Alu repeats as transcriptional regulatory platforms in macrophage
... mechanism of early macrophage transcriptional responses to Mtb, highlighting the role of Alu element transposition in shaping human transcription programs during innate immunity. ...
... mechanism of early macrophage transcriptional responses to Mtb, highlighting the role of Alu element transposition in shaping human transcription programs during innate immunity. ...
Perk Is Essential for Translational Regulation and Cell Survival
... Figure 2. The Perk Mutation Prevents Attenuation of Protein Synthesis and Phosphorylation of eIF2␣ (A) Protein synthesis rates measured by the incorporation of [35S]methionine/cysteine into proteins during a 10 min pulse of labeling that followed 30 min of exposure to the indicated concentrations of ...
... Figure 2. The Perk Mutation Prevents Attenuation of Protein Synthesis and Phosphorylation of eIF2␣ (A) Protein synthesis rates measured by the incorporation of [35S]methionine/cysteine into proteins during a 10 min pulse of labeling that followed 30 min of exposure to the indicated concentrations of ...
Maintenance of Shoot and Floral Meristem Cell
... and the specific way in which it is organized enables plants to produce organs throughout their lives. The SAM of flowering plants consists of three radially distinct domains depending on the relative position of the cells (Fig. 1A). A central zone of cells at the very tip of the SAM corresponds to ...
... and the specific way in which it is organized enables plants to produce organs throughout their lives. The SAM of flowering plants consists of three radially distinct domains depending on the relative position of the cells (Fig. 1A). A central zone of cells at the very tip of the SAM corresponds to ...
An Enhancer Trap Screen for Ecdysone
... myosin and is attached to the inner surface of the cell at intercellular adherens junctions. The involvement of the apical contractile belt in this process is supported by the observation that cytochalasins (agents that disrupt actin filaments) reversibly inhibit leg elongation in culture (Fristrom ...
... myosin and is attached to the inner surface of the cell at intercellular adherens junctions. The involvement of the apical contractile belt in this process is supported by the observation that cytochalasins (agents that disrupt actin filaments) reversibly inhibit leg elongation in culture (Fristrom ...
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... model system with which to study glutamatergic synapse formation and remodeling. Several proteins have been implicated in these processes, including components of canonical Wingless (Drosophila Wnt1) signaling and the giant isoforms of the membrane-cytoskeleton linker Ankyrin 2, but possible interco ...
... model system with which to study glutamatergic synapse formation and remodeling. Several proteins have been implicated in these processes, including components of canonical Wingless (Drosophila Wnt1) signaling and the giant isoforms of the membrane-cytoskeleton linker Ankyrin 2, but possible interco ...
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... The TGF-β superfamily of secreted signalling molecules plays a pivotal role in the regulation of early embryogenesis, organogenesis and adult tissue homeostasis. Here we report the identification of Xenopus N-acetylgalactosaminyltransferase-like 1 (xGalntl-1) as a novel important regulator of TGF-β ...
... The TGF-β superfamily of secreted signalling molecules plays a pivotal role in the regulation of early embryogenesis, organogenesis and adult tissue homeostasis. Here we report the identification of Xenopus N-acetylgalactosaminyltransferase-like 1 (xGalntl-1) as a novel important regulator of TGF-β ...
genetic analysis of hormone signaling
... even with the protagonists in hand, the roles of these substances in plant development are still unclear. For example, within a plant, a single hormone can regulate many different processes and at the same time different hormones can influence a single process. Does the flexibility of hormone action ...
... even with the protagonists in hand, the roles of these substances in plant development are still unclear. For example, within a plant, a single hormone can regulate many different processes and at the same time different hormones can influence a single process. Does the flexibility of hormone action ...
Makorin ortholog LEP-2 regulates LIN-28 stability to
... The heterochronic genes lin-28, let-7 and lin-41 regulate fundamental developmental transitions in animals, such as stemness versus differentiation and juvenile versus adult states. We identify a new heterochronic gene, lep-2, in Caenorhabditis elegans. Mutations in lep-2 cause a delay in the juveni ...
... The heterochronic genes lin-28, let-7 and lin-41 regulate fundamental developmental transitions in animals, such as stemness versus differentiation and juvenile versus adult states. We identify a new heterochronic gene, lep-2, in Caenorhabditis elegans. Mutations in lep-2 cause a delay in the juveni ...
The lipid phosphatase LPP3 regulates extra
... action as intracellular second messengers, although they may also be acting through other, as yet unidentified, receptors. Given their effects on cells, recent evidence has revealed that these lipid mediators are important to embryogenesis, particularly in guiding cell migration. This was first show ...
... action as intracellular second messengers, although they may also be acting through other, as yet unidentified, receptors. Given their effects on cells, recent evidence has revealed that these lipid mediators are important to embryogenesis, particularly in guiding cell migration. This was first show ...
Endoplasmic Reticulum Protein Quality Control and
... in vivo chaperone activity (Klein et al., 2006). Interestingly, the substrates/targets of At-SHD seem to be very specific. Null mutants of At-SHD have defects in meristem size control, resembling the phenotypes of clavata mutants. Genetic analysis showed that At-SHD is essential for the synthesis of ...
... in vivo chaperone activity (Klein et al., 2006). Interestingly, the substrates/targets of At-SHD seem to be very specific. Null mutants of At-SHD have defects in meristem size control, resembling the phenotypes of clavata mutants. Genetic analysis showed that At-SHD is essential for the synthesis of ...
Non-specific chemical inhibition of the Fanconi anemia pathway
... Background: Platinum compounds such as cisplatin and carboplatin are DNA crosslinking agents widely used for cancer chemotherapy. However, the effectiveness of platinum compounds is often tempered by the acquisition of cellular drug resistance. Until now, no pharmacological approach has successfully ...
... Background: Platinum compounds such as cisplatin and carboplatin are DNA crosslinking agents widely used for cancer chemotherapy. However, the effectiveness of platinum compounds is often tempered by the acquisition of cellular drug resistance. Until now, no pharmacological approach has successfully ...
Journal of Biological Chemistry. 2004 Feb 20
... poikiloderma followed by cutaneous atrophy (16,17). The clinical presentation of this disease is similar to patients with junctional epidermolysis bullosa harboring mutations in α6 and β4 integrin genes (18,19). Kindlerin (also known as URP1 for UNC-112 related protein 1 or kindlin) is a member of a ...
... poikiloderma followed by cutaneous atrophy (16,17). The clinical presentation of this disease is similar to patients with junctional epidermolysis bullosa harboring mutations in α6 and β4 integrin genes (18,19). Kindlerin (also known as URP1 for UNC-112 related protein 1 or kindlin) is a member of a ...
8. ARTÍCULOS
... Abbreviations: aa, amino acid residues; PBS, phosphate-bu¡ered saline; GST, glutathione-S-transferase ...
... Abbreviations: aa, amino acid residues; PBS, phosphate-bu¡ered saline; GST, glutathione-S-transferase ...
Microarray Analysis of Gene Expression in Saccharomyces
... 0.78% (four genes) of the filtered gene list, respectively, but comprise only 3.52% and 0.13% of the genome. Finally, sporulation, meiosis, and pheromone-dependent signal transduction involved in conjugation with cellular fusion made up 3.14% (16 genes), 3.73% (19 genes), and 1.18% (6 genes) of the fi ...
... 0.78% (four genes) of the filtered gene list, respectively, but comprise only 3.52% and 0.13% of the genome. Finally, sporulation, meiosis, and pheromone-dependent signal transduction involved in conjugation with cellular fusion made up 3.14% (16 genes), 3.73% (19 genes), and 1.18% (6 genes) of the fi ...
Coordinated Regulation of AIB1 Transcriptional Activity by
... nucleus. In addition, AIB1 functions as a cofactor that coactivates estrogen receptor-mediated transcription in the nucleus under the treatment of E2. In light of the observation that sumoylated AIB1 was only detected in the absence of E2 stimulation, we wished to know whether the sumoylation of AIB ...
... nucleus. In addition, AIB1 functions as a cofactor that coactivates estrogen receptor-mediated transcription in the nucleus under the treatment of E2. In light of the observation that sumoylated AIB1 was only detected in the absence of E2 stimulation, we wished to know whether the sumoylation of AIB ...
Protein kinase signaling networks in plant innate immunity
... occurring within minutes, including anion efflux, ROS production and gene expression involved in the biosynthesis of antimicrobial chemicals and peptides. These responses mainly mediated through CDPKs are co-regulated by MAPK cascades that can be further modulated by CAM. Ca2+ rise also regulates la ...
... occurring within minutes, including anion efflux, ROS production and gene expression involved in the biosynthesis of antimicrobial chemicals and peptides. These responses mainly mediated through CDPKs are co-regulated by MAPK cascades that can be further modulated by CAM. Ca2+ rise also regulates la ...
SETD6 is a negative regulator of oxidative stress response
... in a given protein can be mono-, di- or tri-methylated by protein lysine (K) methyltransferases (PKMTs) [2,3]. The PKMT SET domain containing protein 6 (SETD6) mono-methylates the major NFKB subunit RelA on K310 and suppresses RelA-regulated target genes through GLPdependent H3K9 methylation [4,5]. ...
... in a given protein can be mono-, di- or tri-methylated by protein lysine (K) methyltransferases (PKMTs) [2,3]. The PKMT SET domain containing protein 6 (SETD6) mono-methylates the major NFKB subunit RelA on K310 and suppresses RelA-regulated target genes through GLPdependent H3K9 methylation [4,5]. ...
NEK1 Facilitates Cohesin Removal during Mammalian
... include the SC protein SYCP3 [6] and FKBP6 [7]. During zygonema, the central element begins to form between the homologs, consisting of proteins such as SYCP1, SYCE1 and SYCE2 [8–12], thus tethering them together and ensuring they are paired along their entire lengths at pachynema. Mutations in the ...
... include the SC protein SYCP3 [6] and FKBP6 [7]. During zygonema, the central element begins to form between the homologs, consisting of proteins such as SYCP1, SYCE1 and SYCE2 [8–12], thus tethering them together and ensuring they are paired along their entire lengths at pachynema. Mutations in the ...
wingless acts through the shaggy/zeste-white 3
... cells expressing wg and the imaginal disc primordium in the embryo. The secreted Wg protein provides a positional signal to recruit nearby cells into the disc primordium. The row of wg-expressing cells is incomplete along the dorsal-ventral axis of the embryonic segment at the stage when the disc pr ...
... cells expressing wg and the imaginal disc primordium in the embryo. The secreted Wg protein provides a positional signal to recruit nearby cells into the disc primordium. The row of wg-expressing cells is incomplete along the dorsal-ventral axis of the embryonic segment at the stage when the disc pr ...
Structural basis of ubiquitylation Andrew P VanDemark and
... terminus to substrate lysine residues, a process known as ubiquitylation, targets the substrate for a range of possible fates, the best known of which is degradation by the 26S proteasome, but which also include endocytosis, targeting to lysosomes, and modification of protein function [1]. These res ...
... terminus to substrate lysine residues, a process known as ubiquitylation, targets the substrate for a range of possible fates, the best known of which is degradation by the 26S proteasome, but which also include endocytosis, targeting to lysosomes, and modification of protein function [1]. These res ...
Supplement Supporting Materials and Methods Site
... Western blot analysis. At 48 h after shRNA transfection, total cell lysates were prepared and normalized for protein concentration. The expression of gapdh was used to control equal protein loading. Results shown are representative of three independent experiments. B, P300 shRNA or CBP shRNA abolish ...
... Western blot analysis. At 48 h after shRNA transfection, total cell lysates were prepared and normalized for protein concentration. The expression of gapdh was used to control equal protein loading. Results shown are representative of three independent experiments. B, P300 shRNA or CBP shRNA abolish ...
Drosophila asymmetric division, polarity and cancer - e
... larval NBs. Markers that are asymmetrically localized at the apical (blue) or basal (red) cortex have been observed during mitosis, from prophase to late telophase. No such markers have been observed during interphase, thus opening the question of how cell polarity is maintained or reestablished fro ...
... larval NBs. Markers that are asymmetrically localized at the apical (blue) or basal (red) cortex have been observed during mitosis, from prophase to late telophase. No such markers have been observed during interphase, thus opening the question of how cell polarity is maintained or reestablished fro ...
The water of life: osmoregulation in Saccharomyces cerevisiae
... Interactions between the target of rapamycin (TOR) and the CWI pathways during nutrient stress, and effects on osmotolerance ...
... Interactions between the target of rapamycin (TOR) and the CWI pathways during nutrient stress, and effects on osmotolerance ...
TRANSMEMBRANE ADAPTOR PROTEINS: ORGANIZERS OF
... essential role of LAT in T-cell signalling was first indicated by analysing LAT-deficient variants of the Jurkat T-cell line9,10. In these cells, it was found that key elements of the TCR-mediated signalling cascades that lead to interleukin-2 (IL-2)-gene expression are completely abolished, includi ...
... essential role of LAT in T-cell signalling was first indicated by analysing LAT-deficient variants of the Jurkat T-cell line9,10. In these cells, it was found that key elements of the TCR-mediated signalling cascades that lead to interleukin-2 (IL-2)-gene expression are completely abolished, includi ...
Vertebrate somitogenesis: a novel paradigm for animal segmentation?
... Fig. 1. (A) Schematized view of the somitogenesis process in vertebrates. Such a scheme also applies for segmentation of many invertebrate species. (B) Progressive segment formation during embryogenesis. Vertebrates and many invertebrates produce their segments in this way. Abbreviations: A, anterio ...
... Fig. 1. (A) Schematized view of the somitogenesis process in vertebrates. Such a scheme also applies for segmentation of many invertebrate species. (B) Progressive segment formation during embryogenesis. Vertebrates and many invertebrates produce their segments in this way. Abbreviations: A, anterio ...
Hedgehog signaling pathway
The Hedgehog signaling pathway (or signalling pathway; see spelling differences) is a signaling pathway that transmits information to embryonic cells required for proper development. Different parts of the embryo have different concentrations of hedgehog signaling proteins. The pathway also has roles in the adult. Diseases associated with the malfunction of this pathway include basal cell carcinoma.The Hedgehog signaling pathway is one of the key regulators of animal development and is present in all bilaterians. The pathway takes its name from its polypeptide ligand, an intercellular signaling molecule called Hedgehog (Hh) found in fruit flies of the genus Drosophila. Hh is one of Drosophila's segment polarity gene products, involved in establishing the basis of the fly body plan. The molecule remains important during later stages of embryogenesis and metamorphosis.Mammals have three Hedgehog homologues, DHH, IHH, and SHH, of which Sonic (SHH) is the best studied. The pathway is equally important during vertebrate embryonic development. In knockout mice lacking components of the pathway, the brain, skeleton, musculature, gastrointestinal tract and lungs fail to develop correctly. Recent studies point to the role of Hedgehog signaling in regulating adult stem cells involved in maintenance and regeneration of adult tissues. The pathway has also been implicated in the development of some cancers. Drugs that specifically target Hedgehog signaling to fight this disease are being actively developed by a number of pharmaceutical companies.