Profilin regulates the activity of p42 , a novel Myb
... environment, p42POP and profilin are found in the same protein complex. In luciferase assays, p42POP acts as repressor and this activity is substantially reduced by profilins, indicating that profilin can regulate p42POP activity and is therefore involved in gene regulation. ...
... environment, p42POP and profilin are found in the same protein complex. In luciferase assays, p42POP acts as repressor and this activity is substantially reduced by profilins, indicating that profilin can regulate p42POP activity and is therefore involved in gene regulation. ...
The head organizer in Hydra
... The head organizer in an adult Hydra An adult Hydra has the shape of a cylindrical shell consisting of two tissue layers: an ectoderm and an endoderm that make up the head, body column and basal disk (Fig. 1). An organizer is usually associated with the early stages of the development of an embryo. ...
... The head organizer in an adult Hydra An adult Hydra has the shape of a cylindrical shell consisting of two tissue layers: an ectoderm and an endoderm that make up the head, body column and basal disk (Fig. 1). An organizer is usually associated with the early stages of the development of an embryo. ...
Fear-of-intimacy mediated zinc transport controls the
... muscle pattern observed in late embryos and its lack of innervation. Finally, the morphogenesis of the midgut is compromised by a failure in the formation or positioning of the midgut constrictions. In the latter case, the defects can be associated to modifications in the expression in the visceral ...
... muscle pattern observed in late embryos and its lack of innervation. Finally, the morphogenesis of the midgut is compromised by a failure in the formation or positioning of the midgut constrictions. In the latter case, the defects can be associated to modifications in the expression in the visceral ...
MAPK-mediated Phosphorylation of GATA-1 Promotes Expression and Cell Survival* Bcl-X □
... Downloaded from www.jbc.org at Albert Einstein College of Medicine, on July 6, 2010 ...
... Downloaded from www.jbc.org at Albert Einstein College of Medicine, on July 6, 2010 ...
View Full PDF - Essays in Biochemistry
... fast. Like mammalian ODC, AdoMetDC is degraded by the 26S proteasome [7]. However, unlike the degradation of ODC by the 26S proteasome, the degradation of AdoMetDC is dependent on ubiquitination of the protein. Interestingly, the degradation rate appears to be very dependent on the availability of t ...
... fast. Like mammalian ODC, AdoMetDC is degraded by the 26S proteasome [7]. However, unlike the degradation of ODC by the 26S proteasome, the degradation of AdoMetDC is dependent on ubiquitination of the protein. Interestingly, the degradation rate appears to be very dependent on the availability of t ...
- Nottingham ePrints
... Myogenesis has been extensively studied during embryo development and provides an excellent paradigm to understand how inductive signals regulate differentiation. Much of this work has focused on somites and extensive work has shown that interactions between Wnt, Shh and BMP signalling in both chick ...
... Myogenesis has been extensively studied during embryo development and provides an excellent paradigm to understand how inductive signals regulate differentiation. Much of this work has focused on somites and extensive work has shown that interactions between Wnt, Shh and BMP signalling in both chick ...
Full-Text PDF
... in the common ancestor of the Thermus-Deinococcus clade [5]. In thermophilic archaea, the helicase HerA is an essential enzyme encoded in a UV-induced operon that includes a NurA nuclease and DNA repair protein homologs to the eukaryotic Mre11 and Rad50 proteins. These eukaryotic Mre11 and Rad50 cou ...
... in the common ancestor of the Thermus-Deinococcus clade [5]. In thermophilic archaea, the helicase HerA is an essential enzyme encoded in a UV-induced operon that includes a NurA nuclease and DNA repair protein homologs to the eukaryotic Mre11 and Rad50 proteins. These eukaryotic Mre11 and Rad50 cou ...
Transforming Growth Factor- Signaling Strength Determines Target
... Surprisingly little is known about how the two fundamentally different responses to TGF are regulated. In principle, response specificity could be controlled at several different levels, including ligand concentration, receptor availability, receptor kinase activity or Smad activation [2]. As the T ...
... Surprisingly little is known about how the two fundamentally different responses to TGF are regulated. In principle, response specificity could be controlled at several different levels, including ligand concentration, receptor availability, receptor kinase activity or Smad activation [2]. As the T ...
EGFR/Ras Signaling Controls Drosophila Intestinal Stem
... Cic Controls Stem Cell Proliferation in Fly Midgut ...
... Cic Controls Stem Cell Proliferation in Fly Midgut ...
Calcium binding chaperones of the endoplasmic reticulum
... fully active to bind mis-folded proteins. Both the secretory pathway and Ca2+ dependent transcriptional processes are also fully active. ...
... fully active to bind mis-folded proteins. Both the secretory pathway and Ca2+ dependent transcriptional processes are also fully active. ...
Document
... Striated muscle adapts its structure, size, and metabolism to changes in functional demand. This is in part communicated by neural and mechanical input. While the events downstream a neural impulse have been characterised in depth, little is known about the role of mechanotransduction in the regulat ...
... Striated muscle adapts its structure, size, and metabolism to changes in functional demand. This is in part communicated by neural and mechanical input. While the events downstream a neural impulse have been characterised in depth, little is known about the role of mechanotransduction in the regulat ...
Tendon development and musculoskeletal assembly: emerging
... Shukunami et al., 2006). At the ultrastructural level, the loss of Scx disrupts the sheaths that surround each fascicle of collagen fibrils as well as cellular processes, which normally encircle the fibrils (Murchison et al., 2007). These results demonstrate that Scx controls tendon ECM production, ...
... Shukunami et al., 2006). At the ultrastructural level, the loss of Scx disrupts the sheaths that surround each fascicle of collagen fibrils as well as cellular processes, which normally encircle the fibrils (Murchison et al., 2007). These results demonstrate that Scx controls tendon ECM production, ...
You can answer the question Yourself with a few
... one type of whey. You might see whey protein isolate, whey protein hydrolysate (aka hydrolyzed whey protein), or whey protein concentrate. To be considered a great whey protein, the product must list whey ...
... one type of whey. You might see whey protein isolate, whey protein hydrolysate (aka hydrolyzed whey protein), or whey protein concentrate. To be considered a great whey protein, the product must list whey ...
Conservation of PHO pathway in ascomycetes and the role of Pho84
... transporters are required to facilitate entry of phosphate inside the cells, which are active over wide range of pH and environmental phosphate concentration (Persson et al. 1999). 2.1.1 Low-affinity transport system: This consists of two H+/ Pi symporters: Pho87 and Pho90 (Roomans et al. 1977; Pers ...
... transporters are required to facilitate entry of phosphate inside the cells, which are active over wide range of pH and environmental phosphate concentration (Persson et al. 1999). 2.1.1 Low-affinity transport system: This consists of two H+/ Pi symporters: Pho87 and Pho90 (Roomans et al. 1977; Pers ...
A C-terminus Mitochondrial-localization Region and BH3 Domain of
... List of Abbreviations........................................................................................................viii Preface................................................................................................................................ix ...
... List of Abbreviations........................................................................................................viii Preface................................................................................................................................ix ...
Basic region of residues 228-231 of protein kinase CK1[alpha] is
... Protein kinase CK1, also known as casein kinase 1, participates in the phosphorylation of b-catenin, which regulates the functioning of the Wnt signaling cascade involved in embryogenesis and carcinogenesis. b-catenin phosphorylation occurs in a multiprotein complex assembled on the scaffold protein ...
... Protein kinase CK1, also known as casein kinase 1, participates in the phosphorylation of b-catenin, which regulates the functioning of the Wnt signaling cascade involved in embryogenesis and carcinogenesis. b-catenin phosphorylation occurs in a multiprotein complex assembled on the scaffold protein ...
when to switch to flowering
... Genes that affect flowering time in Arabidopsis have been identified through two complementary strategies. The first has utilized the variation present in naturally occurring ecotypes of Arabidopsis that vary in flowering time. The second approach has utilized a diverse spectrum of induced mutations ...
... Genes that affect flowering time in Arabidopsis have been identified through two complementary strategies. The first has utilized the variation present in naturally occurring ecotypes of Arabidopsis that vary in flowering time. The second approach has utilized a diverse spectrum of induced mutations ...
Innate antiviral defense of zebrafish : from signalling to specialized
... participant in IFN signalling. Mammalian promyelocytic leukaemia zinc finger protein (PLZF) could be considered as one of the transcription factors that tune ISG profile specificity to a virus, as it participates in the upregulation of a particular subset of ISGs. In zebrafish there are two PLZF ort ...
... participant in IFN signalling. Mammalian promyelocytic leukaemia zinc finger protein (PLZF) could be considered as one of the transcription factors that tune ISG profile specificity to a virus, as it participates in the upregulation of a particular subset of ISGs. In zebrafish there are two PLZF ort ...
The Shwachman-Diamond SBDS protein localizes to the nucleolus
... identified in our patient series are diagramed (not drawn to scale). The SBDS gene is composed of 5 exons (depicted with boxes). The translated mRNA regions are shaded gray. (B) SBDS expression in fibroblasts. Bone marrow fibroblast protein lysates were analyzed by immunoblotting for SBDS protein (t ...
... identified in our patient series are diagramed (not drawn to scale). The SBDS gene is composed of 5 exons (depicted with boxes). The translated mRNA regions are shaded gray. (B) SBDS expression in fibroblasts. Bone marrow fibroblast protein lysates were analyzed by immunoblotting for SBDS protein (t ...
DEFINING THE ROLE OF THE SHP2 PROTEIN TYROSINE
... Upon arrival at peripheral tissues, the committed mast cell progenitors develop into mature mucosal or connective tissue mast cells (with specialized granule contents, etc.) in response to factors released by the local tissue5. The two varieties of mast cells are differentiated by their tissue of r ...
... Upon arrival at peripheral tissues, the committed mast cell progenitors develop into mature mucosal or connective tissue mast cells (with specialized granule contents, etc.) in response to factors released by the local tissue5. The two varieties of mast cells are differentiated by their tissue of r ...
MEF2 responds to multiple calciumregulated signals in the control of
... neuron over ®ber type-speci®c gene expression is demonstrated most clearly by experiments in which crossinnervation or electrical pacing can convert one myo®ber subtype to another (Romanul and Van der Meulen, 1966; Williams et al., 1986; Pette and Vrbova, 1992). Although our understanding of muscle ...
... neuron over ®ber type-speci®c gene expression is demonstrated most clearly by experiments in which crossinnervation or electrical pacing can convert one myo®ber subtype to another (Romanul and Van der Meulen, 1966; Williams et al., 1986; Pette and Vrbova, 1992). Although our understanding of muscle ...
Mitochondrial Antiviral Signaling Protein Innate Immunity by
... of IFN-b synthesis by dislodging MAVS from the mitochondria. To determine whether RIG-I–MDA5 signaling was disrupted by HBV infection, we ectopically expressed N–RIG-I or MAVS together with a luciferase reporter driven by the IFN-b promoter (IFN-b–Luc) in HepG2 cells transfected with a head-to-tail ...
... of IFN-b synthesis by dislodging MAVS from the mitochondria. To determine whether RIG-I–MDA5 signaling was disrupted by HBV infection, we ectopically expressed N–RIG-I or MAVS together with a luciferase reporter driven by the IFN-b promoter (IFN-b–Luc) in HepG2 cells transfected with a head-to-tail ...
Giant nuclei is essential in the cell cycle transition from meiosis to
... homozygous females will be referred to here as plu, png or gnu oocytes, eggs or embryos. Pan gu and Plu co-immunoprecipitate from egg and embryo extracts suggesting they act in a complex. However, the level of Plu is reduced in null png mutants (Elfring et al., 1997) leaving open the possibility tha ...
... homozygous females will be referred to here as plu, png or gnu oocytes, eggs or embryos. Pan gu and Plu co-immunoprecipitate from egg and embryo extracts suggesting they act in a complex. However, the level of Plu is reduced in null png mutants (Elfring et al., 1997) leaving open the possibility tha ...
Definition of a p53 transactivation function-deficient mutant
... colony formation assay performed with H1299 (Figure 1) and Saos-2 (data not shown) cell lines, which are both p537/7, M22/23 displays a phenotype which is intermediate between the inactive tumor-derived mutant, D281G, and p53 wild-type (p53 WT). This assay enables growth suppression in its most gene ...
... colony formation assay performed with H1299 (Figure 1) and Saos-2 (data not shown) cell lines, which are both p537/7, M22/23 displays a phenotype which is intermediate between the inactive tumor-derived mutant, D281G, and p53 wild-type (p53 WT). This assay enables growth suppression in its most gene ...
brachyenteron function in the mesoderm
... Many of the factors that play important roles in the ontogenesis of different taxa share high structural similarites in functionally relevant domains, such as DNA-binding or protein-protein interaction domains. These similarities allow factors to be grouped into families such as homeodomain proteins ...
... Many of the factors that play important roles in the ontogenesis of different taxa share high structural similarites in functionally relevant domains, such as DNA-binding or protein-protein interaction domains. These similarities allow factors to be grouped into families such as homeodomain proteins ...
Hedgehog signaling pathway
The Hedgehog signaling pathway (or signalling pathway; see spelling differences) is a signaling pathway that transmits information to embryonic cells required for proper development. Different parts of the embryo have different concentrations of hedgehog signaling proteins. The pathway also has roles in the adult. Diseases associated with the malfunction of this pathway include basal cell carcinoma.The Hedgehog signaling pathway is one of the key regulators of animal development and is present in all bilaterians. The pathway takes its name from its polypeptide ligand, an intercellular signaling molecule called Hedgehog (Hh) found in fruit flies of the genus Drosophila. Hh is one of Drosophila's segment polarity gene products, involved in establishing the basis of the fly body plan. The molecule remains important during later stages of embryogenesis and metamorphosis.Mammals have three Hedgehog homologues, DHH, IHH, and SHH, of which Sonic (SHH) is the best studied. The pathway is equally important during vertebrate embryonic development. In knockout mice lacking components of the pathway, the brain, skeleton, musculature, gastrointestinal tract and lungs fail to develop correctly. Recent studies point to the role of Hedgehog signaling in regulating adult stem cells involved in maintenance and regeneration of adult tissues. The pathway has also been implicated in the development of some cancers. Drugs that specifically target Hedgehog signaling to fight this disease are being actively developed by a number of pharmaceutical companies.