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Slide - Smith Lab
Slide - Smith Lab

... Retention of T cells with specificity to ocular antigens due to Weak negative selection in individuals with particular HLA types Previous infection or trauma primed for ocular antigens in an ...
Autoimmune diseases
Autoimmune diseases

... It is a mucocutaneous T cell mediated autoimmune diseases, the oral lesion is of many different forms; reticular, atrophic, bullous, erosive and ulcerative. T cells produce cytokins that attack epithelial layer resulting in apoptosis (induced death of the cell) Myasthenia Gravis It is caused by auto ...
Slide 1 - AccessMedicine
Slide 1 - AccessMedicine

... The mechanisms operative in the initiation, expression, and downregulation of skin-derived immune responses. Induction of T cell immunity via the skin: Antigens administered to or occurring in the skin (microbial products, haptens, etc.) will be picked up, engulfed, processed and presented by dendri ...
Lymphatic Review Sheet
Lymphatic Review Sheet

... 13. What do allergens release? __________________________________ -A severe case of this can cause a person to go into _________________________ 14. Where do T-cells mature? ______________________ B cells? _____________________ 15. Bacteria will either stain ________________________ or _____________ ...
LOYOLA COLLEGE (AUTONOMOUS), CHENNAI – 600 034
LOYOLA COLLEGE (AUTONOMOUS), CHENNAI – 600 034

... a) carbohydrate b) lipid c) protein d) nucleic acid II. State whether the following are True or False; state reason 6. CD 45 is a signal transduction molecule found on B lymphocytes. 7. Dendritic cell is not an example of professional antigen presenting cell. 8. Apoptosis is a physiological phenomen ...
Cell Mediated Immunity
Cell Mediated Immunity

Cells of the innate immune system
Cells of the innate immune system

... szekvenciák - limitált specificitás ...
sheet of notes
sheet of notes

... on the B cell surface Cell-mediated immunity • Active against bacteria and viruses within infected body cells and against fungi, protozoa, and parasitic worms • It kills target cell primarily by releasing perforin, a protein that forms pores in the target cell’s membrane • As water flows into the ta ...
the original file
the original file

... from pathogens and list the key features for each category. 3. A dendritic cell phagocytoses a gram-negative bacteria. Which PAMP(s) may be detected? Which innate immune receptor will be detecting the PAMP(s)? 4. What type of pathogens do surface TLRs recognize? Endosomal TLRs? 5. Why is it logical ...
The Immune System - Blue Valley School District
The Immune System - Blue Valley School District

... • Becomes activated as physical barriers and inflammation fail. Phagocytic cells produce cytokines that initiate the acquired immune response. • Specialized lymphocytes called B and T-cells initiate the humoral and cellmediated responses, respectively. ...
PFIZER’S CENTERS FOR THERAPEUTIC INNOVATION (CTI) CTI:
PFIZER’S CENTERS FOR THERAPEUTIC INNOVATION (CTI) CTI:

... either harness the immune system for tumor eradication or, conversely, targeted therapies to provide selective immunosuppression or immunoregulation for autoimmune diseases ...
Viruses (dellpassovoy) - Ms. Pass's Biology Web Page
Viruses (dellpassovoy) - Ms. Pass's Biology Web Page

... Strictly speaking, they should not be considered "living" organisms at all. However, they are more complex than a lifeless collection of macromolecules and they do show one of the most important signs of life: the ability to ...
Abstract
Abstract

... Department of Life Science, Gwangju Institute of Science and Technology, 1 Oryong-dong, Puk-ku, Gwangju 500-712 Korea Attacking of self-components by auto-reactive T cells and/or B cells causes a damage or loss of organ function resulting in diverse immune disorders. Autonomic neuropathies often cau ...
Unit Question: What is life and how does it maintain balance? Notes
Unit Question: What is life and how does it maintain balance? Notes

... 1. Pathogens release antigens (foreign substances) 2. Antibodies are released by the immune system to fight the pathogen. 3. Antibodies have receptors on their cell membranes that recognize and bind to the antigens. ...
Kuby Immunology 6/e - Dr. Jennifer Capers, PhD
Kuby Immunology 6/e - Dr. Jennifer Capers, PhD

... ○ Some can cross epithelial layers to be ...
APCellOrganelles13
APCellOrganelles13

... Before there were cells… ...
sCD100 Human Chinese Hamster Ovary Cells (CHO)
sCD100 Human Chinese Hamster Ovary Cells (CHO)

... Description The Semphorins are a large family of phylogenetically conserved proteins that play a pivotal role in maintaining homeostasis in the immune system. Twenty members of this family have been identified and categorized into eight subclasses based on sequence similarity and distinctive structu ...
1.3 Viruses are not alive but affect living things. Vocabulary Host cell
1.3 Viruses are not alive but affect living things. Vocabulary Host cell

... 1.3 Viruses are not alive but affect living things. Vocabulary Host cell Viruses share some characteristics with living things ...
microbio 7 [4-20
microbio 7 [4-20

...  Pro-B cells produce Recombination activation genes (Rag-1 and Rag-2)  Pre-B cells synthesize a surrogate light chain  Mature B cells express surface IgD and IgM monomers  Plasma cells are the end-stage differentiation, and they secrete immunoglobin 15. What are the two methods of dendritic cell ...
Lecture 22
Lecture 22

TOLERANCE
TOLERANCE

... SUMMARY To combat the diversity of pathogenic antigens that might be encountered by the host, the immune system must produce populations of lymphocytes with receptors of equal diversity ...
Title - Iowa State University
Title - Iowa State University

... 6. The second line of defense makes use of many different cell types. Name two cell types involved in the innate defenses. Name two other non-cellular defenses in the innate immune system. ...
L18, Part 2: Immunune System, continued
L18, Part 2: Immunune System, continued

... • Dendritic cells presenting (viral) antigen in both MHC I and MHC II • Helper T cell activation ...
For more information
For more information

... important role in the humoral part of the adaptive immune response where they carry out several functions; they produce antibodies, induce memory and secrete cytokines in addition to being antigen presenting cells. Toll-like receptors (TLRs) are pattern recognition receptors that recognize conserved ...
Immunology-Uveitis
Immunology-Uveitis

... Retention of T cells with specificity to ocular antigens due to Weak negative selection in individuals with particular HLA types Previous infection or trauma primed for ocular antigens in an ...
< 1 ... 501 502 503 504 505 506 507 508 509 ... 514 >

Molecular mimicry

Molecular mimicry is defined as the theoretical possibility that sequence similarities between foreign and self-peptides are sufficient to result in the cross-activation of autoreactive T or B cells by pathogen-derived peptides. Despite the promiscuity of several peptide sequences which can be both foreign and self in nature, a single antibody or TCR (T cell receptor) can be activated by even a few crucial residues which stresses the importance of structural homology in the theory of molecular mimicry. Upon the activation of B or T cells, it is believed that these ""peptide mimic"" specific T or B cells can cross-react with self-epitopes, thus leading to tissue pathology (autoimmunity). Molecular mimicry is a phenomenon that has been just recently discovered as one of several ways in which autoimmunity can be evoked. A molecular mimicking event is, however, more than an epiphenomenon despite its low statistical probability of occurring and these events have serious implications in the onset of many human autoimmune disorders. In the past decade the study of autoimmunity, the failure to recognize self antigens as ""self,"" has grown immensely. Autoimmunity is a result of a loss of immunological tolerance, the ability for an individual to discriminate between self and non-self. Growth in the field of autoimmunity has resulted in more and more frequent diagnosis of autoimmune diseases. Consequently, recent data show that autoimmune diseases affect approximately 1 in 31 people within the general population. Growth has also led to a greater characterization of what autoimmunity is and how it can be studied and treated. With an increased amount of research, there has been tremendous growth in the study of the several different ways in which autoimmunity can occur, one of which is molecular mimicry. The mechanism by which pathogens have evolved, or obtained by chance, similar amino acid sequences or the homologous three-dimensional crystal structure of immunodominant epitopes remains a mystery.
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