The Immune Response to Helicobacter pylori
... vaccinated with a control protein (FlaA) or negative control. Antibody titers remained high even 8 months after the last immunization. Antibodies were able to bind native flagellin from H. pylori lysate. Vaccination with chimeric flagellin provided mice with significant protection against H. pylori. ...
... vaccinated with a control protein (FlaA) or negative control. Antibody titers remained high even 8 months after the last immunization. Antibodies were able to bind native flagellin from H. pylori lysate. Vaccination with chimeric flagellin provided mice with significant protection against H. pylori. ...
ABSTRACT
... Macrophages play an important role in innate immunity and provide antigen interaction and co-stimulation to adaptive immune cells. These cells are efficient at phagocytosis, and their primary function is to destroy ingested material in their highly acidic phagolysosomes. Upon phagocytosis, macrophag ...
... Macrophages play an important role in innate immunity and provide antigen interaction and co-stimulation to adaptive immune cells. These cells are efficient at phagocytosis, and their primary function is to destroy ingested material in their highly acidic phagolysosomes. Upon phagocytosis, macrophag ...
Is there a scientific question to answer?
... • Responses to Measles, Mumps and Rubella are similar irrespective if given singly or in combination • MMR does not interfere with responses to concomitant vaccines • MMR does not lead to susceptibility to infections in the 90 days post infection • Combined vaccines may display reduced responses du ...
... • Responses to Measles, Mumps and Rubella are similar irrespective if given singly or in combination • MMR does not interfere with responses to concomitant vaccines • MMR does not lead to susceptibility to infections in the 90 days post infection • Combined vaccines may display reduced responses du ...
Nitric oxide—Important messenger in human body
... of the NO action and understanding of this signal cascade it critical for research of novel pharmacological applications [4]. Similar mechanism is employed in the action of NO released from thiol group. Recent studies revealed that NO is capable to activate potassium channels, mainly calcium depende ...
... of the NO action and understanding of this signal cascade it critical for research of novel pharmacological applications [4]. Similar mechanism is employed in the action of NO released from thiol group. Recent studies revealed that NO is capable to activate potassium channels, mainly calcium depende ...
INVESTIGATING ANTIGEN PRESENTATION BY INACTIVATED LYMPHOCYTIC CHORIOMENINGITIS VIRUS AND BY
... Figure 3: Direct and cross-presentation pathways.............................................................................. 8 Figure 4: Detection of LCMV nucleoprotein expression levels in pAPCs following infection with live or inactivated virus.................................................... ...
... Figure 3: Direct and cross-presentation pathways.............................................................................. 8 Figure 4: Detection of LCMV nucleoprotein expression levels in pAPCs following infection with live or inactivated virus.................................................... ...
Dual role for B-1a cells in immunity to influenza virus infection
... S. pneumoniae after their adoptive transfer into Rag1⫺/⫺ recipient mice (17). B-1a cells did not mount anti–PPS-3 responses after immunization with heat-killed S. pneumoniae. Instead, they secreted high amounts of natural antibodies against phosphocholine, which is another antigenic determinant on S ...
... S. pneumoniae after their adoptive transfer into Rag1⫺/⫺ recipient mice (17). B-1a cells did not mount anti–PPS-3 responses after immunization with heat-killed S. pneumoniae. Instead, they secreted high amounts of natural antibodies against phosphocholine, which is another antigenic determinant on S ...
Restoring the Balance of the Autonomic Nervous System as an
... system is able to detect and regulate inflammation in peripheral tissues and is involved in maintaining immune homeostasis. An overview of the role of the autonomic nervous system in inflammation is shown in Figure 1. Several observations have supported the notion that there may be an interaction be ...
... system is able to detect and regulate inflammation in peripheral tissues and is involved in maintaining immune homeostasis. An overview of the role of the autonomic nervous system in inflammation is shown in Figure 1. Several observations have supported the notion that there may be an interaction be ...
Human Disease Ch 2
... Immunity: The ability of the body to defend itself against infectious agents, foreign cells and even abnormal body cells. Specific immunity: Also known as acquired immunity, effective against particular identified foreign agents and develops in response to contact with that agent. Autoimmunity: Occu ...
... Immunity: The ability of the body to defend itself against infectious agents, foreign cells and even abnormal body cells. Specific immunity: Also known as acquired immunity, effective against particular identified foreign agents and develops in response to contact with that agent. Autoimmunity: Occu ...
Licentiate-thesis from the Department of Immunology, Wenner-Gren Institute, Stockholm University, Sweden
... lymphocytes that are primed in the PP migrate to the MLN for further differentiation, then enter the bloodstream and further accumulate in the mucosa. As with B lymphocytes, T lymphocytes up regulate the adhesion molecules CCR9 and α4β7 which facilitates the migration to the gut mucosa. Both CD4+ a ...
... lymphocytes that are primed in the PP migrate to the MLN for further differentiation, then enter the bloodstream and further accumulate in the mucosa. As with B lymphocytes, T lymphocytes up regulate the adhesion molecules CCR9 and α4β7 which facilitates the migration to the gut mucosa. Both CD4+ a ...
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... non-peptide neurotransmitters that serve as a link between the ENS and CNS. Neuropeptides are defined as any peptide released from the nervous system that serves as an intercellular signaling molecule [3]. Neuropeptides and other neurotransmitters, when released at the nerve endings in the colon side ...
... non-peptide neurotransmitters that serve as a link between the ENS and CNS. Neuropeptides are defined as any peptide released from the nervous system that serves as an intercellular signaling molecule [3]. Neuropeptides and other neurotransmitters, when released at the nerve endings in the colon side ...
Identification of Gelsolin, a Ca`-dependent Regulatory Protein of
... lysis is not likely to account for the bulk of gelsolin in serum and that gelsolin is present normally in the extracellular fluid component of blood. Since blood contains millimolar concentrations of Ca", gelsolin should be able to maintain any actin released into the blood stream as a result of cel ...
... lysis is not likely to account for the bulk of gelsolin in serum and that gelsolin is present normally in the extracellular fluid component of blood. Since blood contains millimolar concentrations of Ca", gelsolin should be able to maintain any actin released into the blood stream as a result of cel ...
The avian lung-associated immune system: a review
... particle uptake by these cells has not been observed and characteristic organelles such as apical vesicles are absent [21]. It has been suggested that these cells may not be involved in antigen uptake and processing, but participate in tissue repair [20]. More detailed studies are required to unders ...
... particle uptake by these cells has not been observed and characteristic organelles such as apical vesicles are absent [21]. It has been suggested that these cells may not be involved in antigen uptake and processing, but participate in tissue repair [20]. More detailed studies are required to unders ...
Peptide Vaccine: Progress and Challenges
... 3. Induction of Protective T-Cell and B-Cell Mediated Immunity by Peptide Vaccines A successful vaccine must induce a strong and long memory humoral and cellular immune response, but more importantly, protect against the disease being targeted. Therefore, it is important to evaluate whether the pept ...
... 3. Induction of Protective T-Cell and B-Cell Mediated Immunity by Peptide Vaccines A successful vaccine must induce a strong and long memory humoral and cellular immune response, but more importantly, protect against the disease being targeted. Therefore, it is important to evaluate whether the pept ...
The Influence of Melatonin on Immune System and Cancer
... anti-cancer properties. Melatonin is a regulator of hemopoiesis and modifies various cells and cytokines of the immune system. Melatonin elicits oncostatic properties in a variety of different tumor cells. A number of studies have documented that melatonin, given in combination with chemotherapy to ...
... anti-cancer properties. Melatonin is a regulator of hemopoiesis and modifies various cells and cytokines of the immune system. Melatonin elicits oncostatic properties in a variety of different tumor cells. A number of studies have documented that melatonin, given in combination with chemotherapy to ...
Temeyer 2016 tick salivary cholinesterase
... In addition to a plausible role of tick salivary ChE for detoxification of the bloodmeal, the prolonged attachment of ticks to the host may suggest another potentially significant role for tick salivary ChE. Tissue damage and introduction of “foreign” material into the host during and subsequent to ...
... In addition to a plausible role of tick salivary ChE for detoxification of the bloodmeal, the prolonged attachment of ticks to the host may suggest another potentially significant role for tick salivary ChE. Tissue damage and introduction of “foreign” material into the host during and subsequent to ...
Publications de l`équipe - Centre de recherche de l`Institut Curie
... their exosomes. We show that immature and mature murine DCs secrete morphologically similar exosomes. Extensive proteomic analysis of the two exosome populations showed identical overall protein composition, and provided an exhaustive image of the protein composition of DC-derived exosomes. By quant ...
... their exosomes. We show that immature and mature murine DCs secrete morphologically similar exosomes. Extensive proteomic analysis of the two exosome populations showed identical overall protein composition, and provided an exhaustive image of the protein composition of DC-derived exosomes. By quant ...
Analyzing the antibody against H-Y antigen in hematopoietic cell
... The second procedure, the allogeneic transplant, engrafts stem cells from a donor who is genetically matched to the patient for genes in the human leukocyte antigen (HLA) super-locus. Matching is necessary because the HLA genes govern the interactions between the immune system and all other cells. ...
... The second procedure, the allogeneic transplant, engrafts stem cells from a donor who is genetically matched to the patient for genes in the human leukocyte antigen (HLA) super-locus. Matching is necessary because the HLA genes govern the interactions between the immune system and all other cells. ...
Department of Immunology, the Wenner-Gren Institute Stockholm University, Stockholm, Sweden Doctoral thesis
... Ju mer man tänker, desto mer inser man att det inte finns något enkelt svar. Nalle Puh – AA Milne ...
... Ju mer man tänker, desto mer inser man att det inte finns något enkelt svar. Nalle Puh – AA Milne ...
Association between Tuberculin Skin Test Reactivity, the Memory
... expand after restimulation in the skin and give rise to the characteristic type IV delayed-type hypersensitivity reaction, although positive TST reactions can also be observed in individuals infected with nontuberculous mycobacteria, including the vaccine strain bacille Calmette-Guérin. In addition ...
... expand after restimulation in the skin and give rise to the characteristic type IV delayed-type hypersensitivity reaction, although positive TST reactions can also be observed in individuals infected with nontuberculous mycobacteria, including the vaccine strain bacille Calmette-Guérin. In addition ...
Evaluating the efficacy, safety and possible selenium
... properties of Phse using the carrageenan-induced paw oedema rat model and finally to evaluate the effect of Phse on acute phase proteins in the rat model Methods. For the cytotoxicity effects on lymphocytes, the MTT assay was used where lymphocytes were isolated and divided in to two groups, one gro ...
... properties of Phse using the carrageenan-induced paw oedema rat model and finally to evaluate the effect of Phse on acute phase proteins in the rat model Methods. For the cytotoxicity effects on lymphocytes, the MTT assay was used where lymphocytes were isolated and divided in to two groups, one gro ...
Article
... We next sought to analyze whether the control of MCMV spread was associated with an amplification of γδ T cells in infected organs. S2 Fig. shows the gating strategy used for γδ T cell flow cytometry analysis. After a slight decrease at day 3, γδ T cell numbers increased importantly in the lungs unt ...
... We next sought to analyze whether the control of MCMV spread was associated with an amplification of γδ T cells in infected organs. S2 Fig. shows the gating strategy used for γδ T cell flow cytometry analysis. After a slight decrease at day 3, γδ T cell numbers increased importantly in the lungs unt ...
The Effects of Atrazine on Tail Regeneration in
... indicators because they have thin moist skin, which is used as a respiratory surface, and because they lay their eggs in the water. In this way, they may be exposed to chemicals and other pollutants very easily. Also, the basic development and the immune system of amphibians are similar to that of h ...
... indicators because they have thin moist skin, which is used as a respiratory surface, and because they lay their eggs in the water. In this way, they may be exposed to chemicals and other pollutants very easily. Also, the basic development and the immune system of amphibians are similar to that of h ...
IOSR Journal of Pharmacy and Biological Sciences (IOSRJPBS)
... SLE patients had lower Vitamin D level than healthy controls We found significant differences the level of vitamin D between SLE patients and healthy controls group. SLE patients tend to have lower vitamin D levels than the healthy controls. Kim, et al reported that level of serum 25(OH)D in Korean ...
... SLE patients had lower Vitamin D level than healthy controls We found significant differences the level of vitamin D between SLE patients and healthy controls group. SLE patients tend to have lower vitamin D levels than the healthy controls. Kim, et al reported that level of serum 25(OH)D in Korean ...
Human Invariant Natural Killer T cells possess
... and CD8+ immunity14 and B cell proliferation and immunoglobulin production.11,15,16 These characteristics enable iNKT cells to play an important role during infection. iNKT cell activation results either from direct recognition of microbial lipid antigens presented by the MHC I- like protein CD1d on ...
... and CD8+ immunity14 and B cell proliferation and immunoglobulin production.11,15,16 These characteristics enable iNKT cells to play an important role during infection. iNKT cell activation results either from direct recognition of microbial lipid antigens presented by the MHC I- like protein CD1d on ...
Controlling a Chronic Viral Infection and Nucleic Acid
... during the control of chronic viral infections and how innate immune activation may influence pathogenesis. The innate immune system senses virus infection primarily, but not exclusively, through the recognition of viral nucleic acid. The main pattern recognition receptors involved in sensing of vir ...
... during the control of chronic viral infections and how innate immune activation may influence pathogenesis. The innate immune system senses virus infection primarily, but not exclusively, through the recognition of viral nucleic acid. The main pattern recognition receptors involved in sensing of vir ...
Immune system
The immune system is a system of many biological structures and processes within an organism that protects against disease. To function properly, an immune system must detect a wide variety of agents, known as pathogens, from viruses to parasitic worms, and distinguish them from the organism's own healthy tissue. In many species, the immune system can be classified into subsystems, such as the innate immune system versus the adaptive immune system, or humoral immunity versus cell-mediated immunity.Pathogens can rapidly evolve and adapt, and thereby avoid detection and neutralization by the immune system; however, multiple defense mechanisms have also evolved to recognize and neutralize pathogens. Even simple unicellular organisms such as bacteria possess a rudimentary immune system, in the form of enzymes that protect against bacteriophage infections. Other basic immune mechanisms evolved in ancient eukaryotes and remain in their modern descendants, such as plants and insects. These mechanisms include phagocytosis, antimicrobial peptides called defensins, and the complement system. Jawed vertebrates, including humans, have even more sophisticated defense mechanisms, including the ability to adapt over time to recognize specific pathogens more efficiently. Adaptive (or acquired) immunity creates immunological memory after an initial response to a specific pathogen, leading to an enhanced response to subsequent encounters with that same pathogen. This process of acquired immunity is the basis of vaccination.Disorders of the immune system can result in autoimmune diseases, inflammatory diseases and cancer.Immunodeficiency occurs when the immune system is less active than normal, resulting in recurring and life-threatening infections. In humans, immunodeficiency can either be the result of a genetic disease such as severe combined immunodeficiency, acquired conditions such as HIV/AIDS, or the use of immunosuppressive medication. In contrast, autoimmunity results from a hyperactive immune system attacking normal tissues as if they were foreign organisms. Common autoimmune diseases include Hashimoto's thyroiditis, rheumatoid arthritis, diabetes mellitus type 1, and systemic lupus erythematosus. Immunology covers the study of all aspects of the immune system.