![A model for immunotherapies against small, solid and motile tumors](http://s1.studyres.com/store/data/005218980_1-fbccfe60866d3588eeae181028d8b980-300x300.png)
Studies on the development of a vaccine against Mycobacterium sp.
... Guèrin (BCG, an attenuated strain of Mycobacterium bovis) and formalin-killed cells (FKC) of Mycobacterium sp. strain 012971, on the immediate and acquired immune response were evaluated in Japanese flounder, Paralichthys olivaceus. On 1, 3 and 7 days post treatments with these candidates, gene expr ...
... Guèrin (BCG, an attenuated strain of Mycobacterium bovis) and formalin-killed cells (FKC) of Mycobacterium sp. strain 012971, on the immediate and acquired immune response were evaluated in Japanese flounder, Paralichthys olivaceus. On 1, 3 and 7 days post treatments with these candidates, gene expr ...
Virology: Research and Treatment
... activator, Tax, which include deregulating mitotic checkpoints, inducing nuclear factor (NF)-κB activation, and inactivating tumor suppressors, play a critical role in the early stages of leukemogenesis.5,6 However, Tax expression may require strict regulation during clinical latency and may be expe ...
... activator, Tax, which include deregulating mitotic checkpoints, inducing nuclear factor (NF)-κB activation, and inactivating tumor suppressors, play a critical role in the early stages of leukemogenesis.5,6 However, Tax expression may require strict regulation during clinical latency and may be expe ...
Therapeutic Protein Immunogenicity Focus Group (TPIFG)
... With summer upon us what better way to spend time than perusing the Biotec Section newsletter and learning something new about the industry and your colleagues. As always, the various focus groups are looking for volunteers. I hope that you will consider volunteering and will find it a rewarding exp ...
... With summer upon us what better way to spend time than perusing the Biotec Section newsletter and learning something new about the industry and your colleagues. As always, the various focus groups are looking for volunteers. I hope that you will consider volunteering and will find it a rewarding exp ...
Stages of Readiness (Prochaska)
... If possible, stand in front of a mirror. Check for any swelling on the scrotal skin. Examine each testicle with both hands. Place the index and middle fingers under the testicle with the thumbs placed on top. Roll the testicle gently between the thumbs and fingers -- you shouldn't feel any pain when ...
... If possible, stand in front of a mirror. Check for any swelling on the scrotal skin. Examine each testicle with both hands. Place the index and middle fingers under the testicle with the thumbs placed on top. Roll the testicle gently between the thumbs and fingers -- you shouldn't feel any pain when ...
Immunodeficiency and Genetic Defects of Pattern
... adaptor molecule that transduces signals from TLR receptors (with the exception of TLR3) and from the receptors for interleukin-1 and interleukin-18.28,29 The signaling involves a cascade of protein kinases, including the serine–threonine kinase IRAK-4.10 Studies in the past decade have identified g ...
... adaptor molecule that transduces signals from TLR receptors (with the exception of TLR3) and from the receptors for interleukin-1 and interleukin-18.28,29 The signaling involves a cascade of protein kinases, including the serine–threonine kinase IRAK-4.10 Studies in the past decade have identified g ...
Protocol S1.
... HIV-1 infections by the end of 2010. Scientific advances in virology and molecular biology have made it possible to identify each step of the viral cycle and this has enabled us to develop combined drug therapy that acts on the different steps of the cycle (ie, reverse transcriptase and protease). T ...
... HIV-1 infections by the end of 2010. Scientific advances in virology and molecular biology have made it possible to identify each step of the viral cycle and this has enabled us to develop combined drug therapy that acts on the different steps of the cycle (ie, reverse transcriptase and protease). T ...
Cytokine responses in birds challenged with the human food
... can infect a host. On recognition of a pathogen the host immune response involves a number of cells (e.g. natural killer, helper T (Th) cells) and signalling molecules resulting in a complex network of interactions involving the innate and adaptive immune systems [1,2]. A key component of this immun ...
... can infect a host. On recognition of a pathogen the host immune response involves a number of cells (e.g. natural killer, helper T (Th) cells) and signalling molecules resulting in a complex network of interactions involving the innate and adaptive immune systems [1,2]. A key component of this immun ...
Article
... population. Asymptomatic in healthy people, HCMV infection may lead to increased morbidity and mortality in immunocompromised individuals. Overall survival following transplantation is decreased when either the donor or the recipient is HCMV-seropositive [1,2,3]. Because of drug-related adverse effe ...
... population. Asymptomatic in healthy people, HCMV infection may lead to increased morbidity and mortality in immunocompromised individuals. Overall survival following transplantation is decreased when either the donor or the recipient is HCMV-seropositive [1,2,3]. Because of drug-related adverse effe ...
Macrophages and Dendritic Cells
... the concept of the mononuclear phagocyte system—which asserts tissue macrophages develop exclusively from circulating bone marrow–derived monocytes—has prevailed for nearly a half century.3 However, recent studies using sophisticated fatemapping approaches have determined that some tissue macrophage ...
... the concept of the mononuclear phagocyte system—which asserts tissue macrophages develop exclusively from circulating bone marrow–derived monocytes—has prevailed for nearly a half century.3 However, recent studies using sophisticated fatemapping approaches have determined that some tissue macrophage ...
The role of polyunsaturated fatty acids in immune function
... lead to alterations in dietary intake of polyunsaturated fatty acids (PUFA). The objective of this experiment is to confirm whether striped bass feeding on variable levels of PUFA will demonstrate a diminished immune response that may lead to greater progression of mycobacteriosis. Aquaculture-reare ...
... lead to alterations in dietary intake of polyunsaturated fatty acids (PUFA). The objective of this experiment is to confirm whether striped bass feeding on variable levels of PUFA will demonstrate a diminished immune response that may lead to greater progression of mycobacteriosis. Aquaculture-reare ...
IMMUNOREGULATION OF HEPATITIS B VIRUS INFECTION
... inhibitory receptors on their surface, such as programmed death-1 (PD-1), and the interaction between PD-1 and its ligand, PD-1 ligand 1 (PD-L1) are thought to be the major inhibitory receptor pathways involved in T-cell exhaustion.66-68) Indeed, PD-1 is shown to be overexpressed on HBV-specific T-c ...
... inhibitory receptors on their surface, such as programmed death-1 (PD-1), and the interaction between PD-1 and its ligand, PD-1 ligand 1 (PD-L1) are thought to be the major inhibitory receptor pathways involved in T-cell exhaustion.66-68) Indeed, PD-1 is shown to be overexpressed on HBV-specific T-c ...
Aspirin-induced asthma
... Fig. 1. This illustration could represent either a mast cell or eosinophil, the 2 most prominent cells detected in the respiratory mucosa of patients with AIA. Other inflammatory cells could also participate, although PMNs and macrophages predominantly synthesize LTB4 . During inflammatory respirat ...
... Fig. 1. This illustration could represent either a mast cell or eosinophil, the 2 most prominent cells detected in the respiratory mucosa of patients with AIA. Other inflammatory cells could also participate, although PMNs and macrophages predominantly synthesize LTB4 . During inflammatory respirat ...
Federica Chessa Dr. sc. hum. Dendritic cell function in different renal
... from 300 mOsm/L in the cortex up to 1200 mOsm/L in the inner medulla. A major contribution to the strong osmolarity increase in medulla is given by interstitial sodium. An aspect so far not investigated is whether non-immunologic biophysical factors within the kidney, such as medullary hyperosmolari ...
... from 300 mOsm/L in the cortex up to 1200 mOsm/L in the inner medulla. A major contribution to the strong osmolarity increase in medulla is given by interstitial sodium. An aspect so far not investigated is whether non-immunologic biophysical factors within the kidney, such as medullary hyperosmolari ...
Sperm-based contraceptive vaccine for wild rabbit
... (Vertebrate Biocontrol Center, Canberra), the main strategy has been to use a recombinant viral vector (myxoma virus, cytomegalovirus) expressing a common egg protein (ZPC) as a vaccine. However, this GMO approach is questionable, since there is limited control after release of virus into the enviro ...
... (Vertebrate Biocontrol Center, Canberra), the main strategy has been to use a recombinant viral vector (myxoma virus, cytomegalovirus) expressing a common egg protein (ZPC) as a vaccine. However, this GMO approach is questionable, since there is limited control after release of virus into the enviro ...
Jeopardy - Waukee Community School District Blogs
... Explain 3 types of non-specific immune system responses and the specific response including all cells. ...
... Explain 3 types of non-specific immune system responses and the specific response including all cells. ...
Expression of SpC3, the sea urchin complement component, in
... that there is homology among the innate immune systems within this animal lineage (Smith et al. 1996). The complement system is a major mediator of innate immunity in deuterostomes. In higher vertebrates, it is composed of four pathways; the three initiating pathways, classical, alternative, and lec ...
... that there is homology among the innate immune systems within this animal lineage (Smith et al. 1996). The complement system is a major mediator of innate immunity in deuterostomes. In higher vertebrates, it is composed of four pathways; the three initiating pathways, classical, alternative, and lec ...
Microbiology
... Coley’s toxin (gram-negative bacteria) stimulates TNF Vaccines used against ...
... Coley’s toxin (gram-negative bacteria) stimulates TNF Vaccines used against ...
Epigenetic Regulation of Innate Immunity by microRNAs
... activation of M2 macrophages leads to a dramatic increase in the expression of miR-223 in mouse bone marrow derived macrophages. Elevated levels of pro-inflammatory cytokines, such as Tumor Necrotic factor α (TNFα) and IL-6, and decrease in M2 associated markers, PPARγ and Arginase-1, were also repo ...
... activation of M2 macrophages leads to a dramatic increase in the expression of miR-223 in mouse bone marrow derived macrophages. Elevated levels of pro-inflammatory cytokines, such as Tumor Necrotic factor α (TNFα) and IL-6, and decrease in M2 associated markers, PPARγ and Arginase-1, were also repo ...
In Vitro Generation of Interleukin 10–producing - Direct-MS
... Th1 and Th2 type responses, suggesting an important negative feedback role for this cytokine (15, 16). In addition, a number of studies suggest that IL-10–producing T cells may be induced in the absence of Th1 and Th2 responses and are involved in establishing non responsiveness (15, 17–19). These r ...
... Th1 and Th2 type responses, suggesting an important negative feedback role for this cytokine (15, 16). In addition, a number of studies suggest that IL-10–producing T cells may be induced in the absence of Th1 and Th2 responses and are involved in establishing non responsiveness (15, 17–19). These r ...
Lymphatic System - El Camino College
... Stroma consists of capsule, Trabeculae, reticular fibers and fibroblasts. Parenchyma has white and red pulps. White pulp has lymphocytes and macrophages around branches of splenic artery. Macrophages eliminate worn out RBC in spleen. Red pulp has venous sinuses and Splenic Cords (Billroth’s) made o ...
... Stroma consists of capsule, Trabeculae, reticular fibers and fibroblasts. Parenchyma has white and red pulps. White pulp has lymphocytes and macrophages around branches of splenic artery. Macrophages eliminate worn out RBC in spleen. Red pulp has venous sinuses and Splenic Cords (Billroth’s) made o ...
The T Cell Marker, CD3 Antigen and Antibodies
... and van Oers 2003, Smith-Garvin et al. 2009). Recruitment of ZAP-70, a syk kinase family member, binds to CD3-ζ. Bound ZAP-70 phosphorylates the transmembrane adapter protein linker of activated T cells (LAT) which then allows the cytosolic adapter protein SH2 domain containing leukocyte phosphoprot ...
... and van Oers 2003, Smith-Garvin et al. 2009). Recruitment of ZAP-70, a syk kinase family member, binds to CD3-ζ. Bound ZAP-70 phosphorylates the transmembrane adapter protein linker of activated T cells (LAT) which then allows the cytosolic adapter protein SH2 domain containing leukocyte phosphoprot ...
Cancer immunotherapy
![](https://commons.wikimedia.org/wiki/Special:FilePath/Peptide_bound_to_Rituximab_FAB.png?width=300)
Cancer immunotherapy (immuno-oncology) is the use of the immune system to treat cancer. Immunotherapies fall into three main groups: cellular, antibody and cytokine. They exploit the fact that cancer cells often have subtly different molecules on their surface that can be detected by the immune system. These molecules, known as cancer antigens, are most commonly proteins, but also include molecules such as carbohydrates. Immunotherapy is used to provoke the immune system into attacking the tumor cells by using these antigens as targets.Antibody therapies are the most successful immunotherapy, treating a wide range of cancers. Antibodies are proteins produced by the immune system that bind to a target antigen on the cell surface. In normal physiology the immune system uses them to fight pathogens. Each antibody is specific to one or a few proteins. Those that bind to cancer antigens are used to treat cancer. Cell surface receptors are common targets for antibody therapies and include the CD20, CD274, and CD279. Once bound to a cancer antigen, antibodies can induce antibody-dependent cell-mediated cytotoxicity, activate the complement system, or prevent a receptor from interacting with its ligand, all of which can lead to cell death. Multiple antibodies are approved to treat cancer, including Alemtuzumab, Ipilimumab, Nivolumab, Ofatumumab, and Rituximab.Cellular therapies, also known as cancer vaccines, usually involve the removal of immune cells from the blood or from a tumor. Immune cells specific for the tumor are activated, cultured and returned to the patient where the immune cells attack the cancer. Cell types that can be used in this way are natural killer cells, lymphokine-activated killer cells, cytotoxic T cells and dendritic cells. The only cell-based therapy approved in the US is Dendreon's Provenge, for the treatment of prostate cancer.Interleukin-2 and interferon-α are examples of cytokines, proteins that regulate and coordinate the behaviour of the immune system. They have the ability to enhance anti-tumor activity and thus can be used as cancer treatments. Interferon-α is used in the treatment of hairy-cell leukaemia, AIDS-related Kaposi's sarcoma, follicular lymphoma, chronic myeloid leukaemia and malignant melanoma. Interleukin-2 is used in the treatment of malignant melanoma and renal cell carcinoma.