Download Gene Section NONO non-POU domain containing, octamer- binding

Atlas of Genetics and Cytogenetics
in Oncology and Haematology
OPEN ACCESS JOURNAL AT INIST-CNRS
Gene Section
Mini Review
NONO non-POU domain containing, octamerbinding
Jean-Loup Huret
Genetics, Dept Medical Information, University of Poitiers, CHU Poitiers Hospital, F-86021 Poitiers, France
(JLH)
Published in Atlas Database: January 1999
Online updated version : http://AtlasGeneticsOncology.org/Genes/NONOID168.html
DOI: 10.4267/2042/37499
This work is licensed under a Creative Commons Attribution-Noncommercial-No Derivative Works 2.0 France Licence.
© 1999 Atlas of Genetics and Cytogenetics in Oncology and Haematology
Identity
active; NONO also enhances the binding of several
DNA-binding proteins (but not all).
HGNC (Hugo): NONO
Location: Xq12
Homology
With PSF and other proteins with a DBHS domain
(Drosophila behaviour, human splicing) which includes
the tandem RNA binding domains.
DNA/RNA
Transcription
Implicated in
Alternative splicing; 2.4 mRNA complete cds; coding
sequence: CDS 129 ... 1550.
inv(X)(p11.2q12) in renal cell carcinoma
--> NonO/TFE3
Protein
Disease
Only one case of papillary renal cell carcinoma.
Hybrid/Mutated gene
5' NONO - 3' TFE3.
Description
The protein encoded by NONO is called p54nrb
(nuclear RNA binbing); 471 amino acids; 54 kDa; Nterm glutamine/histidine rich region, tandem RNA
binding domains (amino acids 75 to 228), helix-turnhelix implicated in DNA binding, and a proline rich
region in C-term; N-term and C-term allow proteinprotein interactions.
Abnormal protein
N-term NONO and most of it except the C-term proline
rich sequence fused to the DNA binding domains of
TFE3 (excluding the acidic transcriptional activation
domain, including the C-term helix-loop-helix, and the
leucine zipper); the reciprocal transcript is found.
Expression
References
Wide.
Function
Dong B, Horowitz DS, Kobayashi R, Krainer AR. Purification
and cDNA cloning of HeLa cell p54nrb, a nuclear protein with
two RNA recognition motifs and extensive homology to human
splicing factor PSF and Drosophila NONA/BJ6. Nucleic Acids
Res. 1993 Aug 25;21(17):4085-92
Binds independantly to DNA and RNA; forms a
heterodimer with PSF, a protein sharing vast
homologies; both form complexes with DNA
topoisomerase I, which renders this enzyme much more
Atlas Genet Cytogenet Oncol Haematol. 1999; 3(2)
54
NONO non-POU domain containing, octamer-binding
Huret JL
Yang YS, Hanke JH, Carayannopoulos L, Craft CM, Capra JD,
Tucker PW. NonO, a non-POU-domain-containing, octamerbinding protein, is the mammalian homolog of Drosophila
nonAdiss. Mol Cell Biol. 1993 Sep;13(9):5593-603
Yang YS, Yang MC, Tucker PW, Capra JD. NonO enhances
the association of many DNA-binding proteins to their targets.
Nucleic Acids Res. 1997 Jun 15;25(12):2284-92
Straub T, Grue P, Uhse A, Lisby M, Knudsen BR, Tange TO,
Westergaard O, Boege F. The RNA-splicing factor PSF/p54
controls DNA-topoisomerase I activity by a direct interaction. J
Biol Chem. 1998 Oct 9;273(41):26261-4
Clark J, Lu YJ, Sidhar SK, Parker C, Gill S, Smedley D,
Hamoudi R, Linehan WM, Shipley J, Cooper CS. Fusion of
splicing factor genes PSF and NonO (p54nrb) to the TFE3
gene in papillary renal cell carcinoma. Oncogene. 1997
Oct;15(18):2233-9
This article should be referenced as such:
Huret JL. NONO non-POU domain containing, octamerbinding. Atlas Genet Cytogenet Oncol Haematol. 1999;
3(2):54-55.
Atlas Genet Cytogenet Oncol Haematol. 1999; 3(2)
55