Zygotic expression of the pebble locus is required for cytokinesis
... arrest in mammalian tissue culture cells and cell cycle regulation is poorly understood, but the recent demonstration that activation of macrophages by the CSF1 growth factor results in the expression of cyclin-like molecules (Matsushime et al., 1991) may be the first clue to such regulation. These ...
... arrest in mammalian tissue culture cells and cell cycle regulation is poorly understood, but the recent demonstration that activation of macrophages by the CSF1 growth factor results in the expression of cyclin-like molecules (Matsushime et al., 1991) may be the first clue to such regulation. These ...
the Adult Drosophila Fat Body
... All strains were raised at 20 and 29°C and after 3, 7, and 14 d of culture were dissected, and adult fat body was fixed in glutaraldehyde and osmium tetroxide, and prepared for electron microscopy, following methods listed in Butterworth et ai. (1988). Thin sections were stained with uranyl acetate ...
... All strains were raised at 20 and 29°C and after 3, 7, and 14 d of culture were dissected, and adult fat body was fixed in glutaraldehyde and osmium tetroxide, and prepared for electron microscopy, following methods listed in Butterworth et ai. (1988). Thin sections were stained with uranyl acetate ...
Caspary T, Larkins CE, Anderson KV. Dev Cell. 2007 May;12(5):767-78. The graded response to Sonic Hedgehog depends on cilia architecture.
... (Huangfu and Anderson, 2005). This hypothesis was supported by the demonstration that several components of the classical Sonic hedgehog (Shh) signaling pathway are enriched in cilia. Smoothened (Smo), a transmembrane protein that is essential for Hh signaling, is enriched in the cilia of Hh respond ...
... (Huangfu and Anderson, 2005). This hypothesis was supported by the demonstration that several components of the classical Sonic hedgehog (Shh) signaling pathway are enriched in cilia. Smoothened (Smo), a transmembrane protein that is essential for Hh signaling, is enriched in the cilia of Hh respond ...
chemoattractant signaling in dictyostelium discoideum
... modular view is that one can begin to analyze signaling network interactions without knowledge of every component and interaction. The modular structure can also be modified and built upon as more knowledge is obtained. A cell first uses an excitation module to sense extracellular cues and transduce ...
... modular view is that one can begin to analyze signaling network interactions without knowledge of every component and interaction. The modular structure can also be modified and built upon as more knowledge is obtained. A cell first uses an excitation module to sense extracellular cues and transduce ...
Transcriptional interference among the murine β
... -minor have been described.16 In short, the primers are exact matches for genes from the D and S haplotypes, but within the amplified region of the cDNA is a restriction site found in one haplotype but not the other. Amplified products were labeled with radioactive nucleotides during the last cycle ...
... -minor have been described.16 In short, the primers are exact matches for genes from the D and S haplotypes, but within the amplified region of the cDNA is a restriction site found in one haplotype but not the other. Amplified products were labeled with radioactive nucleotides during the last cycle ...
Yantar, a conserved arginine-rich protein is involved in Drosophila
... tumor phenotype, and we named their corresponding genes yantar (ytr), polka dots (pkdt), and splotchy (splo). Hemocytes from these mutants were visualized after immunostaining using two hemocyte-specific monoclonal antibodies, MAb H2 and L1. MAb H2 recognizes the hemese antigen present in all Drosop ...
... tumor phenotype, and we named their corresponding genes yantar (ytr), polka dots (pkdt), and splotchy (splo). Hemocytes from these mutants were visualized after immunostaining using two hemocyte-specific monoclonal antibodies, MAb H2 and L1. MAb H2 recognizes the hemese antigen present in all Drosop ...
The FHY3 and FAR1 genes encode transposase
... whereas phyA is completely insensitive. Note that the response is stronger (i.e. closer to wild type) in far1 than in fhy3. The FAR1 gene was originally described as a member of a gene family of unknown function (Hudson et al., 1999). Since then the Arabidopsis genome has been completely sequenced ( ...
... whereas phyA is completely insensitive. Note that the response is stronger (i.e. closer to wild type) in far1 than in fhy3. The FAR1 gene was originally described as a member of a gene family of unknown function (Hudson et al., 1999). Since then the Arabidopsis genome has been completely sequenced ( ...
Supplement_2_-_PLoS_
... localizes to the vacuole; YOR292C is not an essential gene Putative protein of unknown function Putative purine-cytosine permease, very similar to Fcy2p but cannot substitute for its function Putative membrane protein of unknown function Negative regulator of genes in multiple nitrogen degradation p ...
... localizes to the vacuole; YOR292C is not an essential gene Putative protein of unknown function Putative purine-cytosine permease, very similar to Fcy2p but cannot substitute for its function Putative membrane protein of unknown function Negative regulator of genes in multiple nitrogen degradation p ...
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... We used immunohistochemistry to show that endogenous dFmr1 is uniformly cytoplasmic throughout the developing fly retinal neuroepithelium (Figures 4A and 4C) while dLgl is overlapping but accumulates to higher levels at the periphery of cells (Figures 4B and 4C). We have also examined other tissues ...
... We used immunohistochemistry to show that endogenous dFmr1 is uniformly cytoplasmic throughout the developing fly retinal neuroepithelium (Figures 4A and 4C) while dLgl is overlapping but accumulates to higher levels at the periphery of cells (Figures 4B and 4C). We have also examined other tissues ...
Human Signaling Protein 14-3-3 Interacts With
... described.12,14,15 This group may have their kinase activity altered by this binding depending on the experimental conditions used. Recent affinity chromatography experiments using a monoclonal antibody to GPIba led to the coelution of a 29-kD protein with GPIb.16 Amino acid sequencing of the protei ...
... described.12,14,15 This group may have their kinase activity altered by this binding depending on the experimental conditions used. Recent affinity chromatography experiments using a monoclonal antibody to GPIba led to the coelution of a 29-kD protein with GPIb.16 Amino acid sequencing of the protei ...
Caulobacter Export™ Manual
... Because RsaA is the protein that forms the S-layer it must be produced inside the cell and exported to the cell surface. Export is mediated by a secretion mechanism categorized as a Type I transporter. It is a bacterial secretion system that uses ATP to generate the energy needed for protein export ...
... Because RsaA is the protein that forms the S-layer it must be produced inside the cell and exported to the cell surface. Export is mediated by a secretion mechanism categorized as a Type I transporter. It is a bacterial secretion system that uses ATP to generate the energy needed for protein export ...
pdf View
... Eya-So complex (Jemc and Rebay 2007a; Li et al., 2003; Mutsuddi et al., 2005; Rayapureddi et al., 2003; Tootle et al., 2003). Eya is expressed both in the cytoplasm and in the nucleus and its expression is regulated in many levels. The EGFR pathway downstream components Yan/anterior open (Yan) and P ...
... Eya-So complex (Jemc and Rebay 2007a; Li et al., 2003; Mutsuddi et al., 2005; Rayapureddi et al., 2003; Tootle et al., 2003). Eya is expressed both in the cytoplasm and in the nucleus and its expression is regulated in many levels. The EGFR pathway downstream components Yan/anterior open (Yan) and P ...
A Diffusible Signal from Arbuscular Mycorrhizal Fungi Elicits a
... perception of the rhizobial signaling molecule Nod factor is documented as one of the earliest plant responses in legume-rhizobia association (Cardenas et al., 2000). Oscillations in cytosolic free Ca21 concentration ([Ca21]cyt) have been observed in legume root hairs following the initial rapid [Ca ...
... perception of the rhizobial signaling molecule Nod factor is documented as one of the earliest plant responses in legume-rhizobia association (Cardenas et al., 2000). Oscillations in cytosolic free Ca21 concentration ([Ca21]cyt) have been observed in legume root hairs following the initial rapid [Ca ...
Publications_files/Stotland et al 2012
... Seeger et al., 1998). The CSN has several important roles in the eukaryotic cell, the best understood and studied of which is protein degradation via control of the deneddylation of cullins (Wei and Deng, 2003). Briefly, when a protein is targeted for degradation by the proteasomal machinery, it is ...
... Seeger et al., 1998). The CSN has several important roles in the eukaryotic cell, the best understood and studied of which is protein degradation via control of the deneddylation of cullins (Wei and Deng, 2003). Briefly, when a protein is targeted for degradation by the proteasomal machinery, it is ...
Models of infectious diseases in the fruit fly Drosophila melanogaster
... in killing rates between wild-type and Toll or Imd mutant flies. As mentioned above, there is evidence that Toll, as well as Imd, signaling is used to suppress the growth of another strain of S. marscescens in a similar injection model. Flies lacking the imd gene are unexpectedly sensitive to the Gr ...
... in killing rates between wild-type and Toll or Imd mutant flies. As mentioned above, there is evidence that Toll, as well as Imd, signaling is used to suppress the growth of another strain of S. marscescens in a similar injection model. Flies lacking the imd gene are unexpectedly sensitive to the Gr ...
Mapping of Lipid-‐Binding Proteins and Their Ligandability in Cells
... (5-lipoxygenase; 5-LO), and are thus converted into one of four families of eicosanoids: the prostaglandins (PGs), rom the extracellular side of the membrane prostacyclins, thromboxanes (TXs) and leukotrienes. Eicosanoids short half-life, ranging from R. et. al. Nature 2007, 4at 50, ...
... (5-lipoxygenase; 5-LO), and are thus converted into one of four families of eicosanoids: the prostaglandins (PGs), rom the extracellular side of the membrane prostacyclins, thromboxanes (TXs) and leukotrienes. Eicosanoids short half-life, ranging from R. et. al. Nature 2007, 4at 50, ...
Chromatin-based Temporal Clustering of Enhancers in Developing Fly Embryos
... zygotic transition”, eLife, 2014. 3.! Xu, Small et al, “Impacts of the ubiquitous factor Zelda on Bicoid-dependent DNA binding and transcription in Drosophila.” Genes Dev, 2014. 4.! Schulz et al, “Zelda is differentially required for chromatin accessibility, transcription-factor binding and gene exp ...
... zygotic transition”, eLife, 2014. 3.! Xu, Small et al, “Impacts of the ubiquitous factor Zelda on Bicoid-dependent DNA binding and transcription in Drosophila.” Genes Dev, 2014. 4.! Schulz et al, “Zelda is differentially required for chromatin accessibility, transcription-factor binding and gene exp ...
Team Publications - Centre de recherche de l`Institut Curie
... Ezh2 requires PHF1 to efficiently catalyze H3 lysine 27 trimethylation in vivo. Molecular and cellular biology : 2718-31 : DOI : 10.1128/MCB.02017-07 ...
... Ezh2 requires PHF1 to efficiently catalyze H3 lysine 27 trimethylation in vivo. Molecular and cellular biology : 2718-31 : DOI : 10.1128/MCB.02017-07 ...
Wnt signaling: a common theme in animal development
... genes in cultured cells results in accumulation of misfolded protein in the endoplasmic reticulum (ER; Kitajewski et al. 1992). Secreted forms of Wnt proteins can be found in the extracellular matrix or the cell surface (Bradley and Brown 1990; Papkoff and Schryver 1990; Burrus and McMahon 1995; Sch ...
... genes in cultured cells results in accumulation of misfolded protein in the endoplasmic reticulum (ER; Kitajewski et al. 1992). Secreted forms of Wnt proteins can be found in the extracellular matrix or the cell surface (Bradley and Brown 1990; Papkoff and Schryver 1990; Burrus and McMahon 1995; Sch ...
ABA-responsive gene expression - Journal of Cell Science
... mutant abi1-1. However, a subset of genes continued to be appropriately regulated by ABA, which suggests the presence of at least two ABA signaling pathways, only one of which is blocked in abi1-1. ...
... mutant abi1-1. However, a subset of genes continued to be appropriately regulated by ABA, which suggests the presence of at least two ABA signaling pathways, only one of which is blocked in abi1-1. ...
sv-lncs - Department of Computer Science and Engineering
... Abstract. Protein interactions serve as the chemical basis for all living organisms. Proteins fold and interact in intricate arrangements that provide functionality to the components of a cell. These components work cooperatively to form whole body systems. Proteins are composed of different domains ...
... Abstract. Protein interactions serve as the chemical basis for all living organisms. Proteins fold and interact in intricate arrangements that provide functionality to the components of a cell. These components work cooperatively to form whole body systems. Proteins are composed of different domains ...
Drosophila C-terminal Binding Protein Functions as a Context
... interaction of Sin3 and HDAC (see Ref. 11 and references therein). Transcriptional repression plays a major role in segmentation gene expression that leads to proper body patterning during early Drosophila development (cf. Refs. 1 and 4). A number of different transcriptional repressors present in t ...
... interaction of Sin3 and HDAC (see Ref. 11 and references therein). Transcriptional repression plays a major role in segmentation gene expression that leads to proper body patterning during early Drosophila development (cf. Refs. 1 and 4). A number of different transcriptional repressors present in t ...
C4 Photosynthesis - mvhs
... photorespiration? • Bundle sheath cells are far from the surface– less O2 access • PEP Carboxylase doesn’t have an affinity for O2 allows plant to collect a lot of CO2 and concentrate it in the bundle sheath cells (where Rubisco is) ...
... photorespiration? • Bundle sheath cells are far from the surface– less O2 access • PEP Carboxylase doesn’t have an affinity for O2 allows plant to collect a lot of CO2 and concentrate it in the bundle sheath cells (where Rubisco is) ...
Octamer-binding transcription factors: genomics and functions
... of the Oct transcription factors. It is ubiquitously expressed in many tissues and cells and either positively or negatively regulates the expression of a variety of genes. These genes include the RNA polymerase II-transcribed and ubiquitously expressed histone H2B gene (49, 50), tissuespecific immu ...
... of the Oct transcription factors. It is ubiquitously expressed in many tissues and cells and either positively or negatively regulates the expression of a variety of genes. These genes include the RNA polymerase II-transcribed and ubiquitously expressed histone H2B gene (49, 50), tissuespecific immu ...
Surveying Protein Structure and Function Using Bis
... fluorescence when coordinated to simple dithiol ligands such as ethanedithiol (EDT), but became increasingly fluorescent when bound by the four thiols present within the linear sequence CCRECC. When this sequence was encoded at the N- or C-terminus of a protein expressed in mammalian cells, treatmen ...
... fluorescence when coordinated to simple dithiol ligands such as ethanedithiol (EDT), but became increasingly fluorescent when bound by the four thiols present within the linear sequence CCRECC. When this sequence was encoded at the N- or C-terminus of a protein expressed in mammalian cells, treatmen ...
Hedgehog signaling pathway
The Hedgehog signaling pathway (or signalling pathway; see spelling differences) is a signaling pathway that transmits information to embryonic cells required for proper development. Different parts of the embryo have different concentrations of hedgehog signaling proteins. The pathway also has roles in the adult. Diseases associated with the malfunction of this pathway include basal cell carcinoma.The Hedgehog signaling pathway is one of the key regulators of animal development and is present in all bilaterians. The pathway takes its name from its polypeptide ligand, an intercellular signaling molecule called Hedgehog (Hh) found in fruit flies of the genus Drosophila. Hh is one of Drosophila's segment polarity gene products, involved in establishing the basis of the fly body plan. The molecule remains important during later stages of embryogenesis and metamorphosis.Mammals have three Hedgehog homologues, DHH, IHH, and SHH, of which Sonic (SHH) is the best studied. The pathway is equally important during vertebrate embryonic development. In knockout mice lacking components of the pathway, the brain, skeleton, musculature, gastrointestinal tract and lungs fail to develop correctly. Recent studies point to the role of Hedgehog signaling in regulating adult stem cells involved in maintenance and regeneration of adult tissues. The pathway has also been implicated in the development of some cancers. Drugs that specifically target Hedgehog signaling to fight this disease are being actively developed by a number of pharmaceutical companies.