Antiviral Protection Cell Cross-Presentation, CTL Responses, and
... Anna Meyer-Manlapat,*,2 Paul K. Goldsmith,‡ Yan Wang,* David Venzon,x Suzanne L. Epstein,† and David M. Segal* ...
... Anna Meyer-Manlapat,*,2 Paul K. Goldsmith,‡ Yan Wang,* David Venzon,x Suzanne L. Epstein,† and David M. Segal* ...
Control of Herpes Simplex Virus Type 1 Latency in Human
... strongly suggests that similar antigens are present in both TG and that the infiltration of immune cells to the TG is driven by antigen. The morphology of the TG was investigated by immunohistochemistry and in situ hybridization. Analysis of the distribution of T cells throughout the TG provided puz ...
... strongly suggests that similar antigens are present in both TG and that the infiltration of immune cells to the TG is driven by antigen. The morphology of the TG was investigated by immunohistochemistry and in situ hybridization. Analysis of the distribution of T cells throughout the TG provided puz ...
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... associated with elevated production of antibodies and transitional B cells [30]. At the same time, a polymorphism in the gene of the tyrosine phosphatase PTPN22 (C1858T), which is associated with SLE susceptibility, leads to a substitution of a tryptophan to an arginine (R620W) which reduces the bin ...
... associated with elevated production of antibodies and transitional B cells [30]. At the same time, a polymorphism in the gene of the tyrosine phosphatase PTPN22 (C1858T), which is associated with SLE susceptibility, leads to a substitution of a tryptophan to an arginine (R620W) which reduces the bin ...
Immunogenicity of B16 melanoma cells after
... Results ........................................................................................................... 38 ...
... Results ........................................................................................................... 38 ...
Shizuru et al. Hematopoietic Stem and Progenitor Cells: Clinical and
... progeny into the blood with immigration to distant sites occurs under both steady state and conditions of mobilization (i.e., growth factor ± cyclophosphamide) (11, 18, 58–66). In mice, the average residence time of blood HSC from normal or “mobilized” animals is ∼1 min. To maintain the steady state ...
... progeny into the blood with immigration to distant sites occurs under both steady state and conditions of mobilization (i.e., growth factor ± cyclophosphamide) (11, 18, 58–66). In mice, the average residence time of blood HSC from normal or “mobilized” animals is ∼1 min. To maintain the steady state ...
Stem cells are influenced by microbial ligands
... Stem cells are cells that are able to self-renewal and can differentiate into multi-lineages. Stem cells are divided into two main categories; the embryonic stem cell and the adult stem cell. The focus of the report will be on adult stem cells, further referred to as stem cells. Adult stem cells are ...
... Stem cells are cells that are able to self-renewal and can differentiate into multi-lineages. Stem cells are divided into two main categories; the embryonic stem cell and the adult stem cell. The focus of the report will be on adult stem cells, further referred to as stem cells. Adult stem cells are ...
MUSC Student Pre-Matriculation Requirements
... contagious, and will have a normal chest x-ray. Their only evidence of infection will be a positive TB skin test and/or blood assay (BAMT). Therefore, a negative chest x-ray does not rule out the presence of TB or the need for treatment. About 5-10% will develop active pulmonary tuberculosis at some ...
... contagious, and will have a normal chest x-ray. Their only evidence of infection will be a positive TB skin test and/or blood assay (BAMT). Therefore, a negative chest x-ray does not rule out the presence of TB or the need for treatment. About 5-10% will develop active pulmonary tuberculosis at some ...
Annual Report 2008 - Diamantina Institute
... and her colleagues on immunotherapy for autoimmune disease, viral infections and the complications of organ transplantation. A capital grant of $4.3m from the Australian Cancer Research Foundation will provide key equipment on the Princess Alexandra Hospital campus for studies on the molecular and g ...
... and her colleagues on immunotherapy for autoimmune disease, viral infections and the complications of organ transplantation. A capital grant of $4.3m from the Australian Cancer Research Foundation will provide key equipment on the Princess Alexandra Hospital campus for studies on the molecular and g ...
Materials and Methods
... The pathophysiology of GVHD involves cellular as well as cytokine-mediated mechanisms. Tissue damage and cytokine dysregulation caused by the conditioning of the patient provide a pro-inflammatory environment even before allogeneic T cells enter the body. Host reactive donor T cells then respond to ...
... The pathophysiology of GVHD involves cellular as well as cytokine-mediated mechanisms. Tissue damage and cytokine dysregulation caused by the conditioning of the patient provide a pro-inflammatory environment even before allogeneic T cells enter the body. Host reactive donor T cells then respond to ...
Exacerbation of autoantibody-mediated
... phenomenon. Administration of F(ab⬘)2 fragments of antiplatelet polyclonal antibody was not followed by the development of disease, even in infected animals, in contrast to intact immunoglobulin (significant difference between infected mice that received antiplatelet IgG or F(ab⬘)2: P ⫽ .0286; Figur ...
... phenomenon. Administration of F(ab⬘)2 fragments of antiplatelet polyclonal antibody was not followed by the development of disease, even in infected animals, in contrast to intact immunoglobulin (significant difference between infected mice that received antiplatelet IgG or F(ab⬘)2: P ⫽ .0286; Figur ...
Chapter 4 Dendritic cells secrete and target MHC class II carrying
... specificity for a p53 epitope. Unlike human T cells, mouse T cells do not synthesize MHC class II upon activation ((34), see also below). In addition to pathogen related signals, CD4+ T cells can act as activators of DC through ligation to MHC, CD40, FAS and/ or OX40L. DC that are activated in this ...
... specificity for a p53 epitope. Unlike human T cells, mouse T cells do not synthesize MHC class II upon activation ((34), see also below). In addition to pathogen related signals, CD4+ T cells can act as activators of DC through ligation to MHC, CD40, FAS and/ or OX40L. DC that are activated in this ...
Sleep, Immunity, and Circadian Clocks: A Mechanistic Model
... leukocyte subpopulations, including neutrophils, monocytes, dendritic cells, natural killer (NK) cells, B cells, T cells, and regulatory T cells which are (T cells, B cells, NK cells, dendritic cells, monocytes) or are not (neutrophils, regulatory T cells) modulated by sleep. In most of these cases, ...
... leukocyte subpopulations, including neutrophils, monocytes, dendritic cells, natural killer (NK) cells, B cells, T cells, and regulatory T cells which are (T cells, B cells, NK cells, dendritic cells, monocytes) or are not (neutrophils, regulatory T cells) modulated by sleep. In most of these cases, ...
Tips to Remember: What is an allergic reaction
... Antihistamines Allergies are frequently treated by drugs called antihistamines (because they inhibit the activity of histamine). Some contemporary examples are Claritin and Allegra, but antihistamines have been in use since as early as the 1930s and they continue to be an effective way to deal with ...
... Antihistamines Allergies are frequently treated by drugs called antihistamines (because they inhibit the activity of histamine). Some contemporary examples are Claritin and Allegra, but antihistamines have been in use since as early as the 1930s and they continue to be an effective way to deal with ...
A human SARS-CoV neutralizing antibody against epitope on S2
... Preparation of Luc/SARS S pseudovirus. The Luc/SARS S pseudovirus system was prepared based on the method described in [26]. Briefly, mammalian cell 293T was cotransfected by using three vectors that are mammalian expression vector pMT 21-S coding SARS-CoV S protein, pCMVR 8.2 coding for MuLV Gag and ...
... Preparation of Luc/SARS S pseudovirus. The Luc/SARS S pseudovirus system was prepared based on the method described in [26]. Briefly, mammalian cell 293T was cotransfected by using three vectors that are mammalian expression vector pMT 21-S coding SARS-CoV S protein, pCMVR 8.2 coding for MuLV Gag and ...
RECEPTOR TYROSINE KINASES AND THE REGULATION OF
... here have provided the first link between RTK signaling and immune regulation. However, the mechanism by which these RTKs inhibit macrophage activation remains unclear. IL-10, a potent inhibitor of classical activation, induces Stat3 phosphorylation, and mice with a tissue-specific deletion of Stat3 ...
... here have provided the first link between RTK signaling and immune regulation. However, the mechanism by which these RTKs inhibit macrophage activation remains unclear. IL-10, a potent inhibitor of classical activation, induces Stat3 phosphorylation, and mice with a tissue-specific deletion of Stat3 ...
Reliability of Rabbit Monoclonal Antibodies
... The immunohistochemical assessment of estrogen receptors (ERs), progesterone receptors (PRs), and the human epidermal growth factor receptor 2 (HER2) is now required for all patients with newly diagnosed breast cancer to determine the most effective treatment regimens.1-4 A large proportion of these ...
... The immunohistochemical assessment of estrogen receptors (ERs), progesterone receptors (PRs), and the human epidermal growth factor receptor 2 (HER2) is now required for all patients with newly diagnosed breast cancer to determine the most effective treatment regimens.1-4 A large proportion of these ...
Dual role for B-1a cells in immunity to influenza virus infection
... S. pneumoniae after their adoptive transfer into Rag1⫺/⫺ recipient mice (17). B-1a cells did not mount anti–PPS-3 responses after immunization with heat-killed S. pneumoniae. Instead, they secreted high amounts of natural antibodies against phosphocholine, which is another antigenic determinant on S ...
... S. pneumoniae after their adoptive transfer into Rag1⫺/⫺ recipient mice (17). B-1a cells did not mount anti–PPS-3 responses after immunization with heat-killed S. pneumoniae. Instead, they secreted high amounts of natural antibodies against phosphocholine, which is another antigenic determinant on S ...
How HIV Causes AIDS
... clinical trials. The Food and Drug Administration (FDA) has approved one of the socalled fusion inhibitors, T20, for use in HIV-infected people. Studies have identified multiple coreceptors for different types of HIV strains. These coreceptors are promising targets for new anti-HIV drugs, some of wh ...
... clinical trials. The Food and Drug Administration (FDA) has approved one of the socalled fusion inhibitors, T20, for use in HIV-infected people. Studies have identified multiple coreceptors for different types of HIV strains. These coreceptors are promising targets for new anti-HIV drugs, some of wh ...
Inflammatory Monocytes Activate Memory CD8+ T and
... with a combination of interleukin (IL)-12 and IL-18, memory CD8+ T cells can produce interferon gamma (IFN-g) (Berg et al., 2003; Kambayashi et al., 2003); IL-15 is able to trigger their activation by mimicking T cell receptor (TCR) crosslinking (Liu et al., 2002; Yajima et al., 2005; Zhang et al., ...
... with a combination of interleukin (IL)-12 and IL-18, memory CD8+ T cells can produce interferon gamma (IFN-g) (Berg et al., 2003; Kambayashi et al., 2003); IL-15 is able to trigger their activation by mimicking T cell receptor (TCR) crosslinking (Liu et al., 2002; Yajima et al., 2005; Zhang et al., ...
Immune maturation and lymphocyte characteristics in relation
... immune system perform a broad range of effector functions to ensure the accuracy of the conducted responses and the final elimination of the pathogen. The human immune system is generally divided into the innate and the adaptive branch. The innate immune system acts rapidly by detection of pathogens ...
... immune system perform a broad range of effector functions to ensure the accuracy of the conducted responses and the final elimination of the pathogen. The human immune system is generally divided into the innate and the adaptive branch. The innate immune system acts rapidly by detection of pathogens ...
Cancer immunotherapy
Cancer immunotherapy (immuno-oncology) is the use of the immune system to treat cancer. Immunotherapies fall into three main groups: cellular, antibody and cytokine. They exploit the fact that cancer cells often have subtly different molecules on their surface that can be detected by the immune system. These molecules, known as cancer antigens, are most commonly proteins, but also include molecules such as carbohydrates. Immunotherapy is used to provoke the immune system into attacking the tumor cells by using these antigens as targets.Antibody therapies are the most successful immunotherapy, treating a wide range of cancers. Antibodies are proteins produced by the immune system that bind to a target antigen on the cell surface. In normal physiology the immune system uses them to fight pathogens. Each antibody is specific to one or a few proteins. Those that bind to cancer antigens are used to treat cancer. Cell surface receptors are common targets for antibody therapies and include the CD20, CD274, and CD279. Once bound to a cancer antigen, antibodies can induce antibody-dependent cell-mediated cytotoxicity, activate the complement system, or prevent a receptor from interacting with its ligand, all of which can lead to cell death. Multiple antibodies are approved to treat cancer, including Alemtuzumab, Ipilimumab, Nivolumab, Ofatumumab, and Rituximab.Cellular therapies, also known as cancer vaccines, usually involve the removal of immune cells from the blood or from a tumor. Immune cells specific for the tumor are activated, cultured and returned to the patient where the immune cells attack the cancer. Cell types that can be used in this way are natural killer cells, lymphokine-activated killer cells, cytotoxic T cells and dendritic cells. The only cell-based therapy approved in the US is Dendreon's Provenge, for the treatment of prostate cancer.Interleukin-2 and interferon-α are examples of cytokines, proteins that regulate and coordinate the behaviour of the immune system. They have the ability to enhance anti-tumor activity and thus can be used as cancer treatments. Interferon-α is used in the treatment of hairy-cell leukaemia, AIDS-related Kaposi's sarcoma, follicular lymphoma, chronic myeloid leukaemia and malignant melanoma. Interleukin-2 is used in the treatment of malignant melanoma and renal cell carcinoma.