Raulet, D.H. 2003. Roles of the NKG2D immunoreceptor and its ligands. Nat Rev Immunol 3:781-790.
... Finally, NKG2D is expressed by mouse peritoneal exudate macrophages that are activated with lipopolysaccharide (LPS), interferon-α (IFN-α) mixed with IFN-β, or IFN-γ6,7. Most human NK cells also express NKG2D, and the levels are increased by exposure to interleukin-15 (IL-15)8. The pattern of recept ...
... Finally, NKG2D is expressed by mouse peritoneal exudate macrophages that are activated with lipopolysaccharide (LPS), interferon-α (IFN-α) mixed with IFN-β, or IFN-γ6,7. Most human NK cells also express NKG2D, and the levels are increased by exposure to interleukin-15 (IL-15)8. The pattern of recept ...
Publications by Bart Lambrecht, incl. "extra muros" papers
... This page shows "extra muros" publications from Bart Lambrecht (without IRC as affiliation). For copyright reasons, PDF-versions of our publications are available on the intranet only (login required ...
... This page shows "extra muros" publications from Bart Lambrecht (without IRC as affiliation). For copyright reasons, PDF-versions of our publications are available on the intranet only (login required ...
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... Bacterial extracts are specific and non-specific stimulating agents, indicated in the prevention and treatment of respiratory infections, particularly in acute and chronic bronchitis, pharyngitis, tonsillitis, laryngitis, rhinitis, sinusitis and otitis. They can also be used as adjuvants in case of ...
... Bacterial extracts are specific and non-specific stimulating agents, indicated in the prevention and treatment of respiratory infections, particularly in acute and chronic bronchitis, pharyngitis, tonsillitis, laryngitis, rhinitis, sinusitis and otitis. They can also be used as adjuvants in case of ...
The Systemic Inflammatory Response to Cardiac Surgery
... • Proinflammatory cytokines stimulate the inflammatory response; plasma concentrations of specific cytokines are predictive of outcome in critically ill patients. • Tumour necrosis factor α (TNF α) and Interleukin 1β (IL-1 β) are elevated early following cardiac surgery, with IL-6 and IL-8 peaking l ...
... • Proinflammatory cytokines stimulate the inflammatory response; plasma concentrations of specific cytokines are predictive of outcome in critically ill patients. • Tumour necrosis factor α (TNF α) and Interleukin 1β (IL-1 β) are elevated early following cardiac surgery, with IL-6 and IL-8 peaking l ...
Rajagopal Appavu_CV
... by the addictive drug analog and lack of effective yet safe immune adjuvants. The goals of this proposal are to design and develop cocaine vaccines based on designed cocaine analogs in combination with a peptide nanofiber-based delivery platform for eliciting high titers of anti-cocaine antibodies a ...
... by the addictive drug analog and lack of effective yet safe immune adjuvants. The goals of this proposal are to design and develop cocaine vaccines based on designed cocaine analogs in combination with a peptide nanofiber-based delivery platform for eliciting high titers of anti-cocaine antibodies a ...
immunology syllabus 2013 - The University of Texas Medical School
... implications and principles of the case. Describe in as much detail as possible the normal immune mechanisms to combat this infectious agent and how they affect the course of infection (e.g. Macrophages phagocytose and process the antigen and present antigen fragments in association with MHC Class I ...
... implications and principles of the case. Describe in as much detail as possible the normal immune mechanisms to combat this infectious agent and how they affect the course of infection (e.g. Macrophages phagocytose and process the antigen and present antigen fragments in association with MHC Class I ...
Practical Hematology Leukocytosis
... • Streptococcus, Staphylococcus spp. Allergy/asthma Immune mediated disease • Hypereosinophilic syndrome • Eosinophilic granuloma Mast Cell Tumor Other neoplasia • Lymphoma • Mucinous carcinoma Canine estrus ...
... • Streptococcus, Staphylococcus spp. Allergy/asthma Immune mediated disease • Hypereosinophilic syndrome • Eosinophilic granuloma Mast Cell Tumor Other neoplasia • Lymphoma • Mucinous carcinoma Canine estrus ...
Leukocytosis - PowerPoint
... • May be two forms of the same disease • More immature eos in circulation with EL ...
... • May be two forms of the same disease • More immature eos in circulation with EL ...
Subpopulations of bovine WC1 than CD4 CD25 Foxp3
... T cell subpopulations, as distinct ex vivo regulatory cells was assessed in co-culture suppression assays. Our findings revealed that despite the existence of a distinct bovine CD4+ CD25high T cell population, which showed Foxp3 transcription/expression, natural regulatory activity did not reside in ...
... T cell subpopulations, as distinct ex vivo regulatory cells was assessed in co-culture suppression assays. Our findings revealed that despite the existence of a distinct bovine CD4+ CD25high T cell population, which showed Foxp3 transcription/expression, natural regulatory activity did not reside in ...
A Rough look at the tonsils and adenoids, for Bonny Peppa!
... • Exposure to antigens relies on the contact of antigens with cells of the immune system across the epithelium which covers the tonsils. • The epithelium of the palatine and lingual tonsils forms deep crypts into the lymphoid tissue, and the resulting increase of the surface area is one way to facil ...
... • Exposure to antigens relies on the contact of antigens with cells of the immune system across the epithelium which covers the tonsils. • The epithelium of the palatine and lingual tonsils forms deep crypts into the lymphoid tissue, and the resulting increase of the surface area is one way to facil ...
Antihistamines II
... •BLOCK action of histamine at the receptor sites •Compete with histamine for binding at unoccupied receptors. If histamine is already bound, antihistamines cannot remove histamine. •The binding of H1 blockers to the histamine receptors prevents the adverse consequences of histamine stimulation: ...
... •BLOCK action of histamine at the receptor sites •Compete with histamine for binding at unoccupied receptors. If histamine is already bound, antihistamines cannot remove histamine. •The binding of H1 blockers to the histamine receptors prevents the adverse consequences of histamine stimulation: ...
Treatment-dependent Loss of Polyfunctional CD8+ T
... of appropriate immunosuppressive (IS) regimens in this setting is a matter of debate more so than the generally well tolerated ART. In particular, IS regimens including thymoglobulin (ATG), have been associated with an accelerated long-term CD4+ T-cell depletion and increased risk of non-opportunist ...
... of appropriate immunosuppressive (IS) regimens in this setting is a matter of debate more so than the generally well tolerated ART. In particular, IS regimens including thymoglobulin (ATG), have been associated with an accelerated long-term CD4+ T-cell depletion and increased risk of non-opportunist ...
A Novel Size-Based Sorting Mechanism of Pinocytic Luminal
... pinocytosis, and that reactive microglia are capable to present antigens to T cells and initiate immune responses. However, how microglia process the endocytosed contents and evoke an immune response remain unclear. Here we report that a size-dependent selective transport of small soluble contents f ...
... pinocytosis, and that reactive microglia are capable to present antigens to T cells and initiate immune responses. However, how microglia process the endocytosed contents and evoke an immune response remain unclear. Here we report that a size-dependent selective transport of small soluble contents f ...
BLOOD PHYSIOLOGY
... ④ Monocyte Its body is large, diameter about 15~30 µm without granule Function: ...
... ④ Monocyte Its body is large, diameter about 15~30 µm without granule Function: ...
gandhinamita
... the immune response are escape variants selected by nature as they have developed mutations in immune recognition components. To boost immune response to these tumors, several types of immunotherapies are being studied but so far have had minimal success ix ...
... the immune response are escape variants selected by nature as they have developed mutations in immune recognition components. To boost immune response to these tumors, several types of immunotherapies are being studied but so far have had minimal success ix ...
Full-Text PDF
... the skin and mucosa. Therefore, in addition to gold, nickel, copper and mercury salts may activate an innate immune response in keratinocytes [40]. Taken together, these findings reveal a mechanism of skin contact allergy development and might contribute to the elucidation of novel therapeutic strat ...
... the skin and mucosa. Therefore, in addition to gold, nickel, copper and mercury salts may activate an innate immune response in keratinocytes [40]. Taken together, these findings reveal a mechanism of skin contact allergy development and might contribute to the elucidation of novel therapeutic strat ...
thesis - KI Open Archive
... Natural killer (NK) cells have been implicated in tumor immune surveillance and can reject transformed cells expressing ligands for activating NK cell receptors and low levels of HLA class I. Although NK cells are well known for their ability to kill tumor cells, relatively few studies have addresse ...
... Natural killer (NK) cells have been implicated in tumor immune surveillance and can reject transformed cells expressing ligands for activating NK cell receptors and low levels of HLA class I. Although NK cells are well known for their ability to kill tumor cells, relatively few studies have addresse ...
Monocyte-Activation Phenotypes Are Associated With Biomarkers of
... combination ART has been the standard of care in the treatment of HIV infection since 1996, many longitudinal studies of chronically infected, treated patients have been complicated by inclusion of nonstandard or outdated management practices (ie, structured treatment interruptions, sequential monot ...
... combination ART has been the standard of care in the treatment of HIV infection since 1996, many longitudinal studies of chronically infected, treated patients have been complicated by inclusion of nonstandard or outdated management practices (ie, structured treatment interruptions, sequential monot ...
Fractal-like kinetics, a possible link between preconditioning and
... probably explain why therapies aimed at blocking pro-inflammatory mediators may be detrimental to septic hosts who are in a relatively immunosuppressed state (20). Our broad understanding of the complex molecular pathways leading to activation of the immune response and the subsequent development of ...
... probably explain why therapies aimed at blocking pro-inflammatory mediators may be detrimental to septic hosts who are in a relatively immunosuppressed state (20). Our broad understanding of the complex molecular pathways leading to activation of the immune response and the subsequent development of ...
B Cells
... Antimicrobial Peptides and Proteins • Peptides and proteins function in innate defense by attacking microbes directly or ...
... Antimicrobial Peptides and Proteins • Peptides and proteins function in innate defense by attacking microbes directly or ...
Bovine mammary gland
... the elevation in phagocytic cells, lymphocytes, immunoglobulins and Lf These changes occur too slowly and their antibacterial action is compromised by other normal events of involution. Treatment of glands at or near drying off with colchicine, endotoxin or the combination of the two compounds resul ...
... the elevation in phagocytic cells, lymphocytes, immunoglobulins and Lf These changes occur too slowly and their antibacterial action is compromised by other normal events of involution. Treatment of glands at or near drying off with colchicine, endotoxin or the combination of the two compounds resul ...
clever-1 as an immune suppressive molecule
... many studies in the field of immunology and cancer biology. Cell surface proteins expressed specifically on these cells are commonly used as markers to distinguish the different monocyte and macrophage subpopulations. The information regarding these cells and shifts in their characteristics with the ...
... many studies in the field of immunology and cancer biology. Cell surface proteins expressed specifically on these cells are commonly used as markers to distinguish the different monocyte and macrophage subpopulations. The information regarding these cells and shifts in their characteristics with the ...
Cancer immunotherapy
Cancer immunotherapy (immuno-oncology) is the use of the immune system to treat cancer. Immunotherapies fall into three main groups: cellular, antibody and cytokine. They exploit the fact that cancer cells often have subtly different molecules on their surface that can be detected by the immune system. These molecules, known as cancer antigens, are most commonly proteins, but also include molecules such as carbohydrates. Immunotherapy is used to provoke the immune system into attacking the tumor cells by using these antigens as targets.Antibody therapies are the most successful immunotherapy, treating a wide range of cancers. Antibodies are proteins produced by the immune system that bind to a target antigen on the cell surface. In normal physiology the immune system uses them to fight pathogens. Each antibody is specific to one or a few proteins. Those that bind to cancer antigens are used to treat cancer. Cell surface receptors are common targets for antibody therapies and include the CD20, CD274, and CD279. Once bound to a cancer antigen, antibodies can induce antibody-dependent cell-mediated cytotoxicity, activate the complement system, or prevent a receptor from interacting with its ligand, all of which can lead to cell death. Multiple antibodies are approved to treat cancer, including Alemtuzumab, Ipilimumab, Nivolumab, Ofatumumab, and Rituximab.Cellular therapies, also known as cancer vaccines, usually involve the removal of immune cells from the blood or from a tumor. Immune cells specific for the tumor are activated, cultured and returned to the patient where the immune cells attack the cancer. Cell types that can be used in this way are natural killer cells, lymphokine-activated killer cells, cytotoxic T cells and dendritic cells. The only cell-based therapy approved in the US is Dendreon's Provenge, for the treatment of prostate cancer.Interleukin-2 and interferon-α are examples of cytokines, proteins that regulate and coordinate the behaviour of the immune system. They have the ability to enhance anti-tumor activity and thus can be used as cancer treatments. Interferon-α is used in the treatment of hairy-cell leukaemia, AIDS-related Kaposi's sarcoma, follicular lymphoma, chronic myeloid leukaemia and malignant melanoma. Interleukin-2 is used in the treatment of malignant melanoma and renal cell carcinoma.