Immunocompatibility of Bacteriophages as Nanomedicines
... bacterial viruses that exist in two different life cycles and may or may not lyse their bacterial hosts as lytic and temperate bacteriophages, respectively [1–3]. While the ability of phage to attack bacteria has been known since their discovery, our knowledge about phage interactions with mammalian ...
... bacterial viruses that exist in two different life cycles and may or may not lyse their bacterial hosts as lytic and temperate bacteriophages, respectively [1–3]. While the ability of phage to attack bacteria has been known since their discovery, our knowledge about phage interactions with mammalian ...
CNS-CPC - Trinity College Dublin
... Could the body itself be causing damage in its attempts to keep the parasite at bay? CM is the result of an over-vigorous immune response originally evolved for the protection of the host. Evidence in support of this second hypothesis comes from studies in murine malaria models in which T cells, mon ...
... Could the body itself be causing damage in its attempts to keep the parasite at bay? CM is the result of an over-vigorous immune response originally evolved for the protection of the host. Evidence in support of this second hypothesis comes from studies in murine malaria models in which T cells, mon ...
Mesenchymal Stem Cells
... The classic method for differentiation of MSCs to osteoblasts in vitro involves incubating a confluent monolayer of MSCs with ascorbic acid, -glycerophosphate, and dexamethasone for 2–3 weeks. The MSCs form aggregates or nodules and increase their expression of alkaline phosphatase; calcium accumul ...
... The classic method for differentiation of MSCs to osteoblasts in vitro involves incubating a confluent monolayer of MSCs with ascorbic acid, -glycerophosphate, and dexamethasone for 2–3 weeks. The MSCs form aggregates or nodules and increase their expression of alkaline phosphatase; calcium accumul ...
B cell fate following immunization: from memory B cells to plasma cells
... native HIV-1 spike have increased the interest in understanding vaccine-induced neutralizing antibody responses. In addition, the durability of vaccine-induced responses is poorly understood. Thus, a better understanding of how to modulate Env-induced responses by using different immunogens, immuniz ...
... native HIV-1 spike have increased the interest in understanding vaccine-induced neutralizing antibody responses. In addition, the durability of vaccine-induced responses is poorly understood. Thus, a better understanding of how to modulate Env-induced responses by using different immunogens, immuniz ...
A Phase I Study of Recombinant Interleukin 2 plus Recombinant
... immediately followed by IL-2 given s.c. During the course of the study, changes were made in the route of administration due to the develop ment of neutralizing antibody in several patients to the s.c. administered IL-2 and after dose-limiting formulation problems which prevented further IL-2 dose e ...
... immediately followed by IL-2 given s.c. During the course of the study, changes were made in the route of administration due to the develop ment of neutralizing antibody in several patients to the s.c. administered IL-2 and after dose-limiting formulation problems which prevented further IL-2 dose e ...
Simplify Immunophenotyping Using Kits and
... lymphocytes that mediate antigen‐ specific immune responses ...
... lymphocytes that mediate antigen‐ specific immune responses ...
Wiskott-Aldrich syndrome protein–mediated actin dynamics control
... by which perturbation of actin dynamics promote autoimmune phenomena are less clear. Impairment of T and B cell tolerance have been reported in WAS patients and in Wasdeficient mice, but the exact cellular mechanisms that link loss of WASp function to autoimmunity have not been fully elucidated yet ...
... by which perturbation of actin dynamics promote autoimmune phenomena are less clear. Impairment of T and B cell tolerance have been reported in WAS patients and in Wasdeficient mice, but the exact cellular mechanisms that link loss of WASp function to autoimmunity have not been fully elucidated yet ...
Rheumatoid arthritis is an autoimmune disease that causes chronic
... liver reactions that have occurred with the licensed 100mg dose, and in some cases the reactions have been associated with short term use (less than one month). Dr June Raine, Director of Vigilance and Risk Management of Medicines at the MHRA said, “The MHRA carefully reviewed the latest evidence, ...
... liver reactions that have occurred with the licensed 100mg dose, and in some cases the reactions have been associated with short term use (less than one month). Dr June Raine, Director of Vigilance and Risk Management of Medicines at the MHRA said, “The MHRA carefully reviewed the latest evidence, ...
WHIP2015 book - Marine Biological Laboratory
... LYMPHOCYTES – CHAIRs Chris Hunter & Georgia Perona Wright 13:30 Jennifer Cnops -‐-‐-‐ NK, NKT and CD8-‐derived IFNγ drives myeloid cell activation and erythrophagocytosis, ...
... LYMPHOCYTES – CHAIRs Chris Hunter & Georgia Perona Wright 13:30 Jennifer Cnops -‐-‐-‐ NK, NKT and CD8-‐derived IFNγ drives myeloid cell activation and erythrophagocytosis, ...
RNA released from necrotic synovial fluid cells activates rheumatoid
... express pattern-recognition receptors, such as the Tolllike receptors (TLRs), which sense certain highly conserved structures that are found on many different bacterial and viral products. The recognition of specific microbial structures, such as lipopolysaccharide (LPS), by TLRs results in the up-r ...
... express pattern-recognition receptors, such as the Tolllike receptors (TLRs), which sense certain highly conserved structures that are found on many different bacterial and viral products. The recognition of specific microbial structures, such as lipopolysaccharide (LPS), by TLRs results in the up-r ...
The Jekyll and Hyde Functions of Caspases
... response to cytochrome c release resulting from the loss of mitochondrial integrity, while the DISCs assemble after the stimulation of the death receptors by their respective ligands such as Fas ligand (FasL) or tumor necrosis factor-a (TNFa). In addition, the inflammasomes are involved in the activ ...
... response to cytochrome c release resulting from the loss of mitochondrial integrity, while the DISCs assemble after the stimulation of the death receptors by their respective ligands such as Fas ligand (FasL) or tumor necrosis factor-a (TNFa). In addition, the inflammasomes are involved in the activ ...
Blood physiology
... - problems occur if the 2nd baby is also Rh+ - antibodies from mother´s blood enter blood of the fetus through the placenta, attach to baby´s Er - agglutination and hemolysis of Er of the fetus ...
... - problems occur if the 2nd baby is also Rh+ - antibodies from mother´s blood enter blood of the fetus through the placenta, attach to baby´s Er - agglutination and hemolysis of Er of the fetus ...
biographical sketch - Murdough Family Center for Psoriasis
... Hammerberg C, Katiyar SK, Carroll MC, Cooper KD: Activated complement component 3(C3) is required for UV induction of immunosuppression and antigenic tolerance. J Exp Med 187(7):1133-1138, 1998. Szabo SK, Hammerberg C, Yoshida Y, Bata-Csorgo Z, Cooper KD: Identification and quantitation of interfero ...
... Hammerberg C, Katiyar SK, Carroll MC, Cooper KD: Activated complement component 3(C3) is required for UV induction of immunosuppression and antigenic tolerance. J Exp Med 187(7):1133-1138, 1998. Szabo SK, Hammerberg C, Yoshida Y, Bata-Csorgo Z, Cooper KD: Identification and quantitation of interfero ...
Atopy and HIV. Do Basophils Play a Role in Both?
... class switching, stimulating allergenspecific IgE production. It has been hypothesised that abnormal polarization of the immune system from an early age leading to an increased Th2:Th1 ratio could result in an atopic phenotype14,40. IgE-mediated hypersensitivity is thought to be triggered by a sequen ...
... class switching, stimulating allergenspecific IgE production. It has been hypothesised that abnormal polarization of the immune system from an early age leading to an increased Th2:Th1 ratio could result in an atopic phenotype14,40. IgE-mediated hypersensitivity is thought to be triggered by a sequen ...
Strimvelis, Common name - autologous CD34+ - EMA
... incidence ranging from 0.22 to 0.68 per 100,000 live births, or less than 50 children per year in the United States (US) and European Union (EU) combined. The EMA have recognised the importance of supporting development of new treatments for Rare Diseases through its alliance with EURORDIS and throu ...
... incidence ranging from 0.22 to 0.68 per 100,000 live births, or less than 50 children per year in the United States (US) and European Union (EU) combined. The EMA have recognised the importance of supporting development of new treatments for Rare Diseases through its alliance with EURORDIS and throu ...
Plasma Levels of Neopterin and C-Reactive
... depletion is characteristic of HIV disease, subnormal CD4 cell levels can occur in other conditions [3], which may coexist in PLHIV. This includes active TB [4–6]; however the mechanisms involved in TB-related CD4 lymphocytopenia are unclear. In HIV infection, the main cause of CD4 cell depletion an ...
... depletion is characteristic of HIV disease, subnormal CD4 cell levels can occur in other conditions [3], which may coexist in PLHIV. This includes active TB [4–6]; however the mechanisms involved in TB-related CD4 lymphocytopenia are unclear. In HIV infection, the main cause of CD4 cell depletion an ...
Role of PD-1 co-inhibitory pathway in HIV Linköping University Post Print
... and extensive [8]. PD-L1 expression is found in many solid tumors, and high expression is associated with poor disease prognosis [8]. Several recent studies suggested that PD-1– PD-L pathway plays an important role in exhaustion of antitumor as well as anti-viral CD8+ T cells during chronic infectio ...
... and extensive [8]. PD-L1 expression is found in many solid tumors, and high expression is associated with poor disease prognosis [8]. Several recent studies suggested that PD-1– PD-L pathway plays an important role in exhaustion of antitumor as well as anti-viral CD8+ T cells during chronic infectio ...
Lymphatic System
... form tonsillar crypts. These structures, which accumulate all sorts of materials taken into the body through eating and breathing, actually encourage pathogens to penetrate deep into the tonsillar tissues where they are acted upon by numerous lymphoid follicles and eliminated. This seems to be the ...
... form tonsillar crypts. These structures, which accumulate all sorts of materials taken into the body through eating and breathing, actually encourage pathogens to penetrate deep into the tonsillar tissues where they are acted upon by numerous lymphoid follicles and eliminated. This seems to be the ...
Cancer immunotherapy
Cancer immunotherapy (immuno-oncology) is the use of the immune system to treat cancer. Immunotherapies fall into three main groups: cellular, antibody and cytokine. They exploit the fact that cancer cells often have subtly different molecules on their surface that can be detected by the immune system. These molecules, known as cancer antigens, are most commonly proteins, but also include molecules such as carbohydrates. Immunotherapy is used to provoke the immune system into attacking the tumor cells by using these antigens as targets.Antibody therapies are the most successful immunotherapy, treating a wide range of cancers. Antibodies are proteins produced by the immune system that bind to a target antigen on the cell surface. In normal physiology the immune system uses them to fight pathogens. Each antibody is specific to one or a few proteins. Those that bind to cancer antigens are used to treat cancer. Cell surface receptors are common targets for antibody therapies and include the CD20, CD274, and CD279. Once bound to a cancer antigen, antibodies can induce antibody-dependent cell-mediated cytotoxicity, activate the complement system, or prevent a receptor from interacting with its ligand, all of which can lead to cell death. Multiple antibodies are approved to treat cancer, including Alemtuzumab, Ipilimumab, Nivolumab, Ofatumumab, and Rituximab.Cellular therapies, also known as cancer vaccines, usually involve the removal of immune cells from the blood or from a tumor. Immune cells specific for the tumor are activated, cultured and returned to the patient where the immune cells attack the cancer. Cell types that can be used in this way are natural killer cells, lymphokine-activated killer cells, cytotoxic T cells and dendritic cells. The only cell-based therapy approved in the US is Dendreon's Provenge, for the treatment of prostate cancer.Interleukin-2 and interferon-α are examples of cytokines, proteins that regulate and coordinate the behaviour of the immune system. They have the ability to enhance anti-tumor activity and thus can be used as cancer treatments. Interferon-α is used in the treatment of hairy-cell leukaemia, AIDS-related Kaposi's sarcoma, follicular lymphoma, chronic myeloid leukaemia and malignant melanoma. Interleukin-2 is used in the treatment of malignant melanoma and renal cell carcinoma.