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... moderate to sever megaloblastosis, an increased number of plasma cells and megakaryocytic hyperplasia with abnormal morphology. Amastigotes appeared as round or oval bodies found intracellular in monocytes and macrophages in the stained smears. Peripheral blood samples and lymph nodes were obtained ...
... moderate to sever megaloblastosis, an increased number of plasma cells and megakaryocytic hyperplasia with abnormal morphology. Amastigotes appeared as round or oval bodies found intracellular in monocytes and macrophages in the stained smears. Peripheral blood samples and lymph nodes were obtained ...
Epithelial antimicrobial peptides and proteins: their role in
... Antimicrobial polypeptides are produced both by surface epithelial cells and by cells of the submucosal glands. The relative contribution of these sources and the contribution of the various cell types of the surface epithelium to polypeptide synthesis are not known. In vitro epithelial cell culture ...
... Antimicrobial polypeptides are produced both by surface epithelial cells and by cells of the submucosal glands. The relative contribution of these sources and the contribution of the various cell types of the surface epithelium to polypeptide synthesis are not known. In vitro epithelial cell culture ...
B cells from African American lupus patients exhibit an
... suffer from a more severe disease with a higher rate of flares and progression to lupus nephritis (LN) and increased risk of death due to LN-related end-stage-renal disease. Although these disparities can be explained by the genetic background at disease onset, other factors such as poor socioeconom ...
... suffer from a more severe disease with a higher rate of flares and progression to lupus nephritis (LN) and increased risk of death due to LN-related end-stage-renal disease. Although these disparities can be explained by the genetic background at disease onset, other factors such as poor socioeconom ...
Please click here to view the article from the Peninsula Clarion
... nothing we can do for it." Landon's lymphoma has spread to his sinuses and lungs, Rogers said, and a trip to Anchorage will determine how much more his cancer has grown since then. ...
... nothing we can do for it." Landon's lymphoma has spread to his sinuses and lungs, Rogers said, and a trip to Anchorage will determine how much more his cancer has grown since then. ...
Regulators and signalling in insect haemocyte immunity
... Phagocytosis of a microbe by a phagocytic cell is an extremely complex and diverse process which requires multiple successive interactions between the phagocyte and the pathogen as well as sequential signal transduction events. Phagocytosis is induced when phagocyte surface receptors, are activated ...
... Phagocytosis of a microbe by a phagocytic cell is an extremely complex and diverse process which requires multiple successive interactions between the phagocyte and the pathogen as well as sequential signal transduction events. Phagocytosis is induced when phagocyte surface receptors, are activated ...
Principles of Transplantation
... • Campath (Alemtuzumab) Anti CD52 on multiple different lymphocytes causing lympholysis • Infliximab (Remicade) Anti TNF, binds to receptor and prevents TNF activation of lymphocytes ...
... • Campath (Alemtuzumab) Anti CD52 on multiple different lymphocytes causing lympholysis • Infliximab (Remicade) Anti TNF, binds to receptor and prevents TNF activation of lymphocytes ...
Endogenous collagen peptide activation of CD1d
... important role in peripheral tolerance and protection against autoimmune and other diseases. NKT cells are usually activated by CD1d-presented lipid antigens. However, peptide recognition in the context of CD1 has also been documented, although no self-peptide ligands have been reported to date. Her ...
... important role in peripheral tolerance and protection against autoimmune and other diseases. NKT cells are usually activated by CD1d-presented lipid antigens. However, peptide recognition in the context of CD1 has also been documented, although no self-peptide ligands have been reported to date. Her ...
The Most Cunning Parasite From an Immunological Perspective
... prevent phagocytes from accurately targeting them. One of the ways that phagocytes are ...
... prevent phagocytes from accurately targeting them. One of the ways that phagocytes are ...
FoxP3 low cells alter the balance between Treg and
... build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ The exact etiology and pathology of ulcerative colitis (UC) remains unknown. H ...
... build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ The exact etiology and pathology of ulcerative colitis (UC) remains unknown. H ...
Publications de l`équipe - Centre de recherche de l`Institut Curie
... Exosomes are secreted vesicles formed in late endocytic compartments. Immature dendritic cells (DCs) secrete exosomes which transfer functional MHC-peptide complexes to other DCs. Since immature and mature DCs induce different functional T cell responses (i.e., tolerance versus priming), we asked whe ...
... Exosomes are secreted vesicles formed in late endocytic compartments. Immature dendritic cells (DCs) secrete exosomes which transfer functional MHC-peptide complexes to other DCs. Since immature and mature DCs induce different functional T cell responses (i.e., tolerance versus priming), we asked whe ...
IOSR Journal of Pharmacy and Biological Sciences (IOSR-JPBS) e-ISSN: 2278-3008, p-ISSN:2319-7676.
... been identified as a major cause of peptic ulcer disorder (gastric and duodenal ulcers), gastritis chronic and gastric carcinoma even gastric lymphoma. This is unique, because Helicobacter pylori is the only one bacterium known to cause gastric carcinoma (Clyne, et al., 2007). Infectious H. pylori w ...
... been identified as a major cause of peptic ulcer disorder (gastric and duodenal ulcers), gastritis chronic and gastric carcinoma even gastric lymphoma. This is unique, because Helicobacter pylori is the only one bacterium known to cause gastric carcinoma (Clyne, et al., 2007). Infectious H. pylori w ...
Cerebral Innate Immunity in Drosophila Melanogaster
... (PRRs), which in turn has illustrated the broad variety of pathogen detection mechanisms, signaling components, immune modulating factors, and innate-adaptive immune cross-talk, which has revolutionized the field of immunology [1–3]. These initial studies in D. melanogaster, as well as subsequent in ...
... (PRRs), which in turn has illustrated the broad variety of pathogen detection mechanisms, signaling components, immune modulating factors, and innate-adaptive immune cross-talk, which has revolutionized the field of immunology [1–3]. These initial studies in D. melanogaster, as well as subsequent in ...
Improved Survival of Patients with Gastric Cancer or Colon Cancer
... from Lentinus edodes (Shiitake) and protein-bound polysaccharide K (PSK) from Coriolus versicolor. 44,45,46,47 In our investigation, AHCC as a functional food improved the cumulative survival rates of postoperative gastric cancer and colon cancer patients. AHCC is believed to mediate its effects on ...
... from Lentinus edodes (Shiitake) and protein-bound polysaccharide K (PSK) from Coriolus versicolor. 44,45,46,47 In our investigation, AHCC as a functional food improved the cumulative survival rates of postoperative gastric cancer and colon cancer patients. AHCC is believed to mediate its effects on ...
Predictive value of inflammatory Cytokines in preeclampsia
... shape and rearrangement of intracellular actin fibers[17]. IL-6 also increase the thromboxane A2 to prostacyclin ratio, reduce prostacyclin (PG I2) synthesis by inhibiting the cyclooxygenase enzyme[18] and stimulate platelet-derived growth factor. This cytokine could trigger neutrophil activation, e ...
... shape and rearrangement of intracellular actin fibers[17]. IL-6 also increase the thromboxane A2 to prostacyclin ratio, reduce prostacyclin (PG I2) synthesis by inhibiting the cyclooxygenase enzyme[18] and stimulate platelet-derived growth factor. This cytokine could trigger neutrophil activation, e ...
Isotype-switched immunoglobulin G antibodies to HIV Gag proteins
... controllers without ‘protective’ HLA-B alleles from those with these alleles If antibodies to HIV proteins contribute to control of HIV replication, they are likely to be higher in HIV controllers who do not carry „protective‟ HLA-B alleles. Twenty of the 32 (62.5%) HIV controllers carried a „protec ...
... controllers without ‘protective’ HLA-B alleles from those with these alleles If antibodies to HIV proteins contribute to control of HIV replication, they are likely to be higher in HIV controllers who do not carry „protective‟ HLA-B alleles. Twenty of the 32 (62.5%) HIV controllers carried a „protec ...
Cryptic T-Cell Epitopes and their Role in the
... This mechanism is known as antigen processing and is a fundamental early step in the introduction of immunity to protein antigens. Of the many fragments produced by processing, not all are necessarily presented to or recognized by T lymphocytes. However, in certain situations, immune responses to fr ...
... This mechanism is known as antigen processing and is a fundamental early step in the introduction of immunity to protein antigens. Of the many fragments produced by processing, not all are necessarily presented to or recognized by T lymphocytes. However, in certain situations, immune responses to fr ...
HIV-1 Persistence in Macrophage Reservoirs during Antiretroviral
... macrophage transformation to the M2 phenotype [56]. Thioredoxin-1 and adiponectin also promote anti-inflammatory macrophages of the M2 phenotype [57,58]. Macrophage activation inhibitors could include drugs that alter macrophage-signaling pathways and directly treat diseases where infiltrating macro ...
... macrophage transformation to the M2 phenotype [56]. Thioredoxin-1 and adiponectin also promote anti-inflammatory macrophages of the M2 phenotype [57,58]. Macrophage activation inhibitors could include drugs that alter macrophage-signaling pathways and directly treat diseases where infiltrating macro ...
Indirect Effects of Viral Infections in Transplantation.
... • These CD8+ central memory T-cells confer resistance to tolerance induction • The level of resistance to tolerance induction is related to the number of prior infectious exposures • Resistance can be adoptively transferred • Studied vaccinia virus, vesicular stomatitis virus, lymphocytic choriomeni ...
... • These CD8+ central memory T-cells confer resistance to tolerance induction • The level of resistance to tolerance induction is related to the number of prior infectious exposures • Resistance can be adoptively transferred • Studied vaccinia virus, vesicular stomatitis virus, lymphocytic choriomeni ...
2015 Journal
... Research suggests that most, if not all, cancers arise from cancer stem cells. Conventional cancer therapies target rapidly dividing tumor cells, but cancer stem cells have tools to escape chemotherapy and radiation. At some point, the cancer stem cells begin to self-renew, creating a new tumor and ...
... Research suggests that most, if not all, cancers arise from cancer stem cells. Conventional cancer therapies target rapidly dividing tumor cells, but cancer stem cells have tools to escape chemotherapy and radiation. At some point, the cancer stem cells begin to self-renew, creating a new tumor and ...
What is ovarian cancer?
... • Elegant technology: We believe that immunotherapy is an interesting technology in that it uses the body’s own processes to destroy cancer cells, thus decreasing the sideeffect profile of the treatment compared to external chemotherapeutic agents; • Large opportunity: We believe the opportunity is ...
... • Elegant technology: We believe that immunotherapy is an interesting technology in that it uses the body’s own processes to destroy cancer cells, thus decreasing the sideeffect profile of the treatment compared to external chemotherapeutic agents; • Large opportunity: We believe the opportunity is ...
Hedgehog Signaling and Maintenance of Homeostasis in the
... homeostasis of mesenchymal cells in the adult intestine. Accumulation of mesenchymal cells resulted when Hedgehog signaling was increased using two different strategies. One approach used Rosa26CreERT2-Ptch1fl/fl mice in which the Hedgehog pathway can be conditionally activated in a body-wide fashio ...
... homeostasis of mesenchymal cells in the adult intestine. Accumulation of mesenchymal cells resulted when Hedgehog signaling was increased using two different strategies. One approach used Rosa26CreERT2-Ptch1fl/fl mice in which the Hedgehog pathway can be conditionally activated in a body-wide fashio ...
Iris 29 - Body Glyphix Studio
... Gluten, Celiac Disease and Hashimoto’s Many people who suffer from Hashimoto’s should be aware that there may be problems caused by eating gluten and related proteins. However, because of misinformation and the inconvenience of going gluten free, many people ignore these warnings or don’t think thi ...
... Gluten, Celiac Disease and Hashimoto’s Many people who suffer from Hashimoto’s should be aware that there may be problems caused by eating gluten and related proteins. However, because of misinformation and the inconvenience of going gluten free, many people ignore these warnings or don’t think thi ...
Cancer immunotherapy
![](https://commons.wikimedia.org/wiki/Special:FilePath/Peptide_bound_to_Rituximab_FAB.png?width=300)
Cancer immunotherapy (immuno-oncology) is the use of the immune system to treat cancer. Immunotherapies fall into three main groups: cellular, antibody and cytokine. They exploit the fact that cancer cells often have subtly different molecules on their surface that can be detected by the immune system. These molecules, known as cancer antigens, are most commonly proteins, but also include molecules such as carbohydrates. Immunotherapy is used to provoke the immune system into attacking the tumor cells by using these antigens as targets.Antibody therapies are the most successful immunotherapy, treating a wide range of cancers. Antibodies are proteins produced by the immune system that bind to a target antigen on the cell surface. In normal physiology the immune system uses them to fight pathogens. Each antibody is specific to one or a few proteins. Those that bind to cancer antigens are used to treat cancer. Cell surface receptors are common targets for antibody therapies and include the CD20, CD274, and CD279. Once bound to a cancer antigen, antibodies can induce antibody-dependent cell-mediated cytotoxicity, activate the complement system, or prevent a receptor from interacting with its ligand, all of which can lead to cell death. Multiple antibodies are approved to treat cancer, including Alemtuzumab, Ipilimumab, Nivolumab, Ofatumumab, and Rituximab.Cellular therapies, also known as cancer vaccines, usually involve the removal of immune cells from the blood or from a tumor. Immune cells specific for the tumor are activated, cultured and returned to the patient where the immune cells attack the cancer. Cell types that can be used in this way are natural killer cells, lymphokine-activated killer cells, cytotoxic T cells and dendritic cells. The only cell-based therapy approved in the US is Dendreon's Provenge, for the treatment of prostate cancer.Interleukin-2 and interferon-α are examples of cytokines, proteins that regulate and coordinate the behaviour of the immune system. They have the ability to enhance anti-tumor activity and thus can be used as cancer treatments. Interferon-α is used in the treatment of hairy-cell leukaemia, AIDS-related Kaposi's sarcoma, follicular lymphoma, chronic myeloid leukaemia and malignant melanoma. Interleukin-2 is used in the treatment of malignant melanoma and renal cell carcinoma.