TIR-Domain-Containing Adapter-Inducing Interferon
... TRIF (Toll/interleukin-1 receptor domain-containing adapter inducing IFN-β) to initiate innate immune responses to pathogens and activate antigen-presenting cells. Mucosal B cells can be directly activated by antigens and TLR signaling which results in immunoglobulin class switching and rapid secret ...
... TRIF (Toll/interleukin-1 receptor domain-containing adapter inducing IFN-β) to initiate innate immune responses to pathogens and activate antigen-presenting cells. Mucosal B cells can be directly activated by antigens and TLR signaling which results in immunoglobulin class switching and rapid secret ...
The immune system
... P. vulgaris and not R. prowasekii, is used as antigen in this serological in vitro reaction A laboratory worker is protected from being infected ...
... P. vulgaris and not R. prowasekii, is used as antigen in this serological in vitro reaction A laboratory worker is protected from being infected ...
PDF + SI - The Journal of Immunology
... multiple IFN-a genes encoding highly related, but unique, IFN-a subtypes and a single IFN-b gene, all clustered on chromosome 9 (4). Each can be expressed from most nucleated cells of the body and encodes a protein that binds to a common IFN-a/b receptor. The type 1 IFNs also include minor subtypes ...
... multiple IFN-a genes encoding highly related, but unique, IFN-a subtypes and a single IFN-b gene, all clustered on chromosome 9 (4). Each can be expressed from most nucleated cells of the body and encodes a protein that binds to a common IFN-a/b receptor. The type 1 IFNs also include minor subtypes ...
Chapter Twenty Four
... Red and White Pulp of Spleen • The white pulp is associated with the arterial supply and consists of T- and B-lymphocytes and macrophages. • In the center of each cluster is a central artery. • The red pulp is associated with the venous supply. • Red pulp consists of splenic cords and splenic sinus ...
... Red and White Pulp of Spleen • The white pulp is associated with the arterial supply and consists of T- and B-lymphocytes and macrophages. • In the center of each cluster is a central artery. • The red pulp is associated with the venous supply. • Red pulp consists of splenic cords and splenic sinus ...
Peptide trafficking and translocation across membranes in
... Assembly and disassembly of the peptide-loading complex at the ER membrane. De novo synthesized MHC I heavy chain (hc) initially assembles with the chaperones and ER-resident lectin calnexin. After association with b2m, calnexin is replaced by its soluble counterpart calreticulin. This MHC I subcomp ...
... Assembly and disassembly of the peptide-loading complex at the ER membrane. De novo synthesized MHC I heavy chain (hc) initially assembles with the chaperones and ER-resident lectin calnexin. After association with b2m, calnexin is replaced by its soluble counterpart calreticulin. This MHC I subcomp ...
Monoclonal antibodies to equine arteritis virus proteins identify the
... vAVE07 or with vAVE25 and the cell lysates were subjected to immunoprecipitation with a GL-specific anti-peptide serum (Ps), the putative GL-specific MAbs, and a N-specific MAb. To precipitate immune complexes of MAb 17F5 the Omnisorb was first saturated with swine anti-mouse IgA antibodies (Nordic) ...
... vAVE07 or with vAVE25 and the cell lysates were subjected to immunoprecipitation with a GL-specific anti-peptide serum (Ps), the putative GL-specific MAbs, and a N-specific MAb. To precipitate immune complexes of MAb 17F5 the Omnisorb was first saturated with swine anti-mouse IgA antibodies (Nordic) ...
Department of Immunology, the Wenner-Gren Institute Stockholm University, Stockholm, Sweden Doctoral thesis
... with haemoglobin levels and P. falciparum-reactive IgG subclass antibodies were observed. This suggests an influence of these polymorphisms on malaria severity rather than the susceptibility. C-reactive protein levels rise immediately in response to inflammatory stimuli. However, the net-effect of C ...
... with haemoglobin levels and P. falciparum-reactive IgG subclass antibodies were observed. This suggests an influence of these polymorphisms on malaria severity rather than the susceptibility. C-reactive protein levels rise immediately in response to inflammatory stimuli. However, the net-effect of C ...
Childhood Immune Maturation and Allergy Development: Regulation by Maternal
... protects against allergic sensitization and disease, whereas exposures during infancy alone have weaker or no effect at all 13, 25, 26. Continued enhanced postnatal microbial exposure may be required for optimal allergy protection, however 26. Furthermore, in human allergy intervention studies, prob ...
... protects against allergic sensitization and disease, whereas exposures during infancy alone have weaker or no effect at all 13, 25, 26. Continued enhanced postnatal microbial exposure may be required for optimal allergy protection, however 26. Furthermore, in human allergy intervention studies, prob ...
Accepted version
... Neurological involvement ranges from 3.2 to 49% in BD series and may present as headache (the most frequent initial neurological symptom), meningoencephalitis, multiple sclerosis (MS)– like illness, stroke, pseudotumor cerebri, organic confusional syndrome or a combination of the above 3. Neurologic ...
... Neurological involvement ranges from 3.2 to 49% in BD series and may present as headache (the most frequent initial neurological symptom), meningoencephalitis, multiple sclerosis (MS)– like illness, stroke, pseudotumor cerebri, organic confusional syndrome or a combination of the above 3. Neurologic ...
Demyelinating Disease Models of Central Nervous System
... pathogen. Activated MBP-specific T cells have been found in MS patients (43– 45); the subsequent identification of pathogen-derived mimics capable of activating human MBP-specific T cell lines reinforces the theory that pathogens may induce MS via molecular mimicry (46, 47). Pathogen-derived mimics ...
... pathogen. Activated MBP-specific T cells have been found in MS patients (43– 45); the subsequent identification of pathogen-derived mimics capable of activating human MBP-specific T cell lines reinforces the theory that pathogens may induce MS via molecular mimicry (46, 47). Pathogen-derived mimics ...
Antigen Presentation to T Lymphocytes
... phages, and B cells are able to capture exogenous proteins via endocytic vesicles and through specific cell-surface receptors. For B cells, this process of antigen capture can include the B-cell receptor. The peptides that are derived from these proteins are loaded onto MHC class II molecules in spe ...
... phages, and B cells are able to capture exogenous proteins via endocytic vesicles and through specific cell-surface receptors. For B cells, this process of antigen capture can include the B-cell receptor. The peptides that are derived from these proteins are loaded onto MHC class II molecules in spe ...
Model Description Sheet
... sequence identity with RhCE. The RHD gene arose from gene duplication of the RHCE gene and has 93.8% homology. Along with RhAG (Rh associated glycoprotein) both RhD and RhCE are part of the trimeric Rh complex on erythrocytes, essential to the cell’s structural integrity. HDN research led to the dis ...
... sequence identity with RhCE. The RHD gene arose from gene duplication of the RHCE gene and has 93.8% homology. Along with RhAG (Rh associated glycoprotein) both RhD and RhCE are part of the trimeric Rh complex on erythrocytes, essential to the cell’s structural integrity. HDN research led to the dis ...
Cytokine Atlas - Thermo Fisher Scientific
... Local and systemic inflammation is a common pathophysiological mechanisms for various cardiovascular diseases (CVD), for which cytokines have become important biomarkers. Numerous pro- and anti-inflammatory cytokines are used to help stage and diagnose various cardiovascular diseases. The pro-inflam ...
... Local and systemic inflammation is a common pathophysiological mechanisms for various cardiovascular diseases (CVD), for which cytokines have become important biomarkers. Numerous pro- and anti-inflammatory cytokines are used to help stage and diagnose various cardiovascular diseases. The pro-inflam ...
Immunotoxicity - KSU Faculty Member websites
... negatively selected, has not yet been studied for other drugs, but may not be specific to cyclosporin A. It represents a distinct mechanism of autoimmunity induced by the action of toxic compounds on the immune system, mediated via thymic selection. Although the medullary area is reduced in young ra ...
... negatively selected, has not yet been studied for other drugs, but may not be specific to cyclosporin A. It represents a distinct mechanism of autoimmunity induced by the action of toxic compounds on the immune system, mediated via thymic selection. Although the medullary area is reduced in young ra ...
CD4 T cells promote tissue inflammation via CD40 signaling without
... mice.4,6 Thus, the question arises of how T cells function in this innate immunity-dominated response and in the absence of exogenous Ag stimulation? T cells may function in an Ag-independent manner by secreting cytokines and up-regulating costimulatory molecules. The role of T cell– derived CD28, C ...
... mice.4,6 Thus, the question arises of how T cells function in this innate immunity-dominated response and in the absence of exogenous Ag stimulation? T cells may function in an Ag-independent manner by secreting cytokines and up-regulating costimulatory molecules. The role of T cell– derived CD28, C ...
THE INTERLEUKIN-1β-MEDIATED REGULATION OF
... of immune system activation is the astrocytes, glial cells known to synthesize proenkephalin. We have recently shown that these cells also express the messenger RNA transcripts for the opioid receptors µ, ä and ê, raising the question of the functional significance of this opioid peptide and the rel ...
... of immune system activation is the astrocytes, glial cells known to synthesize proenkephalin. We have recently shown that these cells also express the messenger RNA transcripts for the opioid receptors µ, ä and ê, raising the question of the functional significance of this opioid peptide and the rel ...
Simvastatin and Recombinant Antagonist of Receptors of Interleukin
... unable to induce colitis (12). Similarly, MyD88IFNγ production, and ability to promote colitis under lymphopenic conditions (13). TLR4-deficient T cells exacerbated disease in a CD4+ T cell transfer colitis model (14), in which LPS treatment caused CD4+ T cells to lose IFNγ but unregulated IL-17expre ...
... unable to induce colitis (12). Similarly, MyD88IFNγ production, and ability to promote colitis under lymphopenic conditions (13). TLR4-deficient T cells exacerbated disease in a CD4+ T cell transfer colitis model (14), in which LPS treatment caused CD4+ T cells to lose IFNγ but unregulated IL-17expre ...
Answers
... Answers – The tissue in hollow shafts of long bones that produces blood cells for the immune system – Stem cells are immature cells that grow into different types of cells – Lymphocytes are white blood cells that help the body fight infection • B cells and T cells are two major classes of ...
... Answers – The tissue in hollow shafts of long bones that produces blood cells for the immune system – Stem cells are immature cells that grow into different types of cells – Lymphocytes are white blood cells that help the body fight infection • B cells and T cells are two major classes of ...
Programação detalhada
... blastocyst that are in direct contact with maternal blood, and therefore play an essential role in protecting the fetus from attack from the maternal immune system. Trophoblast cells are relatively unique in that they do not express major histocompatibility complex (MHC) class II antigens, either co ...
... blastocyst that are in direct contact with maternal blood, and therefore play an essential role in protecting the fetus from attack from the maternal immune system. Trophoblast cells are relatively unique in that they do not express major histocompatibility complex (MHC) class II antigens, either co ...
Identification of Immunomodulatory Cells Induced By 670 nm Light
... oligodendrocyte glycoprotein (MOG) [10] emulsified in an adjuvant that will promote an inflammatory response to the myelin proteins [11]. PLP and MBP are major constituents of myelin, located internally, important to maintaining the structural integrity of the myelin sheath, whereas MOG, a minor con ...
... oligodendrocyte glycoprotein (MOG) [10] emulsified in an adjuvant that will promote an inflammatory response to the myelin proteins [11]. PLP and MBP are major constituents of myelin, located internally, important to maintaining the structural integrity of the myelin sheath, whereas MOG, a minor con ...
Cancer immunotherapy
Cancer immunotherapy (immuno-oncology) is the use of the immune system to treat cancer. Immunotherapies fall into three main groups: cellular, antibody and cytokine. They exploit the fact that cancer cells often have subtly different molecules on their surface that can be detected by the immune system. These molecules, known as cancer antigens, are most commonly proteins, but also include molecules such as carbohydrates. Immunotherapy is used to provoke the immune system into attacking the tumor cells by using these antigens as targets.Antibody therapies are the most successful immunotherapy, treating a wide range of cancers. Antibodies are proteins produced by the immune system that bind to a target antigen on the cell surface. In normal physiology the immune system uses them to fight pathogens. Each antibody is specific to one or a few proteins. Those that bind to cancer antigens are used to treat cancer. Cell surface receptors are common targets for antibody therapies and include the CD20, CD274, and CD279. Once bound to a cancer antigen, antibodies can induce antibody-dependent cell-mediated cytotoxicity, activate the complement system, or prevent a receptor from interacting with its ligand, all of which can lead to cell death. Multiple antibodies are approved to treat cancer, including Alemtuzumab, Ipilimumab, Nivolumab, Ofatumumab, and Rituximab.Cellular therapies, also known as cancer vaccines, usually involve the removal of immune cells from the blood or from a tumor. Immune cells specific for the tumor are activated, cultured and returned to the patient where the immune cells attack the cancer. Cell types that can be used in this way are natural killer cells, lymphokine-activated killer cells, cytotoxic T cells and dendritic cells. The only cell-based therapy approved in the US is Dendreon's Provenge, for the treatment of prostate cancer.Interleukin-2 and interferon-α are examples of cytokines, proteins that regulate and coordinate the behaviour of the immune system. They have the ability to enhance anti-tumor activity and thus can be used as cancer treatments. Interferon-α is used in the treatment of hairy-cell leukaemia, AIDS-related Kaposi's sarcoma, follicular lymphoma, chronic myeloid leukaemia and malignant melanoma. Interleukin-2 is used in the treatment of malignant melanoma and renal cell carcinoma.