Download The Endocrine System

The Endocrine System
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Objectives
• Be able to define hormone
• Know the three major categories of hormones
• Know the major endocrine glands, the
hormones they secrete and their actions
Endocrine System: Hormones
• Endocrine Glands: ductless organs
• Hormones:
– Chemical messengers
– Circulate in the bloodstream
– Stimulate physiological response
Characteristics
• Access to every cell
• Each hormone acts only on specific cells (target cells)
• Endocrine control slower than nervous system
• Endocrine and nervous systems interact
• Three chemical classes
– Steroids
– Peptides
– monoamines
Hormone Chemistry
• Steroids
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H
• derived from cholesterol
• secreted by gonads and adrenal glands
OH
CH3
H2N
COOH
CH2
CH3
I
O
Testosterone
• Peptides and glycoproteins
I
O
OH
CH3
• created from chains of amino acids
• secreted by pituitary and hypothalamus
I
I
OH
Thyroxine
OH
HO
HO
Estradiol
• Monoamines
C
(a) Steroids
HO
(b) Monoamines
• derived from amino acids
• secreted by adrenal, pineal, and thyroid glands
Insulin
• all hormones made from either cholesterol or
amino acids with carbohydrate added to make
glycoproteins.
Angiotensin II
(c) Peptides
CH
Epinephrine
CH2
NH
CH2
Major Endocrine Organs
Hypothalamus and Hypophysis
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Adenohypophysis & Neurohypophysis
• adenohypophysis constitutes anterior three-quarters of pituitary
– two segments:
• anterior lobe (pars distalis)
• pars tuberalis small mass of cells adhering to stalk
– linked to hypothalamus by hypophyseal portal system
• primary capillaries in hypothalamus connected to secondary capillaries in
adenohypophysis by portal venules
• hypothalamic hormones regulate adenohypophysis cells
• neurohypophysis constitutes the posterior one-quarter of the pituitary
– has 3 parts:
• median eminence, infundibulum, and the posterior lobe (pars nervosa)
– nerve tissue, not a true gland
• nerve cell bodies in hypothalamus pass down the stalk as hypothalamohypophyseal tract and end in posterior lobe
• hypothalamic neurons secrete hormones that are stored in neurohypophysis
until released into blood
Hypophyseal Portal System
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Axons to
primary
capillaries
Neuron
cell body
Superior hypophyseal
artery
Hypothalamic hormones
Gonadotropin-releasing hormone
Thyrotropin-releasing hormone
Corticotropin-releasing hormone
Prolactin-inhibiting hormone
Growth hormone–releasing hormone
Somatostatin
Hypophyseal
portal system:
Primary capillaries
Portal venules
Secondary
capillaries
Anterior lobe hormones
Follicle-stimulating hormone
Luteinizing hormone
Thyroid-stimulating hormone (thyrotropin)
Adrenocorticotropic hormone
Prolactin
Growth hormone
Anterior lobe
Posterior lobe
(b)
• hypothalamic releasing and inhibiting hormones travel in
hypophyseal portal system from hypothalamus to anterior
pituitary
• hormones secreted by anterior pituitary
17-9
Hypothalamic Hormones
• eight hormones produced in hypothalamus
– six regulate the anterior pituitary
– two are released into capillaries in the posterior pituitary when
hypothalamic neurons are stimulated (oxytocin and antidiuretic
hormone)
• six releasing and inhibiting hormones stimulate or inhibit
the anterior pituitary
– TRH, CRH, GnRH, and GHRH are releasing hormones that affect
anterior pituitary secretion of TSH, PRL, ACTH, FSH, LH, and GH
– PIH inhibits secretion of prolactin, and somatostatin inhibits
secretion growth hormone & thyroid stimulating hormone by
the anterior pituitary
Hypothalamic Hormones
• two other hypothalamic hormones are oxytocin (OT)
and antidiuretic hormone (ADH)
– both stored and released by posterior pituitary
– right and left paraventricular nuclei produce oxytocin (OT)
– supraoptic nuclei produce antidiuretic hormone (ADH)
– posterior pituitary does not synthesize them
Histology of Pituitary Gland
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Chromophobe
Basophil
Acidophil
(a) Anterior pituitary
Unmyelinated
nerve fibers
Glial cells
(pituicytes)
(b) Posterior pituitary
a: © Dr. John D. Cunningham/Visuals Unlimited; b: © Science VU/Visuals Unlimited
Anterior Pituitary Hormones
• Synthesizes and secretes six principal
hormones
• two gonadotropin hormones
– FSH (follicle stimulating hormone)
• stimulates secretion of ovarian sex
hormones, development of ovarian follicles,
and sperm production
– LH (luteinizing hormone)
• stimulates ovulation, stimulates corpus
luteum to secrete progesterone, stimulates
testes to secrete testosterone
• TSH (thyroid stimulating hormone)
– stimulates secretion of thyroid hormone
• ACTH (adrenocorticotropic hormone)
– stimulates adrenal cortex to secrete
glucocorticoids
• PRL (prolactin)
– after birth stimulates mammary glands to
synthesize milk, enhances secretion of
testosterone by testes
• GH (growth hormone)
– stimulates mitosis and cellular
differentiation
Hypothalamo-Pituitary-Target Organ
Relationships
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Hypothalamus
TRH
GnRH
CRH
GHRH
Liver
GH
PRL
IGF
Mammary
gland
Fat,
muscle,
bone
TSH
ACTH
Adrenal cortex
Thyroid
LH
FSH
Figure 17.6
Testis
Ovary
• principle hormones and target organs
Posterior Pituitary Hormones
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Anterior
Posterior
Third ventricle of brain
Floor of
hypothalamus
Nuclei of hypothalamus:
Paraventricular nucleus
Supraoptic nucleus
Pineal gland
Cerebral aqueduct
Mammillary body
Optic chiasm
Neurohypophysis:
Adenohypophysis:
Pars tuberalis
Anterior lobe
Median eminence
Hypothalamo–hypophyseal tract
Stalk (infundibulum)
Posterior lobe
Oxytocin
(a)
Antidiuretic hormone
Posterior Pituitary Hormones
• produced in hypothalamus
– transported by hypothalamo-hypophyseal tract to posterior lobe
– releases hormones when hypothalamic neurons are stimulated
• ADH (antidiuretic hormone)
– increases water retention thus reducing urine volume and prevents
dehydration
– also called vasopressin because it can cause vasoconstriction
• OT (oxytocin)
– surge of hormone released during sexual arousal and orgasm
• stimulate uterine contractions and propulsion of semen
– promotes feelings of sexual satisfaction and emotional bonding
between partners
– stimulates labor contractions during childbirth
– stimulates flow of milk during lactation
– promotes emotional bonding between lactating mother and infant
Control of Pituitary Secretion
• Rates of secretion are not constant
– regulated by hypothalamus, other brain centers, and feedback from
target organs
• Hypothalamic and Cerebral Control
– anterior lobe control - releasing hormones and inhibiting hormones
from hypothalamus
– posterior lobe control - neuroendocrine reflexes
• neuroendocrine reflex - hormone release in response to nervous system
signals
• suckling infant stimulates nerve endings  hypothalamus  posterior
lobe  oxytocin  milk ejection
Growth Hormone
• GH has widespread effects on the body tissues
– especially cartilage, bone, muscle, and fat
• induces liver to produce growth stimulants
– insulin-like growth factors (IGF-I) or somatomedins (IGF-II)
• stimulate target cells in diverse tissues
Thymus
• Thymus plays a role in three systems: endocrine, lymphatic, and immune
• Bilobed gland in the mediastinum superior to the heart
– goes through involution after puberty
• T cell maturation
• secretes hormones (thymopoietin, thymosin, and thymulin) that stimulate
development of other lymphatic organs and activity of T-lymphocytes
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Thyroid
Trachea
Thymus
Lung
Heart
Diaphragm
(a) Newborn
Liver
(b) Adult
Thyroid Gland Anatomy
• Largest true endocrine gland
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Superior thyroid
artery and vein
Thyroid
cartilage
Thyroid
gland
Isthmus
Inferior thyroid vein
Trachea
• Thyroid follicles – sacs that compose
most of thyroid
– follicular cells – simple cuboidal
epithelium that lines follicles
– secretes thyroxine (T4) and
triiodothyronine (T3)
– Increases metabolic rate, O2
consumption, heat production
(calorigenic effect), appetite, growth
hormone secretion, alertness and quicker
reflexes
• Parafollicular (C or clear) cells secrete
calcitonin with rising blood calcium
(a)
– stimulates osteoblast activity and bone
formation
Histology of the Thyroid Gland
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Follicular
cells
Colloid of
thyroglobulin
C (parafollicular)
cells
Follicle
(b)
© Robert Calentine/Visuals Unlimited
thyroid follicles are filled with colloid and lined with simple
cuboidal epithelial cells (follicular cells).
Parathyroid Glands
• Secrete parathyroid hormone (PTH)
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– increases blood Ca2+ levels
•
•
•
•
promotes synthesis of calcitriol
increases absorption of Ca2+
decreases urinary excretion
increases bone resorption
Pharynx
(posterior view)
Thyroid gland
Parathyroid
glands
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Esophagus
Adipose tissue
Parathyroid
capsule
Parathyroid gland
cells
Adipocytes
(b)
© John Cunningham/Visuals Unlimited
Trachea
(a)
Adrenal Medulla
• adrenal medulla – inner core, 10% to 20%
of gland
• Neuroendocrine gland
– innervated by sympathetic preganglionic
fibers
– Chromaffin cells
– when stimulated release catecholamines
and a trace of dopamine directly into the
bloodstream
– increases alertness and prepares body for
physical activity
– decreases digestion and urine production
Adrenal Cortex
• surrounds adrenal medulla and produces more than 25
steroid hormones called corticosteroids or corticoids
• secretes 5 major steroid hormones from three layers of
glandular tissue
– zona glomerulosa (thin, outer layer)
• cells are arranged in rounded clusters
• secretes mineralocorticoid – regulate the body’s electrolyte balance
• aldosterone
– zona fasciculata (thick, middle layer)
• cells arranged in fascicles separated by capillaries
• secretes glucocorticoids
• cortisol
– zona reticularis (narrow, inner layer)
• cells in branching network
• secretes sex steroids
Pancreas
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Tail of pancreas
Bile duct
(c)
Pancreatic islet
Exocrine acinus
Pancreatic
ducts
Duodenum
Head of
pancreas
Beta cell
Alpha cell
Delta cell
(a)
(b) Pancreatic islet
c: © Ed Reschke
• exocrine digestive gland and endocrine cell clusters (pancreatic
islets) found retroperitoneal, inferior and posterior to stomach.
Pancreatic Hormones
• 1-2 million pancreatic islets (Islets of Langerhans)
produce hormones
– other 98% of pancreas cells produces digestive enzymes
• insulin secreted by B or beta () cells
– secreted during and after meal when glucose and amino acid
blood levels are rising
– stimulates cells to absorb these nutrients and store or
metabolize them lowering blood glucose levels
– insufficiency or inaction is cause of diabetes mellitus
Pancreatic Hormones
• glucagon – secreted by A or alpha () cells
– released between meals when blood glucose concentration is falling
– in liver, stimulates gluconeogenesis, glycogenolysis, and the release of glucose
into the circulation raising blood glucose level
• somatostatin secreted by D or delta () cells
– partially suppresses secretion of glucagon and insulin
– inhibits nutrient digestion and absorption which prolongs absorption of nutrients
• pancreatic polypeptide secreted by PP cells or F cells)
– inhibits gallbladder contraction and secretion pancreatic digestive enzymes
The Gonads
• ovaries and testes are both endocrine and exocrine
– exocrine product – whole cells - eggs and sperm (cytogenic
glands)
– endocrine product - gonadal hormones – mostly steroids
• ovarian hormones
– estradiol, progesterone, and inhibin
• testicular hormones
– testosterone, weaker androgens, estrogen and inhibin
Histology of Ovary and Testis
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Copyright © The McGraw-Hill Companies, Inc. Permission required for reproduction or display.
Blood vessels
Granulosa cells
(source of
estrogen)
Seminiferous
tubule
Germ cells
Egg nucleus
Connective tissue
wall of tubule
Egg
Sustentacular
cells
Interstitial cells
(source of
testosterone)
Theca
50 µm
Testis
100 µm
Ovary
(a)
(b)
© Manfred Kage/Peter Arnold, Inc.
© Ed Reschke
follicle - egg surrounded by granulosa cells and a
capsule (theca)
Endocrine Functions of Other Organs
• skin
– keratinocytes convert a cholesterol-like steroid into cholecalciferol
• liver – involved in the production of at least five hormones
– converts cholecalciferol into calcidiol
– secretes angiotensinogen (a prohormone)
– secretes 15% of erythropoietin
– hepcidin – promotes intestinal absorption of iron
– source of IGF-I
• kidneys – plays role in production of three hormones
– converts calcidiol to calcitriol, active form of vitamin D
• increases Ca2+ absorption by intestine and inhibits loss in the urine
– secrete renin that converts angiotensinogen to angiotensin I
• angiotensin II created by converting enzyme in lungs
– constricts blood vessels and raises blood pressure
– produces 85% of erythropoietin
Endocrine Functions of Other Organs
• heart
– cardiac muscle secretes ANP and BNP in response to an increase in blood
pressure
– decreases blood volume and pressure – opposes action of angiotensin II
• stomach and small intestine secrete at least ten enteric hormones
secreted by enteroendocrine cells
– coordinate digestive motility and glandular secretion
– cholecystokinin, gastrin, Ghrelin, and peptide YY
• adipose tissue secretes leptin
– slows appetite
• placenta
– secretes estrogen, progesterone and others
• regulate pregnancy, stimulate development of fetus and mammary glands
Endocrine Disorders
• Gigantism, Acromegaly, Pituitary dwarfism
• Congenital hypothyroidism, myxedema
• Cushing syndrome
• Diabetes mellitus