An essential role for decorin in bladder cancer invasiveness
... Although the tumour antigens recognized by these T lymphocytes are not known, next generation sequencing performed on human bladder carcinoma revealed a high rate of non‐silent mutations (Gui et al, 2011), which should provide neo‐antigens suitable for T‐cell recognition. Conversely, we have recentl ...
... Although the tumour antigens recognized by these T lymphocytes are not known, next generation sequencing performed on human bladder carcinoma revealed a high rate of non‐silent mutations (Gui et al, 2011), which should provide neo‐antigens suitable for T‐cell recognition. Conversely, we have recentl ...
Prevention of collagen-induced arthritis by gene delivery of
... joint space.8,9 Furthermore, TNF-␣ induces the release of prostaglandin E2 and collagenase by synovial cells, contributes to fibrosis and facilitates inflammatory cell infiltration by promoting adhesion of neutrophils and lymphocytes to endothelial cells. This has led to the hypothesis that excessiv ...
... joint space.8,9 Furthermore, TNF-␣ induces the release of prostaglandin E2 and collagenase by synovial cells, contributes to fibrosis and facilitates inflammatory cell infiltration by promoting adhesion of neutrophils and lymphocytes to endothelial cells. This has led to the hypothesis that excessiv ...
Endogenous collagen peptide activation of CD1d
... peptide activators of NKT cells may offer promise as novel therapeutics in tissue-specific autoimmune and inflammatory diseases. Introduction The immune system responds to invading pathogens by recognizing their antigenic structures, while remaining unresponsive to self antigens. This simplified mod ...
... peptide activators of NKT cells may offer promise as novel therapeutics in tissue-specific autoimmune and inflammatory diseases. Introduction The immune system responds to invading pathogens by recognizing their antigenic structures, while remaining unresponsive to self antigens. This simplified mod ...
![[NOTE: if using this form [bracketed] text is guidance](http://s1.studyres.com/store/data/007988671_1-14bcfda27166539897509a7a0f8c9da0-300x300.png)
[NOTE: if using this form [bracketed] text is guidance
... ● Oct 1998– Sep 1999: Hitchcock Fellowship Research Grant, Dartmouth Medical School “FcαR signal transduction in membrane rafts” PI: Lang, ML. Direct costs $13,000 (total) Fundable or Scored but Not Awarded ● 2007: NIH, Investigator-Initiated RO3 “CD1d-restricted NKT cells and humoral immunity to ba ...
... ● Oct 1998– Sep 1999: Hitchcock Fellowship Research Grant, Dartmouth Medical School “FcαR signal transduction in membrane rafts” PI: Lang, ML. Direct costs $13,000 (total) Fundable or Scored but Not Awarded ● 2007: NIH, Investigator-Initiated RO3 “CD1d-restricted NKT cells and humoral immunity to ba ...
Tolerogenic dendritic cell-based immunotherapy in Crohn’s disease Raquel Cabezón Cabello
... In order to mount an effective immune response against invading pathogens, a highly specific and long lasting immunity is also required. Adaptive immune cells, especially T-cells, can undergo a complex maturation process to finally adapt and respond to a specific type of antigen, generating differen ...
... In order to mount an effective immune response against invading pathogens, a highly specific and long lasting immunity is also required. Adaptive immune cells, especially T-cells, can undergo a complex maturation process to finally adapt and respond to a specific type of antigen, generating differen ...
Activation of a Nonclassical NKT Cell Subset in a Transgenic
... cells display TCRs of restricted heterogeneity (V␣14J␣281) and recognize lipid antigens (e.g., ␣-galactosyl ceramide) presented by nonpolymorphic CD1 molecules. Recently, other nonclassical NKT subsets have been recognized, including NKT cells not reactive with CD1d-␣-galactosyl ceramide complexes. ...
... cells display TCRs of restricted heterogeneity (V␣14J␣281) and recognize lipid antigens (e.g., ␣-galactosyl ceramide) presented by nonpolymorphic CD1 molecules. Recently, other nonclassical NKT subsets have been recognized, including NKT cells not reactive with CD1d-␣-galactosyl ceramide complexes. ...
CTLA-4-mediated regulatory phenotype of T-cells in tolerant lung recipients , S. Boniface*,
... The present authors hypothesised that interactions of autologous dendritic cells (DCs) with Tcells could differ in OB patients compared with healthy lung transplant recipients (LTRs). Monocyte-derived DCs from 14 OB and 35 non-OB LTRs were cultured with autologous T-cells. T-regulatory (Treg) cells, ...
... The present authors hypothesised that interactions of autologous dendritic cells (DCs) with Tcells could differ in OB patients compared with healthy lung transplant recipients (LTRs). Monocyte-derived DCs from 14 OB and 35 non-OB LTRs were cultured with autologous T-cells. T-regulatory (Treg) cells, ...
Tolerance, Danger, and the Extended Family
... may not react at body temperature. I had similar problems with the evidence that most of us do not get demyelinating diseases, yet normal T cells can be immunizedto myelin basic protein. Then there was the problem of tissue-restricted antigens. What mechanismcan induce tolerance to tissue-specific a ...
... may not react at body temperature. I had similar problems with the evidence that most of us do not get demyelinating diseases, yet normal T cells can be immunizedto myelin basic protein. Then there was the problem of tissue-restricted antigens. What mechanismcan induce tolerance to tissue-specific a ...
Janeway`s Immunology - Cal State LA
... P- and N- nucleotides: nucleotides added during initial gene rearrangement and recombination ...
... P- and N- nucleotides: nucleotides added during initial gene rearrangement and recombination ...
Document
... Patients who are always hypocomplementemic regardless of clinical disease activity may have an underlying complement deficiency! ...
... Patients who are always hypocomplementemic regardless of clinical disease activity may have an underlying complement deficiency! ...
ug - Hanover College
... F4/80 high /Ly6Clow /CD206 pos / MHC-2 pos / CD11b pos / CD11c pos / IL-4R pos/ MAC-3 pos ...
... F4/80 high /Ly6Clow /CD206 pos / MHC-2 pos / CD11b pos / CD11c pos / IL-4R pos/ MAC-3 pos ...
Sleep April.indd
... on antigen-presenting cells (APCs) that can drive T cells toward type 1 or type 2 responses. However, despite this key role of APCs in T cell regulation and recent observations indicating that sleep increases type 1 cytokine activity in an undifferentiated monocyte population,13 so far there are no ...
... on antigen-presenting cells (APCs) that can drive T cells toward type 1 or type 2 responses. However, despite this key role of APCs in T cell regulation and recent observations indicating that sleep increases type 1 cytokine activity in an undifferentiated monocyte population,13 so far there are no ...
A Rough look at the tonsils and adenoids, for Bonny Peppa!
... located in a protective ring - called Waldeyer's ring under mucous membranes in the mouth and back of the throat surrounding the openings of the digestive and respiratory tracts. • Help protect against bacteria that may invade tissues in the area around the openings between the oral and nasal caviti ...
... located in a protective ring - called Waldeyer's ring under mucous membranes in the mouth and back of the throat surrounding the openings of the digestive and respiratory tracts. • Help protect against bacteria that may invade tissues in the area around the openings between the oral and nasal caviti ...
The Cnidaria, Past, Present and Future
... and quantitative real-time polymerase chain reaction (qPCR), have opened the doors for discovery of immunerelated genes, especially in non-model organisms. At this time, there are certainly gaps in our knowledge regarding how and when these pathways are controlled and the downstream and phenotypic e ...
... and quantitative real-time polymerase chain reaction (qPCR), have opened the doors for discovery of immunerelated genes, especially in non-model organisms. At this time, there are certainly gaps in our knowledge regarding how and when these pathways are controlled and the downstream and phenotypic e ...
innate immunity in c. elegans
... share a common domain, the leucine rich repeat (LRR) domain. In a recent study, the role in host defences of each of the 14 predicted transmembrane proteins with LRR domains encoded in the C. elegans genome, was assayed. Loss‑of‑function mutants in one gene, fshr‑1, which encodes a glycopeptide horm ...
... share a common domain, the leucine rich repeat (LRR) domain. In a recent study, the role in host defences of each of the 14 predicted transmembrane proteins with LRR domains encoded in the C. elegans genome, was assayed. Loss‑of‑function mutants in one gene, fshr‑1, which encodes a glycopeptide horm ...
Spin models inferred from patient-derived viral sequence data faithfully
... PACS number(s): 87.10.−e, 87.19.xd, 87.18.Vf, 87.23.Cc ...
... PACS number(s): 87.10.−e, 87.19.xd, 87.18.Vf, 87.23.Cc ...
Homeostatic Competition Among T Cells Revealed by
... Whereas the significance of TCR signaling in the thymus and during immune responses is clear, the nature of its role in T cell homeostasis and postthymic selection of naive T cells is unresolved. It is unclear, for instance, whether TCR signaling in response to endogenous peptide–MHC ligands constit ...
... Whereas the significance of TCR signaling in the thymus and during immune responses is clear, the nature of its role in T cell homeostasis and postthymic selection of naive T cells is unresolved. It is unclear, for instance, whether TCR signaling in response to endogenous peptide–MHC ligands constit ...
The immune response during hepatitis B virus infection
... about immunodominance and protective efficacy of different HBV proteins and epitopes will be discussed later. Despite the cellular immune response being a major contributor to HBV clearance, humoral responses also play a role in controlling HBV. HBV clearance is associated with ...
... about immunodominance and protective efficacy of different HBV proteins and epitopes will be discussed later. Despite the cellular immune response being a major contributor to HBV clearance, humoral responses also play a role in controlling HBV. HBV clearance is associated with ...
Immune-Genetic Algorithm for Traveling Salesman Problem
... drawbacks, for instance, the pre-mature convergence of computations, the poor use of system information during computational evolutions, expensive computation from evolutional procedures, and the poor capability of local search. The immune system, which is made up of special organs, tissues, cells a ...
... drawbacks, for instance, the pre-mature convergence of computations, the poor use of system information during computational evolutions, expensive computation from evolutional procedures, and the poor capability of local search. The immune system, which is made up of special organs, tissues, cells a ...
Tips to Remember: What is an allergic reaction
... the air passages. Asthma may also occur as a result of other stimuli, such as respiratory tract infections or exposure to irritants. Individuals who have allergies to specific foods may have severe and possibly life-threatening reactions if they eat them. The most common food allergy triggers are th ...
... the air passages. Asthma may also occur as a result of other stimuli, such as respiratory tract infections or exposure to irritants. Individuals who have allergies to specific foods may have severe and possibly life-threatening reactions if they eat them. The most common food allergy triggers are th ...
Suppression of adaptive immune responses during primary SIV
... than sham-vaccinated control animals.7 The role of humoral immune responses is more difficult to evaluate. HIV-specific B cells produce HIV envelope-specific antibodies as early as 2 weeks after infection.8 However, neutralizing antibodies (NAbs) develop only after months and are initially highly sp ...
... than sham-vaccinated control animals.7 The role of humoral immune responses is more difficult to evaluate. HIV-specific B cells produce HIV envelope-specific antibodies as early as 2 weeks after infection.8 However, neutralizing antibodies (NAbs) develop only after months and are initially highly sp ...
Immune system
The immune system is a system of many biological structures and processes within an organism that protects against disease. To function properly, an immune system must detect a wide variety of agents, known as pathogens, from viruses to parasitic worms, and distinguish them from the organism's own healthy tissue. In many species, the immune system can be classified into subsystems, such as the innate immune system versus the adaptive immune system, or humoral immunity versus cell-mediated immunity.Pathogens can rapidly evolve and adapt, and thereby avoid detection and neutralization by the immune system; however, multiple defense mechanisms have also evolved to recognize and neutralize pathogens. Even simple unicellular organisms such as bacteria possess a rudimentary immune system, in the form of enzymes that protect against bacteriophage infections. Other basic immune mechanisms evolved in ancient eukaryotes and remain in their modern descendants, such as plants and insects. These mechanisms include phagocytosis, antimicrobial peptides called defensins, and the complement system. Jawed vertebrates, including humans, have even more sophisticated defense mechanisms, including the ability to adapt over time to recognize specific pathogens more efficiently. Adaptive (or acquired) immunity creates immunological memory after an initial response to a specific pathogen, leading to an enhanced response to subsequent encounters with that same pathogen. This process of acquired immunity is the basis of vaccination.Disorders of the immune system can result in autoimmune diseases, inflammatory diseases and cancer.Immunodeficiency occurs when the immune system is less active than normal, resulting in recurring and life-threatening infections. In humans, immunodeficiency can either be the result of a genetic disease such as severe combined immunodeficiency, acquired conditions such as HIV/AIDS, or the use of immunosuppressive medication. In contrast, autoimmunity results from a hyperactive immune system attacking normal tissues as if they were foreign organisms. Common autoimmune diseases include Hashimoto's thyroiditis, rheumatoid arthritis, diabetes mellitus type 1, and systemic lupus erythematosus. Immunology covers the study of all aspects of the immune system.