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Bone Marrow-derived Mesenchymal Stromal Cells Are
... Introduction: There are no studies to date that have examined donor response to major histocompatibility mismatched mesenchymal stem cells (MSCs). The purposes of this study were to: (1) phenotype P2-P8 bone marrow-derived MSCs from horses of known MHC haplotype; and (2) compare the immunogenicity o ...
... Introduction: There are no studies to date that have examined donor response to major histocompatibility mismatched mesenchymal stem cells (MSCs). The purposes of this study were to: (1) phenotype P2-P8 bone marrow-derived MSCs from horses of known MHC haplotype; and (2) compare the immunogenicity o ...
Allergy and immunity to fungal infections and colonization
... second line of defence, formed by neutrophilic granulocytes. They mainly attack hyphae, which are too large for ingestion. These, in turn, are killed by oxidative and nonoxidative mechanisms including different defensins. Each of these two defence systems is able alone to protect the host against la ...
... second line of defence, formed by neutrophilic granulocytes. They mainly attack hyphae, which are too large for ingestion. These, in turn, are killed by oxidative and nonoxidative mechanisms including different defensins. Each of these two defence systems is able alone to protect the host against la ...
Agglutination Reactions
... Clinical application: The agglutinin (specific Abs) titer of an antiserum can be used to diagnose a bacterial infection. Example: Patients with typhoid fever, for example, show a rise in the agglutination titer with Salmonella typhi bacteria. Agglutination reactions also provide a way to type bacter ...
... Clinical application: The agglutinin (specific Abs) titer of an antiserum can be used to diagnose a bacterial infection. Example: Patients with typhoid fever, for example, show a rise in the agglutination titer with Salmonella typhi bacteria. Agglutination reactions also provide a way to type bacter ...
AntihistaminesJC
... immune system normally protects the body against harmful substances. Allergy symptoms occurs when the immune system reacts to allergens that are generally harmless and in most people do not cause an immune response. When a person with allergies breathes in an allergen such as pollen or dust, antib ...
... immune system normally protects the body against harmful substances. Allergy symptoms occurs when the immune system reacts to allergens that are generally harmless and in most people do not cause an immune response. When a person with allergies breathes in an allergen such as pollen or dust, antib ...
cell loss caused by simian immunodeficiency virus (SIV)
... monkeys, using a triple-vector vaccine combination that comprised DNA, Semliki Forest virus (SFV) and modified vaccinia virus Ankara (MVA) (Negri et al., 2004). However, cynomolgus monkeys generally develop lower virus loads after challenge with SIVmac251 than do rhesus macaques (ten Haaft et al., 2 ...
... monkeys, using a triple-vector vaccine combination that comprised DNA, Semliki Forest virus (SFV) and modified vaccinia virus Ankara (MVA) (Negri et al., 2004). However, cynomolgus monkeys generally develop lower virus loads after challenge with SIVmac251 than do rhesus macaques (ten Haaft et al., 2 ...
Brain-resident memory T cells represent an autonomous
... brain were bona fide TRM (from now on referred to as bTRM). To investigate the protective role of bTRM upon brain reinfection, we generated rLCMV memory mice by either i.v. or co-infection (i.c. + i.v.; Fig. 2 A). Co-infection was used to assure similar generation of circulating TM. Indeed, both i ...
... brain were bona fide TRM (from now on referred to as bTRM). To investigate the protective role of bTRM upon brain reinfection, we generated rLCMV memory mice by either i.v. or co-infection (i.c. + i.v.; Fig. 2 A). Co-infection was used to assure similar generation of circulating TM. Indeed, both i ...
Homeostatic Competition Among T Cells Revealed by
... BrdU Labeling and Detection. 8-wk-old mice were provided bromo-deoxyuridine (BrdUrd)* (0.8 mg/ml) in their drinking water for a period of 20 d. On days 5, 10, 15, and 20, mesenteric and inguinal lymph nodes were harvested from selected mice and stained for BrdUrd incorporation using a modification o ...
... BrdU Labeling and Detection. 8-wk-old mice were provided bromo-deoxyuridine (BrdUrd)* (0.8 mg/ml) in their drinking water for a period of 20 d. On days 5, 10, 15, and 20, mesenteric and inguinal lymph nodes were harvested from selected mice and stained for BrdUrd incorporation using a modification o ...
Clinical Management of Immuno
... The actions of the immune system can be divided into what are referred to as the Innate and Adaptive immune responses. In general the innate responses are the first line of immunological defense and are viewed as indiscriminately attacking pathogens, while the adaptive responses (which typically fol ...
... The actions of the immune system can be divided into what are referred to as the Innate and Adaptive immune responses. In general the innate responses are the first line of immunological defense and are viewed as indiscriminately attacking pathogens, while the adaptive responses (which typically fol ...
Article (Author postprint)
... adaptive immune response, DCs are an attractive target for therapeutic manipulation of the immune system [3]. In fact, DC physiology is one of the research areas where basic knowledge has been more readily translated into clinical applications. DC-based vaccines have been rapidly transferred from th ...
... adaptive immune response, DCs are an attractive target for therapeutic manipulation of the immune system [3]. In fact, DC physiology is one of the research areas where basic knowledge has been more readily translated into clinical applications. DC-based vaccines have been rapidly transferred from th ...
CSA Biopharm - Moodle Lille 2
... CSA Biopharm L. Moise et Al. Effect of HLA DR epitope de-immunization of Factor VIII in vitro and in vivo.ClinicalImmunology (2012) ...
... CSA Biopharm L. Moise et Al. Effect of HLA DR epitope de-immunization of Factor VIII in vitro and in vivo.ClinicalImmunology (2012) ...
Identification of a new monosaccharide in Mycobacterium
... outside the plant kingdom. Presumably, the biosynthetic precursor of MTX is methylthioadenosine – a ubiquitous by-product of polyamine biosynthesis that is derived from SAM. Nevertheless, Mtb invests significant biosynthetic effort into incorporating MTX into its cell wall, which implies that this ...
... outside the plant kingdom. Presumably, the biosynthetic precursor of MTX is methylthioadenosine – a ubiquitous by-product of polyamine biosynthesis that is derived from SAM. Nevertheless, Mtb invests significant biosynthetic effort into incorporating MTX into its cell wall, which implies that this ...
Immunogenicity testing of STM1 carrying HIVp24
... are rarely, if ever, induced by vaccination. Cytotoxic T lymphocytes (CTLs) are thought to be another important component of the antiviral immune response. Indeed, the capacity of HIVspecific CTLs to efficiently limit viral replication is suggested by a large decrease in HIV load following the initi ...
... are rarely, if ever, induced by vaccination. Cytotoxic T lymphocytes (CTLs) are thought to be another important component of the antiviral immune response. Indeed, the capacity of HIVspecific CTLs to efficiently limit viral replication is suggested by a large decrease in HIV load following the initi ...
Bee venom therapy and Parkinson disease
... held in Netherlands in 2004, the effectiveness of the bee venom therapy in the MS patients was assessed extensively by both clinical and radiological measures. . Although the participants tolerated the treatment well, no benefits were seen on MRI measures, the frequency and severity of the attacks, ...
... held in Netherlands in 2004, the effectiveness of the bee venom therapy in the MS patients was assessed extensively by both clinical and radiological measures. . Although the participants tolerated the treatment well, no benefits were seen on MRI measures, the frequency and severity of the attacks, ...
The Injectable-Only Contraceptive
... studies the adjusted hazard ratio for HIV-1 acquisition by DMPA, or injectable contraceptives users where the majority of women are on MPA, is higher than that associated with no contraception or oral contraception [18,21–30]. While only a few studies have investigated the risks associated with the ...
... studies the adjusted hazard ratio for HIV-1 acquisition by DMPA, or injectable contraceptives users where the majority of women are on MPA, is higher than that associated with no contraception or oral contraception [18,21–30]. While only a few studies have investigated the risks associated with the ...
ug - Hanover College
... F4/80 high /Ly6Clow /CD206 pos / MHC-2 pos / CD11b pos / CD11c pos / IL-4R pos/ MAC-3 pos ...
... F4/80 high /Ly6Clow /CD206 pos / MHC-2 pos / CD11b pos / CD11c pos / IL-4R pos/ MAC-3 pos ...
carbamazepine in a patient with severe serum
... into sufficient numbers of effector cells. Anaphylatoxins were increased and complement was depressed, suggesting that complement was activated by immune complexes. From the clinical picture and the laboratory findings we deduced that this case was compatible with serum sickness caused by massive am ...
... into sufficient numbers of effector cells. Anaphylatoxins were increased and complement was depressed, suggesting that complement was activated by immune complexes. From the clinical picture and the laboratory findings we deduced that this case was compatible with serum sickness caused by massive am ...
(SLE).
... a normochromic, normocytic anemia is frequently found in SLE. They appears to be related to chronic inflammation, drugrelated haemorrhage. haemolytic anemia as detected by the Coombs’ test is the feature of SLE. on rare occasion, a serum antibody may be produced which impairs red cell production. ...
... a normochromic, normocytic anemia is frequently found in SLE. They appears to be related to chronic inflammation, drugrelated haemorrhage. haemolytic anemia as detected by the Coombs’ test is the feature of SLE. on rare occasion, a serum antibody may be produced which impairs red cell production. ...
Hypersensitivity Associated with Metallic Biomaterials
... Type II (Ab-mediated) hypersensitivity is characterized by activation of the complement system or cytotoxic T-cells, which eliminate cells that display Ag. Host Abs, reacting with foreign Ags, produce pores in the membrane of foreign cells, or serve as targets for guiding phagocytic cells. Typical A ...
... Type II (Ab-mediated) hypersensitivity is characterized by activation of the complement system or cytotoxic T-cells, which eliminate cells that display Ag. Host Abs, reacting with foreign Ags, produce pores in the membrane of foreign cells, or serve as targets for guiding phagocytic cells. Typical A ...
Barcelona-Cincinnati technique for limbal transplantation
... Compared to CLAU and lr-CLAL, the small-sized biopsy minimizes the risk of iatrogenic stem cell failure in the donor eye, and enables another biopsy to be taken if the first fails. However, as no healthy conjunctiva is transplanted, improvement of local microenvironment conditions by reducing conjun ...
... Compared to CLAU and lr-CLAL, the small-sized biopsy minimizes the risk of iatrogenic stem cell failure in the donor eye, and enables another biopsy to be taken if the first fails. However, as no healthy conjunctiva is transplanted, improvement of local microenvironment conditions by reducing conjun ...
Construction of a recombinant human GM
... well of 96-well culture plates. Serially diluted samples were then added. After the plates were incubated at 37°C in a humidified atmosphere containing 5 % C Q in air for 66 h, the cytotoxicity was determined by the MTT incorporation assayL6]. After the treat1 . 2 . 6 Monocyte tumoricidal activity b ...
... well of 96-well culture plates. Serially diluted samples were then added. After the plates were incubated at 37°C in a humidified atmosphere containing 5 % C Q in air for 66 h, the cytotoxicity was determined by the MTT incorporation assayL6]. After the treat1 . 2 . 6 Monocyte tumoricidal activity b ...
B cells from African American lupus patients exhibit an
... suffer from a more severe disease with a higher rate of flares and progression to lupus nephritis (LN) and increased risk of death due to LN-related end-stage-renal disease. Although these disparities can be explained by the genetic background at disease onset, other factors such as poor socioeconom ...
... suffer from a more severe disease with a higher rate of flares and progression to lupus nephritis (LN) and increased risk of death due to LN-related end-stage-renal disease. Although these disparities can be explained by the genetic background at disease onset, other factors such as poor socioeconom ...
Cancer immunotherapy
![](https://commons.wikimedia.org/wiki/Special:FilePath/Peptide_bound_to_Rituximab_FAB.png?width=300)
Cancer immunotherapy (immuno-oncology) is the use of the immune system to treat cancer. Immunotherapies fall into three main groups: cellular, antibody and cytokine. They exploit the fact that cancer cells often have subtly different molecules on their surface that can be detected by the immune system. These molecules, known as cancer antigens, are most commonly proteins, but also include molecules such as carbohydrates. Immunotherapy is used to provoke the immune system into attacking the tumor cells by using these antigens as targets.Antibody therapies are the most successful immunotherapy, treating a wide range of cancers. Antibodies are proteins produced by the immune system that bind to a target antigen on the cell surface. In normal physiology the immune system uses them to fight pathogens. Each antibody is specific to one or a few proteins. Those that bind to cancer antigens are used to treat cancer. Cell surface receptors are common targets for antibody therapies and include the CD20, CD274, and CD279. Once bound to a cancer antigen, antibodies can induce antibody-dependent cell-mediated cytotoxicity, activate the complement system, or prevent a receptor from interacting with its ligand, all of which can lead to cell death. Multiple antibodies are approved to treat cancer, including Alemtuzumab, Ipilimumab, Nivolumab, Ofatumumab, and Rituximab.Cellular therapies, also known as cancer vaccines, usually involve the removal of immune cells from the blood or from a tumor. Immune cells specific for the tumor are activated, cultured and returned to the patient where the immune cells attack the cancer. Cell types that can be used in this way are natural killer cells, lymphokine-activated killer cells, cytotoxic T cells and dendritic cells. The only cell-based therapy approved in the US is Dendreon's Provenge, for the treatment of prostate cancer.Interleukin-2 and interferon-α are examples of cytokines, proteins that regulate and coordinate the behaviour of the immune system. They have the ability to enhance anti-tumor activity and thus can be used as cancer treatments. Interferon-α is used in the treatment of hairy-cell leukaemia, AIDS-related Kaposi's sarcoma, follicular lymphoma, chronic myeloid leukaemia and malignant melanoma. Interleukin-2 is used in the treatment of malignant melanoma and renal cell carcinoma.