Download Genes Section DEK (DEK oncogene) Atlas of Genetics and Cytogenetics

Atlas of Genetics and Cytogenetics
in Oncology and Haematology
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Genes Section
Short Communication
DEK (DEK oncogene)
Jean-Loup Huret
Genetics, Dept Medical Information, University of Poitiers, CHU Poitiers Hospital, F-86021 Poitiers, France
Published in Atlas Database: January 1998
Online version is available at: http://AtlasGeneticsOncology.org/Genes/DEK_23.html
DOI: 10.4267/2042/32091
This work is licensed under a Creative Commons Attribution-Non commercial-No Derivative Works 2.0 France Licence.
© 1998 Atlas of Genetics and Cytogenetics in Oncology and Haematology
Disease
Identity
M2, M4 ANLL or MDS.
Location: 6p23
Prognosis
Remission difficult to obtain.
Cytogenetics
This chromosome anomaly may be over loocked.
Hybrid/Mutated Gene
5' DEK - 3' CAN; chromosome 6 breakpoint clusters in
a single intron.
Abnormal Protein
DEK (6p23) - Courtesy Mariano Rocchi, Resources for
Molecular Cytogenetics. Laboratories willing to validate the
probes are welcome: contact [email protected].
Head to tail DEK/CAN fusion protein (the alternative
SET/CAN is exceptional); almost the entire DEK
protein fused to the C-terminal two-thirds of the CAN
protein; nuclear localization.
DNA/RNA
References
Description
von Lindern M, Fornerod M, van Baal S, Jaeglé M, de Wit T,
Buijs A, Grosveld G. The translocation (6;9), associated with a
specific subtype of acute myeloid leukemia, results in the
fusion of two genes, dek and can, and the expression of a
chimeric, leukemia-specific dek-can mRNA. Mol Cell Biol 1992
Apr;12(4):1687-97.
Spans on a 40 kb genomic segment.
Transcription
2.7 kb mRNA; coding sequence: 1.1 kb.
Protein
Fornerod M, Boer J, van Baal S, Jaeglé M, von Lindern M,
Murti KG, Davis D, Bonten J, Buijs A, Grosveld G. Relocation
of the carboxyterminal part of CAN from the nuclear envelope
to the nucleus as a result of leukemia-specific chromosome
rearrangements. Oncogene 1995 May 4;10(9):1739-48.
Description
375 amino acids; 43 kDa; contains numerous acidic
domains (Asp/Glu rich) and a nuclear localisation
signal.
Fornerod M, Boer J, van Baal S, Morreau H, Grosveld G.
Interaction of cellular proteins with the leukemia specific fusion
proteins DEK-CAN and SET-CAN and their normal
counterpart, the nucleoporin CAN. Oncogene 1996 Oct
17;13(8):1801-8.
Expression
Wide.
Localisation
Fu GK, Grosveld G, Markovitz DM. DEK, an autoantigen
involved in a chromosomal translocation in acute myelogenous
leukemia, binds to the HIV-2 enhancer. Proc Natl Acad Sci
USA 1997 Mar 4;94(5):1811-5.
Potentially nuclear.
Function
Site specific DNA binding protein involved in
transcriptional regulation and signal transduction.
This article should be referenced as such:
Huret JL. DEK (DEK oncogene). Atlas Genet Cytogenet Oncol
Haematol.1998;2(1):5.
Implicated in
t(6;9)(p23;q34)/ANLL or MDS
→DEK/CAN
Atlas Genet Cytogenet Oncol Haematol. 1998; 2(1)
5