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Vitamins, amino acids positive impact on productivity of birds, digestion and the immune systems Dr. Najmul Shah, DVM, MSc(Hons), PhD Product Manager Interchemie Holland Interchemie Product portfolio Veterinary Medicines Water-soluble powders Feed Additives Nutritional watersoluble powders Veterinary Medicines Oral liquids Feed Additives Nutritional oral liquids Veterinary Medicines Injectables Veterinary Medicines Miscellaneous Feed Additives Mineral blocks Disinfectants Video Poultry diet Energy Nutrient Efficient Production Common feed ingredient in poultry diets •Cereals •Fats and oils Energy sources Protein sources •Soyabeans •Animal meal (fish meal) •Canola •Meat and bone meal •Vitamin, amino acids & minerals •Feed enzyme •Antioxidant Feed Additive FEED ADDITIVES (Amino acids) Amino acids 22 Amino Acids •10 are essential amino acids Amino acids comprise body protein •All 22 amino acids are equally important for protein (muscle) deposition Essential amino acids Essential amino acids Essential amino acids Essential amino acids Essential amino acids Amino acids & intestinal physiology Amino Acids & intestinal physiology Ref: Nichols & Bertolo 2008 •Synthesis of intestinal protein •Mucins Extracted amino acids Mucins •Glycosylated protein •Secreted along Intestinal epithelium by exocrine goblet cells •Protect the gut from pathogens and antinutritional factors •Rich in Threonine •28-40% of total AA Ser, Thr, Asp, Arginhibit invading micro-organisms Ref: Ushijima & Seto 1991 Amino acids and immunity Deficiency Impair immune function Increase the sensitivity of animals to infectious challenges or stressful conditions Amino acids and immunity Activation of T-Lymphocytes, Blymphocytes, natural killer cells and macrophages Amino acids Production of antibodies and cytokines Lymphocyte proliferation Amino acids and immunity Methionine Proven beneficial for the immune system in chicken infected with ND virus T-cell proliferation IgG secretion Leucocytes migration Antibody titer Ref: Tsiagbe et al., 1987 Amino acids and immunity Lysine Synthesis of cytokines Proliferation of lymphocytes Optimum function of immune system in response to infection (Konashi et.al., 2000) An inadequate supply of Lys would reduce antibody response and cell-mediated immunity in chicken (Chen et al., 2003) Amino acids and immunity Arginine NO (nitric oxide) production of macrophages, anti-tumor properties Increased lymphoid organ weights & percentage of CD8+ cells Enhanced heterophil to lymphocyte ratio in response to viral infection (Kidd, 2004) Vitamins Vitamins Utilization of nutrients Metabolism Major Functions Vitamins Therapeutic Prophylactic Vitamins deficiency syndrome is gradual process Marginal Sub-clinical Clinical Vit. Def. Syndrome Fat Soluble Vitamin Vitamin A Decreased egg production, weakness and lack of growth Formation and preservation of function of epithelial tissues and mucous membranes Important for fertility Essential for vision Fat Soluble Vitamin Vitamin D Thin shelled eggs, reduced egg production, retarded growth, rickets Role in the uptake of calcium and phosphate from intestine Regulates calcium and phosphate metabolism Essential for the normal development of skeleton and teeth Fat Soluble Vitamin Vitamin E Enlarged hocks, encephalomalacia (crazy chick disease) Intracellular antioxidant Stabilise unsaturated fatty acids Prevent toxic oxidative destruction Water Soluble Vitamin Riboflavin (B2) Curly-toe paralysis, poor growth and poor egg production, diarrehea The B vitamins include vitamin thiamin, riboflavin, niacin, pantothenic acid, pyridoxine, biotin, folic acid, and cyanocobalamin. Water Soluble Vitamin Choline Poor growth, fatty liver, decreased egg production As a constituent of phospholipids, i.e. it is essential in the building and maintenance of cell structure In fat metabolism in the liver, i.e. utilisation and outward transport of fat Water Soluble Vitamin Vitamin B12 Anaemia, poor growth, embryonic mortality Involved with nucleic acid synthesis, carbohydrate and fat metabolism and methyl synthesis When multivitamins, amino acids and minerals supplementation are useful Chicks & brooding period Stress Production Prevention When multivitamins, amino acids and minerals supplementation are useful Chicks & brooding period • • • • • • Good start of chicks Good enteric health High nutritional needs Underdevelop immune system Poor thermoregulation system Absorption of yolk STRESS • • • • • • • Heat Stress Disease Transportation Cold stress Vaccination Debeaking Deworming COST OF STRESS Mortalities Low Fertility Lower resistance to disease Metabolic disorders Productivity Losses PRODUCTIVITY LOSSES (HEAT STRESS) Depressed appetite FCR down by 6-12% Slower growth upto 25% Lower egg yield 8-10% Inferior Carcase quality Indigestibility Loss of acid-base balance When multivitamins, amino acids and minerals supplementation are useful Production • High production • Low production • Poorly birds When multivitamins, amino acids and minerals supplementation are useful Prevention • Prevention of diseases like ND, Gumboro • Prevention of nutritional disorders like Perosis, Rickets, Curled toe paralysis, Encephalomalcia, muscular dystrophy, fatty liver INTERCHEMIE PRODUCTS DURING STRESS (HEAT STRESS) Introvit-C-200 Oral Features Vitamin C Advantages/Benefits Antioxidant Helps to convert iron into a chemical form that is more easily absorbed from the digestive tract It also improves eggshell quality via its role in the formation of the shell's organic matrix. Reduces the effects of stress increases feed utilization and daily weight gains rehydrates the body of the animal Helps in Heat Stress Accelerates wound healing Immune System: Vitamin C makes the epithelial tissues in the mouth less permeable to bacteria Feed Conversion ratio (FCR) FCR 1.85 1.81 1.8 1.75 1.73 1.7 1.65 1.59 1.6 1.55 1.5 1.45 Control no heat Control under heat stress Introvit-C-200 Oral FCR INTERCHEMIE PRODUCTS DURING STRESS Product Description Stressol Oral Vitamins Amino Acids Minerals Stressol Oral Product Stressol Oral Main Benefits To reduce stress (Heat, vaccination, Disease, transport, high humidity) Growth promoters Production promoters Improvement of gut health Help in gut regeneration Energy metabolism Stressol Oral Product Stressol Oral Main Benefits Maintenance of epithelial cells in good condition (skin and the linings of the digestive, reproductive, and respiratory tracts) Improve feed conversation rate Increase weight gain and performance Maximized economical benefits Dosage 1 Litre per 2000 litres of drinking water for 3-5 days Broiler production Intertonic Oral Introvit-ES-100 oral Introvit A+ oral Day 21 Day 28 3D-V-3D Day 1 Vaccination (NDV) Stimulate Liver & Renal function Energy metabolism, Fat into Energy •Chicks from Hatchery •Good start of chicks •To ease transportation stress •To reduce vaccine stress •Increased antibody titer •To support early growth •Improve immune response •Maintain gut integrity Brooding Period To improve Immunity Anti-stress Antioxidant •Improve the performance of broiler under fast production stress • Important for gut functions •Improve FCR Growth period Day 1-7 Day 8 to Day 45 Vaccination (NDV & IBD) Day 35 Day 14 Aminogrow ora Vitol-140 oral Introvit A+ Oral Product Description Introvit A+ Oral Vitamins Amino acids Fat soluble vitamin Building blocks of protein Water soluble vitamin Essential amino acids Introvit A+ Oral Product Introvit A+ Oral Main Benefits Good start of chicks and provide energy Prevention of early chick mortality Stimulate immune system Develop resistance against pullorum, salmonelosis and colibacillosis Improve digestibility Improve Yolk absorption Source of early metabolism Provide energy Dosages Poultry 1litre per 2000 litre drinking water 3-5 days Intertonic oral • Sorbitol • Carnitine hydrochloride • Betaine • Choline chloride • D-panthenol • Magnesium sulphate Intertonic oral Product Intertonic oral Main benefits To improve the oxidation of fatty acids to achieve energy (Energy metabolism, Fat into Energy) Stimulate Liver & Renal functions Intertonic oral Product Intertonic oral Main indications To reduce production stress Prevent Fatty Liver Instant Nutrients, Improve Digestion To improve growth Dosage 1 Kg per 1000 litre drinking water for 3-5 days Feed intake analysis of Group A (Control) N=50 chicks and Group B (Intertonic oral) N=50 chicks 4200 4190 4180 4170 Group A (Control) 4160 4150 Group B (Intertonic oral) 4140 4130 4120 4110 Feed intake 1-42 days Body weight gain analysis of Group A (Control) N=50 chicks and Group B (Intertonic oral) N=50 chicks 2250 2200 2150 2100 Group A Control 2050 2000 Group B Intertonic oral 1950 1900 1850 1800 BW 1-42 days FCR analysis of Group A (Control) N=50 chicks and Group B (Intertonic oral) N=50 chicks 2.2 2.15 2.1 2.05 2 Group A (Control) 1.95 Group B (Intertonic oral) 1.9 1.85 1.8 1.75 1.7 FCR 42 days Vitol-140 oral Product Description Vitol-140 Oral Vitamin A Vitamin D3 Vitamin E Vitol-140 Oral Product Vitol-140 Oral Main Benefits Antioxidant, preventing oxidation of lipids within membranes Strong immune response with enhance resistance of poultry to infectious diseases Highly effective in reducing toxicity of metals such as silver, arsenic and lead, and shows slight effects against cadmium and mercury toxicity(E) Increase Egg Production Strong bones and good egg shell quality Improve calcium and Phosphorus metabolism Dosages 1 litre per 8000 litres of drinking water Introvit-ES-100 Oral Product Introvit-ES-100 Description Vitamin E Sodium selinite Introvit-ES-100 Oral Product Introvit-ES-100 Oral Main Benefits Antioxidant Enhances immune responses Increases antibodies titer Enhances recovery from disease Dosages 1 litre per 4000 litres of drinking water Aminogrow oral Product Description Aminogrow Amino acids Building blocks of protein Essential amino acids Aminogrow Oral Product Aminogrow Oral Main Benefits Synthesis of intestinal proteins which are mainly secreted into the lumen as mucus which protect the gut from pathogens and antinutritional factors Amino acids in Aminogrow such as Ser, Thr, Asp and Arg have been suggested to inhibit invading microorganisms Aminogrow regulate activation of T-lymphocytes, Blymphocytes, natural killer cells and macrophages, lymphocyte proliferation, as well as the production of antibodies and cytokines Dosages 1 litre per 4000 litres of drinking water Fig. 1 Feed intake analysis of Group A (Control) N=5000 chicks and Group B (Interchemie feed additives programme) N=5000 chicks during the early and later stage of broiler chick life. 5000 4500 4000 3500 3000 Grams 2500 2000 1500 1000 500 0 Group A (Control) Group B (Interchemie Feed additives Programme) Feed intake Day Feed intake Day 21 42 Fig. 2 Body weight gain analysis of Group A (Control) N=5000 chicks and Group B (Interchemie feed additives programme) N=5000 chicks during the early and later stage of broiler chick life. 3000 2500 Group A Control 2000 Grams 1500 Group B (Interchemie Products Programme) 1000 500 0 BW 21 days BW 42 days Fig. 3 FCR analysis of Group A (Control) N=5000 chicks and Group B (Interchemie feed additives programme) N=5000 chicks at Day 42 2.5 2 Group A (Control) 1.5 Group B (Interchemie Products Programme) 1 0.5 0 FCR 42 days Layer production Introvit A+ Oral Day 1 Intertonic oral 8-10 wk 10-12wk 12-14 wk 14-16 wk 16-18 wk Day 21 Vitol-140 oral Introvit-C ora Introvit-ES- 10 Introvit D3 or Growing and vaccination •Good start of chicks •To ease transportation stress •To reduce the vaccine stress Week 2-16/18 •To ease vaccine stress and increase immune response •To improve performance •Proper utilization of fat and energy metabolism •Improve bone development •To improve egg production •To prevent multivitamins, amino acids and minerals deficiencies •To reduce production stress •Improved feed conversion ratio •Improve egg shell quality Chicks from Hatchery Laying stage Brooding period Day 1 16/8 Weeks + 20 wk 24 wk 28 wk 32 wk 36 wk Day 14 Vitol-140 Oral Introvit B-complex oral Stressol oral Intertonic oral Introvit D3 oral Vitol-140 oral Feed additives 36 weeks programme effects in layers Feed Conversion Ratio (FCR) Egg Quality Egg weight Feed Conversion Ratio(FCR) 1.95 1.9 1.85 1.8 Interchemie feed additive programme 36 wks 1.75 1.7 Control 1.65 1.6 1.55 1.5 1.45 FCR Egg Quality 3 2.5 2 Interchemie feed additive programme 36 wks 1.5 Control 1 0.5 0 Cracked Broken Egg Weight 74 72 70 68 66 64 Interchemie Prograamme 36 wks 62 Control 60 58 56 54 Egg weight (gms) Costs & return • • • • • • • • Vitol-140 Oral Introvit ES 100 Stressol Oral Introvit A+ Oral Introvit-B-complex Oral Intertonic Oral Calcimin Oral Respimint Oral •Good start of Chick life •Protect from diseases •Strong immune system •Rapid recovery from diseases •Healthy animals •More meat and egg production •Rapid growth •Improve FCR •High profitability Thank you for your attention!