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T cell-mediated immunity The nature of antigen recognition by T
T cell-mediated immunity The nature of antigen recognition by T

... HLA class I proteins present antigen peptides mainly to Tc cells whereas HLA class II proteins present antigen peptides mainly to Th cells. This is because Tc cells express a protein called CD8 that interacts with the 3 domain of HLA class I when the TCR binds to the antigen peptide held in the ant ...
Introduction to the MRC Centre for Inflammation Research video
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Module 6 : Hypersensitivity and immunodeficiency
Module 6 : Hypersensitivity and immunodeficiency

... self and non-self i.e when the individual fails to recognize its own parts as self and develops an immune response against its own cells and tissues. Diseases that occur because of autoimmunity are called as autoimmune diseases. Reactions against microbes Reactions against persistent microbial agent ...
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... selection. The lymphocyte begins to grow and then multiplies rapidly to form cells all exactly like itself and bearing the same antigen-specific receptors. The resulting is identical cells descended from the same ancestor cell is called a clone, and clone formation is the primary humoral response to ...
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... T cells have T-cell receptors, embedded in their cell membranes, that bind to antigens Even though many receptors (antibodies or T-cell receptors) encounter a given type of antigen, only the receptors that are compatible will bind to them [Fig. 43.12] This process is known as clonal selection Secre ...
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Microbiology 204: Cellular and Molecular Immunology Microbiology

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apch19.ppt
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Microbiology – Pathogenecity / Host Defence Mechanisms against
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... can be as a result of direct microbial activity or arise from the host immune response. This definition encompasses classical pathogens and opportunistic pathogens. The latter form part of a group that target susceptible groups in the general population. For example, old people, people with immune f ...
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Biol260exam2summer2012

... a. highly infectious and can be passed from person to person via direct or droplet contact b. maintained in an exanthropic cycle in the United States, where it is endemic in prairie dog populations c. potentially transmitted by flea bites from infected rodents to susceptible hosts such as people or ...
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Molecular mimicry

Molecular mimicry is defined as the theoretical possibility that sequence similarities between foreign and self-peptides are sufficient to result in the cross-activation of autoreactive T or B cells by pathogen-derived peptides. Despite the promiscuity of several peptide sequences which can be both foreign and self in nature, a single antibody or TCR (T cell receptor) can be activated by even a few crucial residues which stresses the importance of structural homology in the theory of molecular mimicry. Upon the activation of B or T cells, it is believed that these ""peptide mimic"" specific T or B cells can cross-react with self-epitopes, thus leading to tissue pathology (autoimmunity). Molecular mimicry is a phenomenon that has been just recently discovered as one of several ways in which autoimmunity can be evoked. A molecular mimicking event is, however, more than an epiphenomenon despite its low statistical probability of occurring and these events have serious implications in the onset of many human autoimmune disorders. In the past decade the study of autoimmunity, the failure to recognize self antigens as ""self,"" has grown immensely. Autoimmunity is a result of a loss of immunological tolerance, the ability for an individual to discriminate between self and non-self. Growth in the field of autoimmunity has resulted in more and more frequent diagnosis of autoimmune diseases. Consequently, recent data show that autoimmune diseases affect approximately 1 in 31 people within the general population. Growth has also led to a greater characterization of what autoimmunity is and how it can be studied and treated. With an increased amount of research, there has been tremendous growth in the study of the several different ways in which autoimmunity can occur, one of which is molecular mimicry. The mechanism by which pathogens have evolved, or obtained by chance, similar amino acid sequences or the homologous three-dimensional crystal structure of immunodominant epitopes remains a mystery.
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