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chapter summary
chapter summary

... that are able to bind lock-and-key fashion with only one specific complex foreign molecule, which is known as an antigen. The tremendous variation in antigen-detecting ability between different lymphocytes arises from the shuffling around of a few different gene segments, coupled with a high inciden ...
ΣΕΛ
ΣΕΛ

... Systemic lupus erythematosus (SLE) is an autoimmune disease in which organs, tissues, and cells undergo damage mediated by tissue-binding autoantibodies and immune complexes. Ninety percent of patients are women of child-bearing years; people of both genders, all ages, and all ethnic groups are sus ...
3.3mb
3.3mb

... Ab or the TCR ...
Ch 14 Lymphatic System
Ch 14 Lymphatic System

... ALLERGENS - antigens that trigger allergic responses Delayed reaction allergy - occurs due to repeated exposure of skin to certain chemicals usually after 48 hrs; ex: detergents, lotions -after repeated exposure - the foreign substance activates T cells and macrophages which cause eruptions and infl ...
Hypersensitivities – 17/03/03
Hypersensitivities – 17/03/03

...  Antigen re-presents, and are presented on APCs and Th1 cells interact with these  get activated. Th1 specific cytokines are released that induce local inflammation and activate macrophages. The macrophages along with other inflammatory cells cause tissue injury.  A variant of Type IV reactions i ...
Major Histocompability Complex (MHC)
Major Histocompability Complex (MHC)

... the cells displaying them are attacked and destroyed. This is why the body rejects grafts and transplants from donors that have not been matched for tissue type. ...
Preventing and fighting disease
Preventing and fighting disease

A1979HZ32100001
A1979HZ32100001

... "In the initial experiment in which we tested for such a soluble molecule, I recall the results were strikingly negative, although there was a peculiar wrinkling of the area of migrated macrophages. While it was tempting to dismiss this as trivial, we made one further effort to produce the in vitro ...
Generation of ligands for the T cell receptor
Generation of ligands for the T cell receptor

Janeway`s Immunology
Janeway`s Immunology

... decline with time after each immunization (contraction, the process that maintains homeostasis). The same features are seen in cell-mediated immune responses. ...
RHEUMATIC FEVER - aetiopathogenesis, aetiology &patholgy
RHEUMATIC FEVER - aetiopathogenesis, aetiology &patholgy

... Genetic susceptibility to RF - Familial tendency for RF had been investigated but no conclusive pattern of inheritance could be elucidated. - HLA-II (Chr 6) is the gene most associated with RF and development of RHD - HLA-DR7 mostly associated with progressive valvular lesions in RHD ...
Adaptive Immune System Chapter 16
Adaptive Immune System Chapter 16

... – Have BCRs complementary to the antigenic determinant that triggered their production – Long-lived cells that persist in the lymphoid tissue – Initiate antibody production if antigen is ...
Immunity - fixurscore
Immunity - fixurscore

... worldwide surveillance was followed-up by vaccination. • However, so far it has failed because: - poor response to the vaccine been shown by some children, who need nutrition. - High birth rates and shifting populations make following-up cases difficult. - Migrants and refugees may spread the diseas ...
Type III (Immune-Complex Mediated)
Type III (Immune-Complex Mediated)

... body produces antibodies and cytotoxic T cells that target normal body cells • Most autoimmune diseases appear to develop spontaneously and at random • Some common features of autoimmune disease have been noted • Occur more often in older individuals • More common in women than men ...
LECTURE OUTLINE
LECTURE OUTLINE

... foreign molecules or cells, after which they proliferate and become activated. The spleen filters the blood. Lymph nodes are packed with B and T cells. 13.2 Innate and Acquired Immunity Immunity is the body’s capability of removing or killing foreign substances, pathogens, and cancer cells. Mechanis ...
The Immune System
The Immune System

... Monocytes change into these as they leave the blood and enter the tissues. • Macrophages enter lymph vessels carring bacteria fragments to lymph nodes • This starts a specific immune response ...
Lecture Notes: Immune System (Part I)
Lecture Notes: Immune System (Part I)

... 10. Antimicrobial proteins i. attack microorganisms directly or inhibit their ability to reproduce ii. interferon a. different types like , , and -interferon b. are small proteins which “interferes” with viral replication. c. not virus specific d.  comes from lymphocytes e.  comes from most oth ...
Immunology – Immune System Overview
Immunology – Immune System Overview

... The immune system is the body’s only protective system, and comprises of various mechanisms whereby non-body particles are killed off or prevented from entering the body’s normal metabolism. There are a number of different pathogenic organisms which cause disease and thus disturb the body’s normal f ...
MICR 201 Microbiology for Health Related Sciences
MICR 201 Microbiology for Health Related Sciences

... Once lymphocytes have encountered their specific antigen they undergo clonal expansion  Some of these cells develop further into memory cells ...
MICR 201 Microbiology for Health Related Sciences
MICR 201 Microbiology for Health Related Sciences

... Once lymphocytes have encountered their specific antigen they undergo clonal expansion  Some of these cells develop further into memory cells ...
Wk8 - ViralSyn
Wk8 - ViralSyn

... – Rapid assembly, disassembly required, for interaction with multiple target cells. ...
White Blood Cells
White Blood Cells

... It is a special defense mechanism which is mobilized when the body is invaded by a foreign organism. ...
HISTORY- Antibody production
HISTORY- Antibody production

Tissue effector memory T cells Lymphoid central memory T cells
Tissue effector memory T cells Lymphoid central memory T cells

... The number of memory T-cells also stays constant over decades ...
CHEMICAL ELEMENTS THAT MAKE UP Carbohydrates Carbon
CHEMICAL ELEMENTS THAT MAKE UP Carbohydrates Carbon

< 1 ... 404 405 406 407 408 409 410 411 412 ... 514 >

Molecular mimicry

Molecular mimicry is defined as the theoretical possibility that sequence similarities between foreign and self-peptides are sufficient to result in the cross-activation of autoreactive T or B cells by pathogen-derived peptides. Despite the promiscuity of several peptide sequences which can be both foreign and self in nature, a single antibody or TCR (T cell receptor) can be activated by even a few crucial residues which stresses the importance of structural homology in the theory of molecular mimicry. Upon the activation of B or T cells, it is believed that these ""peptide mimic"" specific T or B cells can cross-react with self-epitopes, thus leading to tissue pathology (autoimmunity). Molecular mimicry is a phenomenon that has been just recently discovered as one of several ways in which autoimmunity can be evoked. A molecular mimicking event is, however, more than an epiphenomenon despite its low statistical probability of occurring and these events have serious implications in the onset of many human autoimmune disorders. In the past decade the study of autoimmunity, the failure to recognize self antigens as ""self,"" has grown immensely. Autoimmunity is a result of a loss of immunological tolerance, the ability for an individual to discriminate between self and non-self. Growth in the field of autoimmunity has resulted in more and more frequent diagnosis of autoimmune diseases. Consequently, recent data show that autoimmune diseases affect approximately 1 in 31 people within the general population. Growth has also led to a greater characterization of what autoimmunity is and how it can be studied and treated. With an increased amount of research, there has been tremendous growth in the study of the several different ways in which autoimmunity can occur, one of which is molecular mimicry. The mechanism by which pathogens have evolved, or obtained by chance, similar amino acid sequences or the homologous three-dimensional crystal structure of immunodominant epitopes remains a mystery.
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