Download B antigens A - Cloudfront.net

Components of Blood
• Whole blood
– RBCs
– WBCs
– Platelets: cell fragments that aid in clotting
• Plasma
– 90% water (allows materials to dissolve)
– Amino acids, glucose, hormones, vitamins, salts, waste
– Concentrations allows diffusion in/out of blood stream
Click picture to play
Red Blood Cells
•
•
•
•
•
Produced from stem cells in bone marrow
Lose nucleus as they mature
Transport O2 to cells; remove CO2
O2 binds to hemoglobin proteins
Dead cells filtered by liver & spleen
Sickle Cell
Normal
ABO Blood Groups
• Proteins on blood cells determine blood type
• Antigen
– proteins on cells that identify cells as foreign or natural
– on the surface of RBCs
• Antibodies:
– proteins from WBCs to attack invaders
– in the blood plasma
Group A blood
• A antigens on the
surface of your RBCs
• B antibodies in your
blood plasma
Group B blood
• B antigens on the
surface of your RBCs
• A antibodies in your
blood plasma
Group AB blood
• A and B antigens on the
surface of your RBCs
• no A or B antibodies at
all in your blood plasma
Group O blood
• No A or B antigens on
the surface of your
RBCs
• both A and B antibodies
in your blood plasma
Rh Factors
• Rh+
– Protein found in
blood
– Can receive Rh+ or
Rh- blood
• Rh– Lack protein in
blood
– Only receive Rhblood
Francis was just in a bad accident and lost a lot of blood.
He is blood type B+. Can you help save him?
Blood type B+
Antigens: Which does
he have?
A
B
Rh
Antibodies: Which does
he have?
A
B
Rh
B+
This person has B+ blood
type because of the B and
Rh antigens
B
antigens
Rh
antigens
Can he accept B+ blood?
Yes. The A antibodies do not have A antigens
to attack. Therefore, no attacking and
clumping of blood cells will occur.
Vein
B+
B
antigens
Rh
antigens
B+
B
antigens
Rh
antigens
A
antibody
B+
A
antibody
A
antibody
B
antigens
Rh
antigens
This person has B+ blood
type because of the B and
Rh antigens
BB
antigens
Can he accept B- blood?
Yes. The A antibodies do not have A antigens
to attack. Therefore, no attacking and
clumping of blood cells will occur.
Vein
B+
B
antigens
Rh
antigens
B+
B
antigens
Rh
antigens
A
antibody
B+
A
antibody
A
antibody
B
antigens
Rh
antigens
A+
This person has B+ blood
type because of the B and
Rh antigens
A
antigens
Rh
antigens
Can he accept A+ blood?
No. The A antibodies will attack the A
antigens. This will cause the blood cells to
clump, thus stopping blood flow. This person
may die.
Vein
B+
B
antigens
Rh
antigens
B+
B
antigens
Rh
antigens
A
antibody
B+
A
antibody
A
antibody
B
antigens
Rh
antigens
This person has B+ blood
type because of the B and
Rh antigens
AA
antigens
Can he accept A- blood?
No. The A antibodies will attack the A
antigens. This will cause the blood cells to
clump, thus stopping blood flow. This person
may die.
Vein
B+
B
antigens
Rh
antigens
B+
B
antigens
Rh
antigens
A
antibody
B+
A
antibody
A
antibody
B
antigens
Rh
antigens
AB+
This person has B+ blood
type because of the B and
Rh antigens
A
antigens
B
antigens
Rh
antigens
Can he accept AB+ blood?
No. The A antibodies will attack the A
antigens. This will cause the blood cells to
clump, thus stopping blood flow. This person
may die.
Vein
B+
B
antigens
Rh
antigens
B+
B
antigens
Rh
antigens
A
antibody
B+
A
antibody
A
antibody
B
antigens
Rh
antigens
AB-
This person has B+ blood
type because of the B and
Rh antigens
A
antigens
B
antigens
Can he accept AB- blood?
No. The A antibodies will attack the A
antigens. This will cause the blood cells to
clump, thus stopping blood flow. This person
may die.
Vein
B+
B
antigens
Rh
antigens
B+
B
antigens
Rh
antigens
A
antibody
B+
A
antibody
A
antibody
B
antigens
Rh
antigens
This person has B+ blood
type because of the B and
Rh antigens
O+
Rh
antigens
antigens
Can he accept O+ blood?
Yes. The A antibodies do not have A antigens
to attack. Therefore, no attacking and
clumping of blood cells will occur.
Vein
B+
B
antigens
Rh
antigens
B+
B
antigens
Rh
antigens
A
antibody
B+
A
antibody
A
antibody
B
antigens
Rh
antigens
This person has B+ blood
type because of the B and
Rh antigens
ONo
antigens
antigens
Can he accept O- blood?
Yes. The A antibodies do not have A antigens
to attack. Therefore, no attacking and
clumping of blood cells will occur.
Vein
B+
B
antigens
Rh
antigens
B+
B
antigens
Rh
antigens
A
antibody
B+
A
antibody
A
antibody
B
antigens
Rh
antigens
Sebastian was just involved in an accident at work and
lost a lot of blood. He is blood type A-. Can you help
save him?
Blood type AAntigens: Which does
he have?
A
B
Rh
Antibodies: Which does
he have?
A
B
Rh
This person has A- blood
type because of the A
antigen
A-AAA A
antigens
A
antigens
antigens
Can he accept A- blood?
Yes. The B and Rh antibodies do not have
antigens to attack. Therefore, no attacking
and clumping of blood cells will occur.
A-
Rh
antibody
A
antigens
A-
AA
antigens
B
antibody
B
antibody
A
antigens
Rh
antibody
This person has A- blood
type because of the A
antigen
A+
A+
A antigens
A antigens
A+
Rh
ARh
antigens
antigens
antigens
Rh
antigens
Can he accept A+ blood?
No. The Rh antibodies will attack the Rh antigens.
This will cause the blood cells to clump, thus stopping
blood flow. This person may die.
A-
Rh
antibody
A
antigens
A-
AA
antigens
B
antibody
B
antibody
A
antigens
Rh
antibody
This person has A- blood
type because of the A
antigen
B-BBBB
antigens
antigens
B
antigens
Can he accept B- blood?
No. The B antibodies will attack the B antigens. This
will cause the blood cells to clump, thus stopping
blood flow. This person may die.
A-
Rh
antibody
A
antigens
A-
AA
antigens
B
antibody
B
antibody
A
antigens
Rh
antibody
This person has A- blood
type because of the A
antigen
B+
B+
B+
B antigens
B antigens
BRh
antigens
Rh
Rh
antigens
antigens
antigens
Can he accept B+ blood?
No. Both B and Rh antibodies will attack the B and Rh
antigens. This will cause the blood cells to clump, thus
stopping blood flow. This person may die.
A-
Rh
antibody
A
antigens
A-
AA
antigens
B
antibody
B
antibody
A
antigens
Rh
antibody
This person has A- blood
type because of the A
antigen
ABABA antigens
AABantigens
BAantigen
Bantigens
antigen
B antigen
Can he accept AB- blood?
No. The B antibodies will attack the B antigens. This
will cause the blood cells to clump, thus stopping
blood flow. This person may die.
A-
Rh
antibody
A
antigens
A-
AA
antigens
B
antibody
B
antibody
A
antigens
Rh
antibody
This person has A- blood
type because of the A
antigen
AB+
AB+
AB+
A antigens
A antigens
A antigens
B antigens
B
antigens
B Rh
antigens
Rh
Rh
antigens
antigens
antigens
Can he accept AB+ blood?
No. Both B and Rh antibodies will attack the B and Rh
antigens. This will cause the blood cells to clump, thus
stopping blood flow. This person may die.
AA
antigens
Rh
antibody
A-
AA
antigens
B
antibody
B
antibody
A
antigens
Rh
antibody
This person has A- blood
type because of the A
antigen
O-ONoONo
antigens
antigens
No
antigens
Can he accept O- blood?
Yes. The antibodies do not have antigens to
attack. Therefore, no attacking and clumping of
blood cells will occur.
AA
antigens
Rh
antibody
A-
AA
antigens
B
antibody
B
antibody
A
antigens
Rh
antibody
This person has A- blood
type because of the A
antigen
O+
O+
Rh
Rh
O+
antigens
antigens
Rh
antigens
Can he accept O+ blood?
No. Rh antibodies would attack the Rh
antigens and cause clumping.
AA
antigens
Rh
antibody
A-
AA
antigens
B
antibody
B
antibody
A
antigens
Rh
antibody
Blood type AB+
Antigens: Which does
they have?
A
B
Rh
Antibodies: Which does
they have?
A
B
Rh
Blood type O+
Antigens: Which does
they have?
A
B
Rh
Antibodies: Which does
they have?
A
B
Rh
Blood type ABAntigens: Which does
they have?
A
B
Rh
Antibodies: Which does
they have?
A
B
Rh
Blood type B+
Antigens: Which does
they have?
A
B
Rh
Antibodies: Which does
they have?
A
B
Rh
Blood type OAntigens: Which does
they have?
A
B
Rh
Antibodies: Which does
they have?
A
B
Rh
White Blood
Cells
• Remove foreign
invaders & dead
cells
• Able to move
through body
tissue
Platelets
• Form clots when
bleeding
• Proteins form a web
to trap cells &
platelets