, MI. Undergraduate research project by Alyssa Morey in which 60 protein sequences of pyruvate kinases from various species were aligned to elucidate structural, functional and phylogenetic relationships in the enzyme. Comparative Analysis ...
Supplemental file S8 to
... in its representation of the number of PDZ domains encoded per genome and per gene (Fig. S1A, S1C-E). Logarithmic plotting of the various genome sizes and their associated PDZomes shows that this increase in the total number of PDZ domains encoded and the number of PDZ encoding genes can be approxi ...
... in its representation of the number of PDZ domains encoded per genome and per gene (Fig. S1A, S1C-E). Logarithmic plotting of the various genome sizes and their associated PDZomes shows that this increase in the total number of PDZ domains encoded and the number of PDZ encoding genes can be approxi ...
In search of the molecular mechanism of intracellular membrane
... botulinum neurotoxin E and washing away the fragment, we inhibited membrane fusion and transmitter release. By adding back the coil, we showed that release was rescued. Now we had a way to study the relationship between SNARE complex formation, calcium dependence and norepinephrine release. We could ...
... botulinum neurotoxin E and washing away the fragment, we inhibited membrane fusion and transmitter release. By adding back the coil, we showed that release was rescued. Now we had a way to study the relationship between SNARE complex formation, calcium dependence and norepinephrine release. We could ...
Gene Section PPARD (peroxisome proliferator-activated receptor delta) Atlas of Genetics and Cytogenetics
... Kilgore KS, Billin AN. PPARbeta/delta ligands as modulators of the inflammatory response. Curr Opin Investig Drugs. 2008 May;9(5):463-9 ...
... Kilgore KS, Billin AN. PPARbeta/delta ligands as modulators of the inflammatory response. Curr Opin Investig Drugs. 2008 May;9(5):463-9 ...
a proprietary enzyme blend designed
... the individual amino acids themselves, which are then absorbed into the body for use in a variety of functions, including building hormones and neurotransmitters, and also promoting immune function plus tissue repair.10-13 Some of the most important amino acids for skeletal muscle growth, and thus s ...
... the individual amino acids themselves, which are then absorbed into the body for use in a variety of functions, including building hormones and neurotransmitters, and also promoting immune function plus tissue repair.10-13 Some of the most important amino acids for skeletal muscle growth, and thus s ...
Receptor Activation and Homer Differentially Control the Lateral
... receptor (between the Ser-22 and Ser-23 codons of mGluR5a, amino acid 1 being the initiating methionine) or just before the stop codon for the C -terminal epitope-tagged receptor, using a PCR overlap extension method. Sense and antisense oligonucleotides coding the c-myc epitope (TREQK LISEEDL AR) w ...
... receptor (between the Ser-22 and Ser-23 codons of mGluR5a, amino acid 1 being the initiating methionine) or just before the stop codon for the C -terminal epitope-tagged receptor, using a PCR overlap extension method. Sense and antisense oligonucleotides coding the c-myc epitope (TREQK LISEEDL AR) w ...
Mechanisms of enveloped RNA virus budding
... underlie many viral replication strategies. First, the limited coding capacity of RNA viruses forces them to use host cell factors to extend their capabilities. Second, viral proteins often achieve this by mimicking the structures and functions of cellular proteins. Third, different viruses, as well ...
... underlie many viral replication strategies. First, the limited coding capacity of RNA viruses forces them to use host cell factors to extend their capabilities. Second, viral proteins often achieve this by mimicking the structures and functions of cellular proteins. Third, different viruses, as well ...
A protein kinase target of a PDK1 signalling pathway is involved in
... in animals, with the important exception of phosphatidylinositol (3,4,5) triphosphate, the protein targets and signalling pathways of plant phospholipids are largely unknown (Mueller-Roeber and Pical, 2002). In animal cells, PDK1 is a central integrator for signalling events downstream of various re ...
... in animals, with the important exception of phosphatidylinositol (3,4,5) triphosphate, the protein targets and signalling pathways of plant phospholipids are largely unknown (Mueller-Roeber and Pical, 2002). In animal cells, PDK1 is a central integrator for signalling events downstream of various re ...
Protein Solubility as Quality Index for Processed Soybean (PDF
... certain amount of protein by humans or animals [3,4,5]. It is closely related to amino-acid availability. Protein digestibility is a major index of protein quality because a certain amount of amino-acids may be present in a food and it may not necessarily be available to the organism for nourishment ...
... certain amount of protein by humans or animals [3,4,5]. It is closely related to amino-acid availability. Protein digestibility is a major index of protein quality because a certain amount of amino-acids may be present in a food and it may not necessarily be available to the organism for nourishment ...
EF-TU - Soran University
... The focus here will be on structural aspects, and on protein factors involved in initiation, elongation, & termination of protein synthesis. Many of these factors are GTP-binding proteins, & other proteins that control GDP/GTP exchange or GTPase activity of these GTP-binding proteins. Bacterial tra ...
... The focus here will be on structural aspects, and on protein factors involved in initiation, elongation, & termination of protein synthesis. Many of these factors are GTP-binding proteins, & other proteins that control GDP/GTP exchange or GTPase activity of these GTP-binding proteins. Bacterial tra ...
Protein prediction methods – steps of analysis
... classified upon their relationships to phospholipid bilayers i.e., those that are soluble and exist in the cytoplasm, in the lumen of an organelle or in the extracellular environments and those that are membrane attached associated wit a lipid bilayer. They can be integral membrane proteins or they ...
... classified upon their relationships to phospholipid bilayers i.e., those that are soluble and exist in the cytoplasm, in the lumen of an organelle or in the extracellular environments and those that are membrane attached associated wit a lipid bilayer. They can be integral membrane proteins or they ...
Membrane Adaptation and Solute Uptake Systems
... The archaeal protein bacteriorhodopsin (that acts as a light-driven proton pump) from Halobacterium halobium is the only transport protein to have been crystallized in pure form and its three-dimensional structure determined. Consequently, it is used as a paradigm for the folding and insertion of tr ...
... The archaeal protein bacteriorhodopsin (that acts as a light-driven proton pump) from Halobacterium halobium is the only transport protein to have been crystallized in pure form and its three-dimensional structure determined. Consequently, it is used as a paradigm for the folding and insertion of tr ...
The Crystal Structure of Arabidopsis thaliana Allene Oxide Cyclase
... N-terminal His6-tag and some vector-specific residues are disordered in the crystal structure. The barrel forms an elongated cavity, which is lined mostly by aromatic and hydrophobic residues and reaches ;14 Å into the protein (Figure 2C). Three areas of the cavity surface are noteworthy. First, th ...
... N-terminal His6-tag and some vector-specific residues are disordered in the crystal structure. The barrel forms an elongated cavity, which is lined mostly by aromatic and hydrophobic residues and reaches ;14 Å into the protein (Figure 2C). Three areas of the cavity surface are noteworthy. First, th ...
Electrostatic Interactions in Wild
... Ala pMbV68D' V68E' Val68 Glu, CysllO Ala pMbV68E' Val68 Asn. Cysl 10 Ala pMbV68N' V68N' ...
... Ala pMbV68D' V68E' Val68 Glu, CysllO Ala pMbV68E' Val68 Asn. Cysl 10 Ala pMbV68N' V68N' ...
Prediction of protein function using a deep convolutional
... 2.1 Representation of protein structure The building blocks of proteins are amino acids which are linked together by peptide bonds into a chain. The polypeptide folds into a specific conformation depending on the interactions between its amino acid side chains which have different chemistries. Many ...
... 2.1 Representation of protein structure The building blocks of proteins are amino acids which are linked together by peptide bonds into a chain. The polypeptide folds into a specific conformation depending on the interactions between its amino acid side chains which have different chemistries. Many ...
Phosphoproteomics reveals extensive in vivo phosphorylation of
... and turnover of the protein involved. In the past, however, the analysis of phosphorylation sites of proteins has been a great challenge. In the last few years there has been an explosive growth in the amount of studies describing the use of immobilized metal affinity chromatography (IMAC) (1) or ot ...
... and turnover of the protein involved. In the past, however, the analysis of phosphorylation sites of proteins has been a great challenge. In the last few years there has been an explosive growth in the amount of studies describing the use of immobilized metal affinity chromatography (IMAC) (1) or ot ...
A new approach to increase yields and improve
... • Preliminary data applying a similar approach to increase yields of high and low copy number plasmids from E. coli cultures suggest that utilization of an EnPresso growth system optimized for plasmid production could not only enable cultures to reach higher cell densities but may also increase the ...
... • Preliminary data applying a similar approach to increase yields of high and low copy number plasmids from E. coli cultures suggest that utilization of an EnPresso growth system optimized for plasmid production could not only enable cultures to reach higher cell densities but may also increase the ...
A new method for predicting signal sequence cleavage sites
... sequences with known cleavage sites have been added to the data base. Using the same weight-matrix as above (Table 1), 75J of these sites were correctly ...
... sequences with known cleavage sites have been added to the data base. Using the same weight-matrix as above (Table 1), 75J of these sites were correctly ...
ppt - Chair of Computational Biology
... V8 – 3D Modelling of TM proteins Aim: structural modelling of G-protein coupled receptors. - involved in cell communication processes - mediate senses as vision, smell, taste, and pain - regulation of appetite, digestion, blood pressure, reproduction, inflammation Extracellular signals: - chemicals ...
... V8 – 3D Modelling of TM proteins Aim: structural modelling of G-protein coupled receptors. - involved in cell communication processes - mediate senses as vision, smell, taste, and pain - regulation of appetite, digestion, blood pressure, reproduction, inflammation Extracellular signals: - chemicals ...
Full PDF
... segment is replaced with that of a different antibody . The wild-type and mutant crystal structures have been refined to a crystallographic R-factor of 14·9% at a nominal resolution of 1·97 A. A detailed description of the structures is given. Crystal packing results in a dimeric association of doma ...
... segment is replaced with that of a different antibody . The wild-type and mutant crystal structures have been refined to a crystallographic R-factor of 14·9% at a nominal resolution of 1·97 A. A detailed description of the structures is given. Crystal packing results in a dimeric association of doma ...
The origin of the eukaryotic cell: A genomic investigation
... cholesterol, and steroids are synthesized in the smooth ER. The rough ER is so designated because it is a membrane decorated by ribosomes, where proteins are synthesized, folded, and packaged for transport to the Golgi apparatus. This relationship between the smooth and rough ER is indicative of an ...
... cholesterol, and steroids are synthesized in the smooth ER. The rough ER is so designated because it is a membrane decorated by ribosomes, where proteins are synthesized, folded, and packaged for transport to the Golgi apparatus. This relationship between the smooth and rough ER is indicative of an ...
G protein–coupled receptor
G protein–coupled receptors (GPCRs), also known as seven-transmembrane domain receptors, 7TM receptors, heptahelical receptors, serpentine receptor, and G protein–linked receptors (GPLR), constitute a large protein family of receptors that sense molecules outside the cell and activate inside signal transduction pathways and, ultimately, cellular responses. Coupling with G proteins, they are called seven-transmembrane receptors because they pass through the cell membrane seven times.G protein–coupled receptors are found only in eukaryotes, including yeast, choanoflagellates, and animals. The ligands that bind and activate these receptors include light-sensitive compounds, odors, pheromones, hormones, and neurotransmitters, and vary in size from small molecules to peptides to large proteins. G protein–coupled receptors are involved in many diseases, and are also the target of approximately 40% of all modern medicinal drugs. Two of the United States's top five selling drugs (Hydrocodone and Lisinopril) act by targeting a G protein–coupled receptor. The 2012 Nobel Prize in Chemistry was awarded to Brian Kobilka and Robert Lefkowitz for their work that was ""crucial for understanding how G protein–coupled receptors function."". There have been at least seven other Nobel Prizes awarded for some aspect of G protein–mediated signaling.There are two principal signal transduction pathways involving the G protein–coupled receptors: the cAMP signal pathway and the phosphatidylinositol signal pathway. When a ligand binds to the GPCR it causes a conformational change in the GPCR, which allows it to act as a guanine nucleotide exchange factor (GEF). The GPCR can then activate an associated G protein by exchanging its bound GDP for a GTP. The G protein's α subunit, together with the bound GTP, can then dissociate from the β and γ subunits to further affect intracellular signaling proteins or target functional proteins directly depending on the α subunit type (Gαs, Gαi/o, Gαq/11, Gα12/13).