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CURRICULUM VITAE Betsy Clement Herold, M.D. Office Address: Albert Einstein College of Medicine 1300 Morris Park Avenue Forchheimer 702 Bronx, NY 10461 Phone: (718) 430-2974 Fax: (718) 430-8627 Email: [email protected] ACADEMIC APPOINTMENTS 6/2009Tenure, Albert Einstein College of Medicine, Yeshiva University 10/2007Professor of Pediatrics, Microbiology & Immunology, and Obstetrics & Gynecology and Women’s Health Vice Chair for Research Development, Dept. of Pediatrics Albert Einstein College of Medicine 1/05-10/07 Professor with Tenure Department of Pediatrics Mount Sinai School of Medicine 1/06-10/07 Professor of Microbiology Mount Sinai School of Medicine 3/02-10/07 Chief, Division of Pediatric Infectious Diseases Mount Sinai School of Medicine New York, NY 1/00-12/05 Associate Professor of Microbiology Mount Sinai School of Medicine New York, NY 7/98-12/04 Associate Professor of Pediatrics Mount Sinai School of Medicine New York, NY 7/92-6/98 Assistant Professor of Pediatrics and Virology University of Chicago Chicago, IL HOSPITAL APPOINTMENTS 10/2007Pediatrics, Children’s Hospital at Montefiore 7/98-10/07 Pediatrics, Mount Sinai Medical School and Hospital 7/92-6/98 Assistant Professor in Pediatrics, The University of Chicago Children's Hospital Chicago, Illinois 7/90-6/92 Clinical Associate (Track V): University of Chicago 7/85-6/90 Staff Physician: Children’s Memorial Hospital, Chicago, Illinois EDUCATION 1974-1978 1978-1982 Brown University, Providence, RI B.A., Biology University of Pennsylvania Medical School, Philadelphia, PA, M.D. April, 2010 Herold, Betsy Clement POSTDOCTORAL TRAINING 7/90-6/92 Research Associate/Postdoctoral Fellow, Department of Microbiology/ Immunology, Northwestern University, Chicago, IL 7/87-6/90 Fellow, Pediatric Infectious Diseases, Children's Memorial Hospital, Chicago 7/86-6/87 Research Postdoctoral Fellow, Hagedorn Research Laboratory, Gentofte, Denmark 7/85-6/86 Chief Resident in Pediatrics, Children's Memorial Hospital, Chicago, IL 7/82-6/85 Internship and Residency in Pediatrics, Children's Memorial Hospital, Northwestern University, Chicago, IL CERTIFICATION 1983 National Board of Medical Examiners 1986 American Board of Pediatrics 1997-2004 Pediatric Infectious Diseases, American Board of Pediatrics 2004-2011 Recertification, Pediatric Infectious Diseases, American Board of Pediatrics LICENSURE 1982 1998 Illinois - 036-067247 New York: 210077-1 HONORS 1978 1981 1982 1995 1995 1996 1997 2003 2007-2010 2007-2010 Sigma XI, Brown University Alpha Omega Alpha Honor Medical Society, University of Pennsylvania Henry and Jacob Lowenberg Prize in Pediatrics, University of Pennsylvania Pediatric Infectious Disease Society Young Investigator Award Infectious Disease Society of America Burroughs Wellcome Young Investigator Award The U. of Chicago, Dept of Pediatrics, Outstanding Teacher Award Society for Pediatric Research American Pediatric Society Office of AIDS Research Scientific Advisory Council Pediatric Infectious Disease Society Council OTHER PROFESSIONAL APPOINTMENTS Professional Societies: 1997Society for Pediatric Research 2003American Pediatric Society 1993American Society of Microbiology 1998 Infectious Disease Society of America 1988 Pediatric Infectious Disease Society Elected: Nominations and Awards Committee: 2005-2007 Council; 2007-2010 Chair, Membership Committee: 2008-10 Research Affairs Committee: 20102007 American Society of Transplantation Infectious Disease Community of Practice Editorial Boards 2010-2012 American Journal of Reproductive Immunology Study Sections and NIH related activities: 1996-1998 Leukemia Research Foundation National Grant Review Committee 1999 Ad Hoc Member NIHNIAID STD Center Grants 2002 Ad Hoc Member NIH/NICCHD Special Study Section PO1 Review 2002 Ad Hoc Member, NIH/CIPRA Grant Review 2003 Ad Hoc Member, NIDCR Mucosa HIV RFA Study Section 2 April, 2010 2004 2004 2005 2005 2005 2006 2008 2009-10 Herold, Betsy Clement NIAID SBIR/STTR Special Emphasis Panel NIH Advisory Panel on Cytokines for Topical Microbicide Development NIH, Office of AIDS Research, Invited Consultant: “Rationalizing Microbicide Preclinical Assessment”, Washington, D.C. Ad Hoc Member, NIH Oral Mucosal HIV RFA Study Section Ad Hoc Member, NIH/NIAID ACE Study Section NIAID Center for AIDS Research (CFAR) Study Section Viral Pathogenesis Special Emphasis Panel, Chairperson (Jan. 8, 2008) Highly Innovative Tactics to Interrupt Transmission of HIV, Special Emphasis Panel Other National and International Committees: 1997 International Herpes Virus Workshop Steering Committee 1997 International Herpes Virus Workshop Abstract Reviewer 1997 Co-chair Neonatal Infectious Diseases Session, SPR 1998 Reviewer, SPR abstracts; Section Neonatal Infectious Diseases 2001 NIAID Office of Aids Research, Invited Participant: Workshop on Microbicide Research 2002 Moderator, Infectious Disease Session, SPR 2002 Convener: American Society of Virology: Viral Entry Session 2002 Infected Disease Society of America: Invited Panelist 2003-2006 SPR Student Research & House Officer Award Selection Committee 2004 Invited Consultant: Next Steps in Microbicide Development: Funders Consultation, April 2004, Alliance for Microbicide Development and the Bill & Melinda Gates Foundation, Washington, D.C. 2004 Moderator, AIDS Session, Infectious Disease Society of America 42nd Annual Meeting, October, 2004, Boston, MA 2004 Site Review; Microbiology Laboratories St. Christopher’s Hospital for Children, Phila., PA 2005-2006 American Academy of Pediatrics Faculty Member, PREP: The Course 2005 HIV Management 2005: the New York Course, Invited Faculty 2005 Reviewer, SPR Abstracts; Section: Infectious Diseases 2005 Microbicides 2006: Scientific Advisory Committee 2005International Partnership for Microbicides Advisory Board 2006PIDS Taskforce: “How do ID Sections Pay for Themselves” 2006 “Development of Standardized Microbicide Toxicity Tables for Clinical Trials” Invited participant 2007NIH, Microbicides Scientific Advisory Committee 2008 HIV Management 2009: the New York Course, Invited Faculty 2008 UCSF Advances and Controversies in Clinical Pediatrics, Invited Faculty 2008-current Chair, New York Organ Donor Network Infectious Disease Workgroup 2006-09 International Partnership for Microbicides (IPM), Advisory Committee 2008Global Campaign for Microbicides, Advisory Panel 2010 Microbicides 2010 Scientific Advisory Committee MAJOR INSTITUTIONAL COMMITTEE ASSIGNMENTS: University of Chicago: 1993-1998 Member, Committee on Virology 1994-1998 Institutional Biosafety Committee 1994-1998 Committee on Virology, Graduate Student Admissions Committee 1994-1998 Committee on Virology, Graduate Student Thesis (6 students) 3 April, 2010 Herold, Betsy Clement 1995-1998 1995-1998 1995-1998 1996-1998 1997-1998 Director, Pediatric Infectious Diseases Fellowship Training Program Pediatric Representative, Committee on Infection Control and Epidemiology Residency Selection Committee Nephrology Search Committee Committee to Review Developmental Biology Program Mount Sinai School of Medicine 1998-present Infectious Diseases/Clinical Microbiology Coordinating Committee 1999-2003 Institutional Biosafety Committee 1999-2001 Department of Pediatrics Search Committee for Hematology-Oncology Division Head 1999-2001 Department of Microbiology Search Committee for Virologist 1999-2007 Pediatric Research Day Steering Committee 1999-2007 Internship Applicant Committee 2000-2007 MSTP and Graduate School Admissions Interviewer 2000-2007 Pediatric Residency Advisory Board 2000-2003 Ph.D. Thesis Advisory Committee, Laura Gillim 2000-2007 General Clinical Research Center Advisory Committee 2002-2007 Morbidity and Mortality Committee 2002-2007 Infection Control Committee; Bioterrorism subcommittee 2002-2007 Pharmacy and Therapeutics Committee 2003-2004 Bioterrorism Preparedness Coordinator 2003-2007 Search Committee, Medicine/Pediatrics Program Director 2004-2005 Departmental Pediatric Fellowship Core Curriculum Committee, Director 2004-2005 Clinical Practice and Utilization - Antifungals Review, Chair 2004-2007 Dean’s Lecture Ad Hoc Committee 2004-2006 Pediatric Research Day; Director of Steering Committee 2005-2006 Search Committee/ Chair Dept of Ophthomology 2006-2007 Chair, Search Committee, Chief, Division of Hematology-Oncology Division Chief Albert Einstein College of Medicine/Montefiore Medical Center 2008Pediatric Departmental Internal Grant Award Committee-Chair 2008Pediatric Research Day Committee-Chair 2008Transplantation Translational Research Working Group 2008STD Prevention Research Working Group-Director 2008CERC Search Committee 2009Committee on Appointments and Promotions to Professor 2010 Tenure Committee REVIEWER: Journal of General Virology Journal of Infectious Diseases Journal of Virology PLoSOne Pediatric Infectious Disease Journal Journal of Pediatrics Pediatrics JAMA Antiviral Research Virology AIDS JCI Pediatric Transplantation 4 April, 2010 Herold, Betsy Clement Nature Mucosal Immunology PLoS Pathogen TRAINING RECORD Name Susan I Gerber, M.D Level of Learner Fellow Role in Training Lilly H Immergluck,M.D. Fellow Veronica Mas Casullo Fellow Mentor: American Social Health Association Postdoctoral Research Fellow 1999-2001 2005-present Instructor, Mount Sinai School of Medicine Natalia Cheshenko Post-doc Mentor 2000-present Sara Sinha, M.D. Medical student Mentor: National Student Research Forum Honoree; 1999-2003 Assistant Professor, AECOM Fellow (Ob-Gyn) Yale Minnie John, M.D. Fellow NIH T32 Mentor Program Director (PID) 2002-2004 Ana Tuyama, M.D. Postdoc Mentor 2002-2005 Cindy Goldberg, M.D. Fellow Mentor Program Director (PID) 2002-2005 Mount Kisco Pediatrics Maria Josefina Carlucci Postdoc Mentor 2003-2006 Rebecca Madan, M.D. Fellow NIH T32 Mentor Program Director (PID) 7/04-7/07 Universidad de Buenos Aires Assist Prof. AECOM Esra Fakioglu, M.D. Fellow Mentor 7/05-7/07 Assist Prof, AECOM Sarju Patel Mentor 8/04-2006 Vikas Shende, PhD Pedro Mesquita, PhD Janie Trepanier, PhD Gail Shust, M.D. Manisha Patel, M.D. Martha Stefanidu, PhD Medical student Postdoc Postdoc Postdoc Fellow Fellow Postdoc Mentor Mentor Mentor Mentor NIH T32 Mentor Mentor 2006-2008 2007-present 2007-present 2007-2009 2008-present 2009- Doris Duke Fellow Clinical Research India Jenny George, M.D. Faculty Mentor/CRTP 2009- Mentor, NIH Physician Scientist Award Mentor: Pediatric Dept Chairmen Pediatric Career Physician Scientist Award 5 Inclusive Dates 1992-1996 1994-1996 Current Position Chicago Dept of Public Health Assistant Professor U. of Illinois Faculty, Long Island College Hospital Resident MSSM Faculty, MSSM April, 2010 Herold, Betsy Clement TEACHING ACTIVITIES 2010 2009200820072000-2006 2005-2007 2003 2003 1999-2007 1994-1998 1994-1997 Graduate Immunology, Course Lecturer Graduate Virology, Course Lecturer Microbiology Medical School Course Lecturer, AECOM Small Group Leader, Immunology, AECOM Course Director: Integrative Core Block, Year 1, MSSM Lecturer & Small Group Session Leader, PMHD, Year 1 MSSM Lecturer, Advanced Virology, MSSM Lecturer, Public Health and Epidemiology, Columbia University Lecturer, MDT Infectious Diseases Module, MSSM Lecturer, Animal Virology, spring quarter, U. of Chicago Lecturer, Medical Microbiology, U. of Chicago GRADUATE STUDENT THESIS ADVISORY COMMITTEES: 1994-1997 William Ogle, Ph.D. University of Chicago 1996-2000 Glenn Randall, Ph. D. University of Chicago 1999-2002 Laura Gillim, Ph.D. Mount Sinai 1999-2003 Jesus Vargas, Ph.D. Mount Sinai 1999-2002 Beverly Barham, Ph.D. Southern Illinois University 2003-2008 Jamie Potter Southern Illinois University 2006 Laura Glaser Mount Sinai GRANT SUPPORT Current Grants: U19AI076980 9/10/09 – 8/31/13 Intravaginal Ring Delivery of Safe & Effective Microbicides to Prevent HIV & HSV Role: PI and Project Leader, Project 1 AI061679 RO1 Role of calcium signaling in HSV-2 invasion Role: PI 2/15/05-1/31/11 AI065309 RO1 6/15/05-5/31/2015 Impact of HSV-2 on female genital tract mucosal immunity & HIV infection Role: PI R21AI079763 Novel Mucosal Models Predictive of Microbicide Safety Role: PI 09/01/08-8/31/10 1UO1 AI068633 3/1/06-2/28/13 Microbicides Trial Leadership Network PI: Sharon Hillier, Magee-Women’s Health Corporation Role: Science Development Subcommittee Chair: Safety Biomarkers U19 AI70202 (PI: B Ramratnam, Brown U.) siRNA as Vaginal Microbicides Role: Project Leader (P2): “Novel siRNA Microbicides to Prevent and Treat HSV 6 9/30/06-8/31/10 April, 2010 Herold, Betsy Clement UO1 AI 69551-01 (PI: Marla Keller) Microbicide effects on efficacy, safety, innate immunity PI: Marla Keller Role: Co-investigator 9/1/05-2/28/11 RO1AI076169 Antiviral lectins as microbicides PI Kenneth Palmer, U. of Louisville Role: Co-investigator 04/15/08-3/31/12 U01AI035004 8/1/93-12/31//2012 Womens Interagency HIV Study Role: Co-I Supplementary study PI Mucosal immunity in the genital tract in HIV Infected & uninfected women R21AI 08341801 Innate resistance to mucosal HSV infection in humans PI: Christine Posavad, U. of Washington Role: Co-investigator R01 PA07356 Expanded Phase II Trial of carraguard for prevention of HPV PI: Mark Einstein (Albert Einstein College of Medicine) Role: Co-I 7/23/09-6/30/11 6/1/10-3/31/15 R41AI091246 Cotton Rat: Animal model predictive of clinical responsiveness to HSV vaccines 7/0110-6/30/12 CONRAD: Evaluation of Safety of Cellulose Sulfate 2008-2010 International Partnership for Microbicides “Ex vivo Assessment of Pharmacodynamics of Dapivirine: 2009-2011 Completed Grants: 1986-1987 1992-1994 1993-1994 Role of Immune Complexes in Type 1 Diabetes Juvenile Diabetes Foundation Research Grant Role: PI Heparan Sulfate Receptors for HSV Children’s Research Foundation Award, The University of Chicago Role: PI Entry for HSV-1 an HSV-2 Louis H. Block Fund for Basic Research and Advanced Study Award University of Chicago 7 April, 2010 Herold, Betsy Clement 1989-1994 1994-1997 1995-1997 1995-1999 1995-2000 1997-2000 1995-2005 1999-2004 2000-2005 2001-2006 2003-2007 2006-2007 2006-2008 2002-2007 2006-2009 Role: PI Role of Herpes Virus Complement Binding Proteins Physician Scientist Award, NIAID, NIH (K11 AI00945-06) Role: PI Viral Receptors for HSV-1 and HSV-2 American Cancer Society Jr. Faculty Award Role: PI Heparan Sulfate Receptors for HSV-1 and HSV-2 Ronald McDonald Foundation Research Grant Role: PI Defining the pathway of HSV Invasion Infectious Disease Society of America Burroughs Wellcome Young Investigator Award in Virology Role: PI Glycosaminoglycan receptors for HSV-1 and HSV-2 R29AI 36318 Role: PI Host and virus factors regulating herpes simplex virus entry American Cancer Society Research Project Grant PI-R. Roller, University of Iowa Role: Co-investigator Topical microbicides for prevention of STD’s/HIV 2-PO1 AI37940 (PI: L. Stanberry,UT, Galveston) Role: Project Leader, Project 2 Deans’ Research Award (PI Betsy Herold) Development of the Adolescent Health Center as Strategic Site for Multidisciplinary Research for the Prevention and Treatment of STD NIH T-32AI 07623 (PI: M. Klotman) Physician Scientist Research Training Pathogenesis of Viral Diseases Role: Co-PI PO1-HD41763-01 (PI: Mary Klotman) Development of dimandelic acid as a topical microbicide for HIV & HSV Role: Project leader for Project 2 Co-investigator for Project 4 U54 AI057158 (PI: WI Lipkin, Columbia U.) Northeast Biodefense Center Career Development Award Role: Mentor CDA-2 Prospective comparative study of the humoral & CMI responses to the trivalent subviron influenza vaccine in pediatric liver transplant recipients Astrellas Pharmaceuticals Retrospective Study of Fungal Infections in Transplantation Recipients R41AI069659-01NIH/STTR PI: Michael Oldham, YASO Biotechnology Inc. Development of SAMMA based vaginal microbicides Role: Subsite PI CONRAD, Eastern Virginia Medical School Evaluation of candidate topical microbicides for anti-HSV activity Role: PI R41AI071451-01 NIH/STTR PI: Greg Prince, Virion Systems Novel Model to Predict Safety and Efficacy of Microbicides Role: Co-PI 8 April, 2010 Herold, Betsy Clement 2002-2009 2009 PO1HD43733/ 8U19 AI077549 (PI: Betsy Herold) Multitargeted Microbicide Combinations to Block HIV R43AI081552-01 (PI: Thomas Smith) Sustained release acyclovir for prophylaxis of genital herpes Role; Co-investigator PUBLICATIONS: PEER-REVIEWED PUBLICATIONS: 1) Herold BC, Davis AT, Arroyave C, et al. Cryoprecipitates in Kawasaki Syndrome: Association with coronary artery aneurysms. Pediatric Infectious Diseases, 7:255-258, 1988. 2) Herold BC and Shulman ST. Poststreptococcal arthritis. Pediatric Infectious Diseases, 7: 682, 1988. 3) Arditi M, Herold BC, Yogev R. Cefuroxime Failure in Haemophilus Influenzae Meningitis: Case report and review of the literature. Pediatrics, 84: 132-135, 1989. 4) Herold BC, WuDunn D, Soltys N and Spear PG. Glycoprotein C of herpes simplex virus type 1 plays a principal role in the adsorption of virus to cells in infectivity. Journal of Virology, 65:10901098, 1991. 5) Spear PG, Shieh M-T, Herold BC, WuDunn D, and Koshy TI: Heparan sulfate glycosaminoglycans as primary cell surface receptors for herpes simplex virus. Advances in Experimental Medicine and Biology 313:341-353, 1992. 6) Herold BC, Visalli R, Susmarski N, Brandt C, and Spear PG. Glycoprotein C (gC)-independent binding of herpes simplex virus to cells requires cell surface heparan sulfate and virion glycoprotein B (gB). J. of Gen Virol, 75: 1211-1222, 1994. 7) Herold BC, Spear PG. Neomycin differentiates gC-dependent and gB-dependent interactions with heparan sulfate proteoglycans and inhibits subsequent steps in herpes simplex virus infectivity. Virology, 203: 166-171, 1994. 8) Herold BC, Gerber S, Polonsky T, Belval BJ, Shaklee PN, Holme K. Identification of structural features of heparin required for inhibition of herpes simplex virus type 1 binding. Virology, 206: 1108-1116, 1995. 9) Gerber SI, Belval BJ, and Herold BC. Differences in the role of glycoprotein C of HSV-1 and HSV-2 in viral binding may contribute to serotype differences in cell tropism. Virology, 214: 2939, 1995 10) Herold BC, Gerber SI, Belval BJ, Siston A, and Shulman N. Differences in the susceptibility of HSV-1 and HSV-2 to modified heparin compounds suggest serotype differences in viral entry. J. Virol., 70: 3461-3469, 1996 11) Herold BC, Sullivan C, Grayhack JJ, Dorning M, Daum RS. Toxic shock syndrome complicating orthopedic manipulations of the bone. J. Bone and Joint Surgery, 78A: 903-906, 1996. 12) Immergluck LC, Ben-Ami T, and Herold BC. Thymic Abscess Caused by Methicillin-Resistant Staphylococcus Aureus. Pediatric Infectious Diseases, 15:96-97, 1996. 9 April, 2010 Herold, Betsy Clement 13) Zahraa J, Herold BC, Abrahams C, Johnson DJ. Bronchiolitis obliterans: An unusual lung finding in a child with acquired immunodeficiency syndrome. Pediatric Infectious Diseases, 15: 448-451, 1996. 14) Zahraa J, Johnson DJ, Lim-Dunham J, and Herold BC. Unusual features of osteo-articular tuberculosis. J Pediatrics, 129: 597-602, 1996. 15) Seferian E, and Herold BC. Polymicrobial bacteremia: a presentation of Munchäusen Syndrome-by-Proxy. Clinical Pediatrics, July: 419-422, 1997. 16) Roller RJ and Herold BC. Characterization of a BHK(TK-) cell clone resistant to postattachment entry by herpes simplex viruses 1 and 2. J. Virology, 71: 5805-5813, 1997. 17) Herold BC, Siston A, Bremer J, Kirkpatrick R, Fugedi P, Peto C, Wilbanks G, and Cooper M. Sulfated carbohydrate compounds prevent microbial adherence by sexually transmitted disease pathogens. Antimicrobial Agents and Chemotherapy, 41: 2776-2780, 1997. 18) Herold BC, Immergluck LC, Maranan M, Lauderdale DS, Gaskin R, Boyle-Vavra S, and Daum RS. Emergence of methicillin-resistant Staphylococcus aureus (MRSA) as a pediatric community-acquired pathogen. JAMA, 279:593-599, 1998. 19) Immergluck LC, Domowicz MS, Schwartz NB, and Herold BC. Viral and cellular requirements for entry of herpes simplex virus type 1 into primary neuronal cells. J. Gen. Virology, 79:549559, 1998. 20) Herold BC, Kirkpatrick R, Marcellino D, Travelstead A, Pilipenko V, Krasa H, Bremer J, Dong LJ, and Cooper MD. Bile salts: natural detergents for the prevention of sexually transmitted diseases. Antimicrobial Agents and Chemotherapy, 43: 745-51, 1999. 21) Qie L, Marcellino D, and Herold BC. Participation of tyrosine phosphorylation in herpes simplex viral entry. Virology 256: 220-27, 1999. 22) Herold BC, Bourne N, Marcellino D, Kirkpatrick R, Strauss D, Zanenveld LJD, Waller D, Anderson R, Chany C, Stanberry LR, and Cooper MD. Poly(sodium 4-styrenesulfonate): An effective candidate topical antimicrobial for the prevention of sexually transmitted diseases. J. Inf. Dis. 181: 770-3, 2000. 23) Oram RJ, Marcellino D, Strauss D, Gustafson E, Talarico CL, Root AK, Thompson K, Fingeroth JD, Crumpacker C, and Herold BC. Characterization of an acyclovir resistant herpes simplex type 2 strain isolated from a premature neonate. J. Inf. Dis. 181: (4) 1458-61, 2000. 24) Hendrickson BA, Guo J, Brown I, Dennis K, Marcellino D, Hetzel J, and Herold BC. Decreased vaginal disease and mortality in J chain-deficient mice following herpes simplex type 2 genital infection. Virology, 271: 155-62, 2000. 25) Anderson RA, Feathergill K, Diao X, Cooper M, Kirkpatrick R, Spear P, Waller DP, Chany C, Doncel GF, Herold B, Zaneveld LJD. Evaluation of poly(styrene-4-sulfonate) as a preventative agent for conception and sexually transmitted diseases. Journal of Andrology, 21: 862-75, 2000. 26) Mas Casullo V, Bottone E, Herold BC. Peptostreptococcus asaccharolyticus Renal Abscess: A rare cause of fever of unknown origin. Pediatrics, 107: E11, 2001. 10 April, 2010 Herold, Betsy Clement 27) Zaneveld LJD, Waller DP, Anderson RA, Chany C, Rencher WF, Feathergill K, Diao X-H, Doncel GF, Herold B, and Cooper M. Efficacy and safety of a new vaginal contraceptive antimicrobial formulation containing high molecular weight poly(sodium 4-styrenesulfonate). Biology Reprod, 66: 886-894, 2002. 28) Anderson RA, Feathergill KA, Diao X-H, Cooper MD, Kirkpatrick R, Herold BC, Doncel GF, Chany CJ, Waller DP, Rencher WF, and Zaneveld LJD. Preclinical evaluation of sodium cellulose sulfate (UshercellTM) as a contraceptive antimicrobial agent. J. Andrology 23: 426-38, 2002. 29) Zaneveld LJD, Anderson RA, Diao X-H, Walker DP, Chany C, Feathergill K, Doncel G, Cooper MD, and Herold BC. A new antimicrobial contraceptive agent for vaginal prophylactic use: mandelic acid condensation polymer (SAMMA). Fertility & Sterility 78: 1107-15, 2002. 30) Cheshenko N and Herold BC. Glycoprotein B plays key role in mediating HSV-2 binding and is essential for entry and cell-cell spread. J Gen Vir 83: 2247-52, 2002. 31) Herold BC, Scordi-Bello I, Cheshenko N, Marcellino D, Dzuzelewski M, Francois F, Morin R, Mas Casullo V, Anderson RA, Chaney C, Waller DP, Zaneveld LJD, and Klotman ME. Mandelic Acid Condensation Polymer: Novel Candidate Microbicide for Prevention of Human Immunodeficiency Virus and Herpes Simplex Virus Entry. J. Virology 76: 11236-44, 2002. 32) Herold BC, Marcellino D, Marcelin G, Burrow C, Wilson P, and Satlin LM. Herpes simplex virus: a model vector system for gene therapy for renal disease. Kidney International, 61: S1: 3-8, 2002. 33) Kaufman SS, Chatterjee NK, Fuschino ME, Magid MS, Gordon RE, Morse DL, Herold BC, LeLeiko NS, Tschernia A, Florman SS, Gondolesi GE, Fishbein TM. Calicivirus Enteritis in an Intestinal Transplant Recipient. Am J Transplant 6; 764-68, 2003. 34) Donnelly M, Herold BC, Jenkins S, and Daum RS. Obstacles to the eradication of invasive haemophilus influenzae type b: three illustrative cases. Pediatrics 112; 1465-6, 2003. 35) Sinha S, Cheshenko N, Lehrer RI, Herold BC. NP-1, a rabbit a-defensin, prevents the entry and intercellular spread of HSV-2. Antimicrobial Agents & Chemo 47: 494-500, 2003. 36) Cheshenko N, Del Rosario, B, Woda C, Marcellino D, Satlin L, and Herold BC. Calcium signaling pathways are required for herpes simplex virus entry. J Cell Biology 163; 283-93; 2003. 37) Pinchoff RS, Kaufman S, Magid MS, Erdman DD, Mendelson M, Gondolesi GE, Fishbein TM, and Herold BC. Adenovirus: Common pathogen in pediatric small bowel transplantation recipients. Transplantation, 76. 183-9; 2003. 38) Keller MJ, Klotman ME, Herold BC. Topical microbicides for the prevention of HIV and HSV. AJRI 49: 279-84, 2003. 39) Keller MJ, Klotman ME, Herold BC. Rigorous pre-clinical evaluation of topical microbicides to prevent human immunodeficiency virus. J Antimicrob Chemother., 51: 1099-102; 2003. 11 April, 2010 Herold, Betsy Clement 40) Yasin B, Wang W, Pang M, Cheshenko N, Hong T, Waring A, Herold BC, Wagar E, and Lehrer, RI. and entry. J Virology 78; 5147-56, 2004. 41) Cheshenko N, Keller, MJ, MasCasullo V, Jarvis, G, Cheng, H., John, M, Li, J-H., Hogarty, K., Anderson RA, Waller, DP, Zaneveld L, Profy, AT., Klotman ME, and Herold BC. Sulfonated polymers bind HSV glycoprotein B and prevent viral entry and cell-cell spread. AAC 48; 202536, 2004. 42) Jing, B., Janout, V., Herold, BC, Klotman, ME, Heald, T., and Regen, S. Persulfated molecular umbrellas as anti-HIV and anti-HSV agents. J Am Chem Soc; 126(49):15930-1, 2004. 43) Campbell, AL and Herold, BC. Preemptive and Prophylactic Strategies to Prevent CMV in Pediatric Liver Transplantation Recipients. Pediatric Transplantation, 8: 619-27; 2004. 44) Keller, MJ, Tuyama, A., Carlucci, MJ, and Herold, B.C. Topical microbicides for the prevention of genital herpes infection. J Antimicrob Chemother, 55: 420-3, 2005. 45) Scordi-Bello, IQ, Mosoian, A, He, C, Chen, Y, Jarvis, GA, Keller, MJ, Hogarty, K, Waller, DP, Profy, AT, Herold, BC and Klotman, ME. Candidate sulfonated and sulfated topical microbicides: comparison of anti-HIV activity and mechanism of action. Antimicrobial Agents & Chemo, 49: 3607-15, 2005. 46) Cheshenko, N., Liu, W., Satlin, LM, and Herold, BC. Focal adhesion kinase plays a pivotal role in HSV-2 invasion. J Biol Chem, 280: 31116-25, 2005. 47) Campbell, AL and Herold, BC. Immunization of pediatric solid-organ transplantation candidates. Pediatric Transplantation, 9; 652-61. 2005. 48) John, M, Keller, MJ, Cheshenko, N, Hogarty, K, Kasowitz, A, Herold, J, Wallenstein, S, Carlucci, M, Tuyama, A, Lehrer, RI, Klotman, ME and Herold BC. Cervicovaginal secretions convey innate immunity to genital herpes. Journal of Infectious Diseases, 192: 1731-40, 2005. 49) Yim, KC, Carroll, CJ, Tuyama, A, Cheshenko, N, Carlucci, MJ, Porter, DD, Prince, GA, and Herold, BC. Cotton rat provides a novel model to study genital herpes infection and to evaluate preventative strategies. J Virology 79: 14632-9, 2005. 50) MasCasullo, V, Fam, E, Keller, MJ and Herold BC. Role of Mucosal Immunity in Preventing Genital Herpes Infection. Viral Immunology 18: 595-606; 2005. 51) John, M., Gondolesi G, Herold, BC, Kaufman, S, Fishbein, T. and Posada, R. Impact of surveillance stool culture guided selection of antibiotics in the management of small bowel transplantation recipients. Pediatric Transplantation, 10; 198-204, 2006. 52) Keller, MJ, Zerhouni-Layachi, B, Cheshenko N,John, M., Hogarty, K, Kasowtz, A., Goldberg, C., Profy, A.T., Klotman, ME and Herold, BC. PRO 2000/5 gel prevents HIV and HSV infection following vaginal application: a double-blind, placebo controlled trial. JID 193:27-35, 2006. 53) Campbell, AL, Goldberg, CL, Magid, M, Kaufman, S and Herold, BC. First case of toxoplasmosis following SBT and systematic review of tissue-invasive toxoplasmosis following non-cardiac solid organ transplantation. Transplantation 81: 408-17, 2006. 12 April, 2010 Herold, Betsy Clement 54) Kasowitz, AR, McCusker, M, Cour-Doniger, P, Neal, WP, Indyk, D, Burk, RD, Jenkins, S. Ricker VI, and Herold, BC. Stage of change behavioral assessment tool fails to predict the prevalence of Chlamydia in an urban adolescent health clinic. J Pediatr Adolesc Gynecol. 19(4):277-83, 2006 55) Tuyama, ACG, Cheshenko, N Carlucci, MJ, Li, J-H, Goldberg, CL,Waller, DP, Anderson RA Profy AT, Klotman ME, Keller, MJ and Herold, BC. An acid-buffering gel inactivates HSV and prevents genital herpes in a murine model. JID 194(6):795-803. 2006 56) Fakioglu, E, Queenan, AM, Bush, K, Jenkins, SG, and Herold, BC. Amp C beta-lactamaseproducing Escherichia coli in neonatal meningitis: diagnostic and therapeutic challenge. J Perinatol 26(8):515-7, 2006. 57) Galen, B, Cheshenko, N., Tuyama, A., Ramratnam, B., and Herold, BC. Access to Nectin Favors HSV Infection at the Apical Surface of Polarized Human Epithelial Cells. J Virol, 80(24):12209-18, 2006. 58) Keller, MJ and Herold, BC. Impact of Microbicides and Sexually Transmitted Infections on Mucosal Immunity in the Female Genital Tract. AJRI 56(5-6):356-63, 2006 59) Hazrati, E, Galen, B., Lu, W, Wang, W, Ouyang, Y, Keller, MJ, Lehrer, RI, and Herold, BC. Human Alpha- and Beta-Defensins Block Multiple Steps in HSV Infection. The Journal of Immunology 177: 8658–8666, 2006. 60) Kerkar N, Cohen S, Dugan C, Morotti RA, Phelps RG, Herold B, Shneider B, and Emre S. Bullous pemphigoid after liver transplantation for liver failure. Liver Transpl. 12(11):1705-1710, 2006. 61) Madan, R, Keller, MJ, and Herold BC. Prioritizing Prevention of HIV and STI: First-generation vaginal microbicides. Curr Opin Infect Dis, 19: 49-54; 2006. 62) Keller, MJ, Guzman, E., Hazrati, E., Kasowitz, A, Cheshenko, N, Wallenstein,S, Patel, S., Cole, AL,. Cole, AM, Profy, AT, Wira, CR, Hogarty, K, and Herold, BC. PRO 2000 Elicits a Decline in Genital Tract Immune Mediators without Compromising Intrinsic Antimicrobial Activity. AIDS, 21: 467-76, 2007. 63) Galen, BT, Martin, AP, Hasrateean, E, Garin, A, Guzman, E, Wilson, SS, Porter, DD, Lira, SA, Keller, MR and Herold, BC. A Comprehensive Murine Model to Evaluate Topical Vaginal Microbicides: Mucosal Inflammation and Susceptibility to Genital Herpes as Surrogate Markers of Safety. JID, 195(9):1332-9, 2007. 64) Madan, RP, Mesquita, PMM, Cheshenko, N, Jing, B, Shende, V, Guzman, E, Heald, T, Keller, MJ, Regen, S, Shattock, RJ and Herold, BC. Molecular Umbrellas: a Novel Class of Candidate Topical Microbicides to Prevent HIV and HSV. J Virology, 81(14): 7636-46, 2007. 65) Cheshenko, N, Liu, W, Satlin, LM, and Herold, BC. Multiple Receptor Interactions Trigger Release of Membrane and Intracellular Calcium Stores Critical for HSV Entry/ Molecular Biology of the Cell 18(8): 3119-30, 2007. 66) Patel, S., Hazrati, E, Cheshenko, N, Galen, B, Yang, H, Guzman, E, Wang, R, Herold, BC and Keller, MJ. Seminal Plasma Reduces the Effectiveness of Topical Polyanionic Microbicides, JID, 196(9):1394-402, 2007. 13 April, 2010 Herold, Betsy Clement 67) Hogarty, K, Kasowitz, A, Herold, BC and Keller, MJ. Assessment of Adherence to Product Dosing in a Pilot Microbicide Study. Sexually Transmitted Diseases. 34(12):1000-3, 2007 68) Guzman, EM, Natalia Cheshenko, Vikas Shende, Marla J. Keller , Nathalie Goyette, Jean-Marc Juteau, Guy Boivin, Andrew Vaillant, and Betsy C. Herold. Amphipathic DNA Polymers are Candidate Vaginal Microbicides and Block HSV Binding, Entry and Viral Gene Expression. Antiviral Therapy, 12: 1147-1156, 2007 69) Madan, RP, Tan, M, Fernandez-Sesma, A, Moran, T, Emre, S, Campbell, A and Herold, BC. A Prospective, Comparative Study of the Immune Response to Inactivated Influenza Vaccine in Pediatric Liver Transplant Recipients and their Healthy Siblings. Clin Inf Dis, 46: 712-8, 2008. 70) Khine, H, Mayers, M, Avner, JR, Fox, A, Herold, BC, and Goldman D. Associations between HSV-1 infection and idiopathic unilateral facial paralysis in children and adolescents, PIDJ, 27: 468-9, 2008. 71) Fichorova, Raina; Richardson-Harman, Nicola; Alfano, Massimo; Belec, Laurent; Carbonneil, Cedric; Chen, Silvia; Cosentino, Lisa; Curtis, Kelly; Dezzutti, Charlene; Donoval, Betty; Doncel, Gustavo; Donaghay, Melissa; Grivel, Jean-Charles; Guzman, Esmeralda; Hayes, Madeleine; Herold, Betsy; Hillier, Sharon; Lackman-Smith, Carol; Landay, Alan; Margolis, Leonid; Mayer, Kenneth; Pasicznyk, Jenna-Malia; Pallansch-Cokonis, Melanie; Poli, Guido; Reichelderfer, Patricia; Roberts, Paula; Rodriguez, Irma; Saidi, Hela; Sassi, Rosaria Rita; Shattock, Robin; Cummins, James. Biological and technical variables affecting immunoassay recovery of cytokines from serum and simulated vaginal fluid- a multicenter study. Analytical Chemistry, 80: 4741-51, 2008. 72) Feng T, Ye F, Wu J, Jiang S, Coolbaugh J, Shneider B, Herold B, Emre S, Zhang DY. The effect of EBV sequence variation on the performance of a Roche real-time Lightcycler PCR assay. J Clin Microbiol. 46:2463-5, 2008. 73) Mesquita, PMM, Wilson, S, Manlowe, P, Fischetti, L, Keller, MJ, Herold, BC and Shattock RJ. Candidate Microbicide PPCM Blocks HIV-1 Infection in Cell and Tissue Cultures and Prevents Genital Herpes in a Murine Model. J Virol, 82: 6576-84, 2008. 74) Fakioglu, E, Wilson, SS, Mesquito, P, Cheshenko, N, Blaho, J and Herold, BC. Herpes Simplex Virus Down-Regulates Secretory Leukocyte Protease Inhibitor: A Novel Immune Evasion Mechanism. J. Virol, 82(19):9337-44, 2008. 75) Keller, MJ and Herold, BC. Understanding Basic Mechanisms and Optimizing Assays to Evaluate the Efficacy of Vaginal Microbicides. Sexually Transmitted Diseases, 36: S92-5, 2009. 76) Madan, R, Campbell, AL, Shust, G, Kahn, AH, Wistinghausen, B, Posada, R, Kerkar, N, Shneider, BL, Emre, S and Herold, BC. A Hybrid Strategy for Prevention of Cytomegalovirus and Epstein Barr Virus Related Complications in Pediatric Liver Transplant Recipients. Transplantation,87(9):1318-24, 2009. 77) Mesquita, PMM, Cheshenko, N, Wilson, SS, Mhatre, M, Guzman, E, Fakioglu, E, Keller, MJ, and Herold, BC. Disruption of tight junctions by cellulose sulfate facilitates HIV infection: Model of microbicide safety. J Infec Dis, 200: 599-608, 2009. 78) Wilson, SS, Fakioglu, E, Herold BC Novel Approaches in Fighting Herpes Simplex Virus Infections. Expert Review of Anti-infective Therapy, 7 (5): 559-568, 2009. 14 April, 2010 Herold, Betsy Clement 79) Wilson, SS, Cheshenko, N, Fakioglu, E, Mesquita, PMM, Keller, MJ, and Herold, B.C. Susceptibility to genital herpes as a biomarker predictive of increased HIV risk: expansion of a murine model of microbicide safety. Antiviral Therapy, 14(8): 1113-24, 2009. 80) Kerkar, N, Morotti, RA, Madan, R, Shneider, B, Herold, BC, Dugan, C, Miloh, T, Karabicak, I, Strauchen, JA, and Emre, S. The changing face of post transplant lymphoproliferative disease in the era of molecular EBV monitoring. Pediatric Transplantation, 2010. 81) Shust, GF, Cho, S., Kim, M, Madan, RP, Guzman, EM, Pollack, M, Epstein, J, Cohen, HW, Keller, JR, and Herold BC. Female genital tract secretions inhibit HSV infection: correlation with soluble mucosal immune mediators and impact of hormonal contraception. Am J Reprodu Immunol 63: 110-9, 2010. 82) Keller MJ, Mesquita PM, Torres NM, Cho S, Shust G, Madan RP, Cohen HW, Petrie J, Ford T, Soto-Torres L, Profy AT, Herold BC. Postcoital bioavailability and antiviral activity of 0.5% PRO 2000 gel: implications for future microbicide clinical trials. PLoS One. Jan 22;5(1):e878, 2010. 83) Long CB, Madan RP, Herold BC. Diagnosis and management of community-associated MRSA infections in children. .Expert Rev Anti Infect Ther. Feb;8(2):183-95, 2010. 84) Gibbs, KA, Kleinman, LC, Jenkins, ST, Herold, BC and Holzman, IR. The vulnerable very low birth weight infant: late onset bloodstream infections. Journal of Neonatal-Perinatal Medicine; 3(2): 117-125, 2010. 85) Hollman, D, Coupey, SM, Foxy, AS and Herold, BC. Screening for Trichomonas vaginalis in high-risk adolescent females with a new transcription mediated nucleic acid amplification test (NAAT): Associations with ethnicity, symptoms, and prior and current STIs. J Ped Adol Gyn May, 2010. 86) Madan, RP and Herold, BC. Viral infection in pediatric solid organ transplantation recipients and the impact of molecular diagnostic testing. Cur Opin Organ Transplant 15(3):293-300, 2010. 87) Cheshenko, N., Trepanier, JB, Segarra, TJ, Fuller, AO and Herold, BC. HSV usurps eukaryotic initiation factor 3 subunit M for viral protein translation: novel prevention target. PLoS One Jul 27;5(7):e11829, 2010. CHAPTERS, BOOKS, INVITED REVIEWS AND LETTERS: 88) Herold KC and Herold BC. Benefits and risks of exercise (letter). JAMA, 249: 2889, 1983. 89) Pachman L, Herold B, Davis A, et al. Immune complexes in Kawasaki Syndrome: A review. Progress in Clinical & Biological Research. 250: 193-207, 1987. 90) Barmier H, Christie M, Herold B, et al. The Humoral Anti-Islet Response. In: Ginsberg-Fellner and McEvoy, (eds) Autoimmunity and the Pathogenesis of Diabetes, Springer-Verlag, New York, 1990. 91) Herold B, Shulman ST: The Child with Recurrent Infection. In: Stockman JA (ed), Difficult Diagnosis in Pediatrics. W.B. Saunders Co., Philadelphia, 1990. 15 April, 2010 Herold, Betsy Clement 92) Herold BC, and Spear PG: Viral-Host Interactions. In: Shulman ST, Phair J, and Sommers HM (eds), The Biologic and Clinical Basis of Infectious Diseases, Fourth Edition. W.B. Saunders Co., Philadelphia, 1991. 93) Spear PG, Shieh M-T, Herold BC, WuDunn D. Cell Surface Receptors Required for Herpes Simplex Virus Infection Include Heparan Sulfate Glycosaminoglycans. In: Hook M, and Switalski LM (eds), Microbial Adhesion and Invasion. Springer-Verlag, New York, 1994. 94) Herold BC and Spear PG: Viral-Host Interactions. In: Shulman ST, Phair J, Peterson LR, and Warren JR (eds), The Biologic and Clinical Basis of Infectious Diseases, Fifth Edition. W.B. Saunders Co., Philadelphia, 1997, pp.47-64. 95) Herold BC. Therapeutic blockade of sexually transmitted disease pathogens. Ped Inf Dis 16:925-931, 1997. 96) Oram RJ and Herold BC. Antiviral agents for herpesviruses. Ped Inf Dis 17: 652-3, 1998. 97) Herold BC. Topical antimicrobials to prevent sexually transmitted diseases. Current Practice of Medicine, April, 2000. 98) Herold BC, McArdle P, and Stagnaro-Green A. Translational Medicine in the First Year: Integrative Cores. Academic Medicine 77: 1171; 2002 16 April, 2010 Herold, Betsy Clement INVITED INTERNATIONAL and NATIONAL SCIENTIFIC PRESENTATIONS 1996 1997 1997 2000 2001 2002 2002 2002 2002 2003 2003 2003 2003 2003 2003 2003 American Academy of Pediatrics Chicago, IL “Bugs and Drugs: Antiviral Therapy in Pediatrics” Society for Pediatric Research; Pediatric Infectious Disease Symposium Washington, D.C “Therapeutic Blockade of Sexually Transmitted Disease Pathogens” The Society for Glycobiology 25th Conference Long Beach, CA “Identification of Structural Features of Heparan Sulfate Required for Herpes Simplex Virus Adsorption to Cells” NIH Topical Microbicides Preclinical Workshop Washington, D.C. “To Spread or Not to Spread: the Case for Genital Herpes” Society for Pediatric Research: Pediatric Infectious Disease Hot Topics Baltimore, MD “MRSA shows no Mercy” Women & HIV: Translating Research into Practice New York, NY “Topical Microbicides Use for the Prevention of HIV and other STD’s” 22nd Annual Meeting of the American Society of Reproductive Immunology Chicago, IL, Plenary talk: “Topical Microbicides for Prevention of HIV and HSV” New York Academy of Medicine New York, NY “The State of HIV Microbicide Research” Office of Population Affairs; Title X Conference New York, NY “The Status of HIV Microbicides” Mount Sinai Hospital 150th Anniversary Academic Symposium New York, NY “Topical Microbicides for the Prevention of STD’s” New York Chapter 3 Annual American Academy of Pediatrics New York, NY “Impact of Microbial Resistance on Everyday Pediatric Practice” UNOS Region 9 Coordinators Forum New York, NY “Smallpox Vaccination - A Re-Emerging Public Health Issue” Alumni Day: Infant and Children’s Hospital of Brooklyn Brooklyn, NY “Smallpox Vaccination: Re-Emerging Public Health Issue Scientific, ethical and Clinical Issues” Society for Pediatric Research; Infectious Diseases Platform Session Seattle, WA “Herpes Simplex Virus Entry Requires Activation of Calcium Signaling Pathways” Department of Medicine Grand Rounds, Mount Sinai Medical School New York, NY “Neonatal Herpes Simplex Virus Infections: New Approaches to Treatment and Prevention; Antivirals, Vaccines, and Topical Microbicides” 550th Anniversary of the University of Istanbul: Advances in Organ Transplantation, Istanbul, Turkey “Prevention of Herpes Viral Infections Post-transplantation: 17 April, 2010 2003 2003 2003 2004 2004 2004 2005 2005 2005 2005 2006 2005 2006 2006 2006 2006 2007 2007 2007 Herold, Betsy Clement Preemptive or Prophylactic Strategies” Pfizer Global Research and Development Groton, CT “Antimicrobial Resistance: Impact on Decision-Making and Unmet Medical Needs” Pediatric Grand Rounds, Flushing Medical Center New York, NY Neonatal Herpes Simplex Infections: Prevention and Treatment Pediatric Grand Rounds, MSSM New York, NY Topical Microbicides to Prevent HIV, Genital Herpes and other STI Infectious Disease Symposium University of South Carolina Medical School, Charleston, SC “Topical Microbicides for the Prevention of HSV and Other STI” Microbicides 2004 Conference, London, England “Interplay of Microbicides and HSV”, Basic Science Symposium Invited Lectureship 7th Annual Update in Pediatric Disease and Liver Transplantation “CMV Disease in pediatric Liver Transplantation”, New York, NY HIV Management 2005: The New York Course “Topical Microbicides” April, 2005, New York, NY Hormonal Contraception and HIV Transmission: Links? Mechanisms? Implications? May, 2005, New York Academy of Sciences, New York, NY Grand Rounds, Stonybrook Medical Center, Dept of Pediatrics, Nov 16, 2005 “Topical Microbicides to Prevent HIV, HSV and other STI” Invited Seminar Speaker, Dept of Physiology Dartmouth Medical School; Dec. 12, 2005 HSV Modifies Mucosal Milieu: Mechanism of Immune Evasion The Office of Special Populations and Research Training (OSPRT), DEA NIAID, NIH, DHHS: Women and Girls HIV/AIDS Awareness Day Keynote Speaker: “Microbicides: Empowering Women in the Battle against HIV/AIDS & Genital Herpes” NIH Office of AIDS Research Advisory Council (OARAC) “Development of Surrogate Markers for Safety and Efficacy April 6-7, 2006 American Society of Reproductive Immunology, Plenary Speaker June, 2006, Nashville Tennessee Genital Herpes Modifies Mucosal Milieu: Novel Mechanisms of Immune Evasion 17th Annual HIV Symposium, NY Dept of Health AIDS Institute June 6, 2006. Biomarkers for Evaluating Vagina Microbicides & Contraceptives: Discovery and Early Validation; Plenary Speaker. November 15-17, sponsored by CONRAD, Alliance for Microbicides, and Gates Foundation 2006 International Meeting of the Institute of Human Virology “Development of Pre-clinical and Clinical Models to Predict the Efficacy & Safety of Vaginal Microbicides”, Nov. 17-21, Baltimore, MD Microbicide Trial Network Annual Meeting Washington, D.C. April 20-23, 2009 “Can we use biomarkers in microbicide trials?” University of Pennsylvania Dept of Microbiology Graduate Student Seminar Series “HSV Hijacks Calcium Signaling Pathways for Viral Invasion: Novel Targets for Treatment & Prevention”, March 28, 2007 American Pediatric Society/Society for Pediatric Research Annual Meeting 18 April, 2010 2007 2007 2007 2007 2007 2008 2008 2008 2008 2008 2008 2009 2009 2009 2009 Herold, Betsy Clement May 5-8, Toronto, Canada “Meet the Professors” Breakfast 47th Interscience Conference on Antimicrobial Agents & Chemotherapy Sept. 17-20, Chicago, IL “Vaginal Microbicides” 45th Annual Meeting Infectious Disease Society of America Oct. 4-7, San Diego CA “Hot Topics in Pediatric Infectious Diseases” European Commission Workshop on Microbicides Sept. 24-25, Brussels, Belgium “Understanding safety& activity in a mucosal setting” Pediatric Alumni Day, AECOM/Children’s Hospital at Montefiore October 25, Bronx, NY “Preempting the Global AIDS Epidemic: Development of Topical Microbicides” Dept. Obstetrics and Gynecology, AECOM, Grand Rounds November 6, Bronx , NY “Preempting the Global AIDS Epidemic: Development of Topical Microbicides” Yale University, Dept Microbiology, Visiting Professor January 17, 2008 “HSV Hijacks Different Cellular Signaling Pathways to Invade Cells by Fusion and Endocytosis” Alliance for Microbicide Development April 24, 2008 “The Perfect Phase I Trial” Arlington, VA Patricia Spear Symposium April 18, 2008 “Biology behind the Overlapping Epidemics of HSV & HIV: Strategies for Prevention Northwestern University, Chicago, IL HIV Management: The New York Course “Preempting the Global AIDS Epidemic: Development of Microbicides” UCSF Advances and Controversies in Clinical Pediatrics, Invited Faculty “Fever 2008: Approach to Fever in the ER in an Era of Pneumococcal Vaccine” “Herpes Simplex Virus: From Infancy through Adolescence” “Judicious Use of Antibiotics” “Prevention & Treatment of HSV Infections: Infancy through Adolescents” December 2, 2008 Norwalk Hospital; Grand Rounds, Norwalk, CT 5th Annual Virology Colloquium, Center for Molecular and Tumor Virology Louisiana Sate University Health Sciences Center at Shreveport February 15-16, 2009 “Soluble mucosal immunity in the genital tract: Impact on HSV & HIV” Microbicides Trial Network Annual Meeting, Washington, D.C., April 20-22, 2009 “From the Bench to the Bedside & Back Again: Lessons from Microbicide Trials” International Conference on Antiviral Research Miami, FL May 3-7, 2009 Development of Microbicides with Broad Based Anti-infective Action American Society for Reproductive Immunology 29th Annual Meeting, Orlando, FL, June 5-9,2009 “Role of Soluble Mucosal Genital Tract Mucosal Immunity in the Overlapping Epidemics of genital herpes and HIV” 19 April, 2010 Herold, Betsy Clement 2009 NIH Microbicide Phase I Meeting Washington, DC Nov. 30-Dec. 1, 2009 “Perfect Phase I Microbicide Trial” 2009 R BabyMount Sinai Pediatric Infectioius Disease Symposium New York, NY December 9, 2009 Update: Diagnosis & Treatment of HSV: ER Perspective 2010 Mucosal Immunity in the Male and Female Reproductive Tract & HIV Prevention Dartmouth Medical School Lebanon, NH June 30-July 2, 2010 “Effects of Microbicides on Innate and Adaptive Immunity” 20