![Aalborg Universitet Aquaporin-9-expressing neutrophils are required for the establishment of contact hypersensitivity](http://s1.studyres.com/store/data/008652302_1-89fe0773ed11a1b8c2beb6dc41cb87bf-300x300.png)
Aalborg Universitet Aquaporin-9-expressing neutrophils are required for the establishment of contact hypersensitivity
... numbers of infiltrating CD4+ and CD8+ T cells (Fig. 2B) and neutrophils (Fig. 2C; Supplementary Fig. S1B) were observed in the skin of AQP9−/− mice after challenge compared to that of WT mice. Mast cell counts were comparable between WT and AQP9−/− mice (Fig. 2D). To investigate the potential signif ...
... numbers of infiltrating CD4+ and CD8+ T cells (Fig. 2B) and neutrophils (Fig. 2C; Supplementary Fig. S1B) were observed in the skin of AQP9−/− mice after challenge compared to that of WT mice. Mast cell counts were comparable between WT and AQP9−/− mice (Fig. 2D). To investigate the potential signif ...
AbD Serotec - bioNova científica sl
... The complement system is an ancient part of the innate immune system that acts as the first line of defence in the fight against infection. It is composed of at least 30 proteins, mostly synthesised in the liver, which typically circulate as inactive precursors. Then inactive state of the protease e ...
... The complement system is an ancient part of the innate immune system that acts as the first line of defence in the fight against infection. It is composed of at least 30 proteins, mostly synthesised in the liver, which typically circulate as inactive precursors. Then inactive state of the protease e ...
Slide 1
... • MBL alone can account for susceptibility to infection. • There’s no evolutionary advantage, nor disadvantage to different MBL alleles. • MBL can act as a disease modifier in the context of other defects in innate immunity. • Key role in containing and preventing the systemic spread of the bacteria ...
... • MBL alone can account for susceptibility to infection. • There’s no evolutionary advantage, nor disadvantage to different MBL alleles. • MBL can act as a disease modifier in the context of other defects in innate immunity. • Key role in containing and preventing the systemic spread of the bacteria ...
Alternative Activation Is an Innate Response to Injury That Requires CD4
... cycle of these cells, as well as the cells and mediators that are necessary for the induction and upkeep of AAM!, have not been well characterized beyond a requirement for type 2 cytokines. This is in contrast to the type 1 proinflammatory pathway in which the interplay between innate and adaptive i ...
... cycle of these cells, as well as the cells and mediators that are necessary for the induction and upkeep of AAM!, have not been well characterized beyond a requirement for type 2 cytokines. This is in contrast to the type 1 proinflammatory pathway in which the interplay between innate and adaptive i ...
Hematopoietic stem cell transplantation for autoimmune diseases
... In America there are two philosophically divergent approaches towards autologous HSCT for autoimmune diseases. One group advocates aggressive myeloablative regimens that contains total body irradiation which they believe may be more effective than non-myeloablative regimens [6,10]. We, on the other ...
... In America there are two philosophically divergent approaches towards autologous HSCT for autoimmune diseases. One group advocates aggressive myeloablative regimens that contains total body irradiation which they believe may be more effective than non-myeloablative regimens [6,10]. We, on the other ...
Review Article Mesenchymal stem cell and regenerative medicine
... MSCs, are multipotent differentiating through osteogenic, chondrogenic and adipocytic pathways, have immunosuppressive activity in vitro, and they are not transformed. The french national regulatory authority (AFSSaPS) gave the approval to produce MSCs for clinical study by using this method. Now, t ...
... MSCs, are multipotent differentiating through osteogenic, chondrogenic and adipocytic pathways, have immunosuppressive activity in vitro, and they are not transformed. The french national regulatory authority (AFSSaPS) gave the approval to produce MSCs for clinical study by using this method. Now, t ...
Maternal immune characteristics and innate immune responses in the
... The immune system of vertebrates consists of two interrelated components, the innate and adaptive responses, which are jointly required for the resolution of most infections. The innate immune response is the first line of host defense, and is responsible for an immediate recognition and control of ...
... The immune system of vertebrates consists of two interrelated components, the innate and adaptive responses, which are jointly required for the resolution of most infections. The innate immune response is the first line of host defense, and is responsible for an immediate recognition and control of ...
Thesis of Rownok_12376001
... worldwide. Several efforts have been made to develop cholera vaccines that could confer long term protection. T cells play an important role in immunity to cholera and may contribute to the activation of B cells. So, understanding the memory T cell responses is important for optimizing design of ora ...
... worldwide. Several efforts have been made to develop cholera vaccines that could confer long term protection. T cells play an important role in immunity to cholera and may contribute to the activation of B cells. So, understanding the memory T cell responses is important for optimizing design of ora ...
Cervical Cancer Screening Policy Change
... cases occur among women who have not undergone screening or who have had a long interval between Pap tests. In BC, about 58% of the 178 patients diagnosed with invasive cervical cancer in 2014 were five years or more overdue for screening5. The majority of cases are diagnosed in the 30-39 and 40-49 ...
... cases occur among women who have not undergone screening or who have had a long interval between Pap tests. In BC, about 58% of the 178 patients diagnosed with invasive cervical cancer in 2014 were five years or more overdue for screening5. The majority of cases are diagnosed in the 30-39 and 40-49 ...
Human Invariant Natural Killer T cells possess
... and CD8+ immunity14 and B cell proliferation and immunoglobulin production.11,15,16 These characteristics enable iNKT cells to play an important role during infection. iNKT cell activation results either from direct recognition of microbial lipid antigens presented by the MHC I- like protein CD1d on ...
... and CD8+ immunity14 and B cell proliferation and immunoglobulin production.11,15,16 These characteristics enable iNKT cells to play an important role during infection. iNKT cell activation results either from direct recognition of microbial lipid antigens presented by the MHC I- like protein CD1d on ...
... is based on induction of TCR clustering by cross-linking with bivalent IgG and secondary antibodies. Surface adsorbed, bivalent antiCD3 antibodies induce actin-dependent TCR clusters (33–35). Anti-CD3 tethered to planar bilayers can also induce MCs and mature IS (36). Whether these MCs and cSMACs ar ...
Thrombocytopenia: How Best to Determine the Cause
... However, platelet destruction that is immune-mediated also occurs independently of infection. Immune-mediated thrombocytopenia is common. One of the most frequently seen types is idiopathic thrombocytopenic purpura (ITP) (see Case 1 on page 114). In addition, antibodies to platelet surface antigens ...
... However, platelet destruction that is immune-mediated also occurs independently of infection. Immune-mediated thrombocytopenia is common. One of the most frequently seen types is idiopathic thrombocytopenic purpura (ITP) (see Case 1 on page 114). In addition, antibodies to platelet surface antigens ...
An Attacker’s Day into Human Virology 1 Introduction Axelle Apvrille, Guillaume Lovet
... Additionally, macrophages release special proteins - cytokines - that activate Natural Killer lymphocytes [Wikc]. Those cells kill infected or damaged cells they encounter by releasing cytotoxines that create pores in the infected cell’s plasma membrane. This weakens the cell so that other toxins re ...
... Additionally, macrophages release special proteins - cytokines - that activate Natural Killer lymphocytes [Wikc]. Those cells kill infected or damaged cells they encounter by releasing cytotoxines that create pores in the infected cell’s plasma membrane. This weakens the cell so that other toxins re ...
In vitro and in vivo model of a novel immunotherapy
... Cell lines and CLL primary cells The MEC-1 CLL cell line21 was obtained from the German Resource Center for Biologic Material (DSMZ). Wild-type BJAB was obtained from the American Type Culture Collection, and the Jeko-1 lymphoma B cell line was obtained from DMSZ. The latter 2 cell lines were geneti ...
... Cell lines and CLL primary cells The MEC-1 CLL cell line21 was obtained from the German Resource Center for Biologic Material (DSMZ). Wild-type BJAB was obtained from the American Type Culture Collection, and the Jeko-1 lymphoma B cell line was obtained from DMSZ. The latter 2 cell lines were geneti ...
Caspase-8 regulates the expression of pro- and anti
... All TLRs, except TLR3, interact with the adaptor MYD88. MYD88 recruits members of the IRAK (IL-1 receptor-associated kinase) family of serine-threonine kinases, initiating a signaling cascade leading to activation of the transcription factor NF-kB and production of pro-inflammatory cytokines. TLR3, ...
... All TLRs, except TLR3, interact with the adaptor MYD88. MYD88 recruits members of the IRAK (IL-1 receptor-associated kinase) family of serine-threonine kinases, initiating a signaling cascade leading to activation of the transcription factor NF-kB and production of pro-inflammatory cytokines. TLR3, ...
Activation of cytokines corroborate with development of
... antibodies and (ii) a cellular immune response, where CD8+ T cells with cytotoxic and macrophages are activated. CD4+ lymphocytes participate in both responses by antigen recognition and their subsequent differentiation into effector T helper type 1 (Th1) or Th2 subsets. Th1 cells facilitate the cyt ...
... antibodies and (ii) a cellular immune response, where CD8+ T cells with cytotoxic and macrophages are activated. CD4+ lymphocytes participate in both responses by antigen recognition and their subsequent differentiation into effector T helper type 1 (Th1) or Th2 subsets. Th1 cells facilitate the cyt ...
Effect of Highly Active Antiretroviral Therapy (HAART) on Human
... TNF- α, IL-6, IL-1ra and IL-8 [41]. There are contrasting reports of IL-10 levels among patients receiving HAART, as some show reduction and others reveal raised activities [42,43,44]. This needs further studies as IL-10 is found to have therapeutic efficacy. A recent study by Cozzi-Lepri et al have ...
... TNF- α, IL-6, IL-1ra and IL-8 [41]. There are contrasting reports of IL-10 levels among patients receiving HAART, as some show reduction and others reveal raised activities [42,43,44]. This needs further studies as IL-10 is found to have therapeutic efficacy. A recent study by Cozzi-Lepri et al have ...
blood powerpoint 2
... • In 1910, identification of the ABO blood antigen gene explained the observed blood type incompatibilities • Today there are 31 different genes known to contribute to the surface features of RBCs determining compatibility between blood types ...
... • In 1910, identification of the ABO blood antigen gene explained the observed blood type incompatibilities • Today there are 31 different genes known to contribute to the surface features of RBCs determining compatibility between blood types ...
Cancer immunotherapy
![](https://commons.wikimedia.org/wiki/Special:FilePath/Peptide_bound_to_Rituximab_FAB.png?width=300)
Cancer immunotherapy (immuno-oncology) is the use of the immune system to treat cancer. Immunotherapies fall into three main groups: cellular, antibody and cytokine. They exploit the fact that cancer cells often have subtly different molecules on their surface that can be detected by the immune system. These molecules, known as cancer antigens, are most commonly proteins, but also include molecules such as carbohydrates. Immunotherapy is used to provoke the immune system into attacking the tumor cells by using these antigens as targets.Antibody therapies are the most successful immunotherapy, treating a wide range of cancers. Antibodies are proteins produced by the immune system that bind to a target antigen on the cell surface. In normal physiology the immune system uses them to fight pathogens. Each antibody is specific to one or a few proteins. Those that bind to cancer antigens are used to treat cancer. Cell surface receptors are common targets for antibody therapies and include the CD20, CD274, and CD279. Once bound to a cancer antigen, antibodies can induce antibody-dependent cell-mediated cytotoxicity, activate the complement system, or prevent a receptor from interacting with its ligand, all of which can lead to cell death. Multiple antibodies are approved to treat cancer, including Alemtuzumab, Ipilimumab, Nivolumab, Ofatumumab, and Rituximab.Cellular therapies, also known as cancer vaccines, usually involve the removal of immune cells from the blood or from a tumor. Immune cells specific for the tumor are activated, cultured and returned to the patient where the immune cells attack the cancer. Cell types that can be used in this way are natural killer cells, lymphokine-activated killer cells, cytotoxic T cells and dendritic cells. The only cell-based therapy approved in the US is Dendreon's Provenge, for the treatment of prostate cancer.Interleukin-2 and interferon-α are examples of cytokines, proteins that regulate and coordinate the behaviour of the immune system. They have the ability to enhance anti-tumor activity and thus can be used as cancer treatments. Interferon-α is used in the treatment of hairy-cell leukaemia, AIDS-related Kaposi's sarcoma, follicular lymphoma, chronic myeloid leukaemia and malignant melanoma. Interleukin-2 is used in the treatment of malignant melanoma and renal cell carcinoma.