The Plant Journal
... by Kang et al. (2001) suggested that ADL1 is associated with the cell plate. ADL2 was localized to the plastids (Kang et al., 1998). ADL6 was shown to associate with the Golgi apparatus (Jin et al., 2001). The cellular compartment to which ADL3 associates is currently unknown. Apart from difference ...
... by Kang et al. (2001) suggested that ADL1 is associated with the cell plate. ADL2 was localized to the plastids (Kang et al., 1998). ADL6 was shown to associate with the Golgi apparatus (Jin et al., 2001). The cellular compartment to which ADL3 associates is currently unknown. Apart from difference ...
WAVE/Scars in platelets
... initial phase of hemostasis. Among the WASP and WAVE family proteins, platelets express WASP, which becomes strongly tyrosine phosphorylated upon stimulation by collagen or following crosslinking of CD32, a low-affinity Fc receptor for immunoglobulin G (IgG).16 However, despite the very small size o ...
... initial phase of hemostasis. Among the WASP and WAVE family proteins, platelets express WASP, which becomes strongly tyrosine phosphorylated upon stimulation by collagen or following crosslinking of CD32, a low-affinity Fc receptor for immunoglobulin G (IgG).16 However, despite the very small size o ...
Tamberg_BiolOpen2015 - Pitt Hopkins Research Foundation
... result in hypomorphic, non-functional or dominant-negative TCF4 alleles (Sepp et al., 2012). It is unclear whether mutations causing PTHS impair development of the nervous system or functioning of the adult central nervous system (CNS), or both. In addition to PTHS, TCF4 is associated with several o ...
... result in hypomorphic, non-functional or dominant-negative TCF4 alleles (Sepp et al., 2012). It is unclear whether mutations causing PTHS impair development of the nervous system or functioning of the adult central nervous system (CNS), or both. In addition to PTHS, TCF4 is associated with several o ...
- ScienceCentral
... Cyp26 genes have been previously characterized in various species, but their function in Xenopus leavis have not yet been fully identified. The role of Cyp26 during RA utilization and the anteriorization of the neuroectoderm during the early embryonic stages of Xenopus is also unclear. Wnt and FGF a ...
... Cyp26 genes have been previously characterized in various species, but their function in Xenopus leavis have not yet been fully identified. The role of Cyp26 during RA utilization and the anteriorization of the neuroectoderm during the early embryonic stages of Xenopus is also unclear. Wnt and FGF a ...
Western blot Fast purification Comparative performance
... Research. We have included articles covering both upstream and downstream processes, as well as sample preparation. There are articles comparing various techniques such as isolating small quantities of protein from complex samples; comparing differences in optical density analysis between spectropho ...
... Research. We have included articles covering both upstream and downstream processes, as well as sample preparation. There are articles comparing various techniques such as isolating small quantities of protein from complex samples; comparing differences in optical density analysis between spectropho ...
Redox signals as a language of interorganellar
... GSH, the main thiol buffer in plant cells, acts as an antioxidant by scavenging ROS but it also plays a pivotal role in cellular redox regulation. Similarly to AA, changes in the GSH pool and its redox status could act as redox signals integrated into the network that regulates gene expression, incl ...
... GSH, the main thiol buffer in plant cells, acts as an antioxidant by scavenging ROS but it also plays a pivotal role in cellular redox regulation. Similarly to AA, changes in the GSH pool and its redox status could act as redox signals integrated into the network that regulates gene expression, incl ...
full text pdf
... GSH, the main thiol buffer in plant cells, acts as an antioxidant by scavenging ROS but it also plays a pivotal role in cellular redox regulation. Similarly to AA, changes in the GSH pool and its redox status could act as redox signals integrated into the network that regulates gene expression, incl ...
... GSH, the main thiol buffer in plant cells, acts as an antioxidant by scavenging ROS but it also plays a pivotal role in cellular redox regulation. Similarly to AA, changes in the GSH pool and its redox status could act as redox signals integrated into the network that regulates gene expression, incl ...
The enemy within: ricin and plant cells
... et al., 1987). The modification involves the removal of a specific adenine in the large rRNA of the 60S ribosomal subunit (A4324 in rat liver 28S rRNA). This conserved adenine is part of a region of 28S rRNA that is critical for the binding of the EF2 ternary complex in the translocation phase of a ...
... et al., 1987). The modification involves the removal of a specific adenine in the large rRNA of the 60S ribosomal subunit (A4324 in rat liver 28S rRNA). This conserved adenine is part of a region of 28S rRNA that is critical for the binding of the EF2 ternary complex in the translocation phase of a ...
Combinatorial Gli gene function in floor plate and
... known how progenitor cells interpret the positional information provided by inducing signals or how the domains in which distinct groups of neural cells differentiate are defined. Gli proteins may be involved in these processes. In the frog neural plate, we have previously shown that the zinc finger ...
... known how progenitor cells interpret the positional information provided by inducing signals or how the domains in which distinct groups of neural cells differentiate are defined. Gli proteins may be involved in these processes. In the frog neural plate, we have previously shown that the zinc finger ...
Serotonin synchronises convergent extension of
... appears which are 5-ht2Dro-speci®c since they are pharmacologically indistinguishable from those of 5-ht2Dro transfected cells (Colas et al., 1995). As previously reported, concomitant with this expression, there is also a transient peak of 5-HT synthesis (Colas et al., 1995). The serotonin receptor ...
... appears which are 5-ht2Dro-speci®c since they are pharmacologically indistinguishable from those of 5-ht2Dro transfected cells (Colas et al., 1995). As previously reported, concomitant with this expression, there is also a transient peak of 5-HT synthesis (Colas et al., 1995). The serotonin receptor ...
Retinoid signaling regulates primitive (yolk sac
... Meanwhile, the signaling molecules that control blood island development and primitive hematopoiesis are unknown and may be distinct from definitive hematopoietic cytokines. Primitive erythrocytes are a transient population of relatively large, hyperchromatic cells expressing embryonic globins and a ...
... Meanwhile, the signaling molecules that control blood island development and primitive hematopoiesis are unknown and may be distinct from definitive hematopoietic cytokines. Primitive erythrocytes are a transient population of relatively large, hyperchromatic cells expressing embryonic globins and a ...
On the Morphology of the Drosophila Heart
... Abstract: The circulatory system of Drosophila melanogaster represents an easily amenable genetic model whose analysis at different levels, i.e., from single molecules up to functional anatomy, has provided new insights into general aspects of cardiogenesis, heart physiology and cardiac aging, to na ...
... Abstract: The circulatory system of Drosophila melanogaster represents an easily amenable genetic model whose analysis at different levels, i.e., from single molecules up to functional anatomy, has provided new insights into general aspects of cardiogenesis, heart physiology and cardiac aging, to na ...
- The Pawson Lab
... SAM domain and PDZ binding motif were constitutively tyrosine phosphorylated in vivo and catalytically active in vitro. EphA4 induced loss of cell adhesion, ventro-lateral protrusions, and severely expanded posterior structures in Xenopus embryos. Moreover, mutation of a conserved SAM domain tyrosin ...
... SAM domain and PDZ binding motif were constitutively tyrosine phosphorylated in vivo and catalytically active in vitro. EphA4 induced loss of cell adhesion, ventro-lateral protrusions, and severely expanded posterior structures in Xenopus embryos. Moreover, mutation of a conserved SAM domain tyrosin ...
Mitochondria as signaling organelles R E V I E W Open Access
... metabolites. The citric acid cycle, commonly referred to as the TCA cycle, generates metabolites and reducing equivalents (NADH and FADH2). Electrons from reducing equivalents feed into the mitochondrial electron transport chain (ETC), which pumps protons across the mitochondrial inner membrane to g ...
... metabolites. The citric acid cycle, commonly referred to as the TCA cycle, generates metabolites and reducing equivalents (NADH and FADH2). Electrons from reducing equivalents feed into the mitochondrial electron transport chain (ETC), which pumps protons across the mitochondrial inner membrane to g ...
Structure-activity Relationships in Flexible Protein Domains
... inhibit GDP dissociation as well, but have not been evaluated as inhibitors of GTP hydrolysis. The physiological role of the interaction of RhoGDI with the GTP-bound form of a GTPase remains to be established. Overall, when exogenously introduced into cells the GDIs behave as negative regulators by ...
... inhibit GDP dissociation as well, but have not been evaluated as inhibitors of GTP hydrolysis. The physiological role of the interaction of RhoGDI with the GTP-bound form of a GTPase remains to be established. Overall, when exogenously introduced into cells the GDIs behave as negative regulators by ...
Protein Quality Control as a Strategy for Cellular Regulation
... dimethylallyl pyrophosphate (DMAPP) and isopentyl pyrophosphate (IPP) that are used as building blocks to construct myriad isoprenoids, including sterols such as cholesterol. This long biosynthetic pathway is feedback regulated at multiple levels, including transcription, translation, and regulated ...
... dimethylallyl pyrophosphate (DMAPP) and isopentyl pyrophosphate (IPP) that are used as building blocks to construct myriad isoprenoids, including sterols such as cholesterol. This long biosynthetic pathway is feedback regulated at multiple levels, including transcription, translation, and regulated ...
A Difference between Rods and Cones in the Renewal of Outer
... The renewal of protein has been studied in the retinal rods and cones of the adult frog by electron microscope autoradiography after injection of radioactive amino acids. In both classes of photoreceptor cells, the synthesis of protein is concentrated in the niyoid zone of the inner segment. Newly f ...
... The renewal of protein has been studied in the retinal rods and cones of the adult frog by electron microscope autoradiography after injection of radioactive amino acids. In both classes of photoreceptor cells, the synthesis of protein is concentrated in the niyoid zone of the inner segment. Newly f ...
Selenium incorporation using recombinant techniques
... unlabelled protein that has already been secreted is removed. However, in 2007 Cronin and coworkers reported a systematic study of SeMet-labelling proteins in baculovirus expressionvector systems in order to determine an optimal protocol for obtaining consistent and reliable SeMet-labelled protein f ...
... unlabelled protein that has already been secreted is removed. However, in 2007 Cronin and coworkers reported a systematic study of SeMet-labelling proteins in baculovirus expressionvector systems in order to determine an optimal protocol for obtaining consistent and reliable SeMet-labelled protein f ...
PDF
... phenotype and repress the neural gene Otx2. Even more striking were changes in the overall retinal structure in the treated retinas. In approximately one-third of the treated retinas, the outer nuclear layer (ONL) contained ‘mushroom-like’ bulges of photoreceptors (Fig. 4D,I). In the majority of the ...
... phenotype and repress the neural gene Otx2. Even more striking were changes in the overall retinal structure in the treated retinas. In approximately one-third of the treated retinas, the outer nuclear layer (ONL) contained ‘mushroom-like’ bulges of photoreceptors (Fig. 4D,I). In the majority of the ...
Molecular Weight Estimation - Bio-Rad
... are shown in Figure 3. The accuracy of the calculated MW for the sample proteins is dependent on the linearity of the standard curve generated for the markers, represented by the R2 value. The closer the R2 value is to 1.0, the better the fit of the data points to a trend line. The strong linear rel ...
... are shown in Figure 3. The accuracy of the calculated MW for the sample proteins is dependent on the linearity of the standard curve generated for the markers, represented by the R2 value. The closer the R2 value is to 1.0, the better the fit of the data points to a trend line. The strong linear rel ...
PDF - The Journal of Cell Biology
... Delamasure et al., 2002; Gay and Gangloff, 2007). Activation of Toll-1 triggers the degradation of the NF-κB inhibitor Cactus, enabling the nuclear translocation of the NF-κB homologues Dorsal and Dorsal-related immunity factor (Dif), which function as transcription factors. Other Tolls have also be ...
... Delamasure et al., 2002; Gay and Gangloff, 2007). Activation of Toll-1 triggers the degradation of the NF-κB inhibitor Cactus, enabling the nuclear translocation of the NF-κB homologues Dorsal and Dorsal-related immunity factor (Dif), which function as transcription factors. Other Tolls have also be ...
The Role of Two-Component Signal Transduction Systems in
... by two-component signaling pathways that couple changes in environmental conditions to the production of c-di-GMP by phosphorylating response regulators with GGDEF output domains. For instance, in Pseudomonas aeruginosa, a chemotaxis-like system drives the phosphorylation of the response regulator W ...
... by two-component signaling pathways that couple changes in environmental conditions to the production of c-di-GMP by phosphorylating response regulators with GGDEF output domains. For instance, in Pseudomonas aeruginosa, a chemotaxis-like system drives the phosphorylation of the response regulator W ...
Human Dcp2: a catalytically active mRNA decapping enzyme
... functionally related to yeast Dcp1. For Dcp2 and hDcp2, a high level of amino acid similarity was detected at the N-terminus of the protein (33% identity over 249 amino acids), consistent with analysis of proteins from other species. This region contains a Nudix/MutT domain (Bessman et al., 1996) pr ...
... functionally related to yeast Dcp1. For Dcp2 and hDcp2, a high level of amino acid similarity was detected at the N-terminus of the protein (33% identity over 249 amino acids), consistent with analysis of proteins from other species. This region contains a Nudix/MutT domain (Bessman et al., 1996) pr ...
Gene Section PTPRJ (protein tyrosine phosphatase, receptor type, J)
... expressing cells and can replicate the hearing loss feature of Cogan's disease, when infused into mice. It is not determined whether these antibodies are causative for this autoimmune disease and/or others (e.g., pseudo-Pendred syndrome) (Davis et al., 2006). ...
... expressing cells and can replicate the hearing loss feature of Cogan's disease, when infused into mice. It is not determined whether these antibodies are causative for this autoimmune disease and/or others (e.g., pseudo-Pendred syndrome) (Davis et al., 2006). ...
Hedgehog signaling pathway
The Hedgehog signaling pathway (or signalling pathway; see spelling differences) is a signaling pathway that transmits information to embryonic cells required for proper development. Different parts of the embryo have different concentrations of hedgehog signaling proteins. The pathway also has roles in the adult. Diseases associated with the malfunction of this pathway include basal cell carcinoma.The Hedgehog signaling pathway is one of the key regulators of animal development and is present in all bilaterians. The pathway takes its name from its polypeptide ligand, an intercellular signaling molecule called Hedgehog (Hh) found in fruit flies of the genus Drosophila. Hh is one of Drosophila's segment polarity gene products, involved in establishing the basis of the fly body plan. The molecule remains important during later stages of embryogenesis and metamorphosis.Mammals have three Hedgehog homologues, DHH, IHH, and SHH, of which Sonic (SHH) is the best studied. The pathway is equally important during vertebrate embryonic development. In knockout mice lacking components of the pathway, the brain, skeleton, musculature, gastrointestinal tract and lungs fail to develop correctly. Recent studies point to the role of Hedgehog signaling in regulating adult stem cells involved in maintenance and regeneration of adult tissues. The pathway has also been implicated in the development of some cancers. Drugs that specifically target Hedgehog signaling to fight this disease are being actively developed by a number of pharmaceutical companies.