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Application Note Background
Application Note Background

... Note: The monocytes differentiate to M1-like or M2-like polarized macrophages under these conditions. If required, activation and subtype-specific polarization can be achieved by performing the optional activation step (refer to step 8). 7. Continue the differentiation process (day 6) Add another ...
EFFECT OF CROTALUS ATROX VENOM ON PERITONEAL AND SPLEEN CELL... PRODUCTION
EFFECT OF CROTALUS ATROX VENOM ON PERITONEAL AND SPLEEN CELL... PRODUCTION

... toxins, enzymes, growth factors, activators and inhibitors with a wide spectrum of biological activities. The effect of Crotalus atrox venom on human is characterized by cardiovascular system, respiratory system, somatic nerve system, and skeletal muscle [1]. The local effects caused by this venom a ...
Introduction: Biology Today Chapter 1
Introduction: Biology Today Chapter 1

... Surviving T cells enter the medulla of the thymus—macrophages dispose of the dead and dying T cells in the thymic cortex. Process = a natural prolongation or projection from a part of an organism. (http://wordnetweb.princeton.edu) Apoptosis = normal cellular process involving a genetically programme ...
Microbiology
Microbiology

... o Genetic recombination is process by which genetic elements from two separate genomes are brought together into one unit. This is important, because it allows a strong selection to show up in a population in a short amount of time. From a medical viewpoint, this is the most important consequence of ...
Lymphatic System
Lymphatic System

... • The PALS is a place in which the special conditions required for proliferation of B lymphocytes can be met, and at intervals there will be germinal centers along it. ...
Spin models inferred from patient-derived viral sequence data faithfully
Spin models inferred from patient-derived viral sequence data faithfully

... proposed by M. Eigen [15] have been found under certain conditions, in particular for the class of fitness landscapes where fitness is a function of the mutational distance from the wild-type strain [16]. But, these conditions are likely inapplicable for a complex problem like HIV evolution in a pop ...
Infectious Bronchitis in Poultry: Constraints and Biotechnological
Infectious Bronchitis in Poultry: Constraints and Biotechnological

Role of NKT cells in the digestive system. IV. The role of canonical
Role of NKT cells in the digestive system. IV. The role of canonical

... those that express V␣7.2. Both populations are selected by nonpolymorphic major histocompatibility complex class I-like antigen-presenting molecules expressed by hematopoietic cells in the thymus: CD1d for V␣14-expressing NKT cells and MR1 for those cells expressing V␣7.2. The more intensely studied ...
The sympathetic nervous response in inflammation
The sympathetic nervous response in inflammation

... only α-ARs are activated. In the case of innate immune cells, like macrophages, this directly translates into anti-inflammatory (for example, increases in interleukin (IL)-10 via β-AR) or proinflammatory activity (for example, increases in tumor necrosis factor (TNF) via α-AR). Therefore, the simult ...
An integrated model of the recognition of Candida albicans by the
An integrated model of the recognition of Candida albicans by the

Cellular profile and cytokine production at prosthetic interfaces
Cellular profile and cytokine production at prosthetic interfaces

... Our aim in this prospective study was to determine the major cell types and cytokines produced by periprosthetic tissues, using immunohistochemistry and in situ hybridisation. We hypothesised that tissues surrounding well-fixed and loose cemented and cementless prostheses, with and without osteolysi ...
Commercial Poultry Production and Feed Additives
Commercial Poultry Production and Feed Additives

... Strong immune response with enhance resistance of poultry to infectious diseases Highly effective in reducing toxicity of metals such as silver, arsenic and lead, and shows slight effects against cadmium and mercury toxicity(E) ...
Variation in the Human Immune System Is Largely Driven by Non
Variation in the Human Immune System Is Largely Driven by Non

... (Experimental Procedures, ‘‘Structural Equation Modeling to Estimate Heritable and Non-Heritable Influences’’). For each measurement, we subtracted the technical variance estimate from the e-component prior to normalization to correct for noise (Experimental Procedures, ‘‘Correction of Model Estima ...
control measure?
control measure?

... Means that are applied once, and their effect is apparent for a long time (the entire growing season) ...
Tolerogenic dendritic cell-based immunotherapy in Crohn’s disease Raquel Cabezón Cabello
Tolerogenic dendritic cell-based immunotherapy in Crohn’s disease Raquel Cabezón Cabello

... incidence of Crohn’s disease has been determined at 12.7 per 100.000 personyears in Europe, and 20.2 per 100.000 person-years in North America [2]. In both cases, the highest prevalence is around 20 times the incidence rate. The age of onset of Crohn’s disease has a bimodal distribution. The first p ...
Indirect involvement of allergen-captured mast cells
Indirect involvement of allergen-captured mast cells

Striped murrel S1 family serine protease: immune
Striped murrel S1 family serine protease: immune

... which rank among the most biologically vital and widely distributed enzyme. They have been categorized into non-clip domain SPs (or single domain) and clip domain SPs based on the presence of the domain. These SPs are multigene encoded protein family sharing a common catalytic mechanism along with s ...
Artículo de revisión The ocular surface: from physiology to the ocular
Artículo de revisión The ocular surface: from physiology to the ocular

... The conjunctiva is a lining of the outer portion of the eye. Conjunctival tissue begins from the anterior portion of the limbus, and ends at the eyelids margin. Anatomically, conjunctiva is divided into three regions: i) the bulbar conjunctiva, which covers the anterior portion of the sclera; ii) th ...
Changes.
Changes.

... BIOL 6335 Graduate Medical Microbiology (3 semester hours) This course expose students to advanced concepts and principles of medical microbiology. In addition, the course will deal with mechanisms associated with disease processes, microbial virulence, the control of bacterial growth, and host resp ...
Sex steroid hormones
Sex steroid hormones

... The prevalence of autoimmune diseases is higher in women than men, while for cardiovascular disease, there is a male predominance. The sexual dimorphism of autoimmune and cardiovascular diseases probably relates to a number of factors, e.g. difference in exposure to risk factors and response to ther ...
Construction of a new peptide insertion site in the top
Construction of a new peptide insertion site in the top

... aggregation into VP7 crystalline structures. In the second stage of the investigation, a twenty-five amino acid sequence of a VP2 neutralising epitope (Venter et al. , 2000; Bentley et al. , 2000; Martinez-Torrecuadrada et al. , 2001) was chosen to insert into the created site at position 144. This ...
Reproductive Immunology: Biomarkers of
Reproductive Immunology: Biomarkers of

... of cell-mediated immunity which show certain trophoblast antigens (4) and some antitrophoblast antibodies (5) can modulate allogeneic recognition reactions. Although antitrophoblast antibodies have been identified in some normal and abnormal pregnancies (6), such activity cannot be identified in mos ...


... Several proteins and peptides with antimicrobial activity that act on invading pathogens are secreted into the airway surface liquid (ASL) by the airway itself (27). The antimicrobial products (AP) produced by the airway can be small cationic molecules, such as the β-defensins, LL-37, and CCL20, or ...
22 Taurine (from the Latin taurus or bull, because it
22 Taurine (from the Latin taurus or bull, because it

JSAS 2013
JSAS 2013

... Abstract. Since Medawar (1953), much attention has been given to the immunological paradox of the survival and growth of the semi-allogeneic fetus in the maternal uterus. Numerous studies, mainly on the human placenta, have established fundamental mechanisms of this phenomenon; however, many aspects ...
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Molecular mimicry

Molecular mimicry is defined as the theoretical possibility that sequence similarities between foreign and self-peptides are sufficient to result in the cross-activation of autoreactive T or B cells by pathogen-derived peptides. Despite the promiscuity of several peptide sequences which can be both foreign and self in nature, a single antibody or TCR (T cell receptor) can be activated by even a few crucial residues which stresses the importance of structural homology in the theory of molecular mimicry. Upon the activation of B or T cells, it is believed that these ""peptide mimic"" specific T or B cells can cross-react with self-epitopes, thus leading to tissue pathology (autoimmunity). Molecular mimicry is a phenomenon that has been just recently discovered as one of several ways in which autoimmunity can be evoked. A molecular mimicking event is, however, more than an epiphenomenon despite its low statistical probability of occurring and these events have serious implications in the onset of many human autoimmune disorders. In the past decade the study of autoimmunity, the failure to recognize self antigens as ""self,"" has grown immensely. Autoimmunity is a result of a loss of immunological tolerance, the ability for an individual to discriminate between self and non-self. Growth in the field of autoimmunity has resulted in more and more frequent diagnosis of autoimmune diseases. Consequently, recent data show that autoimmune diseases affect approximately 1 in 31 people within the general population. Growth has also led to a greater characterization of what autoimmunity is and how it can be studied and treated. With an increased amount of research, there has been tremendous growth in the study of the several different ways in which autoimmunity can occur, one of which is molecular mimicry. The mechanism by which pathogens have evolved, or obtained by chance, similar amino acid sequences or the homologous three-dimensional crystal structure of immunodominant epitopes remains a mystery.
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