Download Evolution, dispersal of genetics and Fisher’s equation

Survey
yes no Was this document useful for you?
   Thank you for your participation!

* Your assessment is very important for improving the workof artificial intelligence, which forms the content of this project

Document related concepts

Genome (book) wikipedia , lookup

Inbreeding wikipedia , lookup

Hybrid (biology) wikipedia , lookup

Artificial gene synthesis wikipedia , lookup

Behavioural genetics wikipedia , lookup

Twin study wikipedia , lookup

Polymorphism (biology) wikipedia , lookup

Transgenerational epigenetic inheritance wikipedia , lookup

Dual inheritance theory wikipedia , lookup

History of genetic engineering wikipedia , lookup

Gene expression programming wikipedia , lookup

Gene wikipedia , lookup

Genetically modified crops wikipedia , lookup

Pharmacogenomics wikipedia , lookup

Epistasis wikipedia , lookup

Koinophilia wikipedia , lookup

Genetic drift wikipedia , lookup

Designer baby wikipedia , lookup

Population genetics wikipedia , lookup

Hardy–Weinberg principle wikipedia , lookup

Microevolution wikipedia , lookup

Quantitative trait locus wikipedia , lookup

Dominance (genetics) wikipedia , lookup

Transcript
Evolution, dispersal of
genetics and Fisher’s equation
Charles Darwin (1809-1882)
•Many individuals of s species are destined to
die before reaching reproduction age.
•Advantageous gene tends to be persevered,
thus change the characteristics of the species
•Evolution by natural selection (slight
modifications are passed on through
generations)
•But how does it work?
Gregor Mendel (1822-1884)
•Study of the inheritance of traits in pea plants.
Over a period of 7 years he bred and counted
about 28,000 pea plants.
•Traits are passed through generations unchanged,
a child can inherit the trait from either its mother
or its father
•The trait is determined by two factors, one
inherited from each parent, and it comes with
probability from either parent
•For pairs of contrasting traits, one of the two is
dominant and always overrules the other
(recessive) factor
Trait - a variant for a character
Character - a heritable feature
Factor – Mendel’s factor is gene today
Experiments on Plant Hybridization, Gregor Mendel
(1865, Proceedings of the Natural History Society)
http://www.mendelweb.org/Mendel.html (original paper)
Mendel compared seven discrete traits:
• Smoothness of the seeds.
• Color of the seeds.
• Color of the seed coats.
• Shape of the pods.
• Color of unripe pods.
• Position of flowers.
• Length of the stems.
Through experimentation, Mendel discovered that one inheritable trait would
invariably be dominant to its recessive alternative. This model, later known
as Mendelian inheritance or Mendelian genetics, provided an alternative to
blending inheritance, which was the prevailing theory at the time.
Unfortunately, Mendel's work received little attention from the scientific
community and was largely forgotten. It was not until the early 20th
century that Mendel's work was rediscovered and his ideas used to help
form the modern synthesis.
Plant material Mendel used: sweet pea
Examples of Mendel traits
Difference in the
form of the ripe
seeds
Round (R) and
wrinkled (r)
cotyledons
Difference in the
color of the seed
coat
Colored (A)
and white (a)
flowers
Difference in the
color of the seed
albumen
Yellow (I) and
green (i)
cotyledons
Difference in the
color of the unripe
pods
Green (Gp) or
yellow (gp) pod
wall
Genetic Terms
• Phenotype - the outward, physical appearance of a particular trait
round or wrinkled seed phenotype; yellow or green seed phenotype)
(Pea:
• Genotype - genetic make-up of a particular trait, the specific allelic
combination of a certain gene (AA, BB, or AB)
• Allele - one alternative form of a given allelic pair (A or B)
• Homozygote - an individual which contains only one allele at the allelic
•
•
•
pair (AA or BB)
Heterozygote - an individual which contains one of each member of the
gene pair (AB)
Dominant - the allele that expresses itself at the expense of an alternate
allele; the phenotype that is expressed in the F1 generation from the cross
of two pure lines
Recessive - an allele whose expression is suppressed in the presence of a
dominant allele; the phenotype that disappears in the F1 generation from
the cross of two pure lines and reappears in the F2 generation
More general, the probabilities
(frequencies) of allele A or a in a
population can be p and q, where
p+q=1. Then the probability of each
genotype in F2 is
AA: p^2 Aa: 2pq aa: q^2
Hardy-Weinberg’s law: the frequency
remain the same for each genotype
1
pn 1  pn  2 pn qn  p n
2
1
2
qn 1  qn  2 pn qn  qn
2
2
(The equation at page 120 of Britton’s
book is wrong.)
Assumptions in Hardy-Weinberg’s Law
•
•
•
•
•
Expected sex ratio is independent of genotype
Mating is random
Fertility is independent of genotype
Survivorship is independent of genotype
There is no mutation or migration
Different survival rate or fertility rate for the two genotypes could
break Hardy-Weinberg’s law
Evolution of genes under selection:
Fisher-Haldane-Wright equation
Some special cases
Evolution to advantageous gene:
numerical solutions by Matlab
(upper): dominant and advantageous, left: s=0.002, right: s=0.2
(lower): dominant and recessive, left: s=0.002, right: s=0.2
Finally, Fisher’s equation with diffusion !
Traveling wave of Fisher’s equation