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Hereditary mitochondrial diseases disorders of mitochondrial fatty
Hereditary mitochondrial diseases disorders of mitochondrial fatty

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... primarily on the liver where binding to specific extracellular receptors stimulates glycogenolysis and gluconeogenesis with subsequent release of glucose from the liver for the benefit of other body tissues. Glucagon is counter-regulatory to insulin which is secreted by pancreatic $-cells and stimul ...
CHAPTER 14: CARDIOVASCULAR SYSTEM: BLOOD
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The Trp64Arg β3 -adrenergic receptor amino acid
The Trp64Arg β3 -adrenergic receptor amino acid

< 1 ... 58 59 60 61 62 63 64 65 66 ... 231 >

Ketosis



Ketosis /kɨˈtoʊsɨs/ is a metabolic state where most of the body's energy supply comes from ketone bodies in the blood, in contrast to a state of glycolysis where blood glucose provides most of the energy. It is characterised by serum concentrations of ketone bodies over 0.5 millimolar, with low and stable levels of insulin and blood glucose. It is almost always generalized with hyperketonemia, that is, an elevated level of ketone bodies in the blood throughout the body. Ketone bodies are formed by ketogenesis when liver glycogen stores are depleted (or from metabolising medium-chain triglycerides). The main ketone bodies used for energy are acetoacetate and β-hydroxybutyrate, and the levels of ketone bodies are regulated mainly by insulin and glucagon. Most cells in the body can use both glucose and ketone bodies for fuel, and during ketosis, free fatty acids and glucose synthesis (gluconeogenesis) fuel the remainder.Longer-term ketosis may result from fasting or staying on a low-carbohydrate diet, and deliberately induced ketosis serves as a medical intervention for intractable epilepsy. In glycolysis, higher levels of insulin promote storage of body fat and block release of fat from adipose tissues, while in ketosis, fat reserves are readily released and consumed. For this reason, ketosis is sometimes referred to as the body's ""fat burning"" mode.
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