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Blood ST 120 Courtney Shelton CST, BA Day 1 Objectives Identify blood components Distinguish between different types of WBCs Identify formed elements Medical terminology Functions Primary transportation fluid Delivery and pick-up services Provides protection against “invaders” Blood Composition Plasma Liquid or extracellular part Formed elements Cell and cell fragments Blood Plasma Consists of water with many substances dissolved in it Food, oxygen, salts Wastes Hormones and regulatory chemicals Plasma proteins (most abundant solute) Albumins Globulins fibrinogen Serum Plasma minus its clotting factors Ex: fibrinogen Contains antibodies Formed Elements 3 main types and several subtypes Red blood cells (RBC’s) or erythrocytes White blood cells (WBC’s) or leukocytes Platelets or thrombocytes Connective Tissue 2 types make blood cells in the body Myeloid tissue (red bone marrow) Lymphatic tissue RBC’s “caved in” on both sides No nucleus Huge surface area due to shape Few million produced each SECOND! RBC’s Functions Transport carbon dioxide Transport oxygen from lungs to other body cells RBC Terms Anemia: a number of different disease conditions caused by an inability of the blood to carry sufficient oxygen to the body cells. Hemoglobin: red pigment of RBC’s Oxyhemoglobin: hemoglobin binds with oxygen RBC Terms Carbaminohemoglobin: hemoglobin carries a small proportion of the carbon dioxide carried by the blood. Polycythemia: bone marrow produces an excess of RBC’s. Iron deficiency anemia: a result of the body’s inability to manufacture enough hemoglobin due to an inadequate supply of iron in the diet. Anemia Hemorrhagic anemia: decrease in RBC’s due to hemorrhage Aplastic anemia: decrease in RBC’s due to destruction of blood-forming elements in the marrow. Sometimes caused by radiation, chemotherapy, high-dose x-rays Pernicious anemia: decrease in RBC’s because the stomach doesn’t produce enough “intrinsic factor” that allows the absorption of vit B12 Sickle Cell Anemia Severe and sometimes fatal hereditary disease If a person inherits only one defective gene from a parent, they are considered to carry the sickle cell trait. A small amt of RBC’s are damaged. If two defective genes are inherited, the person will have a more severe form of sickle cell anemia because more of the RBC’s are damaged Hematocrit The measure of the total blood volume made up by RBC’s When spun down, the formed elements settle at the bottom The buffy coat is the layer seen between the RBC’s and the plasma above WBC’s 2 subtypes Granular leukocytes Neutrophils Eosinophils Basophils Nongranular leukocytes Lymphocytes Monocytes WBC’s Function to defend the body from microorganisms that have succeeded in invading our body. Attack cancer cells that form inside our tissues. WBC’s Neutrophils and Monocytes Lymphocytes Function in the immune mechanism Eosinophils Engulf microbes through phagocytosis Protect against parasites and irritants Basophils Secrete heparin Also function in allergic reactions WBC Terms Leukopenia: abnormally low WBC count AIDS: a disease characterized by significant leukopenia Leukocytosis: abnormally high WBC count Leukemia: malignant disease where the number of WBC’s increases tremendously Questions What are the two components of blood? Name some of the blood proteins. What are the three types of formed elements? Questions What is the main function of RBC’s? What is the main function of WBC’s? Day 2 Objectives Explain clotting Describe blood types Describe Rh systems Medical Terminology Platelets and Clotting Clots plug torn or cut vessels to stop bleeding Rapid-fire reactions Clotting Steps First, an injury to a blood vessels makes a rough spot in its lining. Almost immediately, damaged tissue cells in the injured vessel wall release certain clotting factors into plasma. These factors react with other factors in the plasma to form prothrombin activator. Clotting, cont’d At the same time, platelets become sticky at the point of injury and begin to accumulate forming a platelet plug. As they accumulate, they release even more clotting factors forming even more prothrombin activator. Prothrombin activator converts prothrombin to thrombin. Clotting, cont’d Thrombin reacts with fibrinogen to change it to a fibrous gel called fibrin. Fibrin looks like a tangle of fine threads with RBC’s caught in the tangle. This mesh forms a more long-term seal. Clotting Terms Thrombus: a clot stays in the place where it was formed. Embolus: occurs when part of the clot dislodges and circulates through the bloodstream. The clot is an embolus. The condition is known as an embolism. Blood Types ABO system Antigen: a substance that can activate the immune system to make certain responses. Antibody: a substance made by the body in response to stimulation by an antigen. Agglutinate: clump Blood Types Type A Type B Type AB “universal recipient” Type O “universal donor” Rh System Rh-positive RBC’s contain an antigen called the Rh factor Includes most Americans Rh-negative RBC’s do not contain the Rh factor Erythroblastosis fetalis Rh-negative mothers carries a baby with Rhpositive blood. She will produce anti-Rh antibodies and later if she carries another Rh-positive fetus, the baby may develop erythroblastosis fetalis. ALL Rh-negative mothers who carry Rh-positive babies should be treated with RhoGAM to prevent harm to the next child. Questions What formed element is essential for clotting? Describe the steps of clotting. What are the four blood types?