Download Einstein Technologies (Tools/Platforms/Software)

Einstein Technologies (Tools/Platforms/Software)
Senior Einstein
Investigator
Link to NonProvisional
Patent
Application
C-740
The present invention provides methods for determining a putative
Methods for determining
antibacterial, the methods comprising determining whether the
chemotherapeutic
putative antibacterial inhibits GlgE or Rv3032. The present invention
agents targeting alpha- also provides the antibacterial, the pharmaceutical composition and William R Jacobs, Jr.
glucan pathways and
the method of making the antibacterial as well as a method of
uses thereof
treating a subject infected with a bacterial comprising administration
of the antibacterial.
US 12/925,633
C-747
The invention provides methods for delivering a NO molecule or
precursor thereof to a vascular compartment of a subject comprising:
administering to the subject, a NO particle formulation, via an
Sustained release nitric intravascular, intraperitoneal, or intramuscular administration, in an
oxide from long lived
amount sufficient to induce vascular smooth muscle relaxation
circulating nanoparticles
thereby delivering the NO molecule or precursor thereof to the
vascular compartment of the subject, wherein the NO particle
formulation comprises NO attached to a nanoparticle or
microparticle.
Joel Friedman
US 13/086,346
C-753
The present invention provides methods of preparing an
oligonucleotide, nucleoside or nucleoside analog for selective
introduction into a subject's cells, the method comprising (1)
selecting a targeted aptamer, internalizing nucleic acid or tumorhoming nucleic acid via iterative rounds of selection, and (i)
hybridizing it to an oligonuceotide, (ii) replacing one or more
nucleotide with a nucleoside or nucleoside analog, or (iii) synthesizing
the it with one or more nucleoside or nucleoside analogs; or (2)
preparing a naive combinatorial aptamer, internalizing nucleic acid or
tumor-homing nucleic acid prodrug library, and running iterative
rounds of selection for the cells. The present invention also provides
the agent, the pharmaceutical composition, and methods of treating
or preventing cancer and/or viral infection, the method comprising
administration of the oligonuleotide, nucleoside or nucleoside analog
for selective introduction into a subject's cells.
Matthew Levy
PCT/US11/00754
C-755
The present invention relates to methods for detecting the activity of
Luciferase-linked analysis
DNA (cytosine 5)-methyltransferase, protein methyltransferase or any
of dnaenzyme that forms S-adenosyl-l- homocysteine (AdoHcy) as a
methyltransferase,
product, and for screening for inhibitors of DNA (cytosine 5)protein
methyltransferase, protein methyltransferase and any enzyme that
methyltransferase and sforms S-adenosyl-l- homocysteine (AdoHcy) as a product using
adenosylhomocysteiene
luciferase-linked assays that convert the S- adenosyl-l-homocysteine
and uses thereof
(AdoHcy) product to a quantifiable luminescent signal.
Vern Schramm
PCT/US2011/000430
C-769
The present invention provides methods for determining a putative
agent that treats or prevent obesity and/or obesity related diseases
Methods for determining comprising contacting cells with the putative agent and measuring
agents that treat or
the activity and/or level of Maf1 and/or the activity and/or level of
prevent obesity and/or KIAA1875. The present invention also provides the agent identified by
the methods herein and methods of treating or preventing obesity
obesity related diseases
and/or obesity related diseases in a subject comprising administering
and methods for
to the subject a therapeutically effective amount of an agent that
treatment therewith
inhibits or downregulates Maf1 and/or activates or upregulates
KIAA1875.
Ian M Willis
US 13/298,370
C-771
Cultures and protocols
for diagnosis of toxigenic
Clostridium difficile
Paul Riska
US 13/068,682
Peng Wu
PCT/US2011/046700
Einstein
Reference
Number
C-776
Title of Patent
Application
Methods of preparing
targeted aptamer
prodrugs
Abstract
Disclosed are culture media, protocols and kits for diagnosis of
toxigenicClostridium difficile , where the culture medium comprises
Cooked Meat Medium with glucose; yeast extract; taurocholate;
cycloserine; and cefoxitin.
Ligands and methods for Disclosed are tris(triazolylmethyl)amine ligands, and kits and methods
labeling biomolecules in for labeling and/or imaging a biomolecule of interest in a subject or
vivo
living system.
***Please note these technologies are representative of the Einstein Intellectual Property
Portfolio that are currently published patents/patent applications and available for licensing.
For non-published technologies please contact [email protected].
Version March 2016
Einstein Technologies (Tools/Platforms/Software)
Senior Einstein
Investigator
Link to NonProvisional
Patent
Application
C-784
Nucleic acid constructs for expressing an antibody on the surface of
bacteriophage are disclosed, as are methods for using the constructs
to identify antibodies that target glycans. The present invention
provides nucleic acid constructs comprising Hindlll (AAGCTT), 2GI2 VL
(SEQ ID NO:l), CL (SEQ ID NO:2), Intragenic region (SEQ ID NO:3), pel B
Constructs and methods (SEQ ID NO:4), Region X (SEQ ID 5), spe I (ACTAGT), VH (SEQ ID NO:6),
CH (SEQ ID NO:7), Hinge (SEQ ID NO:8), GCN4 (SEQ ID NO:9), and Sail
to identify antibodies
(GTCGAC), or a modified version thereof wherein the modification
that target glycans
consists of one or more modification in the sequence of the 2GI2 VL
region and/or on or more modification in the sequence of the VH
region, and wherein the modification consists of a substitution of one
codon for another codon, up to nine such substitutions, and/or
insertion of up to nine additional codons.
Jonathan R Lai
PCT/US2011/061990
C-798
Simultaneous extraction
of dna and rna from ffpe
tissues
The present provides methods and kits for extracting DNA and RNA
from FFPE tissues and samples.
Olivier Loudig
US 14/249,631
C-804
Method for functional
testing of site-specific
DNA methylation
Methods and kits are provided for testing the functional effect of
methylating different cytosine residues, for testing patterns of DNA
methylation on gene expression, and for site-specific methylation, as
well as methylated DNA constructs. Methods are provided that
include steps of denaturing a circular double-stranded DNA construct;
hybridizing primers to separate strands of the denatured circular DNA
construct; contacting the hybridized primers with a DNA polymerase,
deoxynucleoside triphosphates, and copies of the primers; contacting
nicked copies with a DNA ligase so as to form a copy of the circular
DNA construct; contacting the copy of the circular DNA construct
with a methyltransferase enzyme; transfecting a cell with C-5
methylated circular DNA construct; and quantifying expression of a
gene of interest, thereby determining the effect of C-5 methylating
cytosine nucleotide residues of DNA on expression of the gene of
interest.
Simon Spivak
US 13/349,745
C-813
Method for measuring
somatic dna mutational
profiles
Jan Vijg
PCT/US2012/040463
Anne Bresnick
13/419,805
Jan Vijg
14/253,922
Einstein
Reference
Number
C-818
Title of Patent
Application
Abstract
Methods are provided for determining if an agent causes somatic
mutations in a genome, and kits, systems and computer-readable
medium therefor.
Methods and kits are provided for determining if cells of a tumor in
Myosin-iia s1943
an organ or a tissue in a subject are likely to invade another organ or
phosphorylation as a
tissue in the subject and for determining if a cancer in a subject is
marker of tumor invasion
likely to metastasize.
C-910
Method for measuring Methods are provided for determining epimutations in a nucleic acid
dna methylation profiles
sequence of a cell.
C-921
Aptamer-targeted
antigen delivery
A composition is provided comprising an oligonucleotide aptamer
conjugated to an antigen, wherein the aptamer is directed against a
cell-surface target of an antigen- presenting cell. Also provided are
methods of delivering an antigen to a dendritic cell and of eliciting an
immune response in a subject.
Matthew Levy
PCT/US2013/49212
C-924
Transferrin receptor
aptamers and aptamertargeted delivery
Aptamers targeted to a human transferrin receptor which do not
compete with transferrin for binding are provided. Compositions and
methods for aptamer-targeted liposomal drug delivery are also
provided.
Matthew Levy
PCT/US2013/38006
C-937
Methods to isolate
human mesenchymal
stem cells
A method of obtaining a population of PDGFRα+ CD51+ CD146high
stem cells is provided. Compositions comprising PDGFRα+ CD51+
CD146hlgh stem cells, and methods of use of a population of
PDGFRα+ CD51+ CD146high stem cells, are also provided.
Paul S Frenette
PCT/US2013/48851
***Please note these technologies are representative of the Einstein Intellectual Property
Portfolio that are currently published patents/patent applications and available for licensing.
For non-published technologies please contact [email protected].
Version March 2016