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Molecular Biology/Genetics of Prokaryotes
MCB 3612 and MCB 5621
Lecture: Tues. & Thurs., 8:00 - 9:15, Atwater A001
Discussion section Wednesday, 3-5, TLS 301
Daniel Gage
Office: BSP 406
Phone: 486-3092
email: [email protected]
Office hours by appointment
Textbooks
The lac Operon: Benno Muller-Hill (must buy)
Genetics and Molecular Biology: Robert Schlief (pdf provided)
Textbooks at NIH Entrez (see resources at class web site)
Course Grades
•Three exams including the final exam + three small projects
•Problems from problems sets will make up a large portion of
each test--therefore DO THE PROBLEMS! Because problems will
show up on the exams, I will not be providing answers, but you
are welcome to work together, use your text, internet, etc, for
help with the problems
•The assignment of a letter grade will be based on your total
score relative to your student peer group (grad or undergrad).
•Both graduate and undergraduate students will have extra
problems on exams, or due outside of class.
Typical diagrams for learning molecular biology
gal operon of E. coli
trp operon of E. coli
Building a knowledge base
Fact or
concept
Connection
Overview of the course
Goal: Learn how to use genetics to understand the
functioning of bacteria
We will be using work done on the Lac system of E. coli as a
way to learn genetics and molecular biology.
•Many genetic and molecular biology techniques were
invented to work on the E. coli lac system and gave rise to
much of modern molecular biology.
•The lac operon, and related genetic systems, are being used
to investigate current issues in genetics
•We will be looking at old and new work on lac to understand
prokaryotic genetics and molecular biology
Examples of topics in 2nd part of course