Download Marcia Brown-Palmer APPLICATIONS OF STATISTICS AND STOCHASTIC PROCESSES IN CANCER

Department of Mathematics
Prairie View A&M University, Prairie View, TX
COLLOQUIUM
Marcia Brown-Palmer
Department of Mathematics
Prairie View A&M University
Presents
APPLICATIONS OF STATISTICS AND
STOCHASTIC PROCESSES IN CANCER
RESEARCH
Mentor: Dr. A.M. Haghighi
When: Friday, Dec 06, 2013
Time: 3.30 pm
Where: W.R. Banks Building -309
Abstract
In this study, data from the experimental treatment of the ovarian cancer cell line, SKOV-3 cells were
examined. The effects of Chitosan and Docosahexaenoic acid (DHA) on the expression and transcription
activities of two proteins – Osteopontin (OPN) and Nuclear Factor – kappa B (NF-kB); biomarkers of
ovarian cancer - were recorded. The data was analyzed using statistical tools and other mathematical
processes to measure the reactions of OPN and NF-kB to treatment in a dose dependent manner.
The results indicate that, for both NF-kB and OPN proteins, the treatments impacted the cell with a fast
initial response. The analysis show that as time increases changes in these protein levels were due less to
treatment. The Nuclear Factor – kappa B (NF-kB) responded negatively to the treatment - instead of
reduction in the levels of that specific protein, there was an increase in the transcription activity. Conversely,
Osteopontin secretion increased with treatments of both Chitosan and DHA with the highest secretion levels
after 48 hours period. Empirically, it appears that the increased secretion caused a decrease in the expression
on this protein within the cell.
Questions: contact Dr. Natali Hritonenko [email protected]