... factors. We know now that variation in epigenetic marks between two MZ twins [63–65] can also explain phenotypic differences. MZ twins are derived from the same one-cell zygote, thus, share not only their genomic sequence but also the same initial epigenetic factors except for egg cleavage asymmetry. ...
Evolution of Closely Linked Gene Pairs in
... of base pairs between the beginning and/or ends of the transcripts as annotated in Ensembl. In the better annotated genomes, this includes the 5# and 3# untranslated regions (UTR); in poorly annotated genomes, information about the UTRs may be incomplete, and the number of closely linked gene pairs ...
... of base pairs between the beginning and/or ends of the transcripts as annotated in Ensembl. In the better annotated genomes, this includes the 5# and 3# untranslated regions (UTR); in poorly annotated genomes, information about the UTRs may be incomplete, and the number of closely linked gene pairs ...
Mining Multi-Faceted Overviews of Arbitrary Topics in a Text Collection
... • The problem as defined above is challenging is many ways. • First, we cannot rely on training examples to mine multi-faceted overview of arbitrary topics. The reasons are twofold: – 1) it is impossible to create training examples for all ad hoc topics and facets; – 2) it is usually too much burde ...
... • The problem as defined above is challenging is many ways. • First, we cannot rely on training examples to mine multi-faceted overview of arbitrary topics. The reasons are twofold: – 1) it is impossible to create training examples for all ad hoc topics and facets; – 2) it is usually too much burde ...
Secondary Leukemia Associated With The Anti-Cancer Agent
... reliably whether the cumulative dose of epipodophyllotoxins played a major role in the development of AML. The recognition that etoposide is dependent on the cell cycle and proliferation [25] has led to the development of more prolonged dosage schedules. Doses given over a period of several days hav ...
... reliably whether the cumulative dose of epipodophyllotoxins played a major role in the development of AML. The recognition that etoposide is dependent on the cell cycle and proliferation [25] has led to the development of more prolonged dosage schedules. Doses given over a period of several days hav ...
Phylogenetic Relationships between the Western Aster Yellows
... because it is larger and its rRNA has a more complex secondary structure than the 5s rRNA gene. Because of its central role in cell metabolism, the prokaryote 16s rRNA gene is highly conserved across widely divergent taxa, which frequently exhibit at least 70% sequence homology in this gene. Initial ...
... because it is larger and its rRNA has a more complex secondary structure than the 5s rRNA gene. Because of its central role in cell metabolism, the prokaryote 16s rRNA gene is highly conserved across widely divergent taxa, which frequently exhibit at least 70% sequence homology in this gene. Initial ...
HapTree-X: An integrative Bayesian framework for haplotype
... (i.e. compound heterozygote). In many cases, the latter can cause loss of function while the former is healthy; therefore, it is necessary to identify the phase (or diplotype) — the copies of a chromosome that the mutant alleles occur — in addition to the genotype. Identifying phase information of a ...
... (i.e. compound heterozygote). In many cases, the latter can cause loss of function while the former is healthy; therefore, it is necessary to identify the phase (or diplotype) — the copies of a chromosome that the mutant alleles occur — in addition to the genotype. Identifying phase information of a ...
Supplemental Tables
... 1993; VIEIRA et al. 1997). End sequences from 593 of these P1 clones that map to unique sites within the genome were generated to anchor the assembly onto the polytene chromosome map. In cases where a reference sequence of D. virilis was available for the in situ localized probe, position of the seq ...
... 1993; VIEIRA et al. 1997). End sequences from 593 of these P1 clones that map to unique sites within the genome were generated to anchor the assembly onto the polytene chromosome map. In cases where a reference sequence of D. virilis was available for the in situ localized probe, position of the seq ...
Myriad--Ambry -- Final Version of Ambry Preliminary Injunction
... Chromosomes in a human cell are made up of two complementary strands of DNA molecules—one strand is on one side of the double helix and the second strand is on the other side. For any given gene, only one molecule strand (the “template strand”) is actually transcribed into mRNA and ultimately used t ...
... Chromosomes in a human cell are made up of two complementary strands of DNA molecules—one strand is on one side of the double helix and the second strand is on the other side. For any given gene, only one molecule strand (the “template strand”) is actually transcribed into mRNA and ultimately used t ...
A Single Amino Acid Change in the SPRY Domain of Human Trim5
... HR2, and HR1 contain the human Trim5␣ RING motif with progressively longer substitutions of rhesus C-terminal residues. A reciprocal series was also made (RH3, RH2, and RH1) where parts of the rhesus Trim5␣ are substituted by human sequences. Restriction was measured by a previously described two-co ...
... HR2, and HR1 contain the human Trim5␣ RING motif with progressively longer substitutions of rhesus C-terminal residues. A reciprocal series was also made (RH3, RH2, and RH1) where parts of the rhesus Trim5␣ are substituted by human sequences. Restriction was measured by a previously described two-co ...
Missouri Western State University
... first and second, second and third, all three. • The following slide shows Northern Hemisphere of the 2-spatula burnt pancake graph on a globe. ...
... first and second, second and third, all three. • The following slide shows Northern Hemisphere of the 2-spatula burnt pancake graph on a globe. ...
Centromere Locations and Associated Chromosome
... only one parent can be scored, we can score only 99 meioses, but when scorable variants are heterozygous in both parents, 198 meioses were scored. To detect polymorphisms and develop PCR-based markers in the genes selected, sequences of one parent F1 plant and three to seven F2 progeny plants were d ...
... only one parent can be scored, we can score only 99 meioses, but when scorable variants are heterozygous in both parents, 198 meioses were scored. To detect polymorphisms and develop PCR-based markers in the genes selected, sequences of one parent F1 plant and three to seven F2 progeny plants were d ...
Transposon stability and a role for conjugational transfer in adaptive mutability
... utable to jamming of the cells secretory apparatus caused by induction of the tetA gene product at high copy number in the presence of the inducer Tet (13). For the episomal allele, the analysis was carried in the presence of streptomycin (Sm), conditions in which conjugal transfer to scavenger cell ...
... utable to jamming of the cells secretory apparatus caused by induction of the tetA gene product at high copy number in the presence of the inducer Tet (13). For the episomal allele, the analysis was carried in the presence of streptomycin (Sm), conditions in which conjugal transfer to scavenger cell ...
ARTICLES - Weizmann Institute of Science
... Eukaryotic genomes are packaged into nucleosome particles that occlude the DNA from interacting with most DNA binding proteins. Nucleosomes have higher affinity for particular DNA sequences, reflecting the ability of the sequence to bend sharply, as required by the nucleosome structure. However, it ...
... Eukaryotic genomes are packaged into nucleosome particles that occlude the DNA from interacting with most DNA binding proteins. Nucleosomes have higher affinity for particular DNA sequences, reflecting the ability of the sequence to bend sharply, as required by the nucleosome structure. However, it ...
Lecture 10: Control of gene expression
... concluded that they affect ‘inducibility’ locus. Hence the name lacI. The lacI gene encodes lac repressor that inhibits the lac lacZ- or lacY- mutations cause Lac- phenotype operon. The operon is derepressed by lacI- mutations case Lac++ phenotype lactose in the medium. ...
... concluded that they affect ‘inducibility’ locus. Hence the name lacI. The lacI gene encodes lac repressor that inhibits the lac lacZ- or lacY- mutations cause Lac- phenotype operon. The operon is derepressed by lacI- mutations case Lac++ phenotype lactose in the medium. ...
Parallel Genetic and Phenotypic Evolution of DNA Superhelicity in
... DNA supercoiling is the master function that interconnects chromosome structure and global gene transcription. This function has recently been shown to be under strong selection in Escherichia coli. During the evolution of 12 initially identical populations propagated in a defined environment for 20 ...
... DNA supercoiling is the master function that interconnects chromosome structure and global gene transcription. This function has recently been shown to be under strong selection in Escherichia coli. During the evolution of 12 initially identical populations propagated in a defined environment for 20 ...
cis-Regulatory Elements and trans-Acting Factors
... negative regulatory element could bind a specific nuclear protein, present in the submandibular gland, resulting in the inhibition of Reni expression in this tissue.4 Second, the high expression of submandibular Ren2 could be due to the nonfunctionality of the negative regulatory element.4 Recently, ...
... negative regulatory element could bind a specific nuclear protein, present in the submandibular gland, resulting in the inhibition of Reni expression in this tissue.4 Second, the high expression of submandibular Ren2 could be due to the nonfunctionality of the negative regulatory element.4 Recently, ...
High diversity of the `Spumella-like` flagellates: an investigation
... these investigations are based on very few strains (cf. Cowling, 1991) that often lack precise taxonomic identification (Holen and Boraas, 1991; Zwart and Darbyshire, 1992; Rothhaupt, 1997; Boenigk, 2002). In laboratory and field studies, these organisms are usually treated as a black box assuming, ...
... these investigations are based on very few strains (cf. Cowling, 1991) that often lack precise taxonomic identification (Holen and Boraas, 1991; Zwart and Darbyshire, 1992; Rothhaupt, 1997; Boenigk, 2002). In laboratory and field studies, these organisms are usually treated as a black box assuming, ...
Molecular cloning and biochemical characterization of a
... digested with EcoRI. After EcoRI digestion, high molecular weight DNA was fractionated on a sucrose gradient and used to prepare a genomic library in lambda EMBL 4 (Stratagene) according to the manufacturer's instructions. More than 2 105 phages were transferred to Hybond N nylon membrane (Amersha ...
... digested with EcoRI. After EcoRI digestion, high molecular weight DNA was fractionated on a sucrose gradient and used to prepare a genomic library in lambda EMBL 4 (Stratagene) according to the manufacturer's instructions. More than 2 105 phages were transferred to Hybond N nylon membrane (Amersha ...
Efficiency of gene silencing in Arabidopsis
... function phenotype P2. First, we identified microarray elements showing differential expression (P < 0.05) in at least one of the experiments. Then, we identified elements that were down- or up-regulated in hIR and/or transitive events at an arbitrarily chosen 1.5-fold difference level. Hierarchical ...
... function phenotype P2. First, we identified microarray elements showing differential expression (P < 0.05) in at least one of the experiments. Then, we identified elements that were down- or up-regulated in hIR and/or transitive events at an arbitrarily chosen 1.5-fold difference level. Hierarchical ...
JunctionSeq Package User Manual
... to reduce file sizes and processing time, and a number of artificial ”edge cases” were introduced for testing purposes. For example: in the gene annotation, one gene has an artificial transcript that lies on the opposite strand from the other transcripts, to ensure that JunctionSeq deals with that ( ...
... to reduce file sizes and processing time, and a number of artificial ”edge cases” were introduced for testing purposes. For example: in the gene annotation, one gene has an artificial transcript that lies on the opposite strand from the other transcripts, to ensure that JunctionSeq deals with that ( ...
Exploring Genetics Across the Middle School Science
... Exploring Genetics Across the Middle School Science and Math Curriculum has been designed with you in mind. Our team of university scientists, middle grades classroom teachers, middle school students developed and tested the activities in a school setting. The activities are easily implemented and f ...
... Exploring Genetics Across the Middle School Science and Math Curriculum has been designed with you in mind. Our team of university scientists, middle grades classroom teachers, middle school students developed and tested the activities in a school setting. The activities are easily implemented and f ...
Natural variation in nucleolar dominance reveals
... during interphase (6, 7), and where genes encoding the precursor transcript for 18S, 5.8S, and 25S rRNA are tandemly arrayed (8–10), NOR-bearing chromosomes in pure species (nonhybrids) display thin ‘‘secondary constrictions’’ at metaphase (6, 7). Navashin noted that in numerous interspecies hybrids ...
... during interphase (6, 7), and where genes encoding the precursor transcript for 18S, 5.8S, and 25S rRNA are tandemly arrayed (8–10), NOR-bearing chromosomes in pure species (nonhybrids) display thin ‘‘secondary constrictions’’ at metaphase (6, 7). Navashin noted that in numerous interspecies hybrids ...