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How to Obtain Appropriate Executive Decisions Using Artificial Immunologic Systems
... Searching for more suitable ways of decision making is as old as the pre-historic period, when man conducted his decisions by analyzing dreams, animal viscera, smoke, among other elements, [14]. This necessity has been increasingly elaborated through time. Currently, advances in information technolo ...
... Searching for more suitable ways of decision making is as old as the pre-historic period, when man conducted his decisions by analyzing dreams, animal viscera, smoke, among other elements, [14]. This necessity has been increasingly elaborated through time. Currently, advances in information technolo ...
Sleep April.indd
... on antigen-presenting cells (APCs) that can drive T cells toward type 1 or type 2 responses. However, despite this key role of APCs in T cell regulation and recent observations indicating that sleep increases type 1 cytokine activity in an undifferentiated monocyte population,13 so far there are no ...
... on antigen-presenting cells (APCs) that can drive T cells toward type 1 or type 2 responses. However, despite this key role of APCs in T cell regulation and recent observations indicating that sleep increases type 1 cytokine activity in an undifferentiated monocyte population,13 so far there are no ...
Slide 1
... Another hormone, a-Melanocyte Stimulating (a-MSH) is also suspected to confer this privilege. The goal of this project was to determine if Leptin would promote inflammation in the eye by regulating nitric oxide, or NO. Varying concentrations of Leptin were tested for their ability to affect NO on ce ...
... Another hormone, a-Melanocyte Stimulating (a-MSH) is also suspected to confer this privilege. The goal of this project was to determine if Leptin would promote inflammation in the eye by regulating nitric oxide, or NO. Varying concentrations of Leptin were tested for their ability to affect NO on ce ...
Foundations I Schedule 2015
... Foundations I Schedule Course Overview The objective of this course is to familiarize learners with core concepts in immunology, microbiology, and virology. Accordingly, the course is divided into 10 weeklong sessions in which a core component of mammalian immunity is introduced, followed by an exam ...
... Foundations I Schedule Course Overview The objective of this course is to familiarize learners with core concepts in immunology, microbiology, and virology. Accordingly, the course is divided into 10 weeklong sessions in which a core component of mammalian immunity is introduced, followed by an exam ...
Annual Report 2011 - Davos - Swiss Institute of Allergy and Asthma
... 1922 Swiss Research Institute for High Altitude Climate and Tuberculosis 1922-1933 A. Loewy, High Altitude Physiology 1934-1937 F. Roulet, Chemistry of Mycobacterium Tuberculosis 1938-1954 W. Berblinger, Pathology of Tuberculosis 1954-1960 W. A. Vischer, Resistance to Mycobacterium Tuberculosis ...
... 1922 Swiss Research Institute for High Altitude Climate and Tuberculosis 1922-1933 A. Loewy, High Altitude Physiology 1934-1937 F. Roulet, Chemistry of Mycobacterium Tuberculosis 1938-1954 W. Berblinger, Pathology of Tuberculosis 1954-1960 W. A. Vischer, Resistance to Mycobacterium Tuberculosis ...
Establishment of immunohistochemical double staining
... tyrosine-‐ based inhibitory motif which together with a immunoreceptor tyrosine-‐ based switch motif will affect signaling pathways downstream upon ligand binding. Activation of PD1 results in cytokine downregulatio ...
... tyrosine-‐ based inhibitory motif which together with a immunoreceptor tyrosine-‐ based switch motif will affect signaling pathways downstream upon ligand binding. Activation of PD1 results in cytokine downregulatio ...
SERIES ‘‘RARE INTERSTITIAL LUNG DISEASES’’ Number 2 in this Series
... moderate nonspecific increase in eosinophil numbers (usually ,10%) [7, 22]. The proportion of alveolar lymphocytes is normal or diminished, and the CD4/CD8 ratio is decreased, as is observed in smokers. The identification of LCs among cells recovered by lavage using monoclonal antibodies directed ag ...
... moderate nonspecific increase in eosinophil numbers (usually ,10%) [7, 22]. The proportion of alveolar lymphocytes is normal or diminished, and the CD4/CD8 ratio is decreased, as is observed in smokers. The identification of LCs among cells recovered by lavage using monoclonal antibodies directed ag ...
ENDOMORPHIN 1 ACTIVATES NOS 2 ACTIVITY AND
... Endomorphins 1 and 2 are newly discovered opioid tetrapeptides whose structure is more resistant to enzymatic degradation than of other opioid peptides. Endomorphins 1 and 2 are considered as endogenous ligands with a high affinity for µ receptors. A number of studies have shown that opioid peptides ...
... Endomorphins 1 and 2 are newly discovered opioid tetrapeptides whose structure is more resistant to enzymatic degradation than of other opioid peptides. Endomorphins 1 and 2 are considered as endogenous ligands with a high affinity for µ receptors. A number of studies have shown that opioid peptides ...
Helminths in the gastrointestinal tract as modulators of immunity and
... linked to the regulatory arm of the immune system (59,68,105,161). It is interesting to note ...
... linked to the regulatory arm of the immune system (59,68,105,161). It is interesting to note ...
iiiiiiiiii - Cancer Research
... since this table was made during a search for rats with very highly agglutininsensitive red blood corpuscles, degrees of agglutination under ± are not recorded. Agglutinability of a grade below this is relatively common, and is by no means unimportant (Tables XX-XXII). While the degree of sensitivit ...
... since this table was made during a search for rats with very highly agglutininsensitive red blood corpuscles, degrees of agglutination under ± are not recorded. Agglutinability of a grade below this is relatively common, and is by no means unimportant (Tables XX-XXII). While the degree of sensitivit ...
Skin Immunity to Candida albicans
... the nailbeds. The genomic sequencing of HIV-negative CMC patients has identified many genes that are crucial for host defense against Candida albicans. Subsequent mechanistic studies have further defined the importance of specific pattern-recognition receptors, dendritic cells, cytokines, and T cell si ...
... the nailbeds. The genomic sequencing of HIV-negative CMC patients has identified many genes that are crucial for host defense against Candida albicans. Subsequent mechanistic studies have further defined the importance of specific pattern-recognition receptors, dendritic cells, cytokines, and T cell si ...
Patients with oral erosive and cutaneous lichen planus may have
... did not reveal any IgG deposits in the epithelial cells. However, as Solomon et al. underline in their review (7), in vivo ANA can also be detected in other diseases; namely, idiopathic connective tissue diseases such as lupus erythematosus and scleroderma, or mixed connective tissue diseases. In th ...
... did not reveal any IgG deposits in the epithelial cells. However, as Solomon et al. underline in their review (7), in vivo ANA can also be detected in other diseases; namely, idiopathic connective tissue diseases such as lupus erythematosus and scleroderma, or mixed connective tissue diseases. In th ...
MicroRNAs and respiratory diseases REVIEW
... modalities for early detection, prognostication and targeted therapies. miRNA mis-expression has been documented in several solid and haematological malignancies. Their importance in cancer is highlighted by the observation that ,50% of miRNA genes are located in cancer-associated genomic regions or ...
... modalities for early detection, prognostication and targeted therapies. miRNA mis-expression has been documented in several solid and haematological malignancies. Their importance in cancer is highlighted by the observation that ,50% of miRNA genes are located in cancer-associated genomic regions or ...
The machinery of programmed cell death
... 2.2. Caspase substrates during apoptosis . . . . . . . . . . 2.3. Inhibitors of caspases . . . . . . . . . . . . . . . . . Mitochondria and the functions of the Bcl-2 family . . . . . 3.1. The Bcl-2 family of proteins . . . . . . . . . . . . . 3.2. The mitochondrial pathway . . . . . . . . . . . . . ...
... 2.2. Caspase substrates during apoptosis . . . . . . . . . . 2.3. Inhibitors of caspases . . . . . . . . . . . . . . . . . Mitochondria and the functions of the Bcl-2 family . . . . . 3.1. The Bcl-2 family of proteins . . . . . . . . . . . . . 3.2. The mitochondrial pathway . . . . . . . . . . . . . ...
Delayed acquisition of Plasmodium falciparum antigen
... and reduce risk of clinical disease [7]. Of note, production of IFN-γ, TNF, IL-2, IL-6 and IL-4 has been shown in various ways to play a role in anti-malarial immunity [6, 8–13]. IFN-γ has been proposed as the major mediator of parasite clearance during blood stage infection [14]. Continuous malaria ...
... and reduce risk of clinical disease [7]. Of note, production of IFN-γ, TNF, IL-2, IL-6 and IL-4 has been shown in various ways to play a role in anti-malarial immunity [6, 8–13]. IFN-γ has been proposed as the major mediator of parasite clearance during blood stage infection [14]. Continuous malaria ...
Final Program Florence, Italy October 9-12, 2011 9th JOINT MEETING
... Genetic and functional analysis of a panel of truly human monoclonal antibodies against GM-CSF generated from idiopathic pulmonary alveolar proteinosis (IPAP) patients and potential therapeutic uses as an antiinflammatory agent J.W. Schrader, Y.Wang, L. Allan, C. Thomson, L. Jackson, A. Turner, G. A ...
... Genetic and functional analysis of a panel of truly human monoclonal antibodies against GM-CSF generated from idiopathic pulmonary alveolar proteinosis (IPAP) patients and potential therapeutic uses as an antiinflammatory agent J.W. Schrader, Y.Wang, L. Allan, C. Thomson, L. Jackson, A. Turner, G. A ...
Plasmacytoid predendritic cells initiate psoriasis through interferon
... tion, PDCs differentiate into DCs (11, 12) and/ or induce an IFN-–dependent maturation of bystander myeloid DCs with the ability to drive Th1 responses (13), thus providing a unique link between innate and adaptive antiviral immunity. During homeostasis, PDCs are encountered exclusively in the bloo ...
... tion, PDCs differentiate into DCs (11, 12) and/ or induce an IFN-–dependent maturation of bystander myeloid DCs with the ability to drive Th1 responses (13), thus providing a unique link between innate and adaptive antiviral immunity. During homeostasis, PDCs are encountered exclusively in the bloo ...
in MUC1-Transgenic Mice Cells CD8 T Cells by Dendritic/Tumor
... infections, are processed and presented through the MHC class I-restricted pathway to CTL (2). In contrast, exogenous proteins from the extracellular environment are processed and displayed in association with class II molecules and recognized by CD4⫹ T cells (3). Certain exogenous Ags can also be p ...
... infections, are processed and presented through the MHC class I-restricted pathway to CTL (2). In contrast, exogenous proteins from the extracellular environment are processed and displayed in association with class II molecules and recognized by CD4⫹ T cells (3). Certain exogenous Ags can also be p ...
Pre-infection transcript levels of FAM26F in peripheral blood
... CNAR refers to the property of CD8+ T-lymphocytes to suppress HIV-1 replication in acutely infected CD4+ cells without killing them (Levy, 2003; Stranford et al., 1999; Vella & Daniels, 2003; Walker et al., 1991; Wiviott et al., 1990). High CNAR has been reported to correlate with an asymptomatic he ...
... CNAR refers to the property of CD8+ T-lymphocytes to suppress HIV-1 replication in acutely infected CD4+ cells without killing them (Levy, 2003; Stranford et al., 1999; Vella & Daniels, 2003; Walker et al., 1991; Wiviott et al., 1990). High CNAR has been reported to correlate with an asymptomatic he ...
final thesis benoit - edoc
... induce a memory response that is faster and stronger allowing the host to efficaciously eliminate the foreign organism. The immune system is tightly regulated. However, in abnormal situations, it cannot discern between self and nonself and thus launch an attack against the patient’s own cells or tis ...
... induce a memory response that is faster and stronger allowing the host to efficaciously eliminate the foreign organism. The immune system is tightly regulated. However, in abnormal situations, it cannot discern between self and nonself and thus launch an attack against the patient’s own cells or tis ...
Cancer immunotherapy
![](https://commons.wikimedia.org/wiki/Special:FilePath/Peptide_bound_to_Rituximab_FAB.png?width=300)
Cancer immunotherapy (immuno-oncology) is the use of the immune system to treat cancer. Immunotherapies fall into three main groups: cellular, antibody and cytokine. They exploit the fact that cancer cells often have subtly different molecules on their surface that can be detected by the immune system. These molecules, known as cancer antigens, are most commonly proteins, but also include molecules such as carbohydrates. Immunotherapy is used to provoke the immune system into attacking the tumor cells by using these antigens as targets.Antibody therapies are the most successful immunotherapy, treating a wide range of cancers. Antibodies are proteins produced by the immune system that bind to a target antigen on the cell surface. In normal physiology the immune system uses them to fight pathogens. Each antibody is specific to one or a few proteins. Those that bind to cancer antigens are used to treat cancer. Cell surface receptors are common targets for antibody therapies and include the CD20, CD274, and CD279. Once bound to a cancer antigen, antibodies can induce antibody-dependent cell-mediated cytotoxicity, activate the complement system, or prevent a receptor from interacting with its ligand, all of which can lead to cell death. Multiple antibodies are approved to treat cancer, including Alemtuzumab, Ipilimumab, Nivolumab, Ofatumumab, and Rituximab.Cellular therapies, also known as cancer vaccines, usually involve the removal of immune cells from the blood or from a tumor. Immune cells specific for the tumor are activated, cultured and returned to the patient where the immune cells attack the cancer. Cell types that can be used in this way are natural killer cells, lymphokine-activated killer cells, cytotoxic T cells and dendritic cells. The only cell-based therapy approved in the US is Dendreon's Provenge, for the treatment of prostate cancer.Interleukin-2 and interferon-α are examples of cytokines, proteins that regulate and coordinate the behaviour of the immune system. They have the ability to enhance anti-tumor activity and thus can be used as cancer treatments. Interferon-α is used in the treatment of hairy-cell leukaemia, AIDS-related Kaposi's sarcoma, follicular lymphoma, chronic myeloid leukaemia and malignant melanoma. Interleukin-2 is used in the treatment of malignant melanoma and renal cell carcinoma.