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Protein S deficiency
... a membrane composition which has little, if any, effect on the procoagulant reactions. PE and oxidation increase the binding of many antiphospholipid antibodies and the ability of at least some of them to inhibit the APCprotein S complex specifically. IgG purified from several antiphospholipid syndr ...
... a membrane composition which has little, if any, effect on the procoagulant reactions. PE and oxidation increase the binding of many antiphospholipid antibodies and the ability of at least some of them to inhibit the APCprotein S complex specifically. IgG purified from several antiphospholipid syndr ...
PLoS Pathogens
... Gram-negative bacterial pathogens deliver a variety of virulence proteins through the type III secretion system (T3SS) directly into the host cytoplasm. These type III secreted effectors (T3SEs) play an essential role in bacterial infection, mainly by targeting host immunity. However, the molecular ...
... Gram-negative bacterial pathogens deliver a variety of virulence proteins through the type III secretion system (T3SS) directly into the host cytoplasm. These type III secreted effectors (T3SEs) play an essential role in bacterial infection, mainly by targeting host immunity. However, the molecular ...
View PDF - Elly Nedivi
... tion also markedly increased zif/268 mRNA in the dentate gyrus. Other IEG mRNAs, such as c-fos, c-jun, and junB, were less consistently increased under the same experimental conditions, in line with earlier findings (63). While Cole et al. (48) found that stimulation of convergent inhibitory synapti ...
... tion also markedly increased zif/268 mRNA in the dentate gyrus. Other IEG mRNAs, such as c-fos, c-jun, and junB, were less consistently increased under the same experimental conditions, in line with earlier findings (63). While Cole et al. (48) found that stimulation of convergent inhibitory synapti ...
Chlamydia pneumoniae CdsQ functions as a multi
... the inclusion, the EB undergoes a transformation, differentiating into the metabolically active form, the reticulate body (RB) which becomes associated with the inclusion membrane, possibly interacting with the host cell cytoplasm via the T3S apparatus [19, 20]. As the RBs replicate by binary fissio ...
... the inclusion, the EB undergoes a transformation, differentiating into the metabolically active form, the reticulate body (RB) which becomes associated with the inclusion membrane, possibly interacting with the host cell cytoplasm via the T3S apparatus [19, 20]. As the RBs replicate by binary fissio ...
2 Biogenesis and the regulation of the maturation of miRNAs
... mechanism has been described with BRCA1, another tumour suppressor protein, which facilitates the processing of a subset of pri-miRNAs by directly binding to the pri-mRNAs Drosha and p68. It also interacts with p53 and Smad3, two proteins that regulate signalling and miRNA processing [14]. Hormone-m ...
... mechanism has been described with BRCA1, another tumour suppressor protein, which facilitates the processing of a subset of pri-miRNAs by directly binding to the pri-mRNAs Drosha and p68. It also interacts with p53 and Smad3, two proteins that regulate signalling and miRNA processing [14]. Hormone-m ...
Scanned by CamScanner
... Fetal alcohol spectrum disorder is a disease caused by prenatal alcohol exposure. It is characterized by craniofacial abnormalities, growth retardation, central nervous system defects, learning disabilities and a variety of other minor defects. Even though it affects 2-5% of individuals born every y ...
... Fetal alcohol spectrum disorder is a disease caused by prenatal alcohol exposure. It is characterized by craniofacial abnormalities, growth retardation, central nervous system defects, learning disabilities and a variety of other minor defects. Even though it affects 2-5% of individuals born every y ...
Rat maf related genes: specific expression in chondrocytes
... Fragments of Maf-1 and Maf-2 proteins were produced in E coli as fusion proteins with maltose binding protein and glutathione Stransferase, respectively. maf-1 cDNA fragment corresponding to amino acids 49 ± 122 was inserted into pMal-c2 vector (New England Biolab, USA) and a Maf-2 cDNA sequence enc ...
... Fragments of Maf-1 and Maf-2 proteins were produced in E coli as fusion proteins with maltose binding protein and glutathione Stransferase, respectively. maf-1 cDNA fragment corresponding to amino acids 49 ± 122 was inserted into pMal-c2 vector (New England Biolab, USA) and a Maf-2 cDNA sequence enc ...
Recurrent Gene Duplication Diversifies Genome
... et al. 2008; Satyaki et al. 2014), supporting the idea that TE innovation contributes to the directional selection of host defense factors. Although directional selection of single-copy host gene orthologs is a potent mechanism of adaptation against TEs, it is not the only possible source of evoluti ...
... et al. 2008; Satyaki et al. 2014), supporting the idea that TE innovation contributes to the directional selection of host defense factors. Although directional selection of single-copy host gene orthologs is a potent mechanism of adaptation against TEs, it is not the only possible source of evoluti ...
Autophagy in the Eukaryotic Cell - CiteSeerX
... Autophagy is a nonspecific degradative process and is used to deliver bulk cytoplasmic components to the vacuole. In contrast, the Cvt pathway is biosynthetic and selects specific cargo components for transport. Two hydrolases are known to use this route: Ape1 (58) and ␣-mannosidase (Ams1) (38). Aft ...
... Autophagy is a nonspecific degradative process and is used to deliver bulk cytoplasmic components to the vacuole. In contrast, the Cvt pathway is biosynthetic and selects specific cargo components for transport. Two hydrolases are known to use this route: Ape1 (58) and ␣-mannosidase (Ams1) (38). Aft ...
MECHANISMS OF PATTERN FORMATION IN PLANT
... from entering the WUS-expressing OC to repress WUS transcription there (88). The current model for feedback regulation of stem-cell fate in the SAM of Arabidopsis postulates that the homeobox transcription factor WUS acts from an OC in the deeper layers of the meristem to specify stem cells in an ov ...
... from entering the WUS-expressing OC to repress WUS transcription there (88). The current model for feedback regulation of stem-cell fate in the SAM of Arabidopsis postulates that the homeobox transcription factor WUS acts from an OC in the deeper layers of the meristem to specify stem cells in an ov ...
Plant mitochondria contain the protein translocase subunits TatB
... The minimal Tat pathway which is found mostly in archaea and gram-positive bacteria consists of two subunits: TatA (possessing one transmembrane helix (TMH)) and TatC (possessing six TMHs) (Barnett et al., 2008). In general, most Tat systems, including the best studied Escherichia coli Tat system, c ...
... The minimal Tat pathway which is found mostly in archaea and gram-positive bacteria consists of two subunits: TatA (possessing one transmembrane helix (TMH)) and TatC (possessing six TMHs) (Barnett et al., 2008). In general, most Tat systems, including the best studied Escherichia coli Tat system, c ...
Two Domains of the Human bZIP Transcription Factor
... shown to transactivate through the hARE response element in the NAD(P)H:quinone oxidoreductase-1 promoter (9), a site that is important for the induction of NAD(P)H:quinone oxidoreductase-1 in response to xenobiotics and antioxidants. These observations indicate a role for TCF11 in the regulation of ...
... shown to transactivate through the hARE response element in the NAD(P)H:quinone oxidoreductase-1 promoter (9), a site that is important for the induction of NAD(P)H:quinone oxidoreductase-1 in response to xenobiotics and antioxidants. These observations indicate a role for TCF11 in the regulation of ...
Consulta: subjectFacets:"Alternative oxidase" Registros
... Plants and some other organisms including protists possess a complex branched respiratory network in their mitochondria. Some pathways of this network are not energy-conserving and allow sites of energy conservation to be bypassed, leading to a decrease of the energy yield in the cells. It is a chal ...
... Plants and some other organisms including protists possess a complex branched respiratory network in their mitochondria. Some pathways of this network are not energy-conserving and allow sites of energy conservation to be bypassed, leading to a decrease of the energy yield in the cells. It is a chal ...
Xror2 modulates convergent extension
... Spemann organizer is situated above the dorsal blastopore lip at the beginning of gastrulation, and is fated to become the prechordal plate and notochord as gastrulation proceeds. Two major features of the organizer are the capability of induction (dorsalization of the mesoderm, neuralization of the ...
... Spemann organizer is situated above the dorsal blastopore lip at the beginning of gastrulation, and is fated to become the prechordal plate and notochord as gastrulation proceeds. Two major features of the organizer are the capability of induction (dorsalization of the mesoderm, neuralization of the ...
Patterning and morphogenesis of the follicle cell epithelium during
... oogenesis. IA) Drawing of an adulr wild-type ovariole. IB) Drawingof a germar;um. ICI A mature egg remain throughout the completion of oogenesis. Somatic stem cells are located at the border between germarium regions 1 and 2 (Margolis and Spradling, 1995). In region 2, follicle cells migrate from fh ...
... oogenesis. IA) Drawing of an adulr wild-type ovariole. IB) Drawingof a germar;um. ICI A mature egg remain throughout the completion of oogenesis. Somatic stem cells are located at the border between germarium regions 1 and 2 (Margolis and Spradling, 1995). In region 2, follicle cells migrate from fh ...
PDF
... developmental mechanisms and their evolution (McGregor et al., 2008a). In this Primer, we now review the advances made in these areas using Parasteatoda as a model. Specifically, we describe the development of Parasteatoda and summarise the range of tools and resources available that have facilitate ...
... developmental mechanisms and their evolution (McGregor et al., 2008a). In this Primer, we now review the advances made in these areas using Parasteatoda as a model. Specifically, we describe the development of Parasteatoda and summarise the range of tools and resources available that have facilitate ...
the spider Parasteatoda tepidariorum
... developmental mechanisms and their evolution (McGregor et al., 2008a). In this Primer, we now review the advances made in these areas using Parasteatoda as a model. Specifically, we describe the development of Parasteatoda and summarise the range of tools and resources available that have facilitate ...
... developmental mechanisms and their evolution (McGregor et al., 2008a). In this Primer, we now review the advances made in these areas using Parasteatoda as a model. Specifically, we describe the development of Parasteatoda and summarise the range of tools and resources available that have facilitate ...
Latrunculin A Induced Perturbation of the Actin Cytoskeleton
... previous studies have employed an N-terminal GFP-pap1 fusion, it should be noted that this construct places pap1 under the control of the non-native nmt41 promoter and results in the overexpression of the protein relative to the fusion employed in this study. Next, to ensure that we could detect nu ...
... previous studies have employed an N-terminal GFP-pap1 fusion, it should be noted that this construct places pap1 under the control of the non-native nmt41 promoter and results in the overexpression of the protein relative to the fusion employed in this study. Next, to ensure that we could detect nu ...
Dual transcriptional activities of SIX proteins define
... The SIX family of homeodomain-containing DNA-binding proteins play crucial roles in both Drosophila and vertebrate retinal specification. In flies, three such family members exist, but only two, Sine oculis (So) and Optix, are expressed and function within the eye. In vertebrates, the homologs of Op ...
... The SIX family of homeodomain-containing DNA-binding proteins play crucial roles in both Drosophila and vertebrate retinal specification. In flies, three such family members exist, but only two, Sine oculis (So) and Optix, are expressed and function within the eye. In vertebrates, the homologs of Op ...
Transport of virally expressed green fluorescent protein through the
... expression and for protein location using fusions of GFP to proteins of interest. The intrinsic ¯uorescence of the GFP allows non-destructive, in-vivo imaging of events within cells. Fused to the C-terminus of a neuroendocrine secretory protein, GFP has been used to image the secretory pathway (Kaet ...
... expression and for protein location using fusions of GFP to proteins of interest. The intrinsic ¯uorescence of the GFP allows non-destructive, in-vivo imaging of events within cells. Fused to the C-terminus of a neuroendocrine secretory protein, GFP has been used to image the secretory pathway (Kaet ...
Hepatitis C virus (HCV) - HAL
... convoluted electron-dense ER membranes were found to form multiple layers in these cells (Fig. 3). No HCV-LPs or marked clustering of lipid droplets was observed in cells producing this mutant core protein. These observations confirm that the ASC180/3/4VLV core protein remains anchored in the ER mem ...
... convoluted electron-dense ER membranes were found to form multiple layers in these cells (Fig. 3). No HCV-LPs or marked clustering of lipid droplets was observed in cells producing this mutant core protein. These observations confirm that the ASC180/3/4VLV core protein remains anchored in the ER mem ...
A single mutation in the core domain of the lac repressor reduces
... lysed and the fluorescence contained in the soluble protein fraction measured. As shown in Figure 3B, the same conclusions about the behaviour of the W220F mutation can be derived from the two types of analysis. The primary objective of a protein over-expression system is to generate the highest pos ...
... lysed and the fluorescence contained in the soluble protein fraction measured. As shown in Figure 3B, the same conclusions about the behaviour of the W220F mutation can be derived from the two types of analysis. The primary objective of a protein over-expression system is to generate the highest pos ...
An FGF4-FRS2[alpha]-Cdx2 Axis in Trophoblast Stem Cells Induces
... as Cdx2, are specifically expressed in TS cells but not in differentiated trophoblast cells upon withdrawal of FGF4. Cdx2 is a member of the caudal-related homeobox transcription factors [29]. Cdx2 has been reported to be specifically expressed in the TE at the blastocyst stage and its expression is m ...
... as Cdx2, are specifically expressed in TS cells but not in differentiated trophoblast cells upon withdrawal of FGF4. Cdx2 is a member of the caudal-related homeobox transcription factors [29]. Cdx2 has been reported to be specifically expressed in the TE at the blastocyst stage and its expression is m ...
PDF - Oxford Academic
... Plant retinoblastoma-related (RBR) proteins are primarily considered as key regulators of G1/S phase transition, with functional roles in a variety of cellular events during plant growth and organ development. Polyclonal antibody against the C-terminal region of the Arabidopsis RBR1 protein also spe ...
... Plant retinoblastoma-related (RBR) proteins are primarily considered as key regulators of G1/S phase transition, with functional roles in a variety of cellular events during plant growth and organ development. Polyclonal antibody against the C-terminal region of the Arabidopsis RBR1 protein also spe ...
Nitric Oxide Signalling in Plants: Cross
... its control. The effects of NO on Ca2+ channel and transporter activities can be divided into two mechanisms of action: a cGMP-dependent one and a cGMP-independent one. The molecular mechanisms underlying the cGMP-dependent pathway are complex, and at least three processes have been reported. First, ...
... its control. The effects of NO on Ca2+ channel and transporter activities can be divided into two mechanisms of action: a cGMP-dependent one and a cGMP-independent one. The molecular mechanisms underlying the cGMP-dependent pathway are complex, and at least three processes have been reported. First, ...
Hedgehog signaling pathway
![](https://en.wikipedia.org/wiki/Special:FilePath/Denticlebands.png?width=300)
The Hedgehog signaling pathway (or signalling pathway; see spelling differences) is a signaling pathway that transmits information to embryonic cells required for proper development. Different parts of the embryo have different concentrations of hedgehog signaling proteins. The pathway also has roles in the adult. Diseases associated with the malfunction of this pathway include basal cell carcinoma.The Hedgehog signaling pathway is one of the key regulators of animal development and is present in all bilaterians. The pathway takes its name from its polypeptide ligand, an intercellular signaling molecule called Hedgehog (Hh) found in fruit flies of the genus Drosophila. Hh is one of Drosophila's segment polarity gene products, involved in establishing the basis of the fly body plan. The molecule remains important during later stages of embryogenesis and metamorphosis.Mammals have three Hedgehog homologues, DHH, IHH, and SHH, of which Sonic (SHH) is the best studied. The pathway is equally important during vertebrate embryonic development. In knockout mice lacking components of the pathway, the brain, skeleton, musculature, gastrointestinal tract and lungs fail to develop correctly. Recent studies point to the role of Hedgehog signaling in regulating adult stem cells involved in maintenance and regeneration of adult tissues. The pathway has also been implicated in the development of some cancers. Drugs that specifically target Hedgehog signaling to fight this disease are being actively developed by a number of pharmaceutical companies.