Chimeric CLL-1 Antibody Fusion Proteins Containing Granulocyte
... models,10-17 illustrating the importance of localizing cytokines to tumors. However, at the present time, this approach is impractical in the clinical setting. An alternative method is the use of antibody-cytokine fusion proteins to direct such immunologically active molecules to tumor sites.18-20 I ...
... models,10-17 illustrating the importance of localizing cytokines to tumors. However, at the present time, this approach is impractical in the clinical setting. An alternative method is the use of antibody-cytokine fusion proteins to direct such immunologically active molecules to tumor sites.18-20 I ...
IMMUNOLOGY LEARNING OBJECTIVES
... into ER via TAP (transmemb molecule) peptides bind to incompletely folded class I molecules peptide binding induces conformational change in alpha chain causing it to dissociate from calnexin and to stabilize association with beta2m peptide-MHC molecule packaged into secretory vesicle in Golgi ...
... into ER via TAP (transmemb molecule) peptides bind to incompletely folded class I molecules peptide binding induces conformational change in alpha chain causing it to dissociate from calnexin and to stabilize association with beta2m peptide-MHC molecule packaged into secretory vesicle in Golgi ...
Independent of IL-4 Development of Lupus in BXSB Mice Is
... and myasthenia gravis (23), nor by studies of certain organ-specific diseases such as experimental autoimmune encephalomyelitis (24) and experimental autoimmune uveitis (25, 26). In the case of lupus, considerable evidence points to the importance of the Th1 response for disease induction and accele ...
... and myasthenia gravis (23), nor by studies of certain organ-specific diseases such as experimental autoimmune encephalomyelitis (24) and experimental autoimmune uveitis (25, 26). In the case of lupus, considerable evidence points to the importance of the Th1 response for disease induction and accele ...
Immunological Mechanisms and Natalizumab Treatment in Multiple Sclerosis Natalizumab Treatment in Multiple Sclerosis
... neurodegenerative component with accumulating axonal damage and gliosis have been demonstrated and contribute to MS disease characteristics. The inflammatory component is considered autoimmune and mediated by auto-reactive T lymphocytes together with other cell populations of the immune system and t ...
... neurodegenerative component with accumulating axonal damage and gliosis have been demonstrated and contribute to MS disease characteristics. The inflammatory component is considered autoimmune and mediated by auto-reactive T lymphocytes together with other cell populations of the immune system and t ...
Toll-like receptor-4 agonist in post-haemorrhage pneumonia: role
... production of cytokines, as well as presentation of antigen to naive lymphocytes [4]. Natural killer (NK) cells contribute to the anti-bacterial response, particularly through cytotoxic activity against infected cells and production of cytokines [5]. A defect in early activation of NK cells function ...
... production of cytokines, as well as presentation of antigen to naive lymphocytes [4]. Natural killer (NK) cells contribute to the anti-bacterial response, particularly through cytotoxic activity against infected cells and production of cytokines [5]. A defect in early activation of NK cells function ...
Bacterial Evasion of Host Immune Responses - Assets
... antibacterial protection comes from individuals with deficiencies in individual complement genes (Table 4.2). Such genetic deficiencies can be broadly divided into seven categories: (i) classical pathway genes, (ii) mannose-binding lectin, (iii) alternative pathway genes, (iv) C3, (v) genes encoding ...
... antibacterial protection comes from individuals with deficiencies in individual complement genes (Table 4.2). Such genetic deficiencies can be broadly divided into seven categories: (i) classical pathway genes, (ii) mannose-binding lectin, (iii) alternative pathway genes, (iv) C3, (v) genes encoding ...
Lung inflammatory responses
... active in inflammation are typically produced in response to infection by pathogenic microbes or environmental stressors. As a result of chemokine activation, leukocytes from the various tissue sites migrate into the affected lung tissues. The type of leukocyte attracted by the chemokines is importa ...
... active in inflammation are typically produced in response to infection by pathogenic microbes or environmental stressors. As a result of chemokine activation, leukocytes from the various tissue sites migrate into the affected lung tissues. The type of leukocyte attracted by the chemokines is importa ...
acute phase response
... Haptoglobin - hemoglobin binds and thus formed complex acts as peroxidase - an enzyme that promotes the oxidation of various organic substances peroxides. Competitively inhibits cathepsin C and cathepsins B and L. limits the utilization of oxygen by pathogenic bacteria. Inhibitors of enzyme activit ...
... Haptoglobin - hemoglobin binds and thus formed complex acts as peroxidase - an enzyme that promotes the oxidation of various organic substances peroxides. Competitively inhibits cathepsin C and cathepsins B and L. limits the utilization of oxygen by pathogenic bacteria. Inhibitors of enzyme activit ...
Human T-cell leukemia virus type I (HTLV
... thereby resulting in mitotic abnormalities [41]. In contrast to HTLV-I, HTLV-II promotes the proliferation of CD8-positive T-lymphocytes in vivo. Although it was first discovered in a patient with variant hairy cell leukemia, HTLV-II is less likely to have oncogenic properties since there is no obvi ...
... thereby resulting in mitotic abnormalities [41]. In contrast to HTLV-I, HTLV-II promotes the proliferation of CD8-positive T-lymphocytes in vivo. Although it was first discovered in a patient with variant hairy cell leukemia, HTLV-II is less likely to have oncogenic properties since there is no obvi ...
Cytokine responses in birds challenged with the human food
... Innate and adaptive immune responses are initiated sequentially in order to protect against different pathogens [4], although there is feedback and cooperation between the two systems. Innate γδ T cells are considered the first line of defence and development of adaptive naive CD4T cells often marks ...
... Innate and adaptive immune responses are initiated sequentially in order to protect against different pathogens [4], although there is feedback and cooperation between the two systems. Innate γδ T cells are considered the first line of defence and development of adaptive naive CD4T cells often marks ...
Chapter 43 Internal Defense
... • Plasma cells produce specific antibodies, immunoglobulins (Ig), in response to the specific antigens that activated them Copyright © 2005 Brooks/Cole — Thomson Learning ...
... • Plasma cells produce specific antibodies, immunoglobulins (Ig), in response to the specific antigens that activated them Copyright © 2005 Brooks/Cole — Thomson Learning ...
Andrea Cerutti Regulation of B cell Responses by the Innate Immune System
... composed of a VH-C IgH chain and a pseudo (or surrogate) IgL chain formed by the Vpre-B and 5 proteins. Large pre-B cells with in-frame VHDJH rearrangements undergo positive selection and further differentiate to small pre-B cells, which down-regulate surface pre-BCR expression, contain cytoplasmi ...
... composed of a VH-C IgH chain and a pseudo (or surrogate) IgL chain formed by the Vpre-B and 5 proteins. Large pre-B cells with in-frame VHDJH rearrangements undergo positive selection and further differentiate to small pre-B cells, which down-regulate surface pre-BCR expression, contain cytoplasmi ...
The dynamics of T cells during persistent Staphylococcus aureus
... growth during the acute phase of S. aureus infection. To determine their relevance for bacterial containment during the persistent phase, we depleted neutrophils in S. aureus-infected mice at day 28 p.i. by injecting anti-RB6 antibodies. The efficiency of neutrophil (90%) and macrophage (95%) depl ...
... growth during the acute phase of S. aureus infection. To determine their relevance for bacterial containment during the persistent phase, we depleted neutrophils in S. aureus-infected mice at day 28 p.i. by injecting anti-RB6 antibodies. The efficiency of neutrophil (90%) and macrophage (95%) depl ...
Preventing Infection at Mucosal Surfaces
... Most infectious diseases suffered by humans are caused by pathogens much smaller than a human cell. For these microbes, the human body constitutes a vast resource-rich environment in which to live and reproduce. In facing such threats, the body deploys a variety of defense mechanisms that have accum ...
... Most infectious diseases suffered by humans are caused by pathogens much smaller than a human cell. For these microbes, the human body constitutes a vast resource-rich environment in which to live and reproduce. In facing such threats, the body deploys a variety of defense mechanisms that have accum ...
Polarization of T Lymphocytes is Regulated by Mesenchymal Stem Cells in NZBWF1 and BALB/c Mice
... production of type 2 cytokines in SLE patients as well as in murine lupus-prone strains [41-43]. While Bc MSCs, in their ability to inhibit IL-4, IL-10, IL-6 and increase IFN-γ secretion, may orchestrate a shift towards an increase in Th1 cells, which is in line with the report by Deng [35]. TNF-α i ...
... production of type 2 cytokines in SLE patients as well as in murine lupus-prone strains [41-43]. While Bc MSCs, in their ability to inhibit IL-4, IL-10, IL-6 and increase IFN-γ secretion, may orchestrate a shift towards an increase in Th1 cells, which is in line with the report by Deng [35]. TNF-α i ...
Initiation of HAART during acute simian immunodeficiency virus
... accordance with federal guidelines and institutional policies. At euthanasia, macaques were perfused with sterile saline to remove blood from the vasculature prior to sampling organs and tissues. Protocols were approved by the Johns Hopkins University Institutional Animal Care and Use Committee and ...
... accordance with federal guidelines and institutional policies. At euthanasia, macaques were perfused with sterile saline to remove blood from the vasculature prior to sampling organs and tissues. Protocols were approved by the Johns Hopkins University Institutional Animal Care and Use Committee and ...
Full molecular characterization of a simian immunodeficiency virus
... the Ogoué river are infected with SIVmnd-1 but those spanning the regions of southern Cameroon and northern Gabon are infected with SIVmnd-2 (Onanga et al., 2006; Souquiere et al., 2001; Telfer et al., 2003). Even in the absence of rivers as geographical barriers, two viruses can co-circulate in one ...
... the Ogoué river are infected with SIVmnd-1 but those spanning the regions of southern Cameroon and northern Gabon are infected with SIVmnd-2 (Onanga et al., 2006; Souquiere et al., 2001; Telfer et al., 2003). Even in the absence of rivers as geographical barriers, two viruses can co-circulate in one ...
... of death (Figure 4(a)). It seems likely that the cells in this 20% of the population are metabolically “dead” and unable to maintain membrane integrity. Cells stained 3 hr after irradiation showed dose-dependent PI staining up to 300 Gy (25% PI positive), with a decrease to 10% PI positive at the hi ...
Toll-like receptors and immune regulation: their direct and indirect
... Treg cells have been extensively studied in mice and humans. Depletion of the naturally occurring subset of CD4+ CD25+ Treg cells results in various types of autoimmune disease.11,12,27,41 CD4+ CD25+ Treg cells inhibit a wide range of autoimmune and inflammatory manifestations such asgastritis, ooph ...
... Treg cells have been extensively studied in mice and humans. Depletion of the naturally occurring subset of CD4+ CD25+ Treg cells results in various types of autoimmune disease.11,12,27,41 CD4+ CD25+ Treg cells inhibit a wide range of autoimmune and inflammatory manifestations such asgastritis, ooph ...
Phagocytosis and Encapsulation: Cellular Immune Responses in
... but does it contain opsonic factors? The standard test for serum opsonins is (1980) found that a component of Bombyx the addition of serum-treated or untreated mori (L.) serum causes the elongation of test particles (often mammalian erythro- hemocytic filipodia, an action which could cytes) to hemoc ...
... but does it contain opsonic factors? The standard test for serum opsonins is (1980) found that a component of Bombyx the addition of serum-treated or untreated mori (L.) serum causes the elongation of test particles (often mammalian erythro- hemocytic filipodia, an action which could cytes) to hemoc ...
A population of atypical CD56вˆ`CD16+ natural killer cells is
... secrete cytokines and are more resistant to oxidative stress and apoptosis (Campbell and Hasegawa, 2013; Camous et al., 2012). A third subset of NK cells, defined as CD56 CD16+, was originally described as an expanded NK cell population in persons with Human Immunodeficiency Virus type 1 (HIV-1) and ...
... secrete cytokines and are more resistant to oxidative stress and apoptosis (Campbell and Hasegawa, 2013; Camous et al., 2012). A third subset of NK cells, defined as CD56 CD16+, was originally described as an expanded NK cell population in persons with Human Immunodeficiency Virus type 1 (HIV-1) and ...
Memmler`s The Human Body in Health and Disease 11th
... Copyright © 2009 Wolters Kluwer Health | Lippincott Williams & Wilkins ...
... Copyright © 2009 Wolters Kluwer Health | Lippincott Williams & Wilkins ...