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Sex-linked Genetic Disorders & Autosomal Disorders Packet #20 Chapter #7 2 Introduction Sex Linked Genetic Disorders Disorders caused by malfunctioning genes on the sex chromosome. Autosomal Genetic Disorders Disorders caused by malfunctioning genes on an autosome. Tuesday, May 23, 2017 Sex-Linked Disorders 4 Hemophilia Hemophilia is an x-linked recessive disorder Males will show this trait if they have the recessive allele on the X chromosome Females will show this trait if they have the recessive allele on both X chromosomes Hemophilia does not allow individuals to have the ability to clot their blood. Tuesday, May 23, 2017 5 Baldness Baldness is an x-linked dominant disorder XBXb This female will not go bald due to lack of testosterone XBXB This individual will start to lose her hair in the future Tuesday, May 23, 2017 Autosomal Disorders 7 Huntington Disease Produced by a single dominant allele No symptoms appear until 30’s and 40’s Symptoms Uncontrollable body movements Degeneration of the nervous system Usually fatal 10-20 years after onset of symptoms Tuesday, May 23, 2017 8 Sickle Cell Anemia Caused by a change in polypeptides found in hemoglobin Hemoglobin is the protein that carries oxygen in red blood cells Caused ONLY by co-dominance The recessive allele causes the change in the polypeptide chain People that are heterozygous for sickle cell anemia are partially resistant to malaria Malaria Caused by the Protist Plasmodium falciparum Carried by mosquitoes Tuesday, May 23, 2017 9 Sickle Cell Anemia Symptoms Fatigue (feeling tired) Palness Jaundice (Yellowing of the skin and eyes) Shortness of breath Tuesday, May 23, 2017 Review Review Genetic Disorders Malfunctioning Genes Sex Linked Disorders Autosomal Disorders Hemophilia Huntington Disease Baldness Sickle Cell Anemia