Download Supporting information. Rat urinary glycoprotein identified from

Supporting information. Rat urinary glycoprotein identified from lectin captured protein
lectin
C
J
W
Ref
Protein name
glycosylation coverage
function
Displays several functions associated with host defense: it promotes agglutination,
o
o
o
IPI00188225 C-reactive protein
g
26.52
bacterial capsular swelling, phagocytosis and complement fixation through its calciumdependent binding to phosphorylcholine. Can interact with DNA and histones and may
scavenge nuclear material released from damaged circulating cells
o
o
o
IPI00188967 Ig kappa chain C region
ns
55.66
o
o
o
IPI00190943 Glial fibrillary acidic protein, astrocyte
s
2.56
o
o
o
IPI00191711 Major urinary protein
p
82.32
o
o
o
IPI00191715 Alpha-1-acid glycoprotein
po
27.80
o
o
o
IPI00191737
GFAP, a class-III intermediate filament, is a cell-specific marker that, during the
development of the central nervous system, distinguishes astrocytes from other glial cells
Binds pheromones that are released from drying urine of males. These pheromones affect
the sexual behavior of females
Appears to function in modulating the activity of the immune system during the acutephase reaction
Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+),
Serum albumin
ns
67.11
Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of
the colloidal osmotic pressure of blood
Part of prostatein which is the major secretory glycoprotein of ventral prostate gland.
o
o
o
IPI00191771
Prostatic steroid-binding protein C3 chain
g
13.68
Steroid-binding protein; can bind non-polar steroids, cholesterol and a group of small
proline-rich peptides
o
o
o
IPI00191773 Prostatic steroid-binding protein C2 chain
p
35.71
Part of prostatein which is the major secretory glycoprotein of ventral prostate gland
o
o
o
IPI00191774 Prostatic steroid-binding protein C1 chain
s
37.84
Part of prostatein which is the major secretory glycoprotein of ventral prostate gland
o
o
o
IPI00193171 Epididymal secretory protein 1
ns
26.85
o
o
o
IPI00195063 13 kDa protein
ns
10.83
o
o
o
IPI00195148 Liver carboxylesterase 1
po
14.75
o
o
o
IPI00195160 Sulfated glycoprotein 1
po
6.32
o
o
o
IPI00195516 Hemopexin
po
29.78
o
o
o
IPI00195685 CD44 protein
s
3.08
o
o
o
IPI00196249 Limitrin
po
13.8
o
o
o
IPI00196656 Ba1-667
ns
38.88
o
o
o
IPI00198021 Uromodulin
po
30.75
o
o
o
IPI00198466 Amy1 protein
s
51.82
o
o
o
IPI00199448 Mama
s
9.93
o
o
o
IPI00199695
s
10.59
Belongs to the serpin family
o
o
o
IPI00200422 Alpha2u globulin
s
12.15
Belongs to the lipocalin family
o
o
o
IPI00200591 Contrapsin-like protease inhibitor 3
po
40.92
By growth hormone. Reduced during acute inflammation
o
o
o
IPI00200593 Contrapsin-like protease inhibitor 1
po
40.87
Binds to and inhibits kallikreins. Inhibits trypsin but not chymotrypsin or elastase
Serine (Or cysteine) peptidase inhibitor,
clade F, member 2
Involved in the detoxification of xenobiotics and in the activation of ester and amide
prodrugs
Binds heme and transports it to the liver for breakdown and iron recovery, after which the
free hemopexin returns to the circulation
May play a role in the maturation and maintenance of blood-brain barrier
May play a role in regulating the circulating activity of cytokines as it binds to IL-1, IL-2 and
TNF with high affinity
Fibronectins bind cell surfaces and various compounds including collagen, fibrin, heparin,
o
o
o
IPI00200757 Fibronectin
po
2.22
DNA, and actin. Fibronectins are involved in cell adhesion, cell motility, opsonization,
wound healing, and maintenance of cell shape. Interaction with TNR mediates inhibition of
cell adhesion and neurite outgrowth
Protease inhibitor with a wide spectrum of protein targets, which attaches through its
o
o
o
IPI00201262 Alpha-1-inhibitor 3
po
33.51
o
o
o
IPI00201592 Glandular kallikrein-7, submandibular/renal
po
25.29
o
o
o
IPI00201596 Alpha-2u globulin
s
4.97
Belongs to the lipocalin family
o
o
o
IPI00201616.1 ALPHA-2U GLOBULIN.
s
18.23
Belongs to the lipocalin family
o
o
o
IPI00201617.1 ALPHA-2U GLOBULIN.
s
24.86
Belongs to the lipocalin family
thioester function
Glandular kallikreins cleave Met-Lys and Arg-Ser bonds in kininogen to release Lysbradykinin. Predominant kallikrein protein in the kidney
Catalyzes the conversion of PGH2 to PGD2, a prostaglandin involved in smooth muscle
contraction/relaxation and a potent inhibitor of platelet aggregation. Involved in a variety of
CNS functions, such as sedation, NREM sleep and PGE2-induced allodynia, and may
have an anti-apoptotic role in oligodendrocytes. Binds small non-substrate lipophilic
o
o
o
IPI00203102 Prostaglandin-H2 D-isomerase
g
8.99
molecules, including biliverdin, bilirubin, retinal, retinoic acid and thyroid hormone, and may
act as a scavenger for harmful hydrophopic molecules and as a secretory retinoid and
thyroid hormone transporter. Possibly involved in development and maintenance of the
blood-brain, blood-retina, blood-aqueous humor and blood-testis barrier. It is likely to play
important roles in both maturation and maintenance of the central nervous system and
male reproductive system
Receptor for both interleukin 4 and interleukin 13. Couples to the JAK1/2/3-STAT6
pathway. The IL4 response is involved in promoting Th2 differentiation. The IL4/IL13
o
o
o
IPI00203149 Interleukin-4 receptor alpha chain
po
1.62
responses are involved in regulating IgE production and, chemokine and mucus production
at sites of allergic inflammmation. In certain cell types, can signal through activation of
insulin receptor substrates, IRS1/IRS2
o
o
o
IPI00204359 Beta-2-microglobulin
ns
19.33
o
o
o
IPI00204777 Common salivary protein 1
s
55.97
o
o
o
IPI00205208 Cystatin-related protein 1
g
46.59
Beta-2-microglobulin is the beta-chain of major histocompatibility complex class I
molecules
o
o
o
IPI00205210 Cystatin-related protein 2
p
27.27
This receptor binds polymeric IgA and IgM at the basolateral surface of epithelial cells. The
o
o
o
IPI00205255 Polymeric-immunoglobulin receptor
p
11.44
complex is then transported across the cell to be secreted at the apical surface. During this
process a cleavage occurs that separate the extracellular (known as the secretory
component) from the transmembrane segment
o
o
o
IPI00205273 Urinary protein 1
po
32.67
o
o
o
IPI00205275 Urinary protein 2
po
32.67
o
o
o
IPI00205325
po
14.94
o
o
o
IPI00205971 Urinary protein 3
s
35.64
Low-density lipoprotein receptor-related
protein 2
Acts together with cubilin to mediate HDL endocytosis. Receptor-mediated uptake of
polybasic drugs such as aprotinin, aminoglycosides and polymyxin B
Initiates extracellular glutathione (GSH) breakdown, provides cells with a local cysteine
supply and contributes to maintain intracelular GSH level. It is part of the cell antioxidant
o
o
o
IPI00206254 Gamma-glutamyltranspeptidase 1
po
4.58
defense mechanism. Catalyzes the transfer of the glutamyl moiety of glutathione to amino
acids and dipeptide acceptors. Alternatively, glutathione can be hydrolyzed to give Cys-Gly
and gamma glutamate
o
o
o
IPI00206623 Beta-glucuronidase
po
14.04
Plays an important role in the degradation of dermatan and keratan sulfates
Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with
themselves in a homophilic manner in connecting cells; cadherins may thus contribute to
o
o
o
IPI00206662 Epithelial-cadherin
po
12.53
the sorting of heterogeneous cell types. CDH1 is involved in mechanisms regulating cellcell adhesions, mobility and proliferation of epithelial cells. Has a potent invasive
suppressor role. It is a ligand for integrin alpha-E/beta-7
Plasmin dissolves the fibrin of blood clots and acts as a proteolytic factor in a variety of
other processes including embryonic development, tissue remodeling, tumor invasion, and
inflammation; in ovulation it weakens the walls of the Graafian follicle. It activates the
o
o
o
IPI00206780 Plasminogen
ns
12.44
urokinase-type plasminogen activator, collagenases and several complement zymogens,
such as C1 and C5. It cleaves fibrin, fibronectin, thrombospondin, laminin and von
Willebrand factor. Its role in tissue remodeling and tumor invasion may be modulated by
CSPG4. Angiostatin is an angiogenesis inhibitor that blocks neovascularization and growth
of experimental primary and metastatic tumors in vivo
o
o
o
IPI00206823.1 ALPHA-2U GLOBULIN.
s
44.20
o
o
o
IPI00206980 Apomucin
s
6.21
o
o
o
IPI00207668 Afamin
po
33.88
o
o
o
IPI00208410 Probasin
ns
16.38
Belongs to the lipocalin family
Possible role in the transport of yet unknown ligand
Hydrolyzes the polyglutamate sidechains of pteroylpolyglutamates. Progressively removes
gamma-glutamyl residues from pteroylpoly-gamma-glutamate to yield pteroyl-alpha-
o
o
o
IPI00209265 Gamma-glutamyl hydrolase
po
22.71
glutamate (folic acid) and free glutamate. May play an important role in the bioavailability of
dietary pteroylpolyglutamates and in the metabolism of pteroylpolyglutamates and
antifolates. Exhibits either endo- or exopeptidase activity depending upon the tissue of
origin. When secreted, it acts primarily as an endopeptidase
Glandular kallikreins cleave Met-Lys and Arg-Ser bonds in kininogen to release Lys-
o
o
o
IPI00209517 Submandibular glandular kallikrein-9
p
20.46
bradykinin. This enzyme has a vasoconstrictor activity. KLK-9 has both a chymotrypsin-like
and a trypsin-like properties
In response to lowered blood pressure, the enzyme renin cleaves angiotensin-1, from
o
o
o
IPI00209744 Angiotensinogen
po
6.92
angiotensinogen. ACE (angiotensin converting enzyme) then removes a dipeptide to yield
the physiologically active peptide angiotensin-2, the most potent pressor substance known,
which helps regulate volume and mineral balance of body fluids
o
o
o
IPI00210091 Serine protease inhibitor A3M
po
11.69
The single human alpha1-antichymotrypsin gene (SERPINA3) is represented by a cluster
of 6 individual rat paralogs
o
o
o
IPI00210524 40 kDa protein
s
15.36
o
o
o
IPI00210824 Corticosteroid-binding globulin
po
10.86
o
o
o
IPI00210872 Meprin A subunit alpha
po
21.26
Major transport protein for glucocorticoids and progestins in the blood of almost all
vertebrate species
Hydrolysis of protein and peptide substrates preferentially on carboxyl side of hydrophobic
residues
Alpha-1-microglobulin occurs in many physiological fluids including plasma, urine, and
cerebrospinal fluid. It appears not only as a free monomer but also in complexes with IgA
and albumin. Inter-alpha-trypsin inhibitor, present in plasma and urine, inhibits trypsin,
o
o
o
IPI00210900 AMBP protein
po
15.76
plasmin, and lysosomal granulocytic elastase. Trypstatin is a trypsin inhibitor. It inhibits
blood coagulation factor Xa and tryptase about 100-fold more rapidly than porcine
pancreatic trypsin and chymase. It is a monomer but is also found in mast cells as a
complex with tryptase
Factor D cleaves factor B when the latter is complexed with factor C3b, activating the
o
o
o
IPI00212480 Complement factor D
g
10.27
C3bbb complex, which then becomes the C3 convertase of the alternate pathway. Its
function is homologous to that of C1s in the classical pathway
o
o
o
IPI00212697 Napsin
s
16.19
o
o
o
IPI00212708 Fetuin-B
po
30.03
o
o
o
IPI00212731 Cathepsin D
po
7.37
Acid protease active in intracellular protein breakdown
o
o
o
IPI00212767 Anionic trypsin-1
s
8.13
Preferential cleavage: Arg-|-Xaa, Lys-|-Xaa
o
o
o
IPI00212811 Cathepsin B
g
25.07
Belongs to the fetuin family
Thiol protease which is believed to participate in intracellular degradation and turnover of
proteins. Has also been implicated in tumor invasion and metastasis
C4 plays a central role in the activation of the classical pathway of the complement system.
It is processed by activated C1 which removes from the alpha chain the C4a
o
o
o
IPI00213036 Complement C4
g
7.25
anaphylatoxin. Derived from proteolytic degradation of complement C4, C4a anaphylatoxin
is a mediator of local inflammatory processes. It induces the contraction of smooth muscle,
increases vascular permeability and causes histamine release from mast cells and
basophilic leukocytes
o
o
o
IPI00213541 12 kDa protein
ns
11.30
o
o
o
IPI00213958 Prostatic spermine-binding protein
g
15.05
o
o
o
IPI00215300 C-CAM4
s
18.31
Spermine-binding protein is an androgen regulated ventral prostate glycoprotein that binds
various polyamines
Broad specificity aminopeptidase. Plays a role in the final digestion of peptides generated
from hydrolysis of proteins by gastric and pancreatic proteases. May be involved in the
o
o
o
IPI00230862 Aminopeptidase N
po
18.46
metabolism of regulatory peptides of diverse cell types. Found to cleave antigen peptides
bound to major histocompatibility complex class II molecules of presenting cells. May have
a role in angiogenesis
o
o
o
IPI00230876 Deoxyribonuclease-1
po
47.54
o
o
o
IPI00231643 Superoxide dismutase
s
35.95
Among other functions, seems to be involved in cell death by apoptosis. Binds specifically
to G-actin and blocks actin polymerization
Destroys radicals which are normally produced within the cells and which are toxic to
biological systems
As an inhibitor of cysteine proteinases, this protein is thought to serve an important
o
o
o
IPI00231801 Cystatin C
s
42.14
physiological role as a local regulator of this enzyme activity. Known to inhibits cathepsin B,
H, and L
o
o
o
IPI00231848 Pro-epidermal growth factor
po
19.51
o
o
o
IPI00324019 Alpha-1-antiproteinase
po
49.39
EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro
and of some fibroblasts in cell culture
Inhibitor of serine proteases. The primary target is elastase, but also has a moderate
affinity for plasmin and thrombin
o
o
o
IPI00324380 Transthyretin
po
30.61
Thyroid hormone-binding protein. Probably transports thyroxine from the bloodstream to
the brain
Ceruloplasmin is a blue, copper-binding (6-7 atoms per molecule) glycoprotein. It has
o
o
o
IPI00325847 Ceruloplasmin
po
3.6
ferroxidase activity oxidizing iron(II) to iron(III) without releasing radical oxygen species. It
is involved in iron transport across the cell membrane. May also play a role in fetal lung
development or pulmonary antioxidant defense
Is able to inhibit all four classes of proteinases by a unique 'trapping' mechanism. This
protein has a peptide stretch, called the 'bait region' which contains specific cleavage sites
for different proteinases. When a proteinase cleaves the bait region, a conformational
o
o
o
IPI00326140 Alpha-1-macroglobulin
po
28.33
change is induced in the protein which traps the proteinase. The entrapped enzyme
remains active against low molecular weight substrates. Following cleavage in the bait
region a thioester bond is hydrolyzed and mediates the covalent binding of the protein to
the proteinase
Isoform 1 is detectable at all developmental stages starting from postnatal day 1. Isoform 2
o
o
o
IPI00326260 Neuroplastin
po
8.4
is low at postnatal day 1, increases steadily until postnatal days 20-25 and then declines to
an intermediate level
Kininogens are plasma glycoproteins with a number of functions: (1) as precursor of the
active peptide bradykinin they effect smooth muscle contraction, induction of hypotension
o
o
o
IPI00327182 T-kininogen 1
po
26.62
and increase of vascular permeability. (2) They play a role in blood coagulation by helping
to position optimally prekallikrein and factor XI next to factor XII. (3) They are inhibitor of
thiol proteases
Could inhibit both insulin-receptor tyrosine kinase activity and insulin-stimulated receptor
o
o
o
IPI00327469 Alpha-2-HS-glycoprotein
po
18.18
autophosphorylation and, concomitantly, antagonize the mitogenic effect of the hormone in
cultured rat hepatoma cells
o
o
o
IPI00358444 cDNA sequence BC048546
s
17.60
o
o
o
IPI00360737 similar to alpha 3 type VI collagen isoform 2
s
3.34
o
o
o
IPI00361346 LOC367586 protein
s
21.48
o
o
o
IPI00365221
po
19.07
o
o
o
IPI00366081 desmoplakin isoform I isoform
s
5.32
o
o
o
s
26.50
o
o
o
IPI00368219 Gastric triacylglycerol lipase
s
20.03
o
o
o
IPI00371132 Bet-galactosidase
s
14.68
o
o
o
IPI00372372
s
30.54
o
o
o
IPI00388265 48 kDa protein
s
45.62
o
o
o
IPI00390975 57 kDa protein
s
12.5
o
o
o
s
7.18
IPI00367761.4
EGF-containing fibulin-like extracellular
matrix protein 1
SIMILAR TO PROSTATIC SPERMINEBINDING PROTEIN PRECURSOR.
Serine (Or cysteine) peptidase inhibitor,
clade C (Antithrombin), member 1
IPI00392753.2 ALPHA-2U GLOBULIN.
Protease inhibitor with a wide spectrum of protein targets, which attaches through its
thioester function
Belongs to the lipocalin family
Common junctional plaque protein. The membrane-associated plaques are architectural
elements in an important strategic position to influence the arrangement and function of
o
o
o
IPI00421429 Junction plakoglobin
s
14.9
both the cytoskeleton and the cells within the tissue. The presence of plakoglobin in both
the desmosomes and in the intermediate junctions suggests that it plays a central role in
the structure and function of submembranous plaques
o
o
o
IPI00464785 Protective protein for beta-galactosidase
s
10.53
Transferrins are iron binding transport proteins which can bind two Fe(3+) ions in
o
o
o
IPI00475946 Serotransferrin
po
5.85
association with the binding of an anion, usually bicarbonate. It is responsible for the
transport of iron from sites of absorption and heme degradation to those of storage and
utilization. Serum transferrin may also have a further role in stimulating cell proliferation
C3 plays a central role in the activation of the complement system. Its processing by C3
o
o
o
IPI00480639 Complement C3
p
8.72
convertase is the central reaction in both classical and alternative complement pathways.
After activation C3b can bind covalently, via its reactive thioester, to cell surface
carbohydrates or immune aggregates
o
o
o
o
o
o
o
o
o
o
o
o
IPI00559211 11 kDa protein
s
22.92
s
17.22
IPI00763182 Urinary protein 3 precursor
ns
50
o
IPI00763610 lipocalin 13
s
15.47
o
o
IPI00767210 Prostatic steroid-binding protein C1
ns
35.04
o
o
o
s
11.36
o
o
IPI00195173 CD59 glycoprotein
po
7.14
o
o
IPI00196145 Interferon gamma inducible protein 30
s
5.65
o
o
IPI00200614 Regenerating islet-derived protein 3 gamma
s
21.26
o
o
IPI00202887 Decay-accelarating factor
s
2.96
o
o
IPI00206658 Pre-eosinophil-associated ribonuclease-2
s
12.26
o
o
IPI00207475 Endothelial cell-selective adhesion molecule
po
12.18
o
o
IPI00213615
po
5.22
o
o
IPI00325146 Annexin A2
s
4.13
IPI00563352.3 ALPHA-2U GLOBULIN.
IPI00769183.2 SIMILAR TO ROBO-1.
N(4)-(Beta-N-acetylglucosaminyl)-Lasparaginase
Belongs to the lipocalin family
Potent inhibitor of the complement membrane attack complex (MAC) action. Acts at or after
the C5b-8 stage of MAC assembly
Might be a stress protein involved in the control of bacterial proliferation
Can mediate aggregation most likely through a homophilic molecular interaction
Cleaves the GlcNAc-Asn bond which joins oligosaccharides to the peptide of asparaginelinked glycoproteins
Calcium-regulated membrane-binding protein whose affinity for calcium is greatly
enhanced by anionic phospholipids. It binds two calcium ions with high affinity
o
o
IPI00358343 14 kDa protein
ns
23.85
o
o
IPI00371899 15 kDa protein
s
8.7
o
o
s
18.32
o
o
s
10.04
o
o
s
8.84
o
o
IPI00568085 19 kDa protein
s
15.06
o
o
IPI00655254 LRRGT00161
s
5.15
o
o
ns
12.80
Po, O
1.86
s
9.17
IPI00389939.3 15 KDA PROTEIN.
IPI00421761 Glandular kallikrein-11
IPI00554102.3 SIMILAR TO ALPHA2U GLOBULIN.
IPI00780603.1 14 KDA PROTEIN.
o
o
IPI00188909 Collagen alpha-1(I) chain
o
o
IPI00194927 RoBo-1
Belongs to the lipocalin family
Type I collagen is a member of group I collagen (fibrillar forming collagen)
Binds to various kinds of negatively charged substances such as heparin, phospholipids,
o
o
IPI00195241 Beta-2-glycoprotein 1
po
7.41
and dextran sulfate. May prevent activation of the intrinsic blood coagulation cascade by
binding to phospholipids on the surface of damaged cells
Cotransporter which plays a role in lipoprotein, vitamin and iron metabolism, by facilitating
their uptake. Binds to ALB, MB, Kappa and lambda-light chains, TF, hemoglobin, GC,
SCGB1A1, APOA1, high density lipoprotein, and the GIF-cobalamin complex. The binding
of all ligands required calcium. Serves as important transporter in several absorptive
o
o
IPI00196620 Cubilin
po
4.58
epithelia, including intestine, renal proximal tubules and embryonic yolk sac. Interaction
with LRP2 mediates its trafficking throughout vesicles and facilitates the uptake of specific
ligands like GC, hemoglobin, ALB, TF and SCGB1A1. Interaction with AMN controls its
trafficking to the plasma membrane and facilitates endocytosis of ligands. May play an
important role in the development of the peri-implantation embryo through internalization of
APOA1 and cholesterol. Binds to LGALS3 at the maternal-fetal interface
o
o
IPI00198494 Prolactin-inducible protein homolog
po
23.97
Belongs to the PIP family
Involved in the degradation of asparagine-linked glycoproteins. Hydrolyze of N-acetyl-beta-
o
o
IPI00203152 Di-N-acetylchitobiase
po
7.36
D-glucosamine (1-5)N-acetylglucosamine chitobiose core from the reducing end of the
bond, it requires prior cleavage by glycosylasparaginase
o
o
IPI00208422 Dipeptidyl peptidase 4
po
9.00
o
o
IPI00210968 Odorant-binding protein
s
7.95
o
o
IPI00230946 Dipeptidyl-peptidase 2
po
21.8
Removes N-terminal dipeptides sequentially from polypeptides having unsubstituted Ntermini provided that the penultimate residue is proline
Plays an important role in the degradation of some oligopeptides
(1) Kininogens are inhibitors of thiol proteases; (2) HMW-kininogen plays an important role
in blood coagulation by helping to position optimally prekallikrein and factor XI next to
factor XII; (3) HMW-kininogen inhibits the thrombin- and plasmin-induced aggregation of
thrombocytes; (4) the active peptide bradykinin that is released from HMW-kininogen
shows a variety of physiological effects: (4A) influence in smooth muscle contraction, (4B)
o
o
IPI00231282
Kininogen-1
po
2.31
induction of hypotension, (4C) natriuresis and diuresis, (4D) decrease in blood glucose
level, (4E) it is a mediator of inflammation and causes (4E1) increase in vascular
permeability, (4E2) stimulation of nociceptors (4E3) release of other mediators of
inflammation (e.g. prostaglandins), (4F) it has a cardioprotective effect (directly via
bradykinin action, indirectly via endothelium-derived relaxing factor action); (5) LMWkininogen inhibits the aggregation of thrombocytes; (6) LMW-kininogen is in contrast to
HMW-kininogen not involved in blood clotting
o
o
IPI00327398 Glutamyl aminopeptidase
po
6.03
o
o
IPI00365241 L-amino acid oxidase 1
s
11.47
o
o
IPI00368115 46 kDa protein
s
3
o
o
IPI00391338 ICOS ligand
s
2.75
Appears to have a role in the catabolic pathway of the renin-angiotensin system. Isoform 1
has aminopeptidase activity while isoform 2 does not
Is able to inhibit all four classes of proteinases by a unique 'trapping' mechanism. This
protein has a peptide stretch, called the 'bait region' which contains specific cleavage sites
for different proteinases. When a proteinase cleaves the bait region, a conformational
o
o
IPI00392886 Alpha-2-macroglobulin
po
0.88
change is induced in the protein which traps the proteinase. The entrapped enzyme
remains active against low molecular weight substrates (activity against high molecular
weight substrates is greatly reduced). Following cleavage in the bait region a thioester
bond is hydrolyzed and mediates the covalent binding of the protein to the proteinase
o
o
IPI00400579 Lysosomal alpha-glucosidase
o
o
IPI00475984 53 kDa protein
po
1.05
s
5.26
Essential for the degradation of glygogen to glucose in lysosomes
Neurofilaments usually contain three intermediate filament proteins: L, M, and H which are
o
IPI00188524 Neurofilament heavy polypeptide
s
3.10
involved in the maintenance of neuronal caliber. NF-H has an important function in mature
axons that is not subserved by the two smaller NF proteins
o
IPI00188800 103 kDa protein
s
1.96
o
IPI00189036 ABC transporter, white homologue
s
1.28
o
IPI00191437 64 kDa protein
s
5.05
Involved in the initial immune cell clustering during inflammatory response and may
o
IPI00194733 Attractin
po
2.57
regulate chemotactic activity of chemokines. May play a role in melanocortin signaling
pathways that regulate energy homeostasis and hair color. Low-affinity receptor for agouti.
Has a critical role in normal myelination in the central nervous system
o
IPI00199497 Leukemia inhibitory factor receptor
po
1.19
o
IPI00200344 Retinoid-inducible serine carboxypeptidase
po
3.98
o
IPI00201347 Histidine-rich glycoprotein 2
s
1.24
Signal-transducing molecule. May have a common pathway with IL6ST. The soluble form
inhibits the biological activity of LIF by blocking its binding to receptors on target cells
May be involved in vascular wall and kidney homeostasis
Involved in redox regulation of the cell. Reduces peroxides with reducing equivalents
provided through the thioredoxin system. It is not able to receive electrons from
o
IPI00201561 Peroxiredoxin-2
s
0.86
glutaredoxin. May play an important role in eliminating peroxides generated during
metabolism. Might participate in the signaling cascades of growth factors and tumor
necrosis factor-alpha by regulating the intracellular concentrations of H(2)O(2)
o
IPI00203203
Fragile-X mental retardation related protein
2
s
1.93
G protein-coupled receptor that probably associates with the patched protein (PTCH) to
o
IPI00206713 Smoothened homolog
po
1.89
transduce the hedgehog's proteins signal. Binding of sonic hedgehog (SHH) to its receptor
patched is thought to prevent normal inhibition by patched of smoothened (SMO).
o
IPI00208027 Trefoil factor 3
s
19.75
o
IPI00208659 Platelet complement factor H
s
5.83
May have a role in promoting cell migration (motogen)
o
IPI00210193 Titin
s
0.05
Involved in redox regulation of the cell. Reduces peroxides with reducing equivalents
provided through the thioredoxin system but not from glutaredoxin. May play an important
o
IPI00211779 Peroxiredoxin-1
s
5.03
role in eliminating peroxides generated during metabolism. Might participate in the
signaling cascades of growth factors and tumor necrosis factor-alpha by regulating the
intracellular concentrations of H(2)O(2)
o
IPI00211883 Cadherin-11
s
1.26
Functions as a cell surface receptor and performs physiological functions on the surface of
neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Involved in cell
mobility and transcription regulation through protein-protein interactions (By similarity). Can
promote transcription activation through binding to APBB1/Tip60 and inhibit Notch
signaling through interaction with Numb. Couples to apoptosis-inducing pathways such as
those mediated by G(O) and JIP. Inhibits G(o) alpha ATPase activity. Acts as a kinesin I
membrane receptor, mediating the axonal transport of beta-secretase and presenilin 1.
May be involved in copper homeostasis/oxidative stress through copper ion reduction. Can
regulate neurite outgrowth through binding to components of the extracellular matrix such
o
IPI00212319 Amyloid beta A4 protein
Po, O
1.69
as heparin and collagen I and IV. The splice isoforms that contain the BPTI domain
possess protease inhibitor activity. Beta-amyloid peptides are lipophilic metal chelators with
metal-reducing activity. Bind transient metals such as copper, zinc and iron. Rat and
mouse beta-amyloid peptides bind only weakly transient metals and have little reducing
activity due to substitutions of transient metal chelating residues. Beta-APP42 may activate
mononuclear phagocytes in the brain and elicit inflammatory responses. Promotes both tau
aggregation and TPK II-mediated phosphorylation. Appicans elicit adhesion of neural cells
to the extracellular matrix and may regulate neurite outgrowth in the brain. The gammaCTF peptides as well as the caspase-cleaved peptides, including C31, are potent
enhancers of neuronal apoptosis
A proteinase activates the inhibitor by specific proteolysis in the bait region, which, by an
unknown mechanism leads to reaction at the cysteinyl-glutamyl internal thiol ester site and
to a conformational change, whereby the proteinase is trapped and/or covalently bound to
o
IPI00212666 Murinoglobulin-1
po
10.63
the inhibitor. While in the tetrameric proteinase inhibitors steric inhibition is sufficiently
strong, monomeric forms need a covalent linkage between the activated glutamyl residue
of the original thiol ester and a terminal amino group of a lysine or another nucleophilic
group on the proteinase, for inhibition to be effective
o
IPI00212694 EGF receptor
s
1.49
o
IPI00213847 Granulins
po
7.47
o
IPI00231136 Nidogen-1
s
0.96
o
IPI00231631 Beta-enolase
s
4.16
o
IPI00231929 Pyruvate kinase isozymes M1/M2
s
4.32
Belongs to the protein kinase superfamily. Tyr protein kinase family
Granulins have possible cytokine-like activity. They may play a role in inflammation, wound
repair, and tissue remodeling
Appears to have a function in striated muscle development and regeneration
Glycolytic
enzyme
that
catalyzes
the
transfer
of
a
phosphoryl
group
from
phosphoenolpyruvate (PEP) to ADP, generating ATP
Cooperates with MD-2 and TLR4 to mediate the innate immune response to bacterial
o
IPI00231949 Monocyte differentiation antigen CD14
po
2.96
lipopolysaccharide (LPS). Acts via MyD88, TIRAP and TRAF6, leading to NF-kappa-B
activation, cytokine secretion and the inflammatory response. Up-regulates cell surface
molecules, including adhesion molecules
o
IPI00358704 Desmocollin 2
s
1.44
o
IPI00362538 ubiquitin-conjugating enzyme E2Q
s
2.03
o
IPI00367093 Lachrymal protein
s
22.83
o
IPI00368397 Igha_mapped protein
s
7.47
o
IPI00369047 Odorant-binding protein
s
6.36
Beta-2-microglobulin is the beta-chain of major histocompatibility complex class I
molecules
This protein is found in nasal epithelium and it binds a wide variety of chemical odorants
o
IPI00370706 Lactoperoxidase
s
8.04
o
IPI00372469 85 kDa protein
s
2.1
Probable FAD-dependent amine oxidase secreted by the kidney, which circulates in blood
and modulates cardiac function and systemic blood pressure. Degrades catecholamines
o
IPI00372522 Renalase
s
5.71
such as dopamine, norepinephrine and epinephrine in vitro (By similarity). Lowers blood
pressure in vivo by decreasing cardiac contractility and heart rate and preventing a
compensatory increase in peripheral vascular tone, suggesting a causal link to the
increased plasma catecholamine and heightened cardiovascular risk
Haptoglobin combines with free plasma hemoglobin, preventing loss of iron through the
o
IPI00382202 Ba1-647
po
6.82
kidneys and protecting the kidneys from damage by hemoglobin, while making the
hemoglobin accessible to degradative enzymes
o
IPI00392907 keratinocytes proline-rich protein
s
6.54
o
IPI00393340 Hypothetical protein
s
1.81
o
IPI00411191 MHC class Ib antigen
s
3.26
o
IPI00421601 N-acylsphingosine amidohydrolase 1
s
3.05
o
IPI00421857 Cytokeratin type I
s
8
o
IPI00421981 RT1 class I, CE15
s
3.22
Involved in the presentation of foreign antigens to the immune system
o
IPI00421984 RT1 class I, CE11
s
3.27
Involved in the presentation of foreign antigens to the immune system
Involved in the presentation of foreign antigens to the immune system
Functions as an E1 enzyme essential for multisubstrates such as GABARAPL1 and
o
IPI00471650 Autophagy-related protein 7
s
1.58
ATG12. Forms intermediate conjugates with GABARAPL1 (GABARAPL2, GABARAP or
MAP1ALC3). Formation of the final GABARAPL1-PE conjugate is essential for autophagy
o
IPI00561733 29 kDa protein
s
5.11
o
IPI00562229 14 kDa protein
ns
11.57
A proteinase activates the inhibitor by specific proteolysis in the bait region, which, by an
unknown mechanism leads to reaction at the cysteinyl-glutamyl internal thiol ester site and
to a conformational change, whereby the proteinase is trapped and/or covalently bound to
o
IPI00564327 Murinoglobulin 2
po
0.82
the inhibitor. While in the tetrameric proteinase inhibitors steric inhibition is sufficiently
strong, monomeric forms need a covalent linkage between the activated glutamyl residue
of the original thiol ester and a terminal amino group of a lysine or another nucleophilic
group on the proteinase, for inhibition to be effective
o
IPI00567122 17 kDa protein
s
14.12
o
IPI00758468 Pgcp protein
po
5.3
o
IPI00777596 393 kDa protein
s
0.03
o
IPI00778430 37 kDa protein
s
6.73
o
IPI00778633 Apolipoprotein H
s
4.93
o
IPI00781465 29 kDa protein
s
5.3
s
3.00
po
19.17
s
10.08
po
2.27
INTER-ALPHA-INHIBITOR H4 HEAVY
o
o
IPI00188541.3
o
o
IPI00188731.1 CD48 ANTIGEN PRECURSOR.
o
o
IPI00189813.1 ACTIN, ALPHA SKELETAL MUSCLE.
o
o
IPI00189981.1
CHAIN.
PROTHROMBIN PRECURSOR
(FRAGMENT).
Carboxypeptidase that may play an important role in the hydrolysis of circulating peptides
Ligand for CD2. Might facilitate interaction between activated lymphocytes. Probably
involved in regulating T-cell activation
Actins are highly conserved proteins that are involved in various types of cell motility and
are ubiquitously expressed in all eukaryotic cells
Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and
activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C
o
o
IPI00192302.2 99 KDA PROTEIN.
s
2.48
Multifunctional protein found in plasma, ascitic fluid, cerebrospinal fluid, and urine and on
o
o
IPI00194097.5
VITAMIN D-BINDING PROTEIN
PRECURSOR.
the surface of many cell types. In plasma, it carries the vitamin D sterols and prevents
po
22.69
polymerization of actin by binding its monomers. DBP associates with membrane-bound
immunoglobulin on the surface of B-lymphocytes and with IgG Fc receptor on the
membranes of T-lymphocytes
o
o
IPI00200640.1
o
o
o
ISOFORM 1 OF MUCIN AND CADHERIN-
po
4.06
IPI00202440.3 IGH-1A PROTEIN.
s
17.48
o
IPI00204993.1 SIMILAR TO SLIT-LIKE 2.
s
4.16
o
o
IPI00209782.4 SIMILAR TO VOMEROMODULIN.
s
13.10
o
o
IPI00210120.2 AA1018.
s
9.59
o
o
IPI00211075.1 Serine protease inhibitor A3N precursor
po
7.66
o
o
IPI00211648.1
LIKE PROTEIN PRECURSOR.
NEUTRAL AND BASIC AMINO ACID
TRANSPORT PROTEIN RBAT.
Acts as a calcium-dependent cell adhesion protein
The single human alpha1-antichymotrypsin gene (SERPINA3) is represented by a cluster
of 6 individual rat paralogs
Involved in the high-affinity sodium-independent transport of cystine and neutral and
po
6.44
dibasic amino acids (system B(0,+)-like activity). May function as an activator of SLC7A9
and be involved in the high-affinity reabsorption of cystine in the kidney proximal tubule
A proteinase activates the inhibitor by specific proteolysis in the bait region, which, by an
unknown mechanism leads to reaction at the cysteinyl-glutamyl internal thiol ester site and
o
o
IPI00212666.1
ISOFORM 1 OF MURINOGLOBULIN-1
PRECURSOR.
to a conformational change, whereby the proteinase is trapped and/or covalently bound to
po
9.28
the inhibitor. While in the tetrameric proteinase inhibitors steric inhibition is sufficiently
strong, monomeric forms need a covalent linkage between the activated glutamyl residue
of the original thiol ester and a terminal amino group of a lysine or another nucleophilic
group on the proteinase, for inhibition to be effective
o
o
IPI00212753.4 13 KDA PROTEIN.
ns
23.28
Preferential cleavage of Arg-|-Xaa bonds in small molecule substrates. Highly selective
o
o
IPI00231193.3 NERVE GROWTH FACTOR, GAMMA.
p
8.68
action to release kallidin (lysyl-bradykinin) from kininogen involves hydrolysis of Met-|-Xaa
or Leu-|-Xaa
o
o
IPI00231767.4 TRIOSEPHOSPHATE ISOMERASE.
o
o IPI00231848.10
PRO-EPIDERMAL GROWTH FACTOR
PRECURSOR.
s
5.24
po
13.86
D-glyceraldehyde 3-phosphate = glycerone phosphate
EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro
and of some fibroblasts in cell culture
May play a role in cell cycle regulation during anaphase and/or telophase, in relation to the
o
o
IPI00325622.5 Serine/threonine-protein kinase 6
s
15.27
function of the centrosome/spindle pole region during chromosome segregation. Maybe
involved in microtubule formation and/or stabilization. May play a key role during tumor
development and progression
Ceruloplasmin is a blue, copper-binding (6-7 atoms per molecule) glycoprotein. It has
o
o
IPI00325847.3 GPI-ANCHORED CERULOPLASMIN.
po
13.56
ferroxidase activity oxidizing iron(II) to iron(III) without releasing radical oxygen species. It
is involved in iron transport across the cell membrane. May also play a role in fetal lung
development or pulmonary antioxidant defense
SERUM AMYLOID P-COMPONENT
o
o
IPI00327745.1
o
o
IPI00359024.2
o
o
IPI00361342.3 SIMILAR TO CLM3.
PRECURSOR.
EXTRA CELLULAR LINK DOMAINCONTAINING 1.
p
30.26
s
12.83
s
2.27
SAP is a precursor of amyloid component P which is found in basement membrane and
associated with amyloid deposits
Calcium-regulated, actin-modulating protein that binds to the plus (or barbed) ends of actin
o
o
IPI00363974.3 GELSOLIN.
s
12.42
monomers or filaments, preventing monomer exchange (end-blocking or capping). It can
promote the assembly of monomers into filaments (nucleation) as well as sever filaments
already formed
o
o
IPI00364039.3 RGD1311906 PROTEIN (FRAGMENT).
s
1.93
o
o
IPI00368397.2 BWK3.
s
9.34
o
o
IPI00369140.3 38 KDA PROTEIN.
s
15.43
o
o
IPI00370486.3 IG LAMBDA-2 CHAIN C REGION.
s
57.14
o
o
IPI00371830.3 SIMILAR TO PROTEASE INHIBITOR 16.
s
4.97
Beta-3-microglobulin is the beta-chain of major histocompatibility complex class I
molecules
Contains 1 Ig-like (immunoglobulin-like) domain
Probable FAD-dependent amine oxidase secreted by the kidney, which circulates in blood
and modulates cardiac function and systemic blood pressure. Degrades catecholamines
o
o
IPI00372792.1
PLASMA PROTEASE C1 INHIBITOR
PRECURSOR.
po
18.85
such as dopamine, norepinephrine and epinephrine in vitro (By similarity). Lowers blood
pressure in vivo by decreasing cardiac contractility and heart rate and preventing a
compensatory increase in peripheral vascular tone, suggesting a causal link to the
increased plasma catecholamine and heightened cardiovascular risk
o
o
o
o
IPI00382185.2 DA1-24.
IPI00382202.1
ISOFORM 2 OF HAPTOGLOBIN
PRECURSOR.
s
2.68
Haptoglobin combines with free plasma hemoglobin, preventing loss of iron through the
po
7.09
kidneys and protecting the kidneys from damage by hemoglobin, while making the
hemoglobin accessible to degradative enzymes
o
o
IPI00388002.2 LOC500180 PROTEIN.
s
13.68
o
o
IPI00390968.3 14 KDA PROTEIN.
ns
27.48
o
o
IPI00392208.3 15 KDA PROTEIN.
s
9.63
o
o
IPI00392266.3 11 KDA PROTEIN.
ns
32.00
o
o
IPI00393340.2 LOC683313 PROTEIN.
s
3.99
o
o
IPI00393521.2
o
o
o
LEUCINE-RICH ALPHA-2-
s
4.22
IPI00471669.1 GLYPICAN 4.
s
7.18
o
IPI00476292.3 121 KDA PROTEIN.
s
1.23
o
o
IPI00555216.1 IGHA_MAPPED PROTEIN.
s
5.13
o
o
IPI00556973.1 15 KDA PROTEIN.
s
27.01
o
o
IPI00558944.3 12 KDA PROTEIN.
ns
25.23
o
o
IPI00559142.1 PLEXIN DOMAIN CONTAINING 2
s
2.26
o
o
IPI00559877.2 12 KDA PROTEIN.
s
16.67
o
o
IPI00563737.1 14 KDA PROTEIN.
ns
19.20
o
o
IPI00563941.3 13 KDA PROTEIN.
ns
16.24
o
o
IPI00567155.2 14 KDA PROTEIN.
s
11.11
o
o
IPI00568528.1 85 KDA PROTEIN.
s
1.87
o
o
IPI00763182.1
s
58.00
o
o
IPI00785608.1 ALPHA-2U GLOBULIN.
s
13.26
o
IPI00188142.1 ASPARTOACYLASE (AMINOACYLASE) 3.
s
4.08
o
IPI00188688.1 HISTONE H2A.
s
21.54
GLYCOPROTEIN 1.
SIMILAR TO URINARY PROTEIN 3
PRECURSOR.
Belongs to the glypican family
Belongs to the lipocalin family
o
IPI00188879.2 LAMIN C2.
o
IPI00189714.4
o
IPI00190240.1 RIBOSOMAL PROTEIN S27A.
o
IPI00191738.1
o
IPI00191767.5 TRIOSEPHOSPHATE ISOMERASE
o
IPI00193169.1
SIMILAR TO COLLAGEN ALPHA-1(XII)
CHAIN PRECURSOR.
GLUTAMATE--CYSTEINE LIGASE
REGULATORY SUBUNIT
ISOFORM 1 OF WAP FOUR-DISULFIDE
CORE DOMAIN PROTEIN 2 PRECURSOR.
s
2.60
s
1.66
s
10.26
s
5.59
s
15.79
s
7.74
This ribosomal protein is synthesized as a C- terminal extension protein (CEP) of ubiquitin
ATP + L-glutamate + L-cysteine = ADP + phosphate + gamma-L-glutamyl-L-cysteine
D-glyceraldehyde 3-phosphate = glycerone phosphate
Contains 2 WAP domains
Plays a role in formation of mast cell secretory granules and mediates storage of various
compounds in secretory vesicles. Required for storage of some proteases in both
connective tissue and mucosal mast cells and for storage of granzyme B in T lymphocytes.
o
IPI00200683.1
SIMILAR TO PLASMA RETINOL-BINDING
PROTEIN PRECURSOR.
O
3.75
Plays a role in localizing neutrophil elastase in azurophil granules of neutrophils. Mediates
processing of MMP2. Plays a role in cytotoxic cell granule-mediated apoptosis by forming a
complex with granzyme B which is delivered to cells by perforin to induce apoptosis.
Regulates the secretion of TNF- alpha and may also regulate protease secretion. Inhibits
bone mineralization
o
IPI00204818.2 PROTEIN S100-A6.
o
IPI00205201.5
o
IPI00211336.1
o
IPI00230862.7
SIMILAR TO SIALATE OACETYLESTERASE PRECURSOR.
SIMILAR TO SH3 DOMAIN BINDING
GLUTAMIC ACID-RICH PROTEIN-LIKE 3.
PRO-EPIDERMAL GROWTH FACTOR
PRECURSOR.
s
8.99
po
2.21
s
po
Catalyzes the removal of O-acetyl ester groups from position 9 of the parent sialic acid, Nacetylneuraminic acid
10.3
3.42
EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro
and of some fibroblasts in cell culture
o
IPI00231118.4 CALBINDIN.
s
5.00
Buffers cytosolic calcium. May stimulate a membrane Ca(2+)-ATPase and a 3',5'-cyclic
nucleotide phosphodiesterase
C9 is the final component of the complement system to be added in the assembly of the
o
IPI00231423.6 C9 PROTEIN.
po
6.35
membrane attack complex. It is able to enter lipid bilayers, forming transmembrane
channels
Calcium/phospholipid-binding protein which promotes membrane fusion and is involved in
o
IPI00231615.4 ANNEXIN A1.
s
15.65
exocytosis. This protein regulates phospholipase A2 activity. It seems to bind from two to
four calcium ions with high affinity
o
IPI00231848.10 TRANSTHYRETIN PRECURSOR.
o
IPI00324380.3
o
IPI00324445.3 GASTRICSIN PRECURSOR.
o
IPI00339126.2
SIMILAR TO ALPHA 3 TYPE VI
COLLAGEN ISOFORM 2 PRECURSOR.
POTASSIUM VOLTAGE-GATED
CHANNEL SUBFAMILY H MEMBER 1.
o
IPI00358286.4 13 KDA PROTEIN.
o
IPI00358707.3
o
IPI00360196.4 SIMILAR TO CALMODULIN 4.
ZINC FINGER, FYVE DOMAIN
CONTAINING 9
po
3.88
po
43.54
s
3.06
EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro
and of some fibroblasts in cell culture
Thyroid hormone-binding protein. Probably transports thyroxine from the bloodstream to
the brain
Hydrolyzes a variety of proteins
Pore-forming (alpha) subunit of voltage-gated non- inactivating delayed rectifier potassium
po
1.35
channel. Channel properties may be modulated by cAMP and subunit assembly. Mediates
IK(NI) current in myoblasts
ns
13.33
s
2.24
s
15.65
s
1.70
s
5.69
SERINE (OR CYSTEINE) PEPTIDASE
o
IPI00372372.2 INHIBITOR, CLADE C (ANTITHROMBIN),
MEMBER 1.
o
IPI00361798.2
INSULIN-LIKE GROWTH FACTOR
BINDING PROTEIN 7.
Contains 1 IGFBP N-terminal domain
o
IPI00363760.4 SORTING NEXIN 8.
s
3.28
o
IPI00365395.2 EPHRIN-B2 PRECURSOR.
s
10.42
o
IPI00366848.3
s
2.49
o
IPI00372372.2 ALPHA-2U GLOBULIN.
s
2.58
o
IPI00387666.3 17 KDA PROTEIN.
s
17.65
o
IPI00389419.2 IGHA_MAPPED PROTEIN.
s
2.30
o
IPI00389806.4 LOC498793 PROTEIN.
s
2.74
o
IPI00391528.2 13 KDA PROTEIN.
s
10.43
o
IPI00400746.1
po
0.72
o
IPI00421295.2
s
5.91
o
IPI00421832.1 DERMCIDIN.
s
22.73
o
IPI00554226.1
s
4.38
o
IPI00557120.2 12 KDA PROTEIN.
ns
13.76
o
IPI00557643.2 13 KDA PROTEIN.
ns
11.21
o
IPI00557941.3 15 KDA PROTEIN.
s
10.87
SIMILAR TO NONSPECIFIC CYTOTOXIC
CELL RECEPTOR PROTEIN 1.
PROTEIN C1ORF9 HOMOLOG
PRECURSOR
ACIDIC MAMMALIAN CHITINASE
PRECURSOR.
COMPLEMENT COMPONENT FACTOR HLIKE 1.
Belongs to the lipocalin family
Single-pass type I membrane protein
Degrades chitin and chitotriose. May participate in the defense against nematodes and
other pathogens
o
IPI00559211.2
o
SIMILAR TO URINARY PROTEIN 3
s
22.92
IPI00559410.1 14 KDA PROTEIN.
s
10.53
o
IPI00559639.2 12 KDA PROTEIN.
ns
10.19
o
IPI00560431.2 13 KDA PROTEIN.
ns
15.13
o
IPI00561466.1 12 KDA PROTEIN.
s
9.17
o
IPI00562105.2 12 KDA PROTEIN.
ns
17.31
o
IPI00562465.2 14 KDA PROTEIN.
ns
12.90
o
IPI00562653.1 CATHEPSIN B PREPROPROTEIN.
s
3.24
o
IPI00564011.2 12 KDA PROTEIN.
ns
16.67
o
IPI00564145.2 12 KDA PROTEIN.
ns
15.60
s
66.00
PRECURSOR.
SIMILAR TO PROSTATIC STEROID-
o
IPI00763182.1 BINDING PROTEIN C1 CHAIN
PRECURSOR.
o
IPI00779863.1 24 KDA PROTEIN.
s
12.56
o
IPI00779864.1 42 KDA PROTEIN.
s
12.56
IPI00189819.1 ACTIN, CYTOPLASMIC 1.
s
4.80
o
Mediates the binding, internalization, and catabolism of lipoprotein particles. It can serve as
o
IPI00190701.5 APOLIPOPROTEIN E PRECURSOR.
s
3.53
a ligand for the LDL (apo B/E) receptor and for the specific apo-E receptor (chylomicron
remnant) of hepatic tissues
o
IPI00191789.1 HISTIDINE-RICH GLYCOPROTEIN.
s
9.61
o
IPI00198667.7 CLUSTERIN PRECURSOR.
p
8.28
o
IPI00200792.3 56 KDA PROTEIN.
s
9.27
o
IPI00201276.5
po
2.84
o
IPI00201622.3
LYSOSOMAL ACID PHOSPHATASE
PRECURSOR.
GROWTH-ARREST-SPECIFIC PROTEIN 6
PRECURSOR.
o
IPI00204217.2 58 KDA PROTEIN.
o
IPI00204808.5 MEPRIN A SUBUNIT BETA PRECURSOR.
o
IPI00205568.1 KALLISTATIN.
o
IPI00205907.5
o
po
1.78
po
2.13
s
12.77
po
5.56
IPI00207146.1 ZERO BETA-1 GLOBIN.
s
8.16
o
IPI00215382.4 IG KAPPA CHAIN V REGION S211.
s
13.76
o
IPI00327182.7 48 KDA PROTEIN
s
3.13
o
o
IPI00327469.1
IPI00363899.5
ALPHA-2-HS-GLYCOPROTEIN
PRECURSOR.
SIMILAR TO ALPHA-FETOPROTEIN
PRECURSOR.
A phosphate monoester + H(2)O = an alcohol + phosphate
implicated in cell growth and survival, cell adhesion and cell migration. Plays a role in
thrombosis by amplifying platelet aggregation and secretion in response to known agonists
1.58
ASSOCIATED LIPOCALIN PRECURSOR.
membranes and hydrophobic proteins. It has been associated with programmed cell death
Ligand for tyrosine-protein kinase receptors AXL, TYRO3 and MER whose signaling is
s
NEUTROPHIL GELATINASE-
It is known to be expressed in a variety of tissues and it seems to be able to bind to cells,
Hydrolysis of protein and peptide substrates preferentially on carboxyl side of hydrophobic
residues
Could inhibit both insulin-receptor tyrosine kinase activity and insulin-stimulated receptor
po
5.32
autophosphorylation and, concomitantly, antagonize the mitogenic effect of the hormone in
cultured rat hepatoma cells
po
3.86
Binds estrogens, fatty acids and metals
o
IPI00365752.4 COAGULATION FACTOR XII.
s
1.66
o
IPI00366226.3
s
2.21
o
IPI00367761.4 ALPHA-2U GLOBULIN.
s
11.00
o
IPI00368403.3 SIMILAR TO FILAGGRIN 2.
s
1.28
o
IPI00371986.2 PLAKOPHILIN-1.
s
2.06
o
IPI00373745.3
s
6.64
o
IPI00392753.2 11 KDA PROTEIN.
ns
8.34
o
IPI00400749.3
s
3.33
o
IPI00476458.3
s
5.26
o
IPI00558996.2 48 KDA PROTEIN.
s
2.41
o
IPI00560188.2 14 KDA PROTEIN.
s
9.30
o
IPI00564368.2 11 KDA PROTEIN.
ns
24.24
o
IPI00568547.3 ANTHRAX TOXIN RECEPTOR.
s
1.56
s
42.74
GLUCOSAMINE (N-ACETYL)-6SULFATASE.
SIMILAR TO TRIGGERING RECEPTOR
EXPRESSED ON MYELOID CELLS 1.
COXSACKIE VIRUS AND ADENOVIRUS
RECEPTOR-LIKE 1.
GLUTATHIONE PEROXIDASE 3
PRECURSOR.
SIMILAR TO PROSTATIC STEROID-
o
IPI00767210.1 BINDING PROTEIN C1 CHAIN
PRECURSOR.
Contains 1 peptidase S1 domain
Belongs to the lipocalin family
Protects cells and enzymes from oxidative damage, by catalyzing the reduction of
hydrogen peroxide, lipid peroxides and organic hydroperoxide, by glutathione
C : concanavalin A
J : Jacalin
W : WGA
g : N-glycoproteins confirmed by GlycoSuiteDB,
O : O-glycoproteins confirmed by GlycoSuiteDB
p : The term 'Probable' is stronger than the qualifier 'Potential' and there must be at least some experimental evidence
po : The term 'Potential' indicates that there is some logical or conclusive evidence that the given annotation could apply
s : potential glycoproteins predicted by NetNGlyc 1.0.
NS : Not signal